α-Tocopherol modulates liver toxicity of the pyrethroid cypermethrin

Lourdes Aldana, Victor Tsutsumi, Arthur Craigmill, Maria Isabel Silveira, Elvira Gonzalez De Mejia

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of the current study was to analyze the hepatotoxic effect caused by cypermethrin (CYP) in rats, and to evaluate the possible protective effect of the antioxidant α-tocopherol (α-T). Fifty male Wistar rats were given daily i.p. doses of 300 mg/kg per day of CYP during 7 days. Half of them were administered three previous doses of 100 mg/kg per day of α-T, followed by seven subsequent oral doses of 40 mg/kg per day of α-T. The levels of biochemical indicators and histological liver damage were determined, as well as DCVA in urine. CYP altered the lipid metabolism. Such alterations were inhibited 32% by α-T, except for LDL. Alterations in AST were modulated in 29%. In the histology, α-T reduced mitochondria damage, and swelling of the endoplasmic reticulum of the liver cells. The results suggest that α-T can modify CYP metabolism, changing the lipidic profile and the histological analysis.

Original languageEnglish (US)
Pages (from-to)107-116
Number of pages10
JournalToxicology Letters
Volume125
Issue number1-3
DOIs
StatePublished - Nov 30 2001
Externally publishedYes

Keywords

  • Cypermethrin
  • Pyrethroids
  • α-Tocopherol

ASJC Scopus subject areas

  • Toxicology

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