If you made any changes in Pure, your changes will be visible here soon.

Research Output 2003 2019

2019

Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance

Kulkoyluoglu-Cotul, E., Smith, B. P., Wrobel, K., Zhao, Y. C., Chen, K. L. A., Hieronymi, K., Imir, O. B., Duong, K., O’Callaghan, C., Mehta, A., Sahoo, S., Haley, B., Chang, H., Landesman, Y. & Madak-Erdogan, Z., Apr 4 2019, In : Cancers. 11, 4, 479.

Research output: Contribution to journalArticle

Open Access
Estrogen Receptor alpha
Autophagy
Tamoxifen
Metabolic Networks and Pathways
Neoplasms

Coronary Microvascular Dysfunction and Estrogen Receptor Signaling

Tunc, E., Eve, A. A. & Madak-Erdogan, Z., Jan 1 2019, (Accepted/In press) In : Trends in Endocrinology and Metabolism.

Research output: Contribution to journalReview article

Estrogen Receptors
Coronary Disease
Estrogens
Microvessels
Chest Pain

Crosstalk between Estrogen Signaling and Breast Cancer Metabolism

Kulkoyluoglu-Cotul, E., Arca, A. & Madak-Erdogan, Z., Jan 2019, In : Trends in Endocrinology and Metabolism. 30, 1, p. 25-38 14 p.

Research output: Contribution to journalReview article

Estrogens
Breast Neoplasms
Estrogen Receptors
Drug Resistance
Clone Cells

Free fatty acids rewire cancer metabolism in obesity-associated breast cancer via estrogen receptor and mTOR signaling

Madak-Erdogan, Z., Band, S., Zhao, Y. C., Smith, B. P., Kulkoyluoglu-Cotul, E., Zuo, Q., Casiano, A. S., Wrobel, K., Rossi, G., Smith, R. L., Kim, S. H., Katzenellenbogen, J. A., Johnson, M. L., Patel, M., Marino, N., Storniolo, A. M. V. & Flaws, J. A., Jan 1 2019, In : Cancer Research. 79, 10, p. 2494-2510 17 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Nonesterified Fatty Acids
Estrogen Receptors
Obesity
Breast Neoplasms
2018

Estrogens and female liver health

Chen, K. L. & Madak-Erdogan, Z., May 2018, In : Steroids. 133, p. 38-43 6 p.

Research output: Contribution to journalArticle

Liver
Estrogens
Microbiota
Health
Metabolome

Long-Term Administration of Conjugated Estrogen and Bazedoxifene Decreased Murine Fecal β-Glucuronidase Activity Without Impacting Overall Microbiome Community

Chen, K. L. A., Liu, X., Zhao, Y. C., Hieronymi, K., Rossi, G., Auvil, L. S., Welge, M., Bushell, C., Smith, R. L., Carlson, K. E., Kim, S. H., Katzenellenbogen, J. A., Miller, M. J. & Madak-Erdogan, Z., Dec 1 2018, In : Scientific reports. 8, 1, 8166.

Research output: Contribution to journalArticle

Conjugated (USP) Estrogens
Microbiota
Glucuronidase
Estrogens
Lactobacillaceae

Urban Neighborhood and Residential Factors Associated with Breast Cancer in African American Women: a Systematic Review

Smith, B. P. & Madak-Erdogan, Z., Apr 1 2018, In : Hormones and Cancer. 9, 2, p. 71-81 11 p.

Research output: Contribution to journalReview article

African Americans
Breast Neoplasms
Delayed Diagnosis
Mammography
Social Class
2017

Bazedoxifene and conjugated estrogen combination maintains metabolic homeostasis and benefits liver health

Chen, K. L. A., Zhao, Y. C., Hieronymi, K., Smith, B. P. & Madak-Erdogan, Z., Dec 2017, In : PloS one. 12, 12, Y.

Research output: Contribution to journalArticle

conjugated estrogens
Conjugated (USP) Estrogens
Insurance Benefits
Liver
homeostasis
Estrogen Receptor
Systems Biology
Molecular Biology
Genomics
Estrogen Receptors
2016

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

Madak-Erdogan, Z., Kim, S. H., Gong, P., Zhao, Y. C., Zhang, H., Chambliss, K. L., Carlson, K. E., Mayne, C. G., Shaul, P. W., Korach, K. S., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., May 24 2016, In : Science Signaling. 9, 429, ra53.

Research output: Contribution to journalArticle

Blood Vessels
Estrogens
Tissue
Ligands
Estrogen Receptors

Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland

Madak-Erdogan, Z., Gong, P., Zhao, Y. C., Xu, L., Wrobel, K. U., Hartman, J. A., Wang, M., Cam, A., Iwaniec, U. T., Turner, R. T., Twaddle, N. C., Doerge, D. R., Khan, I. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Helferich, W. G., Feb 1 2016, In : Molecular Nutrition and Food Research. 60, 2, p. 369-380 12 p.

Research output: Contribution to journalArticle

Glycyrrhiza
licorice
fatty liver
Human Mammary Glands
mammary glands
Selective Estrogen Receptor Modulators
Conjugated (USP) Estrogens
Cytoplasmic and Nuclear Receptors
Estrogens
Tissue

ERα-XPO1 cross talk controls tamoxifen sensitivity in tumors by altering ERK5 cellular localization

Wrobel, K., Zhao, Y. C., Kulkoyluoglu, E., Chen, K. L. A., Hieronymi, K., Holloway, J., Li, S., Ray, T., Ray, P. S., Landesman, Y., Lipka, A. E., Smith, R. L. & Madak-Erdogan, Z., Oct 2016, In : Molecular Endocrinology. 30, 10, p. 1029-1045 17 p.

Research output: Contribution to journalArticle

Receptor Cross-Talk
Tamoxifen
Estrogen Receptors
Cell Nucleus Active Transport
Neoplasms

Estrogen and Microbiota Crosstalk: Should We Pay Attention?

Chen, K. L. & Madak-Erdogan, Z., Nov 1 2016, In : Trends in Endocrinology and Metabolism. 27, 11, p. 752-755 4 p.

Research output: Contribution to journalShort survey

Microbiota
Estrogens
Obesity
Steroids
Hormones
Aryl Hydrocarbon Receptors
Estrogen Receptors
Estrogens
Gene expression
Crosstalk

Nonnuclear estrogen receptor activation improves hepatic steatosis in female mice

Chambliss, K. L., Barrera, J., Umetani, M., Umetani, J., Kim, S. H., Madak-Erdogan, Z., Huang, L., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C. & Shaul, P. W., Jan 1 2016, In : Endocrinology. 157, 10, p. 3731-3741 11 p.

Research output: Contribution to journalArticle

Dendrimers
Estrogen Receptors
Estrogens
Liver
Adiposity

Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer

Kulkoyluoglu, E. & Madak-Erdogan, Z., Jan 1 2016, In : Steroids. 114, p. 41-47 7 p.

Research output: Contribution to journalReview article

Estrogen Receptor alpha
Crosstalk
Estrogen Receptors
Breast Neoplasms
Estrogen Receptor beta

Science Signaling podcast for 24 May 2016: Designer estrogens

Katzenellenbogen, B. S., Katzenellenbogen, J. A., Madak-Erdogan, Z. & Van hook, A. M., May 24 2016, In : Science Signaling. 9, 429, pc13.

Research output: Contribution to journalReview article

Webcasts
Estrogens
Metabolism
Estradiol Congeners
Bone

Systems biology of metabolic regulation by estrogen receptor signaling in breast cancer

Zhao, Y. C. & Erdogan, Z. M., Mar 17 2016, In : Journal of Visualized Experiments. 2016, 109, e53832.

Research output: Contribution to journalArticle

Metabolomics
Systems Biology
Metabolism
Estrogen Receptors
Transcription factors
2015

Ligand accessibility and bioactivity of a hormone-dendrimer conjugate depend on pH and pH history

Kim, S. H., Madak-Erdogan, Z., Bae, S. C., Carlson, K. E., Mayne, C. G., Granick, S., Katzenellenbogen, B. S. & Katzenellenbogen, J. A., Aug 19 2015, In : Journal of the American Chemical Society. 137, 32, p. 10326-10335 10 p.

Research output: Contribution to journalArticle

Dendrimers
bioactivity
Hormones
Bioactivity
accessibility
2014
Actin Depolymerizing Factors
Estrogen Receptors
Actins
Breast Neoplasms
Hormones
Forkhead Transcription Factors
Neoplastic Stem Cells
Estrogen Receptors
Breast Neoplasms
Gene Regulatory Networks
Gene Regulatory Networks
Estrogen Receptors
Estrogens
Gene Expression
Glycyrrhiza
2013
Mitogen-Activated Protein Kinase 1
Estrogen Receptors
Breast Neoplasms
MicroRNAs
Neoplasms

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

Madak-Erdogan, Z., Charn, T. H., Jiang, Y., Liu, E. T., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Jan 1 2013, In : Molecular Systems Biology. 9, 201328.

Research output: Contribution to journalArticle

Estrogen Receptor
Transcription factors
Transcription Factor
Genomics
Estrogen Receptors

Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

Jiang, Y., Gong, P., Madak-Erdogan, Z., Martin, T. A., Jeyakumar, M., Carlson, K., Khan, I., Smillie, T. J., Chittiboyina, A. G., Rotte, S. C. K., Helferich, W. G., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Nov 1 2013, In : FASEB Journal. 27, 11, p. 4406-4418 13 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Gene expression
Chromatin
Equol
2012
Nuclear Receptor Co-Repressor 1
Aryl Hydrocarbon Receptors
Gene expression
Estrogen Receptors
Chromatin
Mitogen-Activated Protein Kinases
Estrogen Receptors
Macrophages
Breast Neoplasms
Tumor Microenvironment
2011
Mitogen-Activated Protein Kinase 1
Estrogen Receptors
Genes
Cytoplasmic and Nuclear Receptors
Mitogen-Activated Protein Kinases
2010

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

Chambliss, K. L., Wu, Q., Oltmann, S., Konaniah, E. S., Umetani, M., Korach, K. S., Thomas, G. D., Mineo, C., Yuhanna, I. S., Kim, S. H., Madak-Erdogan, Z., Maggi, A., Dineen, S. P., Roland, C. L., Hui, D. Y., Brekken, R. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shaul, P. W., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

Uterine Neoplasms
Dendrimers
Estrogen Receptors
Estrogens
Breast Neoplasms
2009

Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1

Stossi, F., Madak-Erdogan, Z. & Katzenellenbogen, B. S., Apr 1 2009, In : Molecular and cellular biology. 29, 7, p. 1749-1759 11 p.

Research output: Contribution to journalArticle

Genetic Transcription
Estrogen Receptor alpha
Estrogens
Genes
Binding Sites
2008

Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors

Madak-Erdogan, Z., Kieser, K. J., Sung, H. K., Komm, B., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Sep 1 2008, In : Molecular Endocrinology. 22, 9, p. 2116-2127 12 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Estrogen Receptors
Dendrimers
Estrogens
Genes
2006

Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action

Harrington, W. R., Kim, S. H., Funk, C. C., Madak-Erdogan, Z., Schiff, R., Katzenellenbogen, J. A. & Katzenellenbogen, B. S., Mar 1 2006, In : Molecular Endocrinology. 20, 3, p. 491-502 12 p.

Research output: Contribution to journalArticle

Dendrimers
Estrogens
Estradiol
Breast Neoplasms
Genes
2004

Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)- and TLR4-induced NF-κB activation

Equils, O., Shapiro, A., Madak, Z., Liu, C. & Lu, D., Oct 1 2004, In : Antimicrobial Agents and Chemotherapy. 48, 10, p. 3905-3911 7 p.

Research output: Contribution to journalArticle

Open Access
Toll-Like Receptor 2
Toll-Like Receptor 4
Protease Inhibitors
HIV-1
Luciferases

Rac1 and Toll-IL-1 receptor domain-containing adapter protein mediate Toll-like receptor 4 induction of HIV-long terminal repeat

Equils, O., Madak, Z., Liu, C., Michelsen, K. S., Bulut, Y. & Lu, D., Jun 15 2004, In : Journal of Immunology. 172, 12, p. 7642-7646 5 p.

Research output: Contribution to journalArticle

Open Access
HIV Long Terminal Repeat
Toll-Like Receptor 4
Interleukin-1 Receptors
HIV
Proteins
2003

Toll-like receptor 2 (TLR2) and TLR9 signaling results in HIV-long terminal repeat trans-activation and HIV replication in HIV-1 transgenic mouse spleen cells: Implications of simultaneous activation of TLRs on HIV replication

Equils, O., Schito, M. L., Karahashi, H., Madak, Z., Yarali, A., Michelsen, K. S., Sher, A. & Arditi, M., May 15 2003, In : Journal of Immunology. 170, 10, p. 5159-5164 6 p.

Research output: Contribution to journalArticle

Open Access
HIV Long Terminal Repeat
Toll-Like Receptor 2
Transgenic Mice
HIV-1
Spleen