Research Output 2006 2016

2016

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

Madak-Erdogan, Z., Kim, S. H., Gong, P., Zhao, Y. C., Zhang, H., Chambliss, K. L., Carlson, K. E., Mayne, C. G., Shaul, P. W., Korach, K. S., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. May 24 2016 In : Science Signaling. 9, 429, ra53

Research output: Contribution to journalArticle

Blood Vessels
Estrogens
Ligands
Estrogen Receptors
Adipose Tissue
Selective Estrogen Receptor Modulators
Conjugated (USP) Estrogens
Cytoplasmic and Nuclear Receptors
Estrogens
Genes

ERα-XPO1 cross talk controls tamoxifen sensitivity in tumors by altering ERK5 cellular localization

Wrobel, K., Zhao, Y. C., Kulkoyluoglu, E., Chen, K. L. A., Hieronymi, K., Holloway, J., Li, S., Ray, T., Ray, P. S., Landesman, Y., Lipka, A. E., Smith, R. L. & Madak-Erdogan, Z. Oct 1 2016 In : Molecular Endocrinology. 30, 10, p. 1029-1045 17 p.

Research output: Contribution to journalArticle

Tamoxifen
Neoplasms
Cell Nucleus Active Transport
Breast Neoplasms
Recurrence

Estrogen and Microbiota Crosstalk: Should We Pay Attention?

Chen, K. L. & Madak-Erdogan, Z. Nov 1 2016 In : Trends in Endocrinology and Metabolism. 27, 11, p. 752-755 4 p.

Research output: Contribution to journalShort survey

Microbiota
Estrogens
Obesity
Steroids
Hormones

Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells

Gong, P., Madak-Erdogan, Z., Flaws, J. A., Shapiro, D. J., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. Dec 5 2016 In : Molecular and Cellular Endocrinology. 437, p. 190-200 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Estrogen Receptor alpha
Estrogens
Chromatin
Gene Expression

Nonnuclear estrogen receptor activation improves hepatic steatosis in female mice

Chambliss, K. L., Barrera, J., Umetani, M., Umetani, J., Kim, S. H., Madak-Erdogan, Z., Huang, L., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Mineo, C. & Shaul, P. W. 2016 In : Endocrinology. 157, 10, p. 3731-3741 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Liver
Dendrimers
Adiposity

Nuclear and extranuclear-initiated estrogen receptor signaling crosstalk and endocrine resistance in breast cancer

Kulkoyluoglu, E. & Madak-Erdogan, Z. Oct 1 2016 In : Steroids. 114, p. 41-47 7 p.

Research output: Contribution to journalReview article

Estrogen Receptors
Breast Neoplasms
Estrogen Receptor beta
Estrogen Receptor alpha
Estrogens

Science Signaling podcast for 24 May 2016: Designer estrogens

Katzenellenbogen, B. S., Katzenellenbogen, J. A., Madak-Erdogan, Z. & Van hook, A. M. May 24 2016 In : Science Signaling. 9, 429, pc13

Research output: Contribution to journalReview article

Webcasts
Estrogens
Neoplasms
Estradiol Congeners
Hormone Replacement Therapy

Systems biology of metabolic regulation by estrogen receptor signaling in breast cancer

Zhao, Y. C. & Erdogan, Z. M. Mar 17 2016 In : Journal of Visualized Experiments. 2016, 109, e53832

Research output: Contribution to journalArticle

Metabolomics
Systems Biology
Estrogen Receptor alpha
Estrogen Receptors
Transcription Factors
2015

Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland

Madak-Erdogan, Z., Gong, P., Zhao, Y. C., Xu, L., Wrobel, K. U., Hartman, J. A., Wang, M., Cam, A., Iwaniec, U. T., Turner, R. T., Twaddle, N. C., Doerge, D. R., Khan, I. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Helferich, W. G. 2015 In : Molecular Nutrition and Food Research.

Research output: Contribution to journalArticle

Glycyrrhiza
Weight Gain
Diet
Lipids
Liver

Ligand accessibility and bioactivity of a hormone-dendrimer conjugate depend on pH and pH history

Kim, S. H., Madak-Erdogan, Z., Bae, S. C., Carlson, K. E., Mayne, C. G., Granick, S., Katzenellenbogen, B. S. & Katzenellenbogen, J. A. Aug 19 2015 In : Journal of the American Chemical Society. 137, 32, p. 10326-10335 10 p.

Research output: Contribution to journalArticle

Dendrimers
Estrogens
Hormones
Ligands
ligand
2014

Novel roles for ERK5 and cofilin as critical mediators linking ERα-driven transcription, actin reorganization, and invasiveness in breast cancer

Madak-Erdogan, Z., Ventrella, R., Petry, L. & Katzenellenbogen, B. S. 2014 In : Molecular Cancer Research. 12, 5, p. 714-727 14 p.

Research output: Contribution to journalArticle

Actins
Breast Neoplasms
Hormones
Cell Movement
Phosphotransferases

The forkhead transcription factor FOXM1 promotes endocrine resistance and invasiveness in estrogen receptor-positive breast cancer by expansion of stem-like cancer cells

Bergamaschi, A., Madak-Erdogan, Z., Kim, Y. J. I., Choi, Y. L., Lu, H. & Katzenellenbogen, B. S. 2014 In : Breast Cancer Research. 16, 5, p. 436 1 p.

Research output: Contribution to journalArticle

Forkhead Transcription Factors
Neoplastic Stem Cells
Estrogen Receptors
Breast Neoplasms
Neoplasms

Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens

Gong, P., Madak-Erdogan, Z., Li, J., Cheng, J., Greenlief, C. M., Helferich, W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. 2014 In : Nuclear receptor signaling. 12, p. e001

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Gene Regulatory Networks
Estrogens
Genes
Gene Expression
2013

A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor-α and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties

Kim, K., Madak-Erdogan, Z., Ventrella, R. & Katzenellenbogen, B. S. 2013 In : Hormones and Cancer. 4, 2, p. 78-91 14 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Mitogen-Activated Protein Kinase 1
Breast Neoplasms
Neoplasms
Proteins

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

Madak-Erdogan, Z., Charn, T. H., Jiang, Y., Liu, E. T., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. 2013 In : Molecular Systems Biology. 9, 201328

Research output: Contribution to journalArticle

Estrogen Receptor beta
Estrogen Receptor alpha
Genomics
Transcription Factors
Genes

Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

Jiang, Y., Gong, P., Madak-Erdogan, Z., Martin, T., Jeyakumar, M., Carlson, K., Khan, I., Smillie, T. J., Chittiboyina, A. G., Rotte, S. C. K., Helferich, W. G., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. Nov 2013 In : FASEB Journal. 27, 11, p. 4406-4418 13 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Estrogens
Chromatin
Breast Neoplasms
Equol
2012
Nuclear Receptor Co-Repressor 1
Aryl Hydrocarbon Receptors
Estrogen Receptor alpha
Chromatin
Genes

Macrophage-elicited loss of estrogen receptor-α in breast cancer cells via involvement of MAPK and c-Jun at the ESR1 genomic locus

Stossi, F., Madak-Erdoǧan, Z. & Katzenellenbogen, B. S. Apr 5 2012 In : Oncogene. 31, 14, p. 1825-1834 10 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Mitogen-Activated Protein Kinases
Macrophages
Breast Neoplasms
Neoplasms
2011

Genomic collaboration of estrogen receptor α and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs

Madak-Erdogan, Z., Lupien, M., Stossi, F., Brown, M. & Katzenellenbogen, B. S. Jan 2011 In : Molecular and Cellular Biology. 31, 1, p. 226-236 11 p.

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Mitogen-Activated Protein Kinase 1
Genes
Cytoplasmic and Nuclear Receptors
Mitogen-Activated Protein Kinases
2010

Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

Chambliss, K. L., Wu, Q., Oltmann, S., Konaniah, E. S., Umetani, M., Korach, K. S., Thomas, G. D., Mineo, C., Yuhanna, I. S., Kim, S. H., Madak-Erdogan, Z., Maggi, A., Dineen, S. P., Roland, C. L., Hui, D. Y., Brekken, R. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Shaul, P. W. Jul 1 2010 In : Journal of Clinical Investigation. 120, 7, p. 2319-2330 12 p.

Research output: Contribution to journalArticle

Uterine Neoplasms
Estrogen Receptor alpha
Estrogens
Breast Neoplasms
Dendrimers
2009

Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1

Stossi, F., Madak-Erdogan, Z. & Katzenellenbogen, B. S. Apr 2009 In : Molecular and Cellular Biology. 29, 7, p. 1749-1759 11 p.

Research output: Contribution to journalArticle

Genetic Transcription
Estrogen Receptor alpha
Genes
Estrogens
Binding Sites
2008

Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors

Madak-Erdogan, Z., Kieser, K. J., Sung, H. K., Komm, B., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. Sep 2008 In : Molecular Endocrinology. 22, 9, p. 2116-2127 12 p.

Research output: Contribution to journalArticle

Gene Expression Regulation
Estrogen Receptors
Estrogens
Dendrimers
Genes
2006

Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action

Harrington, W. R., Kim, S. H., Funk, C. C., Madak-Erdogan, Z., Schiff, R., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. Mar 2006 In : Molecular Endocrinology. 20, 3, p. 491-502 12 p.

Research output: Contribution to journalArticle

Dendrimers
Estrogens
Genes
Estradiol
Breast Neoplasms