Zaida Ann Luthey-Schulten

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Personal profile

Personal profile

Professor Schulten received a B.S. in Chemistry from the University of Southern California in 1969, a M.S. in Chemistry from Harvard University in 1972, and a Ph.D. in Applied Mathematics from Harvard University in 1975. From 1975 to 1980 she was a Research Fellow at the Max-Planck Institute for Biophysical Chemistry in Goettingen, and from 1980 to 1985 a Research Fellow in the Department of Theoretical Physics at the Technical University of Munich.

Research Interests

Determining the rules of life for a minimal bacteria cell

GPU-based simulations of stochastic/deterministic processes in bacterial and eukaryal cells at biologically relevant length, time, and concentration scales

computational studies of biomolecular energy landscapes to explore the evolution of structure, folding and function; statistical methods of protein folding - thermodynamics and kinetics; design of optimized energy functions for protein structure prediction; structural genomics of metabolic pathways.

Professional Information

Research: From Molecules to Cells - Whole Cell Simulations of Bacterial and Eukaryal Organisms, Rules of Life for a Minimal Cell,  Energy Landscapes of Biological Molecules, Exploring the Evolution of Structure, Function & Folding

Lattice Microbes software for simulating hybrid stochastic-deterministic  dynamics of cellular processes

Essential networks of a minimal cell

Origins of life, Evolution of translation, Physical bioinformatics

VMD/Multiple Alignment: Evolutionary Analysis Tool

Prediction of protein structure and function with QR profiles

Docking with steered molecular dynamics (SMD)

Protein folding: hybrid molecular dynamics

Honors & Awards

Murchison-Mallory Professor of Chemistry 2019
Fellow, Biophysical Society 2019
Fellow, Advanced Studies Institute, LMU Munich 2014
Fellow, American Physical Society, 2000
Fellow, Advanced Studies Institute, Hebrew University, Israel, 1998

Office Address

Department of Chemistry
University of Illinois
A544 CLSL, Box 19-6
600 South Mathews Avenue
Urbana, IL 61801

Office Phone

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Research Output

An in-silico human cell model reveals the influence of spatial organization on RNA splicing

Ghaemi, Z., Peterson, J. R., Gruebele, M. & Luthey-Schulten, Z., Mar 25 2020, In : PLoS computational biology. 16, 3, e1007717.

Research output: Contribution to journalArticle

Open Access
  • Complete structure of the chemosensory array core signalling unit in an E. coli minicell strain

    Burt, A., Cassidy, C. K., Ames, P., Bacia-Verloop, M., Baulard, M., Huard, K., Luthey-Schulten, Z., Desfosses, A., Stansfeld, P. J., Margolin, W., Parkinson, J. S. & Gutsche, I., Dec 1 2020, In : Nature communications. 11, 1, 743.

    Research output: Contribution to journalArticle

    Open Access
  • Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations

    Cassidy, C. K., Himes, B. A., Sun, D., Ma, J., Zhao, G., Parkinson, J. S., Stansfeld, P. J., Luthey-Schulten, Z. & Zhang, P., Dec 1 2020, In : Communications biology. 3, 1, 24.

    Research output: Contribution to journalArticle

    Open Access
  • Atoms to Phenotypes: Molecular Design Principles of Cellular Energy Metabolism

    Singharoy, A., Maffeo, C., Delgado-Magnero, K. H., Swainsbury, D. J. K., Sener, M., Kleinekathöfer, U., Vant, J. W., Nguyen, J., Hitchcock, A., Isralewitz, B., Teo, I., Chandler, D. E., Stone, J. E., Phillips, J. C., Pogorelov, T. V., Mallus, M. I., Chipot, C., Luthey-Schulten, Z., Tieleman, D. P., Hunter, C. N. & 3 others, Tajkhorshid, E., Aksimentiev, A. & Schulten, K., Nov 14 2019, In : Cell. 179, 5, p. 1098-1111.e23

    Research output: Contribution to journalArticle

  • Direction Matters: Monovalent Streptavidin/Biotin Complex under Load

    Sedlak, S. M., Schendel, L. C., Melo, M. C. R., Pippig, D. A., Luthey-Schulten, Z., Gaub, H. E. & Bernardi, R. C., Jun 12 2019, In : Nano letters. 19, 6, p. 3415-3421 7 p.

    Research output: Contribution to journalArticle