Yuan-Xiang Pan

19972019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1997 2019

Filter
Article
2019

Choline supply during negative nutrient balance alters hepatic cystathionine β-synthase, intermediates of the methionine cycle and transsulfuration pathway, and liver function in Holstein cows

Coleman, D. N., Alharthi, A., Lopreiato, V., Trevisi, E., Miura, M., Pan, Y. X. & Loor, J. J., Sep 2019, In : Journal of Dairy Science. 102, 9, p. 8319-8331 13 p.

Research output: Contribution to journalArticle

Cystathionine
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
cystathionine
nutrient balance
liver function

Effects of obesity and exercise on colon cancer induction and hematopoiesis in mice

Emmons, R., Xu, G., Hernández-Saavedra, D., Kriska, A., Pan, Y-X., Chen, H. & De Lisio, M., Feb 1 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 2, p. E210-E220

Research output: Contribution to journalArticle

Hematopoiesis
Colonic Neoplasms
Colorectal Neoplasms
Obesity
High Fat Diet

Epigenetic regulation of carnitine palmitoyltransferase 1 (Cpt1a) by high fat diet

Moody, L., Xu, G. B., Chen, H. & Pan, Y-X., Feb 2019, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1862, 2, p. 141-152 12 p.

Research output: Contribution to journalArticle

Carnitine O-Palmitoyltransferase
High Fat Diet
Nutrition
Epigenomics
Fats

Hepatic 1-carbon metabolism enzyme activity, intermediate metabolites, and growth in neonatal Holstein dairy calves are altered by maternal supply of methionine during late pregnancy

Alharthi, A. S., Coleman, D. N., Liang, Y., Batistel, F., Elolimy, A. A., Yambao, R. C., Abdel-Hamied, E., Pan, Y-X., Parys, C., Alhidary, I. A., Abdelrahman, M. M. & Loor, J. J., Nov 2019, In : Journal of Dairy Science. 102, 11, p. 10291-10303 13 p.

Research output: Contribution to journalArticle

dairy calves
Methionine
methionine
Holstein
Carbon
Betaine-Homocysteine S-Methyltransferase
betaine-homocysteine S-methyltransferase
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
methionine synthase
choline
Open Access
diets
methylation
fats
High Fat Diet
DNA Methylation

Maternal Low-Fat Diet Programs the Hepatic Epigenome despite Exposure to an Obesogenic Postnatal Diet

Moody, L., Shao, J., Chen, H. & Pan, Y-X., Sep 3 2019, In : Nutrients. 11, 9, 2075.

Research output: Contribution to journalArticle

Open Access
Fat-Restricted Diet
low fat diet
DNA Methylation
Mothers
DNA methylation

Methionine Supply during Late-Gestation Triggers Offspring Sex-Specific Divergent Changes in Metabolic and Epigenetic Signatures in Bovine Placenta

Batistel, F., Alharthi, A. S., Yambao, R. R. C., Elolimy, A. A., Pan, Y. X., Parys, C. & Loor, J. J., Jan 1 2019, In : Journal of Nutrition. 149, 1, p. 6-17 12 p.

Research output: Contribution to journalArticle

Epigenomics
Methionine
Placenta
Pregnancy
Diet

Perinatal High-Fat Diet and Bisphenol A: Effects on Behavior and Gene Expression in the Medial Prefrontal Cortex

Wise, L. M., Hernández-Saavedra, D., Boas, S. M., Pan, Y-X. & Juraska, J. M., Sep 1 2019, In : Developmental Neuroscience. 41, 1-2, p. 1-16 16 p.

Research output: Contribution to journalArticle

High Fat Diet
Prefrontal Cortex
Gene Expression
bisphenol A
Fats

Perinatal phthalate and high-fat diet exposure induce sex-specific changes in adipocyte size and DNA methylation

Moody, L., Kougias, D., Jung, P. M., Digan, I., Hong, A., Gorski, A., Chen, H., Juraska, J. M. & Pan, Y-X., Mar 2019, In : Journal of Nutritional Biochemistry. 65, p. 15-25 11 p.

Research output: Contribution to journalArticle

High Fat Diet
DNA Methylation
Nutrition
Adipocytes
Fats
2018

Effects of perinatal exposure to phthalates and a high-fat diet on maternal behavior and pup development and social play

Kougias, D. G., Cortes, L. R., Moody, L., Rhoads, S., Pan, Y-X. & Juraska, J. M., Feb 2018, In : Endocrinology. 159, 2, p. 1088-1105 18 p.

Research output: Contribution to journalArticle

Maternal Behavior
High Fat Diet
Prefrontal Cortex
Oxidative Stress
Body Weight

High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

Zhang, X., Xu, G. B., Zhou, D. & Pan, Y-X., Mar 14 2018, In : Genes and Nutrition. 13, 1, 6.

Research output: Contribution to journalArticle

p16 Genes
Cell Aging
High Fat Diet
Chromatin
Fats
2017

Epigenetic regulation of centromere chromatin stability by dietary and environmental factors

Hernández-Saavedra, D., Strakovsky, R. S., Ostrosky-Wegman, P. & Pan, Y-X., Nov 1 2017, In : Advances in Nutrition. 8, 6, p. 889-904 16 p.

Research output: Contribution to journalArticle

Centromere
centromeres
Nutritional Status
Epigenomics
epigenetics
TOR Serine-Threonine Kinases
Birth Weight
Methionine
Placenta
Sirolimus

Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a maternal high-fat diet

Moody, L., Chen, H. & Pan, Y-X., Nov 2017, In : Epigenomics. 9, 11, p. 1387-1402 16 p.

Research output: Contribution to journalArticle

High Fat Diet
DNA Methylation
Metabolic Networks and Pathways
Mothers
Diet
2016

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Su, H., Zhou, D., Pan, Y-X., Wang, X. & Nakamura, M. T., Jan 1 2016, In : Journal of Lipid Research. 57, 11, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Fatty Acid Desaturases
Omega-3 Fatty Acids
Nutrition
Arachidonic Acid
Gene expression

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y-X., Helferich, W. G. & Flaws, J. A., Feb 15 2016, In : Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Contribution to journalArticle

Genistein
Growth
Phytoestrogens
Cell Cycle
Cells
2015
High Fat Diet
Nutrition
Gene expression
Fats
Parturition

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

Zhou, D., Wang, H., Cui, H., Chen, H. & Pan, Y-X., May 1 2015, In : Journal of Nutritional Biochemistry. 26, 5, p. 433-440 8 p.

Research output: Contribution to journalArticle

High Fat Diet
Nutrition
Histones
Rats
Histone Code

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

Zhang, Y., Wang, H., Zhou, D., Moody, L., Lezmi, S., Chen, H. & Pan, Y-X., Oct 1 2015, In : Physiological genomics. 47, 10, p. 514-523 10 p.

Research output: Contribution to journalArticle

High Fat Diet
Epigenomics
DNA Methylation
Liver
Genes
Activating Transcription Factor 4
Autophagy
Skeletal Muscle
Mothers
Amino Acids
Adipogenesis
Glucose Intolerance
Dietary Fats
Rats
Glucose

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

Liu, Y., Hilakivi-Clarke, L., Zhang, Y., Wang, X., Pan, Y. X., Xuan, J., Fleck, S. C., Doerge, D. R. & Helferich, W. G., Aug 1 2015, In : Molecular Nutrition and Food Research. 59, 8, p. 1419-1430 12 p.

Research output: Contribution to journalArticle

Isoflavones
soy flour
Flour
isoflavones
Nude Mice
2014

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Strakovsky, R. S., Lezmi, S., Flaws, J. A., Schantz, S. L., Pan, Y-X. & Helferich, W. G., Mar 1 2014, In : Toxicological Sciences. 138, 1, p. 161-174 14 p., kft331.

Research output: Contribution to journalArticle

Genistein
Rats
Obesity
Fats
CCAAT-Enhancer-Binding Protein-alpha

The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y-X., Feb 1 2014, In : Journal of Nutritional Biochemistry. 25, 2, p. 170-176 7 p.

Research output: Contribution to journalArticle

Histone Code
High Fat Diet
Nutrition
Histones
Rats
2012

A decrease in DKK1, a WNT inhibitor, contributes to placental lipid accumulation in an obesity-prone rat model

Strakovsky, R. S. & Pan, Y-X., Mar 1 2012, In : Biology of reproduction. 86, 3, 81.

Research output: Contribution to journalArticle

Obesity
Lipids
Placenta
Messenger RNA
Mothers

A gestational low-protein diet represses p21WAF1/Cip1 expression in the mammary gland of offspring rats through promoter histone modifications

Zheng, S., Rollet, M., Yang, K. & Pan, Y-X., Sep 28 2012, In : British Journal of Nutrition. 108, 6, p. 998-1007 10 p.

Research output: Contribution to journalArticle

Histone Code
Protein-Restricted Diet
Human Mammary Glands
Histones
Acetylation
Histone Code
Cell Aging
Obesity
Diet
Liver
p16 Genes
High Fat Diet
Human Mammary Glands
Fats
Histones
Histone Code
Facilitative Glucose Transport Proteins
Genetic Promoter Regions
Histones
Muscle

The skeletal muscle wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model

Zhou, D., Strakovsky, R. S., Zhang, X. & Pan, Y-X., Aug 1 2012, In : Obesity. 20, 8, p. 1577-1584 8 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Muscle Development
Insulin Resistance
Skeletal Muscle
Obesity
2011

A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats

Zhang, X., Strakovsky, R., Zhou, D., Zhang, Y. & Pan, Y-X., Jul 1 2011, In : Journal of Nutrition. 141, 7, p. 1254-1259 6 p.

Research output: Contribution to journalArticle

Cell Aging
High Fat Diet
Antioxidants
Fats
Mothers
MAP Kinase Signaling System
Amino Acids
Messenger RNA
Assays
RNA, Transfer, His

Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y-X., Jun 1 2011, In : Journal of Physiology. 589, 11, p. 2707-2717 11 p.

Research output: Contribution to journalArticle

Histone Code
Phosphoenolpyruvate
High Fat Diet
Fats
Gene Expression
Histone Code
Protein-Restricted Diet
Nutrition
Liver
Histones
Histone Code
DNA Methylation
Human Mammary Glands
Nutrition
Histones
Histone Code
CCAAT-Enhancer-Binding Proteins
Genetic Promoter Regions
Skeletal Muscle
Mothers
2010

A low-protein diet during gestation in rats activates the placental mammalian amino acid response pathway and programs the growth capacity of offspring

Strakovsky, R. S., Zhou, D. & Pan, Y-X., Dec 1 2010, In : Journal of Nutrition. 140, 12, p. 2116-2120 5 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
Amino Acids
Activating Transcription Factor 3
Aspartate-Ammonia Ligase
Pregnancy

Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation

Gong, L., Pan, Y-X. & Chen, H., Oct 2010, In : Epigenetics. 5, 7, p. 619-626 8 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
DNA Methylation
Diet
Gene Expression
Folic Acid
Amino Acid Transport Systems
Placenta
Rats
Messenger RNA
Nutrition
2008

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

Su, N., Pan, Y-X., Zhou, M., Harvey, R. C., Hunger, S. P. & Kilberg, M. S., Feb 1 2008, In : Pediatric Blood and Cancer. 50, 2, p. 274-279 6 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Asparaginase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cell Line
Messenger RNA

Deprivation of protein or amino acid induces C/EBPβ synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription

Thiaville, M. M., Dudenhausen, E. E., Zhong, C., Pan, Y-X. & Kilberg, M. S., Mar 15 2008, In : Biochemical Journal. 410, 3, p. 473-484 12 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Response Elements
Transcription
Protein Binding
Amino Acids

Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients

Abbatiello, S. E., Pan, Y. X., Zhou, M., Wayne, A. S., Veenstra, T. D., Hunger, S. P., Kilberg, M. S., Eyler, J. R., Richards, N. G. J. & Conrads, T. P., Apr 30 2008, In : Journal of Proteomics. 71, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Asparaginase
Transformed Cell Line
2007
Activating Transcription Factor 3
CCAAT-Enhancer-Binding Proteins
Genes
Chemical activation
Amino Acids

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer

Zhong, S., Fields, C. R., Su, N., Pan, Y-X. & Robertson, K. D., Apr 19 2007, In : Oncogene. 26, 18, p. 2621-2634 14 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
DNA Methylation
Epigenomics
Non-Small Cell Lung Carcinoma
Histones
2006

An Inhibitor of Human Asparagine Synthetase Suppresses Proliferation of an L-Asparaginase-Resistant Leukemia Cell Line

Gutierrez, J. A., Pan, Y. X., Koroniak, L., Hiratake, J., Kilberg, M. S. & Richards, N. G. J., Dec 1 2006, In : Chemistry and Biology. 13, 12, p. 1339-1347 9 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Asparaginase
Leukemia
Cells
Cell Line

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Palii, S. S., Thiaville, M. M., Pan, Y. X., Zhong, C. & Kilberg, M. S., May 1 2006, In : Biochemical Journal. 395, 3, p. 517-527 11 p.

Research output: Contribution to journalArticle

Amino Acid Transport System A
Neutral Amino Acid Transport Systems
Response Elements
Genes
Sodium
2005

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, C., Dudenhausen, E., Chen, H., Pan, Y-X., Gjymishka, A. & Kilberg, M. S., Nov 1 2005, In : Biochemical Journal. 391, 3, p. 649-658 10 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Transcription
Genes
Amino Acids
Proteins

Developmental regulation of a Turkey intestinal peptide transporter (PepT1)

Van, L., Pan, Y-X., Bloomquist, J. R., Webb, K. E. & Wong, E. A., Jan 2005, In : Poultry science. 84, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

peptide transporters
Turkey (country)
embryo (animal)
patch-clamp technique
dipeptides

Dietary protein level and stage of development affect expression of an intestinal peptide transporter (cPepT1) in chickens

Chen, H., Pan, Y. X., Wong, E. A. & Webb, K. E., Feb 1 2005, In : Journal of Nutrition. 135, 2, p. 193-198 6 p.

Research output: Contribution to journalArticle

Dietary Proteins
Chickens
Messenger RNA
Avian Proteins
Proteins