Yuan-Xiang Pan

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2020
Open Access
2019

Choline supply during negative nutrient balance alters hepatic cystathionine β-synthase, intermediates of the methionine cycle and transsulfuration pathway, and liver function in Holstein cows

Coleman, D. N., Alharthi, A., Lopreiato, V., Trevisi, E., Miura, M., Pan, Y. X. & Loor, J. J., Sep 2019, In : Journal of Dairy Science. 102, 9, p. 8319-8331 13 p.

Research output: Contribution to journalArticle

Effects of obesity and exercise on colon cancer induction and hematopoiesis in mice

Emmons, R., Xu, G., Hernández-Saavedra, D., Kriska, A., Pan, Y. X., Chen, H. & De Lisio, M., Feb 1 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 316, 2, p. E210-E220

Research output: Contribution to journalArticle

Epigenetic regulation of carnitine palmitoyltransferase 1 (Cpt1a) by high fat diet

Moody, L., Xu, G. B., Chen, H. & Pan, Y. X., Feb 2019, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1862, 2, p. 141-152 12 p.

Research output: Contribution to journalArticle

Hepatic 1-carbon metabolism enzyme activity, intermediate metabolites, and growth in neonatal Holstein dairy calves are altered by maternal supply of methionine during late pregnancy

Alharthi, A. S., Coleman, D. N., Liang, Y., Batistel, F., Elolimy, A. A., Yambao, R. C., Abdel-Hamied, E., Pan, Y. X., Parys, C., Alhidary, I. A., Abdelrahman, M. M. & Loor, J. J., Nov 2019, In : Journal of Dairy Science. 102, 11, p. 10291-10303 13 p.

Research output: Contribution to journalArticle

Open Access

Maternal Low-Fat Diet Programs the Hepatic Epigenome despite Exposure to an Obesogenic Postnatal Diet

Moody, L., Shao, J., Chen, H. & Pan, Y-X., Sep 3 2019, In : Nutrients. 11, 9, 2075.

Research output: Contribution to journalArticle

Open Access

Methionine Supply during Late-Gestation Triggers Offspring Sex-Specific Divergent Changes in Metabolic and Epigenetic Signatures in Bovine Placenta

Batistel, F., Alharthi, A. S., Yambao, R. R. C., Elolimy, A. A., Pan, Y. X., Parys, C. & Loor, J. J., Jan 1 2019, In : Journal of Nutrition. 149, 1, p. 6-17 12 p.

Research output: Contribution to journalArticle

Perinatal High-Fat Diet and Bisphenol A: Effects on Behavior and Gene Expression in the Medial Prefrontal Cortex

Wise, L. M., Hernández-Saavedra, D., Boas, S. M., Pan, Y. X. & Juraska, J. M., Sep 1 2019, In : Developmental Neuroscience. 41, 1-2, p. 1-16 16 p.

Research output: Contribution to journalArticle

Perinatal phthalate and high-fat diet exposure induce sex-specific changes in adipocyte size and DNA methylation

Moody, L., Kougias, D., Jung, P. M., Digan, I., Hong, A., Gorski, A., Chen, H., Juraska, J. & Pan, Y. X., Mar 2019, In : Journal of Nutritional Biochemistry. 65, p. 15-25 11 p.

Research output: Contribution to journalArticle

2018

Effects of perinatal exposure to phthalates and a high-fat diet on maternal behavior and pup development and social play

Kougias, D. G., Cortes, L. R., Moody, L., Rhoads, S., Pan, Y. X. & Juraska, J. M., Feb 2018, In : Endocrinology. 159, 2, p. 1088-1105 18 p.

Research output: Contribution to journalArticle

High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

Zhang, X., Xu, G. B., Zhou, D. & Pan, Y. X., Mar 14 2018, In : Genes and Nutrition. 13, 1, 6.

Research output: Contribution to journalArticle

2017

Epigenetic regulation of centromere chromatin stability by dietary and environmental factors

Hernández-Saavedra, D., Strakovsky, R. S., Ostrosky-Wegman, P. & Pan, Y. X., Nov 1 2017, In : Advances in Nutrition. 8, 6, p. 889-904 16 p.

Research output: Contribution to journalArticle

Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a maternal high-fat diet

Moody, L., Chen, H. & Pan, Y. X., Nov 2017, In : Epigenomics. 9, 11, p. 1387-1402 16 p.

Research output: Contribution to journalArticle

2016

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Su, H., Zhou, D., Pan, Y. X., Wang, X. & Nakamura, M. T., Jan 1 2016, In : Journal of Lipid Research. 57, 11, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y. X., Helferich, W. G. & Flaws, J. A., Feb 15 2016, In : Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Contribution to journalArticle

2015

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

Zhou, D., Wang, H., Cui, H., Chen, H. & Pan, Y. X., May 1 2015, In : Journal of Nutritional Biochemistry. 26, 5, p. 433-440 8 p.

Research output: Contribution to journalArticle

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

Zhang, Y., Wang, H., Zhou, D., Moody, L., Lezmi, S., Chen, H. & Pan, Y-X., Oct 1 2015, In : Physiological genomics. 47, 10, p. 514-523 10 p.

Research output: Contribution to journalArticle

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

Liu, Y., Hilakivi-Clarke, L., Zhang, Y., Wang, X., Pan, Y. X., Xuan, J., Fleck, S. C., Doerge, D. R. & Helferich, W. G., Aug 1 2015, In : Molecular Nutrition and Food Research. 59, 8, p. 1419-1430 12 p.

Research output: Contribution to journalArticle

2014

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Strakovsky, R. S., Lezmi, S., Flaws, J. A., Schantz, S. L., Pan, Y. X. & Helferich, W. G., Mar 1 2014, In : Toxicological Sciences. 138, 1, p. 161-174 14 p., kft331.

Research output: Contribution to journalArticle

The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y. X., Feb 1 2014, In : Journal of Nutritional Biochemistry. 25, 2, p. 170-176 7 p.

Research output: Contribution to journalArticle

2012

A decrease in DKK1, a WNT inhibitor, contributes to placental lipid accumulation in an obesity-prone rat model

Strakovsky, R. S. & Pan, Y. X., Mar 1 2012, In : Biology of reproduction. 86, 3, 81.

Research output: Contribution to journalArticle

A gestational low-protein diet represses p21WAF1/Cip1 expression in the mammary gland of offspring rats through promoter histone modifications

Zheng, S., Rollet, M., Yang, K. & Pan, Y. X., Sep 28 2012, In : British Journal of Nutrition. 108, 6, p. 998-1007 10 p.

Research output: Contribution to journalArticle

Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model

Zhang, X., Zhou, D., Strakovsky, R., Zhang, Y. & Pan, Y. X., Mar 1 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 5, p. G558-G564

Research output: Contribution to journalArticle

The skeletal muscle wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model

Zhou, D., Strakovsky, R. S., Zhang, X. & Pan, Y. X., Aug 1 2012, In : Obesity. 20, 8, p. 1577-1584 8 p.

Research output: Contribution to journalArticle

2011

A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats

Zhang, X., Strakovsky, R., Zhou, D., Zhang, Y. & Pan, Y. X., Jul 1 2011, In : Journal of Nutrition. 141, 7, p. 1254-1259 6 p.

Research output: Contribution to journalArticle

Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y. X., Jun 1 2011, In : Journal of Physiology. 589, 11, p. 2707-2717 11 p.

Research output: Contribution to journalArticle

2010

A low-protein diet during gestation in rats activates the placental mammalian amino acid response pathway and programs the growth capacity of offspring

Strakovsky, R. S., Zhou, D. & Pan, Y. X., Dec 1 2010, In : Journal of Nutrition. 140, 12, p. 2116-2120 5 p.

Research output: Contribution to journalArticle

Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation

Gong, L., Pan, Y-X. & Chen, H., Oct 2010, In : Epigenetics. 5, 7, p. 619-626 8 p.

Research output: Contribution to journalArticle

2008

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

Su, N., Pan, Y. X., Zhou, M., Harvey, R. C., Hunger, S. P. & Kilberg, M. S., Feb 1 2008, In : Pediatric Blood and Cancer. 50, 2, p. 274-279 6 p.

Research output: Contribution to journalArticle

Deprivation of protein or amino acid induces C/EBPβ synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription

Thiaville, M. M., Dudenhausen, E. E., Zhong, C., Pan, Y. X. & Kilberg, M. S., Mar 15 2008, In : Biochemical Journal. 410, 3, p. 473-484 12 p.

Research output: Contribution to journalArticle

Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients

Abbatiello, S. E., Pan, Y. X., Zhou, M., Wayne, A. S., Veenstra, T. D., Hunger, S. P., Kilberg, M. S., Eyler, J. R., Richards, N. G. J. & Conrads, T. P., Apr 30 2008, In : Journal of Proteomics. 71, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

MEK signaling is required for phosphorylation of eIF2α following amino acid limitation of HepG2 human hepatoma cells

Thiaville, M. M., Pan, Y. X., Gjymishka, A., Zhong, C., Kaufman, R. J. & Kilberg, M. S., Apr 18 2008, In : Journal of Biological Chemistry. 283, 16, p. 10848-10857 10 p.

Research output: Contribution to journalArticle

2007

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer

Zhong, S., Fields, C. R., Su, N., Pan, Y. X. & Robertson, K. D., Apr 19 2007, In : Oncogene. 26, 18, p. 2621-2634 14 p.

Research output: Contribution to journalArticle

2006

An Inhibitor of Human Asparagine Synthetase Suppresses Proliferation of an L-Asparaginase-Resistant Leukemia Cell Line

Gutierrez, J. A., Pan, Y. X., Koroniak, L., Hiratake, J., Kilberg, M. S. & Richards, N. G. J., Dec 1 2006, In : Chemistry and Biology. 13, 12, p. 1339-1347 9 p.

Research output: Contribution to journalArticle

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Palii, S. S., Thiaville, M. M., Pan, Y. X., Zhong, C. & Kilberg, M. S., May 1 2006, In : Biochemical Journal. 395, 3, p. 517-527 11 p.

Research output: Contribution to journalArticle

2005

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, C., Dudenhausen, E., Chen, H., Pan, Y. X., Gjymishka, A. & Kilberg, M. S., Nov 1 2005, In : Biochemical Journal. 391, 3, p. 649-658 10 p.

Research output: Contribution to journalArticle