Research Output 1997 2018

2018

Effects of perinatal exposure to phthalates and a high-fat diet on maternal behavior and pup development and social play

Kougias, D. G., Cortes, L. R., Moody, L., Rhoads, S., Pan, Y. X. & Juraska, J. M. Feb 1 2018 In : Endocrinology. 159, 2, p. 1088-1105 18 p.

Research output: Contribution to journalArticle

Maternal Behavior
High Fat Diet
Prefrontal Cortex
Oxidative Stress
Body Weight

High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

Zhang, X., Xu, G. B., Zhou, D. & Pan, Y. X. Mar 14 2018 In : Genes and Nutrition. 13, 1, 6

Research output: Contribution to journalArticle

p16 Genes
Cell Aging
High Fat Diet
Fatty Liver
Chromatin
2017
Epigenomics
cognition
epigenetics
Cognition
learning

Epigenetic regulation of centromere chromatin stability by dietary and environmental factors

Hernández-Saavedra, D., Strakovsky, R. S., Ostrosky-Wegman, P. & Pan, Y. X. Nov 1 2017 In : Advances in Nutrition. 8, 6, p. 889-904 16 p.

Research output: Contribution to journalArticle

Centromere
centromeres
Nutritional Status
Epigenomics
epigenetics
TOR Serine-Threonine Kinases
Birth Weight
Methionine
Placenta
Sirolimus

Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a maternal high-fat diet

Moody, L., Chen, H. & Pan, Y. X. Nov 1 2017 In : Epigenomics. 9, 11, p. 1387-1402 16 p.

Research output: Contribution to journalArticle

High Fat Diet
DNA Methylation
Metabolic Networks and Pathways
Mothers
Diet
2016

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Su, H., Zhou, D., Pan, Y. X., Wang, X. & Nakamura, M. T. Jan 1 2016 In : Journal of Lipid Research. 57, 11, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Fatty Acid Desaturases
Omega-3 Fatty Acids
Nutrition
Arachidonic Acid
Gene expression

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y. X., Helferich, W. G. & Flaws, J. A. Feb 15 2016 In : Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Contribution to journalArticle

Genistein
Growth
Phytoestrogens
Cell Cycle
Cells
2015
High Fat Diet
Nutrition
Gene expression
Fats
Parturition

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

Zhou, D., Wang, H., Cui, H., Chen, H. & Pan, Y. X. May 1 2015 In : Journal of Nutritional Biochemistry. 26, 5, p. 433-440 8 p.

Research output: Contribution to journalArticle

High Fat Diet
Nutrition
Histones
Rats
Histone Code

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

Zhang, Y., Wang, H., Zhou, D., Moody, L., Lezmi, S., Chen, H. & Pan, Y. X. Jan 1 2015 In : Physiological Genomics. 47, 10, p. 514-523 10 p.

Research output: Contribution to journalArticle

High Fat Diet
Epigenomics
DNA Methylation
Liver
Genes
Activating Transcription Factor 4
Autophagy
Skeletal Muscle
Mothers
Amino Acids
Adipogenesis
Glucose Intolerance
Dietary Fats
Rats
Glucose

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

Liu, Y., Hilakivi-Clarke, L., Zhang, Y., Wang, X., Pan, Y. X., Xuan, J., Fleck, S. C., Doerge, D. R. & Helferich, W. G. Aug 1 2015 In : Molecular Nutrition and Food Research. 59, 8, p. 1419-1430 12 p.

Research output: Contribution to journalArticle

Isoflavones
soy flour
Flour
isoflavones
Nude Mice
High Fat Diet
Nutrition
Fats
Mothers
Health
2014

Epigenetic mechanisms of colon cancer prevention: What can nutrition do?

Pan, Y. X., Zhang, Y. & Chen, H. Feb 1 2014 Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. Springer New York, p. 401-426 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epigenomics
Colonic Neoplasms
Neoplasms
Histone Code
Genetic Epigenesis

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Strakovsky, R. S., Lezmi, S., Flaws, J. A., Schantz, S. L., Pan, Y. X. & Helferich, W. G. Mar 1 2014 In : Toxicological Sciences. 138, 1, p. 161-174 14 p., kft331

Research output: Contribution to journalArticle

Genistein
Rats
Obesity
Fats
CCAAT-Enhancer-Binding Protein-alpha

The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y. X. Feb 1 2014 In : Journal of Nutritional Biochemistry. 25, 2, p. 170-176 7 p.

Research output: Contribution to journalArticle

Histone Code
High Fat Diet
Nutrition
Histones
Rats
2012

A decrease in DKK1, a WNT inhibitor, contributes to placental lipid accumulation in an obesity-prone rat model

Strakovsky, R. S. & Pan, Y. X. Mar 1 2012 In : Biology of Reproduction. 86, 3, 81

Research output: Contribution to journalArticle

Obesity
Lipids
Placenta
Messenger RNA
Mothers

A gestational low-protein diet represses p21WAF1/Cip1 expression in the mammary gland of offspring rats through promoter histone modifications

Zheng, S., Rollet, M., Yang, K. & Pan, Y. X. Sep 28 2012 In : British Journal of Nutrition. 108, 6, p. 998-1007 10 p.

Research output: Contribution to journalArticle

Histone Code
Protein-Restricted Diet
Human Mammary Glands
Histones
Acetylation
Histone Code
Cell Aging
Obesity
Diet
Liver
High Fat Diet
Human Mammary Glands
Fats
Histones
Genes

In utero oxidative stress epigenetically programs antioxidant defense capacity and adulthood diseases

Strakovsky, R. S. & Pan, Y. X. Jul 15 2012 In : Antioxidants and Redox Signaling. 17, 2, p. 237-253 17 p.

Research output: Contribution to journalReview article

Oxidative stress
Epigenomics
Oxidative Stress
Antioxidants
Histone Code
Histone Code
Facilitative Glucose Transport Proteins
Genetic Promoter Regions
Histones
Muscle

The skeletal muscle wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model

Zhou, D., Strakovsky, R. S., Zhang, X. & Pan, Y. X. Aug 2012 In : Obesity. 20, 8, p. 1577-1584 8 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Muscle Development
Insulin Resistance
Skeletal Muscle
Obesity
2011

A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats

Zhang, X., Strakovsky, R., Zhou, D., Zhang, Y. & Pan, Y. X. Jul 1 2011 In : Journal of Nutrition. 141, 7, p. 1254-1259 6 p.

Research output: Contribution to journalArticle

Cell Aging
High Fat Diet
Antioxidants
Fats
Mothers
MAP Kinase Signaling System
Amino Acids
Messenger RNA
Assays
RNA, Transfer, His

Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y. X. Jun 2011 In : Journal of Physiology. 589, 11, p. 2707-2717 11 p.

Research output: Contribution to journalArticle

Histone Code
Phosphoenolpyruvate
High Fat Diet
Fats
Gene Expression
Histone Code
DNA Methylation
Human Mammary Glands
Nutrition
Histones
Histone Code
CCAAT-Enhancer-Binding Proteins
Protein-Restricted Diet
Protein C
Genetic Promoter Regions
2010

A low-protein diet during gestation in rats activates the placental mammalian amino acid response pathway and programs the growth capacity of offspring

Strakovsky, R. S., Zhou, D. & Pan, Y. X. Dec 1 2010 In : Journal of Nutrition. 140, 12, p. 2116-2120 5 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
Amino Acids
Activating Transcription Factor 3
Aspartate-Ammonia Ligase
Pregnancy

Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation

Gong, L., Pan, Y. X. & Chen, H. Jan 1 2010 In : Epigenetics. 5, 7, p. 619-626 8 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
DNA Methylation
Diet
Gene Expression
Folic Acid
Amino Acid Transport Systems
Placenta
Rats
Messenger RNA
Nutrition
2008

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

Su, N., Pan, Y. X., Zhou, M., Harvey, R. C., Hunger, S. P. & Kilberg, M. S. Feb 1 2008 In : Pediatric Blood and Cancer. 50, 2, p. 274-279 6 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Asparaginase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cell Line
Messenger RNA

Deprivation of protein or amino acid induces C/EBPβ synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription

Thiaville, M. M., Dudenhausen, E. E., Zhong, C., Pan, Y. X. & Kilberg, M. S. Mar 15 2008 In : Biochemical Journal. 410, 3, p. 473-484 12 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-beta
Response Elements
Transcription
Amino Acids
Proteins

Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients

Abbatiello, S. E., Pan, Y. X., Zhou, M., Wayne, A. S., Veenstra, T. D., Hunger, S. P., Kilberg, M. S., Eyler, J. R., Richards, N. G. J. & Conrads, T. P. Apr 30 2008 In : Journal of Proteomics. 71, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Asparaginase
Transformed Cell Line

MEK signaling is required for phosphorylation of eIF2α following amino acid limitation of HepG2 human hepatoma cells

Thiaville, M. M., Pan, Y. X., Gjymishka, A., Zhong, C., Kaufman, R. J. & Kilberg, M. S. Apr 18 2008 In : Journal of Biological Chemistry. 283, 16, p. 10848-10857 10 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Phosphorylation
Mitogen-Activated Protein Kinase Kinases
Hepatocellular Carcinoma
Amino Acids
2007
Activating Transcription Factor 3
Genes
Chemical activation
Amino Acids
CCAAT-Enhancer-Binding Proteins

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer

Zhong, S., Fields, C. R., Su, N., Pan, Y. X. & Robertson, K. D. Apr 19 2007 In : Oncogene. 26, 18, p. 2621-2634 14 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
DNA Methylation
Epigenomics
Non-Small Cell Lung Carcinoma
Histones
2006

An Inhibitor of Human Asparagine Synthetase Suppresses Proliferation of an L-Asparaginase-Resistant Leukemia Cell Line

Gutierrez, J. A., Pan, Y. X., Koroniak, L., Hiratake, J., Kilberg, M. S. & Richards, N. G. J. Dec 1 2006 In : Chemistry and Biology. 13, 12, p. 1339-1347 9 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Asparaginase
Leukemia
Cells
Cell Line

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Palii, S. S., Thiaville, M. M., Pan, Y. X., Zhong, C. & Kilberg, M. S. May 1 2006 In : Biochemical Journal. 395, 3, p. 517-527 11 p.

Research output: Contribution to journalArticle

Amino Acid Transport System A
Neutral Amino Acid Transport Systems
Response Elements
Genes
Sodium
2005

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, C., Dudenhausen, E., Chen, H., Pan, Y. X., Gjymishka, A. & Kilberg, M. S. Nov 1 2005 In : Biochemical Journal. 391, 3, p. 649-658 10 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-beta
Transcription
Genes
Amino Acids
Proteins

Developmental regulation of a Turkey intestinal peptide transporter (PepT1)

Van, L., Pan, Y. X., Bloomquist, J. R., Webb, K. E. & Wong, E. A. Jan 1 2005 In : Poultry Science. 84, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

peptide transporters
Turkey (country)
embryo (animal)
patch-clamp technique
dipeptides

Dietary protein level and stage of development affect expression of an intestinal peptide transporter (cPepT1) in chickens

Chen, H., Pan, Y., Wong, E. A. & Webb, K. E. Feb 2005 In : Journal of Nutrition. 135, 2, p. 193-198 6 p.

Research output: Contribution to journalArticle

peptide transporters
Dietary Proteins
dietary protein
Chickens
crude protein

Functional characterization of a cloned pig intestinal peptide transporter (pPepT1)

Klang, J. E., Burnworth, L. A., Pan, Y. X., Webb, K. E. & Wong, E. A. Jan 2005 In : Journal of Animal Science. 83, 1, p. 172-181 10 p.

Research output: Contribution to journalArticle

peptide transporters
Swine
peptides
Peptides
swine
RNA-Binding Proteins
3' Untranslated Regions
Stabilization
Amino Acids
Messenger RNA

Nutritional control of gene expression: How mammalian cells respond to amino acid limitation

Kilberg, M. S., Pan, Y. X., Chen, H. & Leung-Pineda, V. 2005 In : Annual Review of Nutrition. 25, p. 59-85 27 p.

Research output: Contribution to journalReview article

Gene Expression
Amino Acids
Activating Transcription Factor 4
Basic-Leucine Zipper Transcription Factors
RNA Splicing
2004
Aspartate-Ammonia Ligase
Basic-Leucine Zipper Transcription Factors
Leucine Zippers
Acetylation
Transcription

Human CCAAT/enhancer-binding protein β gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence

Chen, C., Dudenhausen, E. E., Pan, Y. X., Zhong, C. & Kilberg, M. S. Jul 2 2004 In : Journal of Biological Chemistry. 279, 27, p. 27948-27956 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-beta
Unfolded Protein Response
Endoplasmic Reticulum Stress
Response Elements
Gene expression