Research Output 1997 2016

2016

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Su, H., Zhou, D., Pan, Y. X., Wang, X. & Nakamura, M. T. 2016 In : Journal of Lipid Research. 57, 11, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
Diet
Gene Expression
Fatty Acid Desaturases
Arachidonic Acid

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y. X., Helferich, W. G. & Flaws, J. A. Feb 15 2016 In : Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Contribution to journalArticle

Genistein
Cell Cycle
Enzymes
Phytoestrogens
Dimethyl Sulfoxide
2015
High Fat Diet
Gene Expression
Liver
Fats
Diet

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

Zhou, D., Wang, H., Cui, H., Chen, H. & Pan, Y. X. May 1 2015 In : Journal of Nutritional Biochemistry. 26, 5, p. 433-440 8 p.

Research output: Contribution to journalArticle

High Fat Diet
Histones
Fats
Liver
Phosphoenolpyruvate

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

Zhang, Y., Wang, H., Zhou, D., Moody, L., Lezmi, S., Chen, H. & Pan, Y. X. Oct 1 2015 In : Physiological Genomics. 47, 10, p. 514-523 10 p.

Research output: Contribution to journalArticle

High Fat Diet
Epigenomics
Liver
Genes
DNA Methylation
Activating Transcription Factor 4
Autophagy
Skeletal Muscle
Amino Acids
Proteins
Adipogenesis
Glucose Intolerance
Dietary Fats
Adipocytes
High Fat Diet

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

Liu, Y., Hilakivi-Clarke, L., Zhang, Y., Wang, X., Pan, Y. X., Xuan, J., Fleck, S. C., Doerge, D. R. & Helferich, W. G. Aug 1 2015 In : Molecular Nutrition and Food Research. 59, 8, p. 1419-1430 12 p.

Research output: Contribution to journalArticle

Isoflavones
Flour
Nude Mice
Genome
Breast Neoplasms
High Fat Diet
Inflammation
Health
Fats
Incidence
2014

Epigenetic mechanisms of colon cancer prevention: What can nutrition do?

Pan, Y. X., Zhang, Y. & Chen, H. Feb 1 2014 Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. Springer New York, p. 401-426 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Epigenomics
Colonic Neoplasms
Neoplasms
Histone Code
Genetic Epigenesis

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Strakovsky, R. S., Lezmi, S., Flaws, J. A., Schantz, S. L., Pan, Y. X. & Helferich, W. G. Mar 2014 In : Toxicological Sciences. 138, 1, p. 161-174 14 p., kft331

Research output: Contribution to journalArticle

Genistein
Obesity
Fats
CCAAT-Enhancer-Binding Protein-alpha
CCAAT-Enhancer-Binding Protein-beta

The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y. X. Feb 2014 In : Journal of Nutritional Biochemistry. 25, 2, p. 170-176 7 p.

Research output: Contribution to journalArticle

High Fat Diet
Histones
Liver
Fats
Antioxidants
2012

A decrease in DKK1, a WNT inhibitor, contributes to placental lipid accumulation in an obesity-prone rat model

Strakovsky, R. S. & Pan, Y. X. Mar 1 2012 In : Biology of Reproduction. 86, 3, 81

Research output: Contribution to journalArticle

Obesity
Lipids
Placenta
Messenger RNA
beta Catenin

A gestational low-protein diet represses p21WAF1/Cip1 expression in the mammary gland of offspring rats through promoter histone modifications

Zheng, S., Rollet, M., Yang, K. & Pan, Y. X. Sep 28 2012 In : British Journal of Nutrition. 108, 6, p. 998-1007 10 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
Histones
Proteins
Acetylation
Caseins
Cell Aging
Histones
Obesity
Diet
Liver
Histone Deacetylases
High Fat Diet
Genes
Fats
Histones

In utero oxidative stress epigenetically programs antioxidant defense capacity and adulthood diseases

Strakovsky, R. S. & Pan, Y. X. Jul 15 2012 In : Antioxidants and Redox Signaling. 17, 2, p. 237-253 17 p.

Research output: Contribution to journalReview article

Epigenomics
Oxidative Stress
Antioxidants
Genes
Maternal Exposure
Histones
Skeletal Muscle
Pregnancy
Proteins
Protein-Restricted Diet

The skeletal muscle wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model

Zhou, D., Strakovsky, R. S., Zhang, X. & Pan, Y. X. Aug 2012 In : Obesity. 20, 8, p. 1577-1584 8 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Muscle Development
Insulin Resistance
Skeletal Muscle
Obesity
2011

A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats

Zhang, X., Strakovsky, R., Zhou, D., Zhang, Y. & Pan, Y. X. Jul 1 2011 In : Journal of Nutrition. 141, 7, p. 1254-1259 6 p.

Research output: Contribution to journalArticle

Cell Aging
High Fat Diet
Antioxidants
Fats
Liver
MAP Kinase Signaling System
Amino Acids
Messenger RNA
Genes
RNA, Transfer, His

Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y. X. Jun 2011 In : Journal of Physiology. 589, 11, p. 2707-2717 11 p.

Research output: Contribution to journalArticle

Phosphoenolpyruvate
High Fat Diet
Histones
Fats
Gene Expression
Protein-Restricted Diet
Histones
Transcription Factors
Amino Acids
Liver
DNA Methylation
Histones
Proteins
Diet
Histone Code
CCAAT-Enhancer-Binding Proteins
Protein C
Histones
Skeletal Muscle
Pregnancy
2010

A low-protein diet during gestation in rats activates the placental mammalian amino acid response pathway and programs the growth capacity of offspring

Strakovsky, R. S., Zhou, D. & Pan, Y. X. Dec 1 2010 In : Journal of Nutrition. 140, 12, p. 2116-2120 5 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
Amino Acids
Pregnancy
Placenta
Diet

Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation

Gong, L., Pan, Y. X. & Chen, H. Oct 2010 In : Epigenetics. 5, 7, p. 619-626 8 p.

Research output: Contribution to journalArticle

Protein-Restricted Diet
DNA Methylation
Diet
Gene Expression
Liver
Amino Acid Transport Systems
Placenta
Proteins
Messenger RNA
Up-Regulation
2008

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

Su, N., Pan, Y. X., Zhou, M., Harvey, R. C., Hunger, S. P. & Kilberg, M. S. Feb 2008 In : Pediatric Blood and Cancer. 50, 2, p. 274-279 6 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Asparaginase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cell Line
Messenger RNA

Deprivation of protein or amino acid induces C/EBPβ synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription

Thiaville, M. M., Dudenhausen, E. E., Zhong, C., Pan, Y. X. & Kilberg, M. S. Mar 15 2008 In : Biochemical Journal. 410, 3, p. 473-484 12 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-beta
Response Elements
Amino Acids
Proteins
Liver

Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients

Abbatiello, S. E., Pan, Y. X., Zhou, M., Wayne, A. S., Veenstra, T. D., Hunger, S. P., Kilberg, M. S., Eyler, J. R., Richards, N. G. J. & Conrads, T. P. Apr 30 2008 In : Journal of Proteomics. 71, 1, p. 61-70 10 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Proteins
Asparaginase

MEK signaling is required for phosphorylation of eIF2α following amino acid limitation of HepG2 human hepatoma cells

Thiaville, M. M., Pan, Y. X., Gjymishka, A., Zhong, C., Kaufman, R. J. & Kilberg, M. S. Apr 18 2008 In : Journal of Biological Chemistry. 283, 16, p. 10848-10857 10 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Mitogen-Activated Protein Kinase Kinases
Hepatocellular Carcinoma
Phosphorylation
Amino Acids
2007
Activating Transcription Factor 3
Amino Acids
Genes
CCAAT-Enhancer-Binding Proteins
RNA Polymerase II

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer

Zhong, S., Fields, C. R., Su, N., Pan, Y. X. & Robertson, K. D. Apr 19 2007 In : Oncogene. 26, 18, p. 2621-2634 14 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
DNA Methylation
Epigenomics
Non-Small Cell Lung Carcinoma
Histones
2006

An Inhibitor of Human Asparagine Synthetase Suppresses Proliferation of an L-Asparaginase-Resistant Leukemia Cell Line

Gutierrez, J. A., Pan, Y. X., Koroniak, L., Hiratake, J., Kilberg, M. S. & Richards, N. G. J. Dec 2006 In : Chemistry and Biology. 13, 12, p. 1339-1347 9 p.

Research output: Contribution to journalArticle

Aspartate-Ammonia Ligase
Asparaginase
Leukemia
Cell Line
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Palii, S. S., Thiaville, M. M., Pan, Y. X., Zhong, C. & Kilberg, M. S. May 1 2006 In : Biochemical Journal. 395, 3, p. 517-527 11 p.

Research output: Contribution to journalArticle

Amino Acid Transport System A
Neutral Amino Acid Transport Systems
Response Elements
Sodium
Amino Acids
2005

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, C., Dudenhausen, E., Chen, H., Pan, Y. X., Gjymishka, A. & Kilberg, M. S. Nov 1 2005 In : Biochemical Journal. 391, 3, p. 649-658 10 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-beta
Amino Acids
Genes
Proteins
Activating Transcription Factor 4

Developmental regulation of a Turkey intestinal peptide transporter (PepT1)

Van, L., Pan, Y. X., Bloomquist, J. R., Webb, K. E. & Wong, E. A. Jan 2005 In : Poultry Science. 84, 1, p. 75-82 8 p.

Research output: Contribution to journalArticle

Turkey
Messenger RNA
Peptides
Complementary DNA
Embryonic Structures

Dietary protein level and stage of development affect expression of an intestinal peptide transporter (cPepT1) in chickens

Chen, H., Pan, Y., Wong, E. A. & Webb, K. E. Feb 2005 In : Journal of Nutrition. 135, 2, p. 193-198 6 p.

Research output: Contribution to journalArticle

Dietary Proteins
Chickens
Messenger RNA
Peptides
Proteins

Functional characterization of a cloned pig intestinal peptide transporter (pPepT1)

Klang, J. E., Burnworth, L. A., Pan, Y. X., Webb, K. E. & Wong, E. A. Jan 2005 In : Journal of Animal Science. 83, 1, p. 172-181 10 p.

Research output: Contribution to journalArticle

Swine
Peptides
Dietary Proteins
Dipeptides
Small Intestine
RNA-Binding Proteins
3' Untranslated Regions
Amino Acids
Messenger RNA
Hu Paraneoplastic Encephalomyelitis Antigens

Nutritional control of gene expression: How mammalian cells respond to amino acid limitation

Kilberg, M. S., Pan, Y. X., Chen, H. & Leung-Pineda, V. 2005 In : Annual Review of Nutrition. 25, p. 59-85 27 p.

Research output: Contribution to journalReview article

Gene Expression
Amino Acids
Proteins
Messenger RNA
Activating Transcription Factor 4
2004
Aspartate-Ammonia Ligase
Basic-Leucine Zipper Transcription Factors
Acetylation
Histones
Amino Acids

Human CCAAT/enhancer-binding protein β gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence

Chen, C., Dudenhausen, E. E., Pan, Y. X., Zhong, C. & Kilberg, M. S. Jul 2 2004 In : Journal of Biological Chemistry. 279, 27, p. 27948-27956 9 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Protein-beta
Unfolded Protein Response
Endoplasmic Reticulum Stress
Response Elements
Gene Expression

Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization

Leung-Pineda, V., Pan, Y., Chen, H. & Kilberg, M. S. Apr 1 2004 In : Biochemical Journal. 379, 1, p. 79-88 10 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Amino Acids
Messenger RNA
Histidine
Proteins
2003
Activating Transcription Factor 3
Aspartate-Ammonia Ligase
Endoplasmic Reticulum Stress
Hep G2 Cells
Amino Acids
2002

Molecular cloning and functional expression of a chicken intestinal peptide transporter (cPepT1) in Xenopus oocytes and Chinese hamster ovary cells

Chen, H., Pan, Y., Wong, E. A., Bloomquist, J. R. & Webb, K. E. 2002 In : Journal of Nutrition. 132, 3, p. 387-393 7 p.

Research output: Contribution to journalArticle

Molecular Cloning
Xenopus
Cricetulus
Oocytes
Ovary

Poly(A)+ RNA encoding proteins capable of transporting L-methionine and/or DL-2-hydroxy-4-(methylthio) butanoic acid are present in the intestinal mucosa of broilers

Pan, Y., Wong, E. A., Dibner, J. J., Vázquez-Añón, M. & Webb, K. E. 2002 In : Journal of Nutrition. 132, 3, p. 382-386 5 p.

Research output: Contribution to journalArticle

Poly A
Butyric Acid
Intestinal Mucosa
Methionine
RNA
2001

Expression of a cloned ovine gastrointestinal peptide transporter (oPepT1) in Xenopus oocytes induces uptake of oligopeptides in vitro

Pan, Y., Wong, E. A., Bloomquist, J. R. & Webb, K. E. 2001 In : Journal of Nutrition. 131, 4, p. 1264-1270 7 p.

Research output: Contribution to journalArticle

Oligopeptides
Xenopus
Oocytes
Sheep
Peptides
1997

Poly(A)+ RNA from sheep omasal epithelium induces expression of a peptide transport protein(s) in Xenopus laevis oocytes

Pan, Y. X., Wong, E. A., Bloomquist, J. R. & Webb, K. E. Dec 1997 In : Journal of Animal Science. 75, 12, p. 3323-3330 8 p.

Research output: Contribution to journalArticle

Poly A
Xenopus laevis
Oocytes
Sheep
Carrier Proteins