Yuan-Xiang Pan

2023

Increasing dietary nutrient levels modulates colon immune adaptation and alleviates inflammation in the epithelial heterogeneous nuclear ribonucleoprotein I (Hnrnp I) knockout mice

Xu, G. B., Cai, M., Kadayifci, F. Z., Dong, J., Zheng, S., Mei, W., Zhao, W., Pan, Y. X. & Chen, H., Sep 2023, In: Journal of Nutritional Biochemistry. 119, 109406.

Research output: Contribution to journal › Article › peer-review

Open Access

One-carbon metabolism and related pathways in ruminal and small intestinal epithelium of lactating dairy cows

Jiang, Q., Sherlock, D. N., Zhang, H., Guyader, J., Pan, Y. X. & Loor, J. J., 2023, In: Journal of animal science. 101, skad062.

Research output: Contribution to journal › Article › peer-review

Single-Cell RNA Sequencing (scRNA-seq) Identifies L1CAM as a Key Mediator between Epithelial Tuft Cell and Innate Lymphoid Cell in the Colon of Hnrnp I Knockout Mice

Xu, G., Pan, Y-X., Mei, W. & Chen, H., Oct 2023, In: Biomedicines. 11, 10, 2734.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A maternal low-protein diet during gestation induces hepatic autophagy-related gene expression in a sex-specific manner in Sprague-Dawley rats

Cai, M., Zhang, J., Chen, H. & Pan, Y-X., Aug 28 2022, In: British Journal of Nutrition. 128, 4, p. 592-603 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Genome-wide cross-cancer analysis illustrates the critical role of bimodal miRNA in patient survival and drug responses to PI3K inhibitors

Moody, L., Xu, G. B., Pan, Y. X. & Chen, H., May 2022, In: PLoS computational biology. 18, 5, e1010109.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Caloric restriction following early-life high fat-diet feeding represses skeletal muscle TNF in male rats

Hernández-Saavedra, D., Moody, L., Tang, X., Goldberg, Z. J., Wang, A. P., Chen, H. & Pan, Y. X., May 2021, In: Journal of Nutritional Biochemistry. 91, 108598.

Research output: Contribution to journal › Article › peer-review

Open Access

Maternal high-fat diet activates hepatic interleukin-4 in rat male offspring accompanied by increased eosinophil infiltration

Wang, H., Xu, G. B., Chen, H. & Pan, Y. X., Jan 2021, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 320, 1, p. G81-G92

Research output: Contribution to journal › Article › peer-review

Weight loss with exercise improves muscle architecture and progenitor cell populations compared with weight loss alone in mice with preneoplastic colorectal lesions

Roubos, S., D’souza, D., Hernández-Saavedra, D., Xu, G., Collao, N., Emmons, R., Larkin, J., Lloyd, J., Vanhie, J. J., Pan, Y. X., Chen, H. & De Lisio, M., 2021, In: Applied Physiology, Nutrition and Metabolism. 46, 7, p. 837-845 9 p.

Research output: Contribution to journal › Article › peer-review

2020

Considerations for feature selection using gene pairs and applications in large-scale dataset integration, novel oncogene discovery, and interpretable cancer screening

Moody, L., Chen, H. & Pan, Y. X., Oct 1 2020, In: BMC Medical Genomics. 13, 148.

Research output: Contribution to journal › Article › peer-review

Open Access

Epigenetic stratification of head and neck cancer survivors reveals differences in lycopene levels, alcohol consumption, and methylation of immune regulatory genes

Moody, L., Crowder, S. L., Fruge, A. D., Locher, J. L., Demark-Wahnefried, W., Rogers, L. Q., Delk-Licata, A., Carroll, W. R., Spencer, S. A., Black, M., Erdman, J. W., Chen, H., Pan, Y. X. & Arthur, A. E., Sep 11 2020, In: Clinical epigenetics. 12, 1, 138.

Research output: Contribution to journal › Article › peer-review

Open Access

Low-protein diet during gestation and lactation increases hepatic lipid accumulation through autophagy and histone deacetylase

Wang, H., Xu, G. B., Hernandez-Saavedra, D., Chen, H. & Pan, Y. X., Jul 2020, In: American Journal of Physiology - Endocrinology and Metabolism. 319, 1, p. E11-E25

Research output: Contribution to journal › Article › peer-review

Role of glucocorticoid signaling in exercise-associated changes in high-fat diet preference in rats

Yang, T. Y., Gardner, J. C., Gao, Z., Pan, Y. X. & Liang, N. C., Mar 1 2020, In: American journal of physiology. Regulatory, integrative and comparative physiology. 318, 3, p. R515-R528

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Choline supply during negative nutrient balance alters hepatic cystathionine β-synthase, intermediates of the methionine cycle and transsulfuration pathway, and liver function in Holstein cows

Coleman, D. N., Alharthi, A., Lopreiato, V., Trevisi, E., Miura, M., Pan, Y. X. & Loor, J. J., Sep 2019, In: Journal of Dairy Science. 102, 9, p. 8319-8331 13 p.

Research output: Contribution to journal › Article › peer-review

Computational methods to identify bimodal gene expression and facilitate personalized treatment in cancer patients

Moody, L., Mantha, S., Chen, H. & Pan, Y. X., Mar 2019, In: Journal of Biomedical Informatics: X. 1, 100001.

Research output: Contribution to journal › Review article › peer-review

Early-life programming of type 2 diabetes mellitus: Understanding the association between epigenetics/genetics and environmental factors

Kadayifci, F. Z., Haggard, S., Jeon, S., Ranard, K., Tao, D. & Pan, Y. X., 2019, In: Current Genomics. 20, 6, p. 453-463 11 p.

Research output: Contribution to journal › Review article › peer-review

Effects of obesity and exercise on colon cancer induction and hematopoiesis in mice

Emmons, R., Xu, G., Hernández-Saavedra, D., Kriska, A., Pan, Y. X., Chen, H. & De Lisio, M., Feb 1 2019, In: American Journal of Physiology - Endocrinology and Metabolism. 316, 2, p. E210-E220

Research output: Contribution to journal › Article › peer-review

Epigenetic regulation of carnitine palmitoyltransferase 1 (Cpt1a) by high fat diet

Moody, L., Xu, G. B., Chen, H. & Pan, Y. X., Feb 2019, In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1862, 2, p. 141-152 12 p.

Research output: Contribution to journal › Article › peer-review

Epigenetic Regulation of Metabolism and Inflammation by Calorie Restriction

Hernández-Saavedra, D., Moody, L., Xu, G. B., Chen, H. & Pan, Y. X., May 1 2019, In: Advances in Nutrition. 10, 3, p. 520-536 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Hepatic 1-carbon metabolism enzyme activity, intermediate metabolites, and growth in neonatal Holstein dairy calves are altered by maternal supply of methionine during late pregnancy

Alharthi, A. S., Coleman, D. N., Liang, Y., Batistel, F., Elolimy, A. A., Yambao, R. C., Abdel-Hamied, E., Pan, Y. X., Parys, C., Alhidary, I. A., Abdelrahman, M. M. & Loor, J. J., Nov 2019, In: Journal of Dairy Science. 102, 11, p. 10291-10303 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Hepatic betaine-homocysteine methyltransferase and methionine synthase activity and intermediates of the methionine cycle are altered by choline supply during negative energy balance in Holstein cows

Coleman, D. N., Vailati-Riboni, M., Elolimy, A. A., Cardoso, F. C., Rodriguez-Zas, S. L., Miura, M., Pan, Y. X. & Loor, J. J., Sep 2019, In: Journal of Dairy Science. 102, 9, p. 8305-8318 14 p.

Research output: Contribution to journal › Article › peer-review

Maternal and Post-weaning High-Fat Diets Produce Distinct DNA Methylation Patterns in Hepatic Metabolic Pathways within Specific Genomic Contexts

Moody, L., Wang, H., Jung, P. M., Chen, H. & Pan, Y-X., Jun 30 2019, In: International Journal of Molecular Sciences. 20, 13, 3229.

Research output: Contribution to journal › Article › peer-review

Open Access

Maternal low-fat diet programs the hepatic epigenome despite exposure to an obesogenic postnatal diet

Moody, L., Shao, J., Chen, H. & Pan, Y. X., Sep 2019, In: Nutrients. 11, 9, 2075.

Research output: Contribution to journal › Article › peer-review

Open Access

Methionine Supply during Late-Gestation Triggers Offspring Sex-Specific Divergent Changes in Metabolic and Epigenetic Signatures in Bovine Placenta

Batistel, F., Alharthi, A. S., Yambao, R. R. C., Elolimy, A. A., Pan, Y. X., Parys, C. & Loor, J. J., Jan 1 2019, In: Journal of Nutrition. 149, 1, p. 6-17 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Perinatal High-Fat Diet and Bisphenol A: Effects on Behavior and Gene Expression in the Medial Prefrontal Cortex

Wise, L. M., Hernández-Saavedra, D., Boas, S. M., Pan, Y. X. & Juraska, J. M., Sep 1 2019, In: Developmental Neuroscience. 41, 1-2, p. 1-16 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Perinatal phthalate and high-fat diet exposure induce sex-specific changes in adipocyte size and DNA methylation

Moody, L., Kougias, D., Jung, P. M., Digan, I., Hong, A., Gorski, A., Chen, H., Juraska, J. & Pan, Y. X., Mar 2019, In: Journal of Nutritional Biochemistry. 65, p. 15-25 11 p.

Research output: Contribution to journal › Article › peer-review

The Efficacy of miR-20a as a Diagnostic and Prognostic Biomarker for Colorectal Cancer: A Systematic Review and Meta-Analysis

Moody, L., Dvoretskiy, S., An, R., Mantha, S. & Pan, Y-X., Aug 3 2019, In: Cancers. 11, 8, 1111.

Research output: Contribution to journal › Review article › peer-review

Open Access

Tissue-specific changes in Srebf1 and Srebf2 expression and DNA methylation with perinatal phthalate exposure

Moody, L., Hernández-Saavedra, D., Kougias, D. G., Chen, H., Juraska, J. M. & Pan, Y. X., Apr 1 2019, In: Environmental Epigenetics. 5, 2, dvz009.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Effects of perinatal exposure to phthalates and a high-fat diet on maternal behavior and pup development and social play

Kougias, D. G., Cortes, L. R., Moody, L., Rhoads, S., Pan, Y. X. & Juraska, J. M., Feb 2018, In: Endocrinology. 159, 2, p. 1088-1105 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

Zhang, X., Xu, G. B., Zhou, D. & Pan, Y. X., Mar 14 2018, In: Genes and Nutrition. 13, 1, 6.

Research output: Contribution to journal › Article › peer-review

Open Access

Molecular mechanisms underlying the link between diet and DNA methylation

Kadayifci, F. Z., Zheng, S. & Pan, Y. X., Dec 14 2018, In: International journal of molecular sciences. 19, 12, 4055.

Research output: Contribution to journal › Review article › peer-review

Open Access

2017

Early-life nutritional programming of cognition-the fundamental role of epigenetic mechanisms in mediating the relation between early-life environment and learning and memory process

Moody, L., Chen, H. & Pan, Y. X., Mar 1 2017, In: Advances in Nutrition. 8, 2, p. 337-350 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Epigenetic regulation of centromere chromatin stability by dietary and environmental factors

Hernández-Saavedra, D., Strakovsky, R. S., Ostrosky-Wegman, P. & Pan, Y. X., Nov 1 2017, In: Advances in Nutrition. 8, 6, p. 889-904 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Methods and novel technology for microRNA quantification in colorectal cancer screening

Moody, L., He, H., Pan, Y. X. & Chen, H., 2017, In: Clinical epigenetics. 9, p. 119 1 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Placentome nutrient transporters and mammalian target of rapamycin signaling proteins are altered by the methionine supply during late gestation in dairy cows and are associated with newborn birth weight

Batistel, F., Alharthi, A. S. M., Wang, L., Parys, C., Pan, Y. X., Cardoso, F. C. & Loor, J. J., Sep 1 2017, In: Journal of Nutrition. 147, 9, p. 1640-1647 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a maternal high-fat diet

Moody, L., Chen, H. & Pan, Y. X., Nov 2017, In: Epigenomics. 9, 11, p. 1387-1402 16 p.

Research output: Contribution to journal › Article › peer-review

2016

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Su, H., Zhou, D., Pan, Y. X., Wang, X. & Nakamura, M. T., 2016, In: Journal of Lipid Research. 57, 11, p. 1995-2004 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y. X., Helferich, W. G. & Flaws, J. A., Feb 15 2016, In: Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Contribution to journal › Article › peer-review

2015

Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis

Strakovsky, R. S., Wang, H., Engeseth, N. J., Flaws, J. A., Helferich, W. G., Pan, Y. X. & Lezmi, S., Apr 5 2015, In: Toxicology and Applied Pharmacology. 284, 2, p. 101-112 12 p.

Research output: Contribution to journal › Article › peer-review

Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

Zhou, D., Wang, H., Cui, H., Chen, H. & Pan, Y. X., May 1 2015, In: Journal of Nutritional Biochemistry. 26, 5, p. 433-440 8 p.

Research output: Contribution to journal › Article › peer-review

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

Zhang, Y., Wang, H., Zhou, D., Moody, L., Lezmi, S., Chen, H. & Pan, Y. X., Oct 1 2015, In: Physiological genomics. 47, 10, p. 514-523 10 p.

Research output: Contribution to journal › Article › peer-review

Induction of autophagy through the activating transcription factor 4 (ATF4)-dependent amino acid response pathway in maternal skeletal muscle may function as the molecular memory in response to gestational protein restriction to alert offspring to maternal nutrition

Wang, H., Wilson, G. J., Zhou, D., Lezmi, S., Chen, X., Layman, D. K. & Pan, Y. X., Aug 28 2015, In: British Journal of Nutrition. 114, 4, p. 519-532 14 p.

Research output: Contribution to journal › Article › peer-review

In utero growth restriction and catch-up adipogenesis after developmental di (2-ethylhexyl) phthalate exposure cause glucose intolerance in adult male rats following a high-fat dietary challenge

Strakovsky, R. S., Lezmi, S., Shkoda, I., Flaws, J. A., Helferich, W. G. & Pan, Y. X., Nov 2015, In: Journal of Nutritional Biochemistry. 26, 11, p. 1208-1220 13 p.

Research output: Contribution to journal › Article › peer-review

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

Liu, Y., Hilakivi-Clarke, L., Zhang, Y., Wang, X., Pan, Y. X., Xuan, J., Fleck, S. C., Doerge, D. R. & Helferich, W. G., Aug 1 2015, In: Molecular Nutrition and Food Research. 59, 8, p. 1419-1430 12 p.

Research output: Contribution to journal › Article › peer-review

Pathophysiological basis for compromised health beyond generations: Role of maternal high-fat diet and low-grade chronic inflammation

Zhou, D. & Pan, Y. X., 2015, In: Journal of Nutritional Biochemistry. 26, 1, p. 1-8 8 p.

Research output: Contribution to journal › Review article › peer-review

2014

Epigenetic mechanisms of colon cancer prevention: What can nutrition do?

Pan, Y. X., Zhang, Y. & Chen, H., Feb 1 2014, Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. Springer, p. 401-426 26 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Strakovsky, R. S., Lezmi, S., Flaws, J. A., Schantz, S. L., Pan, Y. X. & Helferich, W. G., Mar 2014, In: Toxicological Sciences. 138, 1, p. 161-174 14 p., kft331.

Research output: Contribution to journal › Article › peer-review

The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y. X., Feb 2014, In: Journal of Nutritional Biochemistry. 25, 2, p. 170-176 7 p.

Research output: Contribution to journal › Article › peer-review

2012

A decrease in DKK1, a WNT inhibitor, contributes to placental lipid accumulation in an obesity-prone rat model

Strakovsky, R. S. & Pan, Y. X., Mar 1 2012, In: Biology of reproduction. 86, 3, 81, 1-11.

Research output: Contribution to journal › Article › peer-review

Open Access

A gestational low-protein diet represses p21^WAF1/Cip1 expression in the mammary gland of offspring rats through promoter histone modifications

Zheng, S., Rollet, M., Yang, K. & Pan, Y. X., Sep 28 2012, In: British Journal of Nutrition. 108, 6, p. 998-1007 10 p.

Research output: Contribution to journal › Article › peer-review

Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model

Zhang, X., Zhou, D., Strakovsky, R., Zhang, Y. & Pan, Y. X., Mar 2012, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 5, p. G558-G564

Research output: Contribution to journal › Article › peer-review

Yuan-Xiang Pan

Research output

Search results