Research Output 1997 2017

2017
cognition
epigenetics
learning
Epigenomics
Cognition
2016

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Su, H., Zhou, D., Pan, Y. X., Wang, X. & Nakamura, M. T. 2016 In : Journal of Lipid Research. 57, 11, p. 1995-2004 10 p.

Research output: Research - peer-reviewArticle

Fatty Acid Desaturases
Omega-3 Fatty Acids
Nutrition
Arachidonic Acid
Gene expression

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y. X., Helferich, W. G. & Flaws, J. A. Feb 15 2016 In : Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Research - peer-reviewArticle

Genistein
Growth
Antral
Cell Cycle
Enzymes
2015
High Fat Diet
Parturition
Gene Expression
Liver
bisphenol A
High Fat Diet
Fats
Liver
Nutrition
Histones

High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

Zhang, Y., Wang, H., Zhou, D., Moody, L., Lezmi, S., Chen, H. & Pan, Y. X. Oct 1 2015 In : Physiological Genomics. 47, 10, p. 514-523 10 p.

Research output: Research - peer-reviewArticle

High Fat Diet
Epigenomics
Liver
Genes
DNA Methylation
Activating Transcription Factor 4
Autophagy
Skeletal Muscle
Mothers
Amino Acids
Adipogenesis
Glucose Intolerance
Dietary Fats
Growth
phthalic acid

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

Liu, Y., Hilakivi-Clarke, L., Zhang, Y., Wang, X., Pan, Y. X., Xuan, J., Fleck, S. C., Doerge, D. R. & Helferich, W. G. Aug 1 2015 In : Molecular Nutrition and Food Research. 59, 8, p. 1419-1430 12 p.

Research output: Research - peer-reviewArticle

soy flour
isoflavones
breast neoplasms
neoplasms
genome
High Fat Diet
Mothers
Inflammation
Health
Nutrition
2014

Epigenetic mechanisms of colon cancer prevention: What can nutrition do?

Pan, Y. X., Zhang, Y. & Chen, H. Feb 1 2014 Molecular Mechanisms and Physiology of Disease: Implications for Epigenetics and Health. Springer New York, p. 401-426 26 p.

Research output: ResearchChapter

Epigenomics
Colonic Neoplasms
Neoplasms
Histone Code
Genetic Epigenesis

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Strakovsky, R. S., Lezmi, S., Flaws, J. A., Schantz, S. L., Pan, Y. X. & Helferich, W. G. Mar 2014 In : Toxicological Sciences. 138, 1, p. 161-174 14 p., kft331

Research output: Research - peer-reviewArticle

Genistein
Obesity
Rats
Fats
CCAAT-Enhancer-Binding Protein-alpha

The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y. X. Feb 2014 In : Journal of Nutritional Biochemistry. 25, 2, p. 170-176 7 p.

Research output: Research - peer-reviewArticle

Histone Code
High Fat Diet
Fats
Mothers
Liver
2012

A decrease in DKK1, a WNT inhibitor, contributes to placental lipid accumulation in an obesity-prone rat model

Strakovsky, R. S. & Pan, Y. X. Mar 1 2012 In : Biology of Reproduction. 86, 3, 81

Research output: Research - peer-reviewArticle

Obesity
Lipids
Placenta
Messenger RNA
Mothers

A gestational low-protein diet represses p21WAF1/Cip1 expression in the mammary gland of offspring rats through promoter histone modifications

Zheng, S., Rollet, M., Yang, K. & Pan, Y. X. Sep 28 2012 In : British Journal of Nutrition. 108, 6, p. 998-1007 10 p.

Research output: Research - peer-reviewArticle

Histone Code
Protein-Restricted Diet
Human Mammary Glands
Proteins
Histones
Histone Code
Cell Aging
Obesity
Diet
Liver
High Fat Diet
Human Mammary Glands
Genes
histone deacetylase 3
Fats

In utero oxidative stress epigenetically programs antioxidant defense capacity and adulthood diseases

Strakovsky, R. S. & Pan, Y. X. Jul 15 2012 In : Antioxidants and Redox Signaling. 17, 2, p. 237-253 17 p.

Research output: Research - peer-reviewReview article

Epigenomics
Oxidative Stress
Antioxidants
Oxidative stress
Genes
Histone Code
Facilitative Glucose Transport Proteins
Genetic Promoter Regions
Skeletal Muscle
Pregnancy

The skeletal muscle wnt pathway may modulate insulin resistance and muscle development in a diet-induced obese rat model

Zhou, D., Strakovsky, R. S., Zhang, X. & Pan, Y. X. Aug 2012 In : Obesity. 20, 8, p. 1577-1584 8 p.

Research output: Research - peer-reviewArticle

Wnt Signaling Pathway
Muscle Development
Insulin Resistance
Skeletal Muscle
Obesity
2011

A maternal high-fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats

Zhang, X., Strakovsky, R., Zhou, D., Zhang, Y. & Pan, Y. X. Jul 1 2011 In : Journal of Nutrition. 141, 7, p. 1254-1259 6 p.

Research output: Research - peer-reviewArticle

Cell Aging
High Fat Diet
Antioxidants
Fats
Mothers
MAP Kinase Signaling System
Amino Acids
Messenger RNA
Genes
RNA, Transfer, His

Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats

Strakovsky, R. S., Zhang, X., Zhou, D. & Pan, Y. X. Jun 2011 In : Journal of Physiology. 589, 11, p. 2707-2717 11 p.

Research output: Research - peer-reviewArticle

Histone Code
Phosphoenolpyruvate
High Fat Diet
Fats
Gene Expression
Histone Code
Protein-Restricted Diet
Transcription Factors
Amino Acids
Liver
Histone Code
DNA Methylation
Human Mammary Glands
Mothers
Proteins
Histone Code
CCAAT-Enhancer-Binding Proteins
Protein C
Genetic Promoter Regions
Skeletal Muscle
2010

A low-protein diet during gestation in rats activates the placental mammalian amino acid response pathway and programs the growth capacity of offspring

Strakovsky, R. S., Zhou, D. & Pan, Y. X. Dec 1 2010 In : Journal of Nutrition. 140, 12, p. 2116-2120 5 p.

Research output: Research - peer-reviewArticle

Protein-Restricted Diet
Amino Acids
Pregnancy
Growth
Placenta
Protein-Restricted Diet
DNA Methylation
Diet
Gene Expression
Liver
Amino Acid Transport Systems
Placenta
Proteins
Rats
Messenger RNA
2008

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

Su, N., Pan, Y. X., Zhou, M., Harvey, R. C., Hunger, S. P. & Kilberg, M. S. Feb 2008 In : Pediatric Blood and Cancer. 50, 2, p. 274-279 6 p.

Research output: Research - peer-reviewArticle

Aspartate-Ammonia Ligase
Asparaginase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cell Line
Messenger RNA

Deprivation of protein or amino acid induces C/EBPβ synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription

Thiaville, M. M., Dudenhausen, E. E., Zhong, C., Pan, Y. X. & Kilberg, M. S. Mar 15 2008 In : Biochemical Journal. 410, 3, p. 473-484 12 p.

Research output: Research - peer-reviewArticle

CCAAT-Enhancer-Binding Protein-beta
Response Elements
Transcription
Amino Acids
Proteins

Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients

Abbatiello, S. E., Pan, Y. X., Zhou, M., Wayne, A. S., Veenstra, T. D., Hunger, S. P., Kilberg, M. S., Eyler, J. R., Richards, N. G. J. & Conrads, T. P. Apr 30 2008 In : Journal of Proteomics. 71, 1, p. 61-70 10 p.

Research output: Research - peer-reviewArticle

Aspartate-Ammonia Ligase
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Proteins
Asparaginase

MEK signaling is required for phosphorylation of eIF2α following amino acid limitation of HepG2 human hepatoma cells

Thiaville, M. M., Pan, Y. X., Gjymishka, A., Zhong, C., Kaufman, R. J. & Kilberg, M. S. Apr 18 2008 In : Journal of Biological Chemistry. 283, 16, p. 10848-10857 10 p.

Research output: Research - peer-reviewArticle

Eukaryotic Initiation Factors
Mitogen-Activated Protein Kinase Kinases
Hepatocellular Carcinoma
Phosphorylation
Amino Acids
2007
Activating Transcription Factor 3
Genes
Chemical activation
Amino Acids
CCAAT-Enhancer-Binding Proteins

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer

Zhong, S., Fields, C. R., Su, N., Pan, Y. X. & Robertson, K. D. Apr 19 2007 In : Oncogene. 26, 18, p. 2621-2634 14 p.

Research output: Research - peer-reviewArticle

Gene Expression Profiling
DNA Methylation
Epigenomics
Non-Small Cell Lung Carcinoma
Histones
2006

An Inhibitor of Human Asparagine Synthetase Suppresses Proliferation of an L-Asparaginase-Resistant Leukemia Cell Line

Gutierrez, J. A., Pan, Y. X., Koroniak, L., Hiratake, J., Kilberg, M. S. & Richards, N. G. J. Dec 2006 In : Chemistry and Biology. 13, 12, p. 1339-1347 9 p.

Research output: Research - peer-reviewArticle

Aspartate-Ammonia Ligase
Asparaginase
Leukemia
Cell Line
Cells

Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

Palii, S. S., Thiaville, M. M., Pan, Y. X., Zhong, C. & Kilberg, M. S. May 1 2006 In : Biochemical Journal. 395, 3, p. 517-527 11 p.

Research output: Research - peer-reviewArticle

Amino Acid Transport System A
Neutral Amino Acid Transport Systems
Response Elements
Sodium
Amino Acids
2005

Amino-acid limitation induces transcription from the human C/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

Chen, C., Dudenhausen, E., Chen, H., Pan, Y. X., Gjymishka, A. & Kilberg, M. S. Nov 1 2005 In : Biochemical Journal. 391, 3, p. 649-658 10 p.

Research output: Research - peer-reviewArticle

CCAAT-Enhancer-Binding Protein-beta
Transcription
Genes
Amino Acids
Proteins

Developmental regulation of a Turkey intestinal peptide transporter (PepT1)

Van, L., Pan, Y. X., Bloomquist, J. R., Webb, K. E. & Wong, E. A. Jan 2005 In : Poultry Science. 84, 1, p. 75-82 8 p.

Research output: Research - peer-reviewArticle

peptide transporters
Turkey (country)
embryo (animal)
patch-clamp technique
dipeptides

Dietary protein level and stage of development affect expression of an intestinal peptide transporter (cPepT1) in chickens

Chen, H., Pan, Y., Wong, E. A. & Webb, K. E. Feb 2005 In : Journal of Nutrition. 135, 2, p. 193-198 6 p.

Research output: Research - peer-reviewArticle

peptide transporters
dietary protein
crude protein
chickens
Dietary Proteins

Functional characterization of a cloned pig intestinal peptide transporter (pPepT1)

Klang, J. E., Burnworth, L. A., Pan, Y. X., Webb, K. E. & Wong, E. A. Jan 2005 In : Journal of Animal Science. 83, 1, p. 172-181 10 p.

Research output: Research - peer-reviewArticle

Swine
Peptides
intestinal peptide-proton cotransporter
peptide transporters
peptides
RNA-Binding Proteins
3' Untranslated Regions
Amino Acids
Messenger RNA
ELAV-Like Protein 1

Nutritional control of gene expression: How mammalian cells respond to amino acid limitation

Kilberg, M. S., Pan, Y. X., Chen, H. & Leung-Pineda, V. 2005 In : Annual Review of Nutrition. 25, p. 59-85 27 p.

Research output: Research - peer-reviewReview article

Gene Expression
Amino Acids
Proteins
Messenger RNA
Activating Transcription Factor 4
2004
Aspartate-Ammonia Ligase
Leucine Zippers
Acetylation
Transcription
Histones

Human CCAAT/enhancer-binding protein β gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence

Chen, C., Dudenhausen, E. E., Pan, Y. X., Zhong, C. & Kilberg, M. S. Jul 2 2004 In : Journal of Biological Chemistry. 279, 27, p. 27948-27956 9 p.

Research output: Research - peer-reviewArticle

CCAAT-Enhancer-Binding Protein-beta
Unfolded Protein Response
Endoplasmic Reticulum Stress
Response Elements
Gene Expression

Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization

Leung-Pineda, V., Pan, Y., Chen, H. & Kilberg, M. S. Apr 1 2004 In : Biochemical Journal. 379, 1, p. 79-88 10 p.

Research output: Research - peer-reviewArticle

Hepatocellular Carcinoma
Amino Acids
Messenger RNA
Histidine
Proteins
2003
Activating Transcription Factor 3
Aspartate-Ammonia Ligase
Endoplasmic Reticulum Stress
Hep G2 Cells
Amino Acids
2002

Molecular cloning and functional expression of a chicken intestinal peptide transporter (cPepT1) in Xenopus oocytes and Chinese hamster ovary cells

Chen, H., Pan, Y., Wong, E. A., Bloomquist, J. R. & Webb, K. E. 2002 In : Journal of Nutrition. 132, 3, p. 387-393 7 p.

Research output: Research - peer-reviewArticle

Molecular Cloning
Xenopus
Cricetulus
Oocytes
Ovary

Poly(A)+ RNA encoding proteins capable of transporting L-methionine and/or DL-2-hydroxy-4-(methylthio) butanoic acid are present in the intestinal mucosa of broilers

Pan, Y., Wong, E. A., Dibner, J. J., Vázquez-Añón, M. & Webb, K. E. 2002 In : Journal of Nutrition. 132, 3, p. 382-386 5 p.

Research output: Research - peer-reviewArticle

intestinal mucosa
methionine
broiler chickens
RNA
acids
2001

Expression of a cloned ovine gastrointestinal peptide transporter (oPepT1) in Xenopus oocytes induces uptake of oligopeptides in vitro

Pan, Y., Wong, E. A., Bloomquist, J. R. & Webb, K. E. 2001 In : Journal of Nutrition. 131, 4, p. 1264-1270 7 p.

Research output: Research - peer-reviewArticle

peptide transporters
oligopeptides
Xenopus
oocytes
uptake mechanisms