William W Metcalf

1990 …2020
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Research Output 1990 2020

A computational framework to explore large-scale biosynthetic diversity

Navarro-Muñoz, J. C., Selem-Mojica, N., Mullowney, M. W., Kautsar, S. A., Tryon, J. H., Parkinson, E. I., De Los Santos, E. L. C., Yeong, M., Cruz-Morales, P., Abubucker, S., Roeters, A., Lokhorst, W., Fernandez-Guerra, A., Cappelini, L. T. D., Goering, A. W., Thomson, R. J., Metcalf, W. W., Kelleher, N. L., Barona-Gomez, F. & Medema, M. H., Jan 1 2020, In : Nature chemical biology. 16, 1, p. 60-68 9 p.

Research output: Contribution to journalArticle

Multigene Family
Biological Products
Cluster Analysis
Genome
Metabolomics

Biochemical characterization of the methylmercaptopropionate: Cob(I)alamin Methyltransferase from Methanosarcina acetivorans

Fu, H., Goettge, M. N. & Metcalf, W. W., Jan 1 2019, In : Journal of bacteriology. 201, 12, e00130-19.

Research output: Contribution to journalArticle

Methanosarcina
Corrinoids
Methyltransferases
Proteins
Methylation
Methanosarcina
Hydrogenase
Archaea
Methane
formic acid

Fosmidomycin biosynthesis diverges from related phosphonate natural products

Parkinson, E. I., Erb, A., Eliot, A. C., Ju, K. S. & Metcalf, W. W., Nov 1 2019, In : Nature chemical biology. 15, 11, p. 1049-1056 8 p.

Research output: Contribution to journalArticle

Organophosphonates
Biological Products
Biosynthetic Pathways
Carbon
Dioxygenases

GDGT cyclization proteins identify the dominant archaeal sources of tetraether lipids in the ocean

Zeng, Z., Liu, X. L., Farley, K. R., Wei, J. H., Metcalf, W. W., Summons, R. E. & Welander, P. V., Nov 5 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 45, p. 22505-22511 7 p.

Research output: Contribution to journalArticle

Open Access
Cyclization
Oceans and Seas
Glycerol
Lipids
Proteins