Research output per year
Research output per year
Personal profile
Research Interests
Research Topics
Cell-Cell Interactions, Cytoskeleton
Education
Ph.D. University of California, San Francisco
Postdoc. Harvard Medical School
Professional Information
Cytoskeleton and Cell Adhesion
Our lab is interested in understanding how cells organize an actin cytoskeleton. Current projects focus on how actin filaments are assembled at cell-cell adhesive junctions, how actin filaments disassemble, and how signals trigger actin assembly. We use a combination of biochemical, biophysical, and cell biological techniques to address these questions which are fundamental for understanding cell shape, cell motility, and morphogenesis. Some of our research provides insight into the molecular basis of inherited kidney disease.
Honors & Awards
LAS Dean's Award for Excellence in Undergraduate Teaching.
Fingerprint
Fingerprint is based on mining the text of the expert's scholarly documents to create an index of weighted terms, which defines the key subjects of each individual researcher.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Revisiting bacterial cytolethal distending toxin structure and function
Chen, H., Ang, C. J., Crowder, M., Brieher, W. M. & Blanke, S. R., 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 1289359.Research output: Contribution to journal › Article › peer-review
Open Access -
Synaptopodin stress fiber and contractomere at the epithelial junction
Morris, T., Sue, E., Geniesse, C., Brieher, W. M. & Tang, V. W., May 2 2022, In: Journal of Cell Biology. 221, 5, e202011162.Research output: Contribution to journal › Article › peer-review
Open Access -
Cadherin puncta are interdigitated dynamic actin protrusions necessary for stable cadherin adhesion
Li, J. X. H., Tang, V. W., Boateng, K. A. & Brieher, W. M., Jun 15 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 24, e2023510118.Research output: Contribution to journal › Article › peer-review
Open Access -
Actin protrusions push at apical junctions to maintain E-cadherin adhesion
Li, J. X. H., Tang, V. W. & Brieher, W. M., Jan 7 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 1, p. 432-438 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Catastrophic actin filament bursting by cofilin, Aip1, and coronin
Tang, V. W., Nadkarni, A. V. & Brieher, W. M., Sep 18 2020, In: Journal of Biological Chemistry. 295, 38, p. 13299-13313 15 p.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Data for Revisiting bacterial cytolethal distending toxin structure and function
Chen, H. (Creator), Ang, C. (Creator), Crowder, M. (Creator), Brieher, W. M. (Creator) & Blanke, S. R. (Creator), University of Illinois Urbana-Champaign, Jul 1 2024
DOI: 10.13012/B2IDB-4024145_V1
Dataset