William Harold Witola

2024

Characterization of a unique catechol-O-methyltransferase as a molecular drug target in parasitic filarial nematodes

Mia, M., Allaie, I. M., Zhang, X., Li, K., Khan, S. M., Kadotani, S. & Witola, W. H., Aug 2024, In: PLoS neglected tropical diseases. 18, 8, e0012473.

Research output: Contribution to journal › Article › peer-review

Open Access

Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus

Greigert, V., Saraav, I., Son, J., Zhu, Y., Dayao, D., Antia, A., Tzipori, S., Witola, W. H., Stappenbeck, T. S., Ding, S. & Sibley, L. D., 2024, In: Gut Microbes. 16, 1, 2297897.

Research output: Contribution to journal › Article › peer-review

Open Access

Mendelian segregation and high recombination rates facilitate genetic analyses in Cryptosporidium parvum

Kimball, A., Funkhouser-Jones, L., Huang, W., Xu, R., Witola, W. H. & Sibley, L. D., Jun 17 2024, In: PLoS genetics. 20, 6 June, e1011162.

Research output: Contribution to journal › Article › peer-review

Open Access

Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum

Xu, R., Beatty, W. L., Greigert, V., Witola, W. H. & Sibley, L. D., Dec 2024, In: Nature communications. 15, 1, 380.

Research output: Contribution to journal › Article › peer-review

Open Access

Selective targeting of phosphodiesterases to develop potent antiparasitic drugs

Khan, S. M., Mia, M. M. & Witola, W. H., Dec 2024, In: Trends in Parasitology. 40, 12, p. 1075-1076 2 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

Signal recognition particle RNA is critical for genetic competence and virulence of Streptococcus pneumoniae

Lin, J., Chong, S. Y., Oh, M. W., Lew, S. Q., Zhu, L., Zhang, X., Witola, W. H. & Lau, G. W., Sep 19 2024, In: Journal of bacteriology. 206, 9, p. e0000424

Research output: Contribution to journal › Article › peer-review

2023

Alternatives to piperidine in Knoevenagel condensation of 2-cyanoacetamide with benzaldehydes

Stec, J. & Witola, W. H., Dec 2023, In: Results in Chemistry. 6, 101212.

Research output: Contribution to journal › Article › peer-review

Open Access

Broad-Spectrum Inhibitors for Conserved Unique Phosphoethanolamine Methyltransferases in Parasitic Nematodes Possess Anthelmintic Efficacy

Zhang, X., Gianechini, L. S., Li, K., Kaplan, R. M. & Witola, W. H., Jun 2023, In: Antimicrobial Agents and Chemotherapy. 67, 6

Research output: Contribution to journal › Article › peer-review

Open Access

Combination of inhibitors for two glycolytic enzymes portrays high synergistic efficacy against Cryptosporidium parvum

Khan, S. M., Bajwa, M. R., Lahar, R. Y. & Witola, W. H., Oct 2023, In: Antimicrobial Agents and Chemotherapy. 67, 10

Research output: Contribution to journal › Article › peer-review

Open Access

Editorial: Advances in molecular biology, pathogenesis, diagnosis, vaccines, and treatment of diseases caused by apicomplexan parasites

Liu, M., Xia, N., Witola, W. H. & Li, K., 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 1205563.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Past, current, and potential treatments for cryptosporidiosis in humans and farm animals: A comprehensive review

Khan, S. M. & Witola, W. H., Jan 24 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 1115522.

Research output: Contribution to journal › Review article › peer-review

Open Access

2022

Activity of (1-benzyl-4-triazolyl)-indole-2-carboxamides against Toxoplasma gondii and Cryptosporidium parvum

Khan, S. M., Garcia Hernandez, A., Allaie, I. M., Grooms, G. M., Li, K., Witola, W. H. & Stec, J., Aug 2022, In: International Journal for Parasitology: Drugs and Drug Resistance. 19, p. 6-20 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Cryptosporidium parvum Pyruvate Kinase Inhibitors With in vivo Anti-cryptosporidial Efficacy

Khan, S. M., Zhang, X. & Witola, W. H., Jan 3 2022, In: Frontiers in Microbiology. 12, 800293.

Research output: Contribution to journal › Article › peer-review

Open Access

Plasmodium relictum MSP-1 capture antigen-based ELISA for detection of avian malaria antibodies in African penguins (Spheniscus demersus)

Zhang, X., Meadows, S. N. A., Martin, T., Doran, A., Angles, R., Sander, S., Bronson, E. & Witola, W. H., Dec 2022, In: International Journal for Parasitology: Parasites and Wildlife. 19, p. 89-95 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Anti-protozoal activity of Thymol and a Thymol ester against Cryptosporidium parvum in cell culture

Dominguez-Uscanga, A., Aycart, D. F., Li, K., Witola, W. H. & Andrade Laborde, J. E., Apr 2021, In: International Journal for Parasitology: Drugs and Drug Resistance. 15, p. 126-133 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Interaction of apigenin-7-O-glucoside with pyrimethamine against Toxoplasma gondii growth

Abugri, D. A. & Witola, W. H., Mar 1 2020, In: Journal of Parasitic Diseases. 44, 1, p. 221-229 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

In Vitro Culture of Cryptosporidium parvum Using Stem Cell-Derived Intestinal Epithelial Monolayers

Wilke, G., Wang, Y., Ravindran, S., Stappenbeck, T., Witola, W. H. & Sibley, L. D., 2020, Methods in Molecular Biology. Humana Press Inc., p. 351-372 22 p. (Methods in Molecular Biology; vol. 2052).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Novel acyl carbamates and acyl / diacyl ureas show in vitro efficacy against Toxoplasma gondii and Cryptosporidium parvum

Li, K., Grooms, G. M., Khan, S. M., Hernandez, A. G., Witola, W. H. & Stec, J., Dec 2020, In: International Journal for Parasitology: Drugs and Drug Resistance. 14, p. 80-90 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Anti-Toxoplasma activity of Sorghum bicolor-derived lipophilic fractions

Abugri, D. A., Jaynes, J. M. & Witola, W. H., Oct 24 2019, In: BMC Research Notes. 12, 1, 688.

Research output: Contribution to journal › Article › peer-review

Open Access

A review of Cyclospora cayetanensis transport in the environment

Onstad, N. H., Miller, M. R., Green, M. L., Witola, W. H. & Davidson, P. C., 2019, In: Transactions of the ASABE. 62, 3, p. 795-802 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability

Wilke, G., Funkhouser-Jones, L. J., Wang, Y., Ravindran, S., Wang, Q., Beatty, W. L., Baldridge, M. T., VanDussen, K. L., Shen, B., Kuhlenschmidt, M. S., Kuhlenschmidt, T. B., Witola, W. H., Stappenbeck, T. S. & Sibley, L. D., Jul 10 2019, In: Cell Host and Microbe. 26, 1, p. 123-134.e8

Research output: Contribution to journal › Article › peer-review

Open Access

Cyclospora Cayetanensis Presence in the Environment—A Case Study in the Chicago Metropolitan Area

Onstad, N. H., Beever, J. E., Miller, M. R., Green, M. L., Witola, W. H. & Davidson, P. C., Jul 6 2019, In: Environments. 6, 7, 80.

Research output: Contribution to journal › Article › peer-review

Open Access

Novel lactate dehydrogenase inhibitors with in vivo efficacy against Cryptosporidium parvum

Li, K., Nader, S. M., Zhang, X., Ray, B. C., Kim, C. Y., Das, A. & Witola, W. H., Jul 2019, In: PLoS pathogens. 15, 7, e1007953.

Research output: Contribution to journal › Article › peer-review

Open Access

Pulmonary Paragonimus infection and other pathologic findings in feral swine (Sus scrofa) from Macon County, Alabama

Gilbreath, E. T., Gorham, S. L., Anderson, D. L., Witola, W. H., Casimir, R. H., Bridges, E. R. & Gaston, W. D., Jun 2019, In: Journal of Swine Health and Production. 27, 3, p. 125-132 8 p.

Research output: Contribution to journal › Review article › peer-review

System to Evaluate Movement of Biological Contaminants in Soil

Miller, M. R., Onstad, N. H., Green, M. L., Witola, W. H. & Davidson, P. C., Mar 2019, In: Environments. 6, 3, 19 p., 33.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

In vitro activity of the interaction between taxifolin (dihydroquercetin) and pyrimethamine against Toxoplasma gondii

Abugri, D. A., Witola, W. H., Russell, A. E. & Troy, R. M., Jan 2018, In: Chemical Biology and Drug Design. 91, 1, p. 194-201 8 p.

Research output: Contribution to journal › Article › peer-review

Morpholino-mediated in vivo silencing of Cryptosporidium parvum lactate dehydrogenase decreases oocyst shedding and infectivity

Zhang, X., Kim, C. Y., Worthen, T. & Witola, W. H., Jul 2018, In: International Journal for Parasitology. 48, 8, p. 649-656 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Small GTPase immunity-associated proteins mediate resistance to Toxoplasma gondii infection in Lewis rat

Kim, C. Y., Zhang, X. & Witola, W. H., Apr 1 2018, In: Infection and immunity. 86, 4, e00582-17.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Inherent oxidative stress in the Lewis rat is associated with resistance to toxoplasmosis

Witola, W. H., Kim, C. Y. & Zhang, X., 2017, In: Infection and immunity. 85, 10, e00289-17.

Research output: Contribution to journal › Article › peer-review

Open Access

In vitro antagonistic and indifferent activity of combination of 3-deoxyanthocyanidins against Toxoplasma gondii

Abugri, D. A., Witola, W. H. & Jaynes, J. M., Dec 1 2017, In: Parasitology Research. 116, 12, p. 3387-3400 14 p.

Research output: Contribution to journal › Article › peer-review

Targeted gene knockdown validates the essential role of lactate dehydrogenase in Cryptosporidium parvum

Witola, W. H., Zhang, X. & Kim, C. Y., Nov 2017, In: International Journal for Parasitology. 47, 13, p. 867-874 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

In vitro activity of Sorghum bicolor extracts, 3-deoxyanthocyanidins, against Toxoplasma gondii

Abugri, D. A., Witola, W. H., Jaynes, J. M. & Toufic, N., May 1 2016, In: Experimental Parasitology. 164, p. 12-19 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

In vitro anthelmintic efficacy of inhibitors of phosphoethanolamine Methyltransferases in Haemonchus contortus

Witola, W. H., Matthews, K. & McHugh, M., Apr 1 2016, In: International Journal for Parasitology: Drugs and Drug Resistance. 6, 1, p. 44-53 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Knockdown of phosphoethanolamine transmethylation enzymes decreases viability of Haemonchus contortus

Witola, W. H., Cooks-Fagbodun, S., Ordonez, A. R., Matthews, K., Abugri, D. A. & McHugh, M., Jun 15 2016, In: Veterinary parasitology. 223, p. 1-6 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2014

ALOX12 in human toxoplasmosis

Witola, W. H., Liu, S. R., Montpetit, A., Welti, R., Hypolite, M., Roth, M., Zhou, Y., Mui, E., Cesbron-Delauw, M. F., Fournie, G. J., Cavailles, P., Bisanz, C., Boyer, K., Withers, S., Gwendolyn Noble, A., Swisher, C. N., Heydemann, P. T., Rabiah, P., Muench, S. P. & McLeod, R., Jul 2014, In: Infection and immunity. 82, 7, p. 2670-2679 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Silencing of GRA10 protein expression inhibits Toxoplasma gondii intracellular growth and development

Witola, W. H., Bauman, B., McHugh, M. & Matthews, K., Oct 2014, In: Parasitology International. 63, 5, p. 651-658 8 p.

Research output: Contribution to journal › Article › peer-review

2013

Isolation, cloning, and pathologic analysis of Trypanosoma evansi field isolates

Mekata, H., Konnai, S., Mingala, C. N., Abes, N. S., Gutierrez, C. A., Dargantes, A. P., Witola, W. H., Inoue, N., Onuma, M., Murata, S. & Ohashi, K., Apr 2013, In: Parasitology Research. 112, 4, p. 1513-1521 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission

Bobenchik, A. M., Witola, W. H., Augagneur, Y., Lochlainn, L. N., Garg, A., Pachikara, N., Choi, J. Y., Zhao, Y. O., Usmani-Brown, S., Lee, A., Adjalley, S. H., Samanta, S., Fidock, D. A., Voelker, D. R., Fikrig, E. & Mamoun, C. B., Nov 5 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 45, p. 18262-18267 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2012

Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection

Mekata, H., Konnai, S., Mingala, C. N., Abes, N. S., Gutierrez, C. A., Dargantes, A. P., Witola, W. H., Inoue, N., Onuma, M., Murata, S. & Ohashi, K., Jun 2012, In: Parasite Immunology. 34, 6, p. 318-329 12 p.

Research output: Contribution to journal › Article › peer-review

Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections

Lai, B. S., Witola, W. H., El Bissati, K., Zhou, Y., Mui, E., Fomovska, A. & McLeod, R., Aug 28 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 35, p. 14182-14187 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway

Fomovska, A., Huang, Q., El Bissati, K., Mui, E. J., Witola, W. H., Cheng, G., Zhou, Y., Sommerville, C., Roberts, C. W., Bettis, S., Prigge, S. T., Afanador, G. A., Hickman, M. R., Lee, P. J., Leed, S. E., Auschwitz, J. M., Pieroni, M., Stec, J., Muench, S. P. & Rice, D. W. & 2 others, Kozikowski, A. P. & McLeod, R., May 2012, In: Antimicrobial Agents and Chemotherapy. 56, 5, p. 2666-2682 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Synthesis, biological evaluation, and structure-activity relationships of N -benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), trypanosomes, and leishmania

Stec, J., Huang, Q., Pieroni, M., Kaiser, M., Fomovska, A., Mui, E., Witola, W. H., Bettis, S., McLeod, R., Brun, R. & Kozikowski, A. P., Apr 12 2012, In: Journal of Medicinal Chemistry. 55, 7, p. 3088-3100 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Toxoplasma gondii HLA-B0702-restricted GRA7 _20-28 peptide with adjuvants and a universal helper T cell epitope elicits CD8 ⁺ T cells producing interferon-γ and reduces parasite burden in HLA-B0702 mice

Cong, H., Mui, E. J., Witola, W. H., Sidney, J., Alexander, J., Sette, A., Maewal, A., El Bissati, K., Zhou, Y., Suzuki, Y., Lee, D., Woods, S., Sommerville, C., Henriquez, F. L., Roberts, C. W. & McLeod, R., Jan 2012, In: Human Immunology. 73, 1, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2011

NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells

Witola, W. H., Mui, E., Hargrave, A., Liu, S., Hypolite, M., Montpetit, A., Cavailles, P., Bisanz, C., Cesbron-Delauw, M. F., Fournié, G. J. & McLeod, R., Feb 2011, In: Infection and immunity. 79, 2, p. 756-766 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Towards an immunosense vaccine to prevent toxoplasmosis: Protective Toxoplasma gondii epitopes restricted by HLA-A*0201

Cong, H., Mui, E. J., Witola, W. H., Sidney, J., Alexander, J., Sette, A., Maewal, A. & McLeod, R., Jan 17 2011, In: Vaccine. 29, 4, p. 754-762 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2010

Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CD8⁺T cell epitope based, adjuvanted vaccine protective against Toxoplasma gondii

Cong, H., Mui, E. J., Witola, W. H., Sidney, J., Alexander, J., Sette, A., Maewal, A. & McLeod, R., 2010, In: Immunome Research. 6, 1, 12.

Research output: Contribution to journal › Article › peer-review

Open Access

Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans

Tan, T. G., Mui, E., Cong, H., Witola, W. H., Montpetit, A., Muench, S. P., Sidney, J., Alexander, J., Sette, A., Grigg, M. E., Maewal, A. & McLeod, R., May 21 2010, In: Vaccine. 28, 23, p. 3977-3989 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

P2X₇ receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages

Lees, M. P., Fuller, S. J., McLeod, R., Boulter, N. R., Miller, C. M., Zakrzewski, A. M., Mui, E. J., Witola, W. H., Coyne, J. J., Hargrave, A. C., Jamieson, S. E., Blackwell, J. M., Wiley, J. S. & Smith, N. C., Jun 15 2010, In: Journal of Immunology. 184, 12, p. 7040-7046 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest

Hutson, S. L., Mui, E., Kinsley, K., Witola, W. H., Behnke, M. S., El Bissati, K., Muench, S. P., Rohrman, B., Liu, S. R., Wollmann, R., Ogata, Y., Sarkeshik, A., Yates, J. R. & McLeod, R., 2010, In: PloS one. 5, 11, e14057.

Research output: Contribution to journal › Article › peer-review

Open Access

The malarial CDK Pfmrk and its effector PfMAT1 phosphorylate DNA replication proteins and co-localize in the nucleus

Jirage, D., Chen, Y., Caridha, D., O'Neil, M. T., Eyase, F., Witola, W. H., Mamoun, C. B. & Waters, N. C., Jul 2010, In: Molecular and Biochemical Parasitology. 172, 1, p. 9-18 10 p.

Research output: Contribution to journal › Article › peer-review

William Harold Witola

Research output

Search results