Research Output 1979 2018

2018

A chiral pool approach for asymmetric syntheses of both antipodes of equol and sativan

Yalamanchili, C., Chittiboyina, A. G., Chandra Kumar Rotte, S., Katzenellenbogen, J. A., Helferich, W. G. & Khan, I. A. Apr 19 2018 In : Tetrahedron. 74, 16, p. 2020-2029 10 p.

Research output: Contribution to journalArticle

Equol
Vehicle springs
Pharmacology
Isoflavones
Boron

Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J. May 1 2018 In : Biomaterials Science. 6, 5, p. 1189-1200 12 p.

Research output: Contribution to journalArticle

Nanoconjugates
IIR filters
Tumors
Bearings (structural)
Medical nanotechnology

The effects of the botanical estrogen, isoliquiritigenin on delayed spatial alternation

Kundu, P., Neese, S. L., Bandara, S., Monaikul, S., Helferich, W. G., Doerge, D. R., Khan, I. A. & Schantz, S. L. Mar 1 2018 In : Neurotoxicology and Teratology. 66, p. 55-62 8 p.

Research output: Contribution to journalArticle

Estrogens
Short-Term Memory
Rats
Brain
Dietary supplements
2017

Extract of Ginkgo biloba exacerbates liver metastasis in a mouse colon cancer Xenograft model

Wang, H., Wu, X., Lezmi, S., Li, Q., Helferich, W. G., Xu, Y. & Chen, H. Dec 2 2017 In : BMC Complementary and Alternative Medicine. 17, 1, 516

Research output: Contribution to journalArticle

Ginkgo biloba
Heterografts
Colonic Neoplasms
Neoplasm Metastasis
Liver

Lifetime genistein intake increases the response of mammary tumors to tamoxifen in rats

Zhang, X., Cook, K. L., Warri, A., Cruz, I. M., Rosim, M., Riskin, J., Helferich, W., Doerge, D., Clarke, R. & Hilakivi-Clarke, L. Feb 1 2017 In : Clinical Cancer Research. 23, 3, p. 814-824 11 p.

Research output: Contribution to journalArticle

Genistein
Tamoxifen
Breast Neoplasms
Diet
Unfolded Protein Response

Low calcium diet increases 4T1 mammary tumor carcinoma cell burden and bone pathology in mice

Wang, W., Gordon, J. L., Philbrick, K. A., Yang, X., Branscum, A. J., Löhr, C. V., Haschek, W. M., Turner, R. T., Iwaniec, U. T. & Helferich, W. G. Jul 1 2017 In : PLoS ONE. 12, 7, e0180886

Research output: Contribution to journalArticle

mammary neoplasms (animal)
Pathology
Nutrition
carcinoma
Tumors

Preconception exposure to dietary levels of genistein affects female reproductive outcomes

Patel, S., Hartman, J. A., Helferich, W. G. & Flaws, J. A. Dec 1 2017 In : Reproductive Toxicology. 74, p. 174-180 7 p.

Research output: Contribution to journalArticle

Genistein
Litter Size
Birth Rate
Fertility
Estradiol
2016

Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland

Madak-Erdogan, Z., Gong, P., Zhao, Y. C., Xu, L., Wrobel, K. U., Hartman, J. A., Wang, M., Cam, A., Iwaniec, U. T., Turner, R. T., Twaddle, N. C., Doerge, D. R., Khan, I. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Helferich, W. G. Feb 1 2016 In : Molecular Nutrition and Food Research. 60, 2, p. 369-380 12 p.

Research output: Contribution to journalArticle

Glycyrrhiza
licorice
fatty liver
Human Mammary Glands
mammary glands

Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis

Mahalingam, S., Gao, L., Eisner, J., Helferich, W. & Flaws, J. A. Dec 1 2016 In : Reproductive Toxicology. 66, p. 107-114 8 p.

Research output: Contribution to journalArticle

Ovarian Follicle
Growth
Steroid 17-alpha-Hydroxylase
Dimethyl Sulfoxide
Estradiol

Effects of letrozole on breast cancer micro-metastatic tumor growth in bone and lung in mice inoculated with murine 4T1 cells

Wang, W., Belosay, A., Yang, X., Hartman, J. A., Song, H., Iwaniec, U. T., Turner, R. T., Churchwell, M. I., Doerge, D. R. & Helferich, W. G. Jun 1 2016 In : Clinical and Experimental Metastasis. 33, 5, p. 475-485 11 p.

Research output: Contribution to journalArticle

letrozole
Bone Development
Breast Neoplasms
Lung
Neoplasms

Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles in vitro

Mahalingam, S., Gao, L., Gonnering, M., Helferich, W. & Flaws, J. A. Mar 15 2016 In : Toxicology and Applied Pharmacology. 295, p. 47-55 9 p.

Research output: Contribution to journalArticle

Equol
Growth
Isoflavones
Ovarian Follicle
Metabolites

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y. X., Helferich, W. G. & Flaws, J. A. Feb 15 2016 In : Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Contribution to journalArticle

Genistein
Growth
Phytoestrogens
Cell Cycle
Cells

Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action

Zheng, X., Andruska, N., Yu, L., Mao, C., Kim, J. E., Livezey, M., Helferich, W. G. & Shapiro, D. J. Jan 1 2016 In : Steroids. 114, p. 2-6 5 p.

Research output: Contribution to journalReview article

Steroid hormones
Unfolded Protein Response
Cytoplasmic and Nuclear Receptors
Estrogen Receptor alpha
Chemical activation

Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities

Boonmuen, N., Gong, P., Ali, Z., Chittiboyina, A. G., Khan, I., Doerge, D. R., Helferich, W. G., Carlson, K. E., Martin, T., Piyachaturawat, P., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. Jan 1 2016 In : Steroids. 105, p. 42-49 8 p.

Research output: Contribution to journalArticle

Dietary supplements
Glycyrrhiza
Selective Estrogen Receptor Modulators
Dietary Supplements
Estrogens

Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer

Rendeiro, C., Sheriff, A., Bhattacharya, T. K., Gogola, J. V., Baxter, J. H., Chen, H., Helferich, W. G., Roy, E. J. & Rhodes, J. S. Dec 15 2016 In : Behavioural Brain Research. 315, p. 10-22 13 p.

Research output: Contribution to journalArticle

Neurogenesis
Breast Neoplasms
Drug Therapy
Bromodeoxyuridine
Cognition

Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

Yin, Q., Tang, L., Cai, K., Tong, R., Sternberg, R., Yang, X., Dobrucki, L. W., Borst, L. B., Kamstock, D., Song, Z., Helferich, W. G., Cheng, J. & Fan, T. M. Aug 9 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4601-E4609

Research output: Contribution to journalArticle

pamidronate
Nanoconjugates
Osteolysis
Nanoparticles
Doxorubicin

Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys

Doerge, D. R., Woodling, K. A., Churchwell, M. I., Fleck, S. C. & Helferich, W. G. Jun 1 2016 In : Food and Chemical Toxicology. 92, p. 165-176 12 p.

Research output: Contribution to journalArticle

Infant Formula
Isoflavones
Pharmacokinetics
infant formulas
isoflavones

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro

Aumsuwan, P., Khan, S. I., Khan, I. A., Ali, Z., Avula, B., Walker, L. A., Shariat-Madar, Z., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K. Feb 1 2016 In : Archives of Biochemistry and Biophysics. 591, p. 98-110 13 p.

Research output: Contribution to journalArticle

Dioscorea
Saponins
Cells
Breast Neoplasms
Cell Line
2015

A multi-targeted approach to suppress tumor-promoting inflammation

Samadi, A. K. , Bilsland, A. , Georgakilas, A. G. , Amedei, A. , Amin, A. , Bishayee, A. , Azmi, A. S. , Lokeshwar, B. L. , Grue, B. , Panis, C. , Boosani, C. S. , Poudyal, D. , Stafforini, D. M. , Bhakta, D. , Niccolai, E. , Guha, G. , Vasantha Rupasinghe, H. P. , Fujii, H. , Honoki, K. , Mehta, K. & 15 others Aquilano, K., Lowe, L., Hofseth, L. J., Ricciardiello, L., Ciriolo, M. R., Singh, N., Whelan, R. L., Chaturvedi, R., Ashraf, S. S., Shantha Kumara, H. M. C., Nowsheen, S., Mohammed, S. I., Keith, W. N., Helferich, W. G. & Yang, X. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S151-S184

Research output: Contribution to journalReview article

Inflammation
Neoplasms
Anti-Inflammatory Agents
Macrophage Migration-Inhibitory Factors
CXC Chemokines

Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer

Andruska, N., Zheng, X., Yang, X., Helferich, W. G. & Shapiro, D. J. Jul 21 2015 In : Oncogene. 34, 29, p. 3760-3769 10 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Estrogen Receptor alpha
Estrogens
Cell Proliferation
Breast Neoplasms

Broad targeting of resistance to apoptosis in cancer

Mohammad, R. M. , Muqbil, I. , Lowe, L. , Yedjou, C. , Hsu, H. Y. , Lin, L. T. , Siegelin, M. D. , Fimognari, C. , Kumar, N. B. , Dou, Q. P. , Yang, H. , Samadi, A. K. , Russo, G. L. , Spagnuolo, C. , Ray, S. K. , Chakrabarti, M. , Morre, J. D. , Coley, H. M. , Honoki, K. , Fujii, H. & 19 others Georgakilas, A. G., Amedei, A., Niccolai, E., Amin, A., Ashraf, S. S., Helferich, W. G., Yang, X., Boosani, C. S., Guha, G., Bhakta, D., Ciriolo, M. R., Aquilano, K., Chen, S., Mohammed, S. I., Keith, W. N., Bilsland, A., Halicka, D., Nowsheen, S. & Azmi, A. S. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S78-S103

Research output: Contribution to journalReview article

Apoptosis
Neoplasms
Cell Death
Gossypol
Cell Nucleus Active Transport

Cancer prevention and therapy through the modulation of the tumor microenvironment

Casey, S. C. , Amedei, A. , Aquilano, K. , Azmi, A. S. , Benencia, F. , Bhakta, D. , Bilsland, A. E. , Boosani, C. S. , Chen, S. , Ciriolo, M. R. , Crawford, S. , Fujii, H. , Georgakilas, A. G. , Guha, G. , Halicka, D. , Helferich, W. G. , Heneberg, P. , Honoki, K. , Keith, W. N. , Kerkar, S. P. & 11 others Mohammed, S. I., Niccolai, E., Nowsheen, S., Vasantha Rupasinghe, H. P., Samadi, A., Singh, N., Talib, W. H., Venkateswaran, V., Whelan, R. L., Yang, X. & Felsher, D. W. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S199-S223

Research output: Contribution to journalReview article

Tumor Microenvironment
piperine
Neoplasms
Carcinogenesis
Indoleamine-Pyrrole 2,3,-Dioxygenase

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Block, K. I. , Gyllenhaal, C. , Lowe, L. , Amedei, A. , Ruhul Amin, A. R. M. , Amin, A. , Aquilano, K. , Arbiser, J. , Arreola, A. , Arzumanyan, A. , Salman Ashraf, S. , Azmi, A. S. , Benencia, F. , Bhakta, D. , Bilsland, A. , Bishayee, A. , Blain, S. W. , Block, P. B. , Boosani, C. S. , Carey, T. E. & 30 others Carnero, A., Carotenuto, M., Casey, S. C., Chakrabarti, M., Chaturvedi, R., Chen, G. Z., Chen, H., Chen, S., Chen, Y. C., Choi, B. K., Ciriolo, M. R., Coley, H. M., Collins, A. R., Connell, M., Crawford, S., Curran, C. S., Dabrosin, C., Damia, G., Dasgupta, S., DeBerardinis, R. J., Decker, W. K., Dhawan, P., Diehl, A. M. E., Dong, J. T., Dou, Q. P., Drewa, J. E., Elkord, E., El-Rayes, B., Feitelson, M. A. & Felsheru, D. W. Jan 1 2015 In : Seminars in Cancer Biology. 35, p. S276-S304

Research output: Contribution to journalReview article

Tumor Microenvironment
Recurrence
Neoplasms
Genetic Heterogeneity
Poisons
High Fat Diet
Nutrition
Gene expression
Fats
Parturition

Development of a point-of-use fortification technology for delivery of micronutrients in Honduras

Andrade, J. E., Rosales, E., Lopez, J. R., Carrillo, E. P., Engeseth, N. J. & Helferich, W. G. Jan 1 2015 In : Journal of the Science of Food and Agriculture. 95, 2, p. 393-400 8 p.

Research output: Contribution to journalArticle

Honduras
Micronutrients
dietary minerals
Technology
rice

Dietary soy isoflavones increase metastasis to lungs in an experimental model of breast cancer with bone micro-tumors

Yang, X., Belosay, A., Hartman, J. A., Song, H., Zhang, Y., Wang, W., Doerge, D. R. & Helferich, W. G. Apr 8 2015 In : Clinical and Experimental Metastasis. 32, 4, p. 323-333 11 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Isoflavones
Theoretical Models
Breast Neoplasms
Neoplasm Metastasis

Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression

Andruska, N. D., Zheng, X., Yang, X., Mao, C., Cherian, M. M., Mahapatra, L., Helferich, W. G. & Shapiro, D. J. Apr 14 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 15, p. 4737-4742 6 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Estrogen Receptor alpha
Endoplasmic Reticulum
Neoplasms
Peptide Elongation Factor 2

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

Ferguson, L. R. , Chen, H. , Collins, A. R. , Connell, M. , Damia, G. , Dasgupta, S. , Malhotra, M. , Meeker, A. K. , Amedei, A. , Amin, A. , Ashraf, S. S. , Aquilano, K. , Azmi, A. S. , Bhakta, D. , Bilsland, A. , Boosani, C. S. , Chen, S. , Ciriolo, M. R. , Fujii, H. , Guha, G. & 15 others Halicka, D., Helferich, W. G., Keith, W. N., Mohammed, S. I., Niccolai, E., Yang, X., Honoki, K., Parslow, V. R., Prakash, S., Rezazadeh, S., Shackelford, R. E., Sidransky, D., Tran, P. T., Yang, E. S. & Maxwell, C. A. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S5-S24

Research output: Contribution to journalReview article

Genomic Instability
Diet
Neoplasms
DNA Damage
Centrosome

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

Vinay, D. S. , Ryan, E. P. , Pawelec, G. , Talib, W. H. , Stagg, J. , Elkord, E. , Lichtor, T. , Decker, W. K. , Whelan, R. L. , Kumara, H. M. C. S. , Signori, E. , Honoki, K. , Georgakilas, A. G. , Amin, A. , Helferich, W. G. , Boosani, C. S. , Guha, G. , Ciriolo, M. R. , Chen, S. , Mohammed, S. I. & 12 others Azmi, A. S., Keith, W. N., Bilsland, A., Bhakta, D., Halicka, D., Fujii, H., Aquilano, K., Ashraf, S. S., Nowsheen, S., Yang, X., Choi, B. K. & Kwon, B. S. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S185-S198

Research output: Contribution to journalReview article

Immune Evasion
Neoplasms
Therapeutics
Phytochemicals
Tumor Escape
Adipogenesis
Glucose Intolerance
Dietary Fats
Rats
Glucose

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

Liu, Y., Hilakivi-Clarke, L., Zhang, Y., Wang, X., Pan, Y. X., Xuan, J., Fleck, S. C., Doerge, D. R. & Helferich, W. G. Aug 1 2015 In : Molecular Nutrition and Food Research. 59, 8, p. 1419-1430 12 p.

Research output: Contribution to journalArticle

Isoflavones
soy flour
Flour
isoflavones
Nude Mice

Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model

Andrade, J. E., Ju, Y. H., Baker, C., Doerge, D. R. & Helferich, W. G. Mar 1 2015 In : Molecular Nutrition and Food Research. 59, 3, p. 413-423 11 p.

Research output: Contribution to journalArticle

Genistein
genistein
chronic exposure
Heterografts
breast neoplasms

Redox-responsive self-assembled chain-shattering polymeric therapeutics

Cai, K., Yen, J., Yin, Q., Liu, Y., Song, Z., Lezmi, S., Zhang, Y., Yang, X., Helferich, W. G. & Cheng, J. Jan 1 2015 In : Biomaterials Science. 3, 7, p. 1061-1065 5 p.

Research output: Contribution to journalArticle

Polyethylene glycols
Nanoparticles
Polycondensation
Pharmaceutical Preparations
Particle size

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

Jiang, W. G. , Sanders, A. J. , Katoh, M. , Ungefroren, H. , Gieseler, F. , Prince, M. , Thompson, S. K. , Zollo, M. , Spano, D. , Dhawan, P. , Sliva, D. , Subbarayan, P. R. , Sarkar, M. , Honoki, K. , Fujii, H. , Georgakilas, A. G. , Amedei, A. , Niccolai, E. , Amin, A. , Ashraf, S. S. & 16 others Ye, L., Helferich, W. G., Yang, X., Boosani, C. S., Guha, G., Ciriolo, M. R., Aquilano, K., Chen, S., Azmi, A. S., Keith, W. N., Bilsland, A., Bhakta, D., Halicka, D., Nowsheen, S., Pantano, F. & Santini, D. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S244-S275

Research output: Contribution to journalReview article

Neoplasm Metastasis
Neoplasms
Transforming Growth Factor beta
Milk Thistle
Cordyceps
2014

Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells

Aumsuwan, P., Khan, S. I., Khan, I. A., Avula, B., Walker, L. A., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K. Jan 1 2014 In : In Vitro Cellular and Developmental Biology - Animal. 51, 1, p. 59-71 13 p.

Research output: Contribution to journalArticle

Dioscorea villosa
5-methyldeoxycytidine
Dioscorea
yams
Epigenomics

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Strakovsky, R. S., Lezmi, S., Flaws, J. A., Schantz, S. L., Pan, Y. X. & Helferich, W. G. Mar 1 2014 In : Toxicological Sciences. 138, 1, p. 161-174 14 p., kft331

Research output: Contribution to journalArticle

Genistein
Rats
Obesity
Fats
CCAAT-Enhancer-Binding Protein-alpha

Investigating the optimal size of anticancer nanomedicine

Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., Dobrucki, I. T., Dobrucki, L. W., Borst, L. B., Lezmi, S., Helferich, W. G., Ferguson, A. L., Fan, T. M. & Cheng, J. Oct 28 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15344-15349 6 p.

Research output: Contribution to journalArticle

Nanomedicine
Neoplasms
Nanoconjugates
United States Food and Drug Administration
Particle Size

The effects of dietary treatment with S-equol on learning and memory processes in middle-aged ovariectomized rats

Neese, S. L., Pisani, S. L., Doerge, D. R., Helferich, W. G., Sepehr, E., Chittiboyina, A. G., Rotte, S. C. K., Smillie, T. J., Khan, I. A., Korol, D. L. & Schantz, S. L. Jan 1 2014 In : Neurotoxicology and Teratology. 41, p. 80-88 9 p.

Research output: Contribution to journalArticle

Equol
Rats
Learning
Genistein
Data storage equipment
Estrogen Receptor alpha
Gene Regulatory Networks
Estrogens
Gene Expression
Glycyrrhiza
2013

Association between Absolute Tumor Burden and Serum Bone-Specific Alkaline Phosphatase in Canine Appendicular Osteosarcoma

Sternberg, R. A., Pondenis, H. C., Yang, X., Mitchell, M. A., O'Brien, R. T., Garrett, L. D., Helferich, W. G., Hoffmann, W. E. & Fan, T. M. Jul 2013 In : Journal of Veterinary Internal Medicine. 27, 4, p. 955-963 9 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Tumor Burden
Alkaline Phosphatase
alkaline phosphatase

Estradiol increases ER-negative breast cancer metastasis in an experimental model

Yang, X., Belosay, A., Du, M., Fan, T. M., Turner, R. T., Iwaniec, U. T. & Helferich, W. G. Aug 1 2013 In : Clinical and Experimental Metastasis. 30, 6, p. 711-721 11 p.

Research output: Contribution to journalArticle

Estradiol
Theoretical Models
Breast Neoplasms
Neoplasm Metastasis
Neoplasms

Genistein administered as a once-daily oral supplement had no beneficial effect on the tibia in rat models for postmenopausal bone loss

Turner, R. T., Iwaniec, U. T., Andrade, J. E., Branscum, A. J., Neese, S. L., Olson, D. A., Wagner, L., Wang, V. C., Schantz, S. L. & Helferich, W. G. Jun 1 2013 In : Menopause. 20, 6, p. 677-686 10 p.

Research output: Contribution to journalArticle

Postmenopausal Osteoporosis
Genistein
Tibia
Bone and Bones
Dietary Supplements

Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

Jiang, Y., Gong, P., Madak-Erdogan, Z., Martin, T., Jeyakumar, M., Carlson, K., Khan, I., Smillie, T. J., Chittiboyina, A. G., Rotte, S. C. K., Helferich, W. G., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. Nov 2013 In : FASEB Journal. 27, 11, p. 4406-4418 13 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Estrogens
Gene expression
Chromatin
Equol

Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

Xing, H., Tang, L., Yang, X., Hwang, K., Wang, W., Yin, Q., Wong, N. Y., Dobrucki, L. W., Yasui, N., Katzenellenbogen, J. A., Helferich, W. G., Cheng, J. & Lu, Y. Oct 21 2013 In : Journal of Materials Chemistry B. 1, 39, p. 5288-5297 10 p.

Research output: Contribution to journalArticle

Liposomes
Cells
Nucleotide Aptamers
Breast Neoplasms
Nude Mice
2012

Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats

Pisani, S. L., Neese, S. L., Doerge, D. R., Helferich, W. G., Schantz, S. L. & Korol, D. L. Sep 1 2012 In : Hormones and Behavior. 62, 4, p. 491-499 9 p.

Research output: Contribution to journalArticle

Genistein
Young Adult
Estradiol
Learning
Therapeutics

Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

Tang, L., Yang, X., Dobrucki, L. W., Chaudhury, I., Yin, Q., Yao, C., Lezmi, S., Helferich, W. G., Fan, T. M. & Cheng, J. Dec 14 2012 In : Angewandte Chemie - International Edition. 51, 51, p. 12721-12726 6 p.

Research output: Contribution to journalArticle

Nanoconjugates
Silicon Dioxide
Tumors
Silica
Imaging techniques

Effects of multiple daily genistein treatments on delayed alternation and a differential reinforcement of low rates of responding task in middle-aged rats

Neese, S. L., Bandara, S. B., Doerge, D. R., Helferich, W. G., Korol, D. L. & Schantz, S. L. Jan 1 2012 In : Neurotoxicology and Teratology. 34, 1, p. 187-195 9 p.

Research output: Contribution to journalArticle

Genistein
Rats
Reinforcement
Phytoestrogens
Long Evans Rats

Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice

Du, M., Yang, X., Hartman, J. A., Cooke, P. S., Doerge, D. R., Ju, Y. H. & Helferich, W. G. 2012 In : Carcinogenesis. 33, 4, p. 895-901 7 p.

Research output: Contribution to journalArticle

Genistein
Therapeutic Uses
Tamoxifen
Nude Mice
Estrogens
2011

Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression

De Assis, S., Warri, A., Benitez, C., Helferich, W. & Hilakivi-Clarke, L. Sep 2011 In : Cancer Prevention Research. 4, 9, p. 1436-1448 13 p.

Research output: Contribution to journalArticle

Genistein
Carcinogenesis
Breast
Diet
Human Mammary Glands
2010

Absolute bioavailability of isoflavones from soy protein isolate-containing food in female Balb/c mice

Andrade, J. E., Twaddle, N. C., Helferich, W. G. & Doerge, D. R. Apr 14 2010 In : Journal of Agricultural and Food Chemistry. 58, 7, p. 4529-4536 8 p.

Research output: Contribution to journalArticle

Soybean Proteins
Isoflavones
soy protein isolate
isoflavones
Biological Availability