Research Output 1979 2017

2017

Lifetime genistein intake increases the response of mammary tumors to tamoxifen in rats

Zhang, X., Cook, K. L., Warri, A., Cruz, I. M., Rosim, M., Riskin, J., Helferich, W., Doerge, D., Clarke, R. & Hilakivi-Clarke, L. Feb 1 2017 In : Clinical Cancer Research. 23, 3, p. 814-824 11 p.

Research output: Contribution to journalArticle

Genistein
Tamoxifen
Breast Neoplasms
Diet
Unfolded Protein Response
2016

Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis

Mahalingam, S., Gao, L., Eisner, J., Helferich, W. & Flaws, J. A. Dec 1 2016 In : Reproductive Toxicology. 66, p. 107-114 8 p.

Research output: Contribution to journalArticle

Ovarian Follicle
Steroid 17-alpha-Hydroxylase
Dimethyl Sulfoxide
Estradiol
Estrogens

Effects of letrozole on breast cancer micro-metastatic tumor growth in bone and lung in mice inoculated with murine 4T1 cells

Wang, W., Belosay, A., Yang, X., Hartman, J. A., Song, H., Iwaniec, U. T., Turner, R. T., Churchwell, M. I., Doerge, D. R. & Helferich, W. G. Jun 1 2016 In : Clinical and Experimental Metastasis. 33, 5, p. 475-485 11 p.

Research output: Contribution to journalArticle

Bone Development
Breast Neoplasms
Lung
Neoplasms
Neoplasm Metastasis

Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles in vitro

Mahalingam, S., Gao, L., Gonnering, M., Helferich, W. & Flaws, J. A. Mar 15 2016 In : Toxicology and Applied Pharmacology. 295, p. 47-55 9 p.

Research output: Contribution to journalArticle

Equol
In Vitro Techniques
Isoflavones
Ovarian Follicle
Dimethyl Sulfoxide

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y. X., Helferich, W. G. & Flaws, J. A. Feb 15 2016 In : Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Contribution to journalArticle

Genistein
Cell Cycle
Enzymes
Phytoestrogens
Dimethyl Sulfoxide

Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action

Zheng, X., Andruska, N., Yu, L., Mao, C., Kim, J. E., Livezey, M., Helferich, W. G. & Shapiro, D. J. Oct 1 2016 In : Steroids. 114, p. 2-6 5 p.

Research output: Contribution to journalReview article

Unfolded Protein Response
Cytoplasmic and Nuclear Receptors
Steroids
Hormones
Estrogen Receptor alpha

Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities

Boonmuen, N., Gong, P., Ali, Z., Chittiboyina, A. G., Khan, I., Doerge, D. R., Helferich, W. G., Carlson, K. E., Martin, T., Piyachaturawat, P., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. Jan 1 2016 In : Steroids. 105, p. 42-49 8 p.

Research output: Contribution to journalArticle

Glycyrrhiza
Selective Estrogen Receptor Modulators
Dietary Supplements
Estrogens
Hep G2 Cells

Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer

Rendeiro, C., Sheriff, A., Bhattacharya, T. K., Gogola, J. V., Baxter, J. H., Chen, H., Helferich, W. G., Roy, E. J. & Rhodes, J. S. Dec 15 2016 In : Behavioural Brain Research. 315, p. 10-22 13 p.

Research output: Contribution to journalArticle

Neurogenesis
Breast Neoplasms
Drug Therapy
Spatial Memory
Spatial Learning

Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

Yin, Q., Tang, L., Cai, K., Tong, R., Sternberg, R., Yang, X., Dobrucki, L. W., Borst, L. B., Kamstock, D., Song, Z., Helferich, W. G., Cheng, J. & Fan, T. M. Aug 9 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4601-E4609

Research output: Contribution to journalArticle

Nanoconjugates
Osteolysis
Nanoparticles
tumor
Neoplasms

Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys

Doerge, D. R., Woodling, K. A., Churchwell, M. I., Fleck, S. C. & Helferich, W. G. Jun 1 2016 In : Food and Chemical Toxicology. 92, p. 165-176 12 p.

Research output: Contribution to journalArticle

Infant Formula
Isoflavones
Macaca mulatta
Pharmacokinetics
Genistein

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro

Aumsuwan, P., Khan, S. I., Khan, I. A., Ali, Z., Avula, B., Walker, L. A., Shariat-Madar, Z., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K. Feb 1 2016 In : Archives of Biochemistry and Biophysics. 591, p. 98-110 13 p.

Research output: Contribution to journalArticle

Dioscorea
Saponins
Breast Neoplasms
Cell Line
In Vitro Techniques
2015

A multi-targeted approach to suppress tumor-promoting inflammation

Helferich, W. G. & 34 others Samadi, A. K., Bilsland, A., Georgakilas, A. G., Amedei, A., Amin, A., Bishayee, A., Azmi, A. S., Lokeshwar, B. L., Grue, B., Panis, C., Boosani, C. S., Poudyal, D., Stafforini, D. M., Bhakta, D., Niccolai, E., Guha, G., Vasantha Rupasinghe, H. P., Fujii, H., Honoki, K., Mehta, K., Aquilano, K., Lowe, L., Hofseth, L. J., Ricciardiello, L., Ciriolo, M. R., Singh, N., Whelan, R. L., Chaturvedi, R., Ashraf, S. S., Shantha Kumara, H. M. C., Nowsheen, S., Mohammed, S. I., Keith, W. N. & Yang, X. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S151-S184

Research output: Contribution to journalReview article

Inflammation
Neoplasms
Anti-Inflammatory Agents
Macrophage Migration-Inhibitory Factors
CXC Chemokines

Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer

Andruska, N., Zheng, X., Yang, X., Helferich, W. G. & Shapiro, D. J. Jul 21 2015 In : Oncogene. 34, 29, p. 3760-3769 10 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Estrogen Receptor alpha
Estrogens
Cell Proliferation
Breast Neoplasms

Broad targeting of resistance to apoptosis in cancer

Helferich, W. G. & 38 others Mohammad, R. M., Muqbil, I., Lowe, L., Yedjou, C., Hsu, H. Y., Lin, L. T., Siegelin, M. D., Fimognari, C., Kumar, N. B., Dou, Q. P., Yang, H., Samadi, A. K., Russo, G. L., Spagnuolo, C., Ray, S. K., Chakrabarti, M., Morre, J. D., Coley, H. M., Honoki, K., Fujii, H., Georgakilas, A. G., Amedei, A., Niccolai, E., Amin, A., Ashraf, S. S., Yang, X., Boosani, C. S., Guha, G., Bhakta, D., Ciriolo, M. R., Aquilano, K., Chen, S., Mohammed, S. I., Keith, W. N., Bilsland, A., Halicka, D., Nowsheen, S. & Azmi, A. S. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S78-S103

Research output: Contribution to journalReview article

Apoptosis
Neoplasms
Cell Death
Gossypol
Cell Nucleus Active Transport

Cancer prevention and therapy through the modulation of the tumor microenvironment

Guha, G. & 30 others Casey, S. C., Amedei, A., Aquilano, K., Azmi, A. S., Benencia, F., Bhakta, D., Bilsland, A. E., Boosani, C. S., Chen, S., Ciriolo, M. R., Crawford, S., Fujii, H., Georgakilas, A. G., Halicka, D., Helferich, W. G., Heneberg, P., Honoki, K., Keith, W. N., Kerkar, S. P., Mohammed, S. I., Niccolai, E., Nowsheen, S., Vasantha Rupasinghe, H. P., Samadi, A., Singh, N., Talib, W. H., Venkateswaran, V., Whelan, R. L., Yang, X. & Felsher, D. W. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S199-S223

Research output: Contribution to journalReview article

Tumor Microenvironment
Neoplasms
Carcinogenesis
Anoxia
Indoleamine-Pyrrole 2,3,-Dioxygenase

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Helferich, W. G. & 179 others Block, K. I., Gyllenhaal, C., Lowe, L., Amedei, A., Ruhul Amin, A. R. M., Amin, A., Aquilano, K., Arbiser, J., Arreola, A., Arzumanyan, A., Salman Ashraf, S., Azmi, A. S., Benencia, F., Bhakta, D., Bilsland, A., Bishayee, A., Blain, S. W., Block, P. B., Boosani, C. S., Carey, T. E., Carnero, A., Carotenuto, M., Casey, S. C., Chakrabarti, M., Chaturvedi, R., Chen, G. Z., Chen, H., Chen, S., Chen, Y. C., Choi, B. K., Ciriolo, M. R., Coley, H. M., Collins, A. R., Connell, M., Crawford, S., Curran, C. S., Dabrosin, C., Damia, G., Dasgupta, S., DeBerardinis, R. J., Decker, W. K., Dhawan, P., Diehl, A. M. E., Dong, J. T., Dou, Q. P., Drewa, J. E., Elkord, E., El-Rayes, B., Feitelson, M. A., Felsheru, D. W., Ferguson, L. R., Fimognari, C., Firestone, G. L., Frezza, C., Fujii, H., Fuster, M. M., Generali, D., Georgakilas, A. G., Gieseler, F., Gilbertson, M., Green, M. F., Grue, B., Guhal, G., Halicka, D., Heneberg, P., Hentosh, P., Hirschey, M. D., Hofseth, L. J., Holcombe, R. F., Honoki, K., Hsu, H. Y., Huang, G. S., Jensen, L. D., Jiang, W. G., Jones, L. W., Karpowicz, P. A., Keith, W. N., Kerkar, S. P., Khan, G. N., Khatami, M., Ko, Y. H., Kucuk, O., Kulathinal, R. J., Kumar, N. B., Kwon, B. S., Leb, A., Leab, M. A., Lee, H. Y., Lichtor, T., Lin, L. T., Locasale, J. W., Lokeshwar, B. L., Longo, V. D., Lyssiotis, C. A., MacKenzie, K. L., Malhotra, M., Marino, M., Martinez-Chantar, M. L., Matheu, A., Maxwellx, C., McDonnell, E., Meeker, A. K., Mehrmohamadi, M., Mehta, K., Michelotti, G. A., Mohammad, R. M., Mohammed, S. I., Morre, D. J., Muqbil, I., Muralidharcq, V., Murphy, M. P., Nagaraju, G. P., Nahta, R., Niccolai, E., Nowsheen, S., Panis, C., Pantano, F., Parslow, V. R., Pawelec, G., Pedersen, P. L., Poore, B., Poudyal, D., Prakash, S., Prince, M., Raffaghello, L., Rathmell, J. C., Rathmell, W. K., Ray, S. K., Reichrath, J., Rezazadeh, S., Ribatti, D., Ricciardiello, L., Robeydf, R. B., Rodierdh, F., Rupasinghe, H. P. V., Russo, G. L., Ryan, E. P., Samadi, A. K., Sanchez-Garcia, I., Sanders, A. J., Santini, D., Sarkar, M., Sasada, T., Saxena, N. K., Shackelford, R. E., Shantha Kumara, H. M. C., Sharma, D., Shin, D. M., Sidransky, D., Siegelin, M. D., Signori, E., Singh, N., Sivanand, S., Sliva, D., Smythe, C., Spagnuolo, C., Stafforini, D. M., Stagg, J., Subbarayan, P. R., Sundin, T., Talib, W. H., Thompson, S. K., Tran, P. T., Ungefroren, H., Vander Heiden, M. G., Venkateswaran, V., Vinay, D. S., Vlachostergios, P. J., Wang, Z., Wellen, K. E., Whelan, R. L., Yang, E. S., Yang, H., Yang, X., Yaswen, P., Yedjou, C., Yin, X., Zhu, J. & Zollo, M. 2015 In : Seminars in Cancer Biology. 35, p. S276-S304

Research output: Contribution to journalReview article

Neoplasms
Recurrence
Tumor Microenvironment
Genetic Heterogeneity
Poisons
High Fat Diet
Gene Expression
Liver
Fats
Diet

Development of a point-of-use fortification technology for delivery of micronutrients in Honduras

Andrade, J. E., Rosales, E., Lopez, J. R., Carrillo, E. P., Engeseth, N. J. & Helferich, W. G. Jan 30 2015 In : Journal of the Science of Food and Agriculture. 95, 2, p. 393-400 8 p.

Research output: Contribution to journalArticle

Honduras
Micronutrients
Technology
Oryza sativa
Meals

Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland

Madak-Erdogan, Z., Gong, P., Zhao, Y. C., Xu, L., Wrobel, K. U., Hartman, J. A., Wang, M., Cam, A., Iwaniec, U. T., Turner, R. T., Twaddle, N. C., Doerge, D. R., Khan, I. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Helferich, W. G. 2015 In : Molecular Nutrition and Food Research.

Research output: Contribution to journalArticle

Glycyrrhiza
Weight Gain
Diet
Lipids
Liver

Dietary soy isoflavones increase metastasis to lungs in an experimental model of breast cancer with bone micro-tumors

Yang, X., Belosay, A., Hartman, J. A., Song, H., Zhang, Y., Wang, W., Doerge, D. R. & Helferich, W. G. Apr 8 2015 In : Clinical and Experimental Metastasis. 32, 4, p. 323-333 11 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Isoflavones
Breast Neoplasms
Neoplasm Metastasis
Lung

Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression

Andruska, N. D., Zheng, X., Yang, X., Mao, C., Cherian, M. M., Mahapatra, L., Helferich, W. G. & Shapiro, D. J. Apr 14 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 15, p. 4737-4742 6 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Estrogen Receptor alpha
Neoplasms
Proteins
Endoplasmic Reticulum

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

Helferich, W. G. & 34 others Ferguson, L. R., Chen, H., Collins, A. R., Connell, M., Damia, G., Dasgupta, S., Malhotra, M., Meeker, A. K., Amedei, A., Amin, A., Ashraf, S. S., Aquilano, K., Azmi, A. S., Bhakta, D., Bilsland, A., Boosani, C. S., Chen, S., Ciriolo, M. R., Fujii, H., Guha, G., Halicka, D., Keith, W. N., Mohammed, S. I., Niccolai, E., Yang, X., Honoki, K., Parslow, V. R., Prakash, S., Rezazadeh, S., Shackelford, R. E., Sidransky, D., Tran, P. T., Yang, E. S. & Maxwell, C. A. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S5-S24

Research output: Contribution to journalReview article

Genomic Instability
Neoplasms
DNA Damage
Centrosome
DNA Repair-Deficiency Disorders

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

Helferich, W. G. & 31 others Vinay, D. S., Ryan, E. P., Pawelec, G., Talib, W. H., Stagg, J., Elkord, E., Lichtor, T., Decker, W. K., Whelan, R. L., Kumara, H. M. C. S., Signori, E., Honoki, K., Georgakilas, A. G., Amin, A., Boosani, C. S., Guha, G., Ciriolo, M. R., Chen, S., Mohammed, S. I., Azmi, A. S., Keith, W. N., Bilsland, A., Bhakta, D., Halicka, D., Fujii, H., Aquilano, K., Ashraf, S. S., Nowsheen, S., Yang, X., Choi, B. K. & Kwon, B. S. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S185-S198

Research output: Contribution to journalReview article

Immune Evasion
Neoplasms
Phytochemicals
Tumor Escape
Plant Structures
Adipogenesis
Glucose Intolerance
Dietary Fats
Adipocytes
High Fat Diet

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

Liu, Y., Hilakivi-Clarke, L., Zhang, Y., Wang, X., Pan, Y. X., Xuan, J., Fleck, S. C., Doerge, D. R. & Helferich, W. G. Aug 1 2015 In : Molecular Nutrition and Food Research. 59, 8, p. 1419-1430 12 p.

Research output: Contribution to journalArticle

Isoflavones
Flour
Nude Mice
Genome
Breast Neoplasms

Long-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft model

Andrade, J. E., Ju, Y. H., Baker, C., Doerge, D. R. & Helferich, W. G. Mar 1 2015 In : Molecular Nutrition and Food Research. 59, 3, p. 413-423 11 p.

Research output: Contribution to journalArticle

Genistein
Heterografts
Estrogens
Breast Neoplasms
Neoplasms

Redox-responsive self-assembled chain-shattering polymeric therapeutics

Cai, K., Yen, J., Yin, Q., Liu, Y., Song, Z., Lezmi, S., Zhang, Y., Yang, X., Helferich, W. G. & Cheng, J. Jul 1 2015 In : Biomaterials Science. 3, 7, p. 1061-1065 5 p.

Research output: Contribution to journalArticle

Polyethylene glycols
Nanoparticles
Polycondensation
Particle size

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

Helferich, W. G. & 35 others Jiang, W. G., Sanders, A. J., Katoh, M., Ungefroren, H., Gieseler, F., Prince, M., Thompson, S. K., Zollo, M., Spano, D., Dhawan, P., Sliva, D., Subbarayan, P. R., Sarkar, M., Honoki, K., Fujii, H., Georgakilas, A. G., Amedei, A., Niccolai, E., Amin, A., Ashraf, S. S., Ye, L., Yang, X., Boosani, C. S., Guha, G., Ciriolo, M. R., Aquilano, K., Chen, S., Azmi, A. S., Keith, W. N., Bilsland, A., Bhakta, D., Halicka, D., Nowsheen, S., Pantano, F. & Santini, D. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S244-S275

Research output: Contribution to journalReview article

Neoplasm Metastasis
Neoplasms
Transforming Growth Factor beta
Mortality
Poria
2014

Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells

Aumsuwan, P., Khan, S. I., Khan, I. A., Avula, B., Walker, L. A., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K. 2014 In : In Vitro Cellular and Developmental Biology - Animal. 51, 1, p. 59-71 13 p.

Research output: Contribution to journalArticle

Dioscorea
Epigenomics
Breast Neoplasms
Messenger RNA
Deoxycytidine

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Strakovsky, R. S., Lezmi, S., Flaws, J. A., Schantz, S. L., Pan, Y. X. & Helferich, W. G. Mar 2014 In : Toxicological Sciences. 138, 1, p. 161-174 14 p., kft331

Research output: Contribution to journalArticle

Genistein
Obesity
Fats
CCAAT-Enhancer-Binding Protein-alpha
CCAAT-Enhancer-Binding Protein-beta

Investigating the optimal size of anticancer nanomedicine

Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., Dobrucki, I. T., Dobrucki, L. W., Borst, L. B., Lezmi, S., Helferich, W. G., Ferguson, A. L., Fan, T. M. & Cheng, J. Oct 28 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15344-15349 6 p.

Research output: Contribution to journalArticle

Nanomedicine
Neoplasms
Nanoconjugates
United States Food and Drug Administration
Particle Size

The effects of dietary treatment with S-equol on learning and memory processes in middle-aged ovariectomized rats

Neese, S. L., Pisani, S. L., Doerge, D. R., Helferich, W. G., Sepehr, E., Chittiboyina, A. G., Rotte, S. C. K., Smillie, T. J., Khan, I. A., Korol, D. L. & Schantz, S. L. Jan 2014 In : Neurotoxicology and Teratology. 41, p. 80-88 9 p.

Research output: Contribution to journalArticle

Equol
Learning
Genistein
Isoflavones
Long Evans Rats

Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens

Gong, P., Madak-Erdogan, Z., Li, J., Cheng, J., Greenlief, C. M., Helferich, W., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. 2014 In : Nuclear receptor signaling. 12, p. e001

Research output: Contribution to journalArticle

Estrogen Receptor alpha
Gene Regulatory Networks
Estrogens
Genes
Gene Expression
2013

Association between Absolute Tumor Burden and Serum Bone-Specific Alkaline Phosphatase in Canine Appendicular Osteosarcoma

Sternberg, R. A., Pondenis, H. C., Yang, X., Mitchell, M. A., O'Brien, R. T., Garrett, L. D., Helferich, W. G., Hoffmann, W. E. & Fan, T. M. Jul 2013 In : Journal of Veterinary Internal Medicine. 27, 4, p. 955-963 9 p.

Research output: Contribution to journalArticle

Osteosarcoma
Tumor Burden
Alkaline Phosphatase
Canidae
Bone and Bones

Estradiol increases ER-negative breast cancer metastasis in an experimental model

Yang, X., Belosay, A., Du, M., Fan, T. M., Turner, R. T., Iwaniec, U. T. & Helferich, W. G. Aug 2013 In : Clinical and Experimental Metastasis. 30, 6, p. 711-721 11 p.

Research output: Contribution to journalArticle

Estradiol
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Lung

Genistein administered as a once-daily oral supplement had no beneficial effect on the tibia in rat models for postmenopausal bone loss

Turner, R. T., Iwaniec, U. T., Andrade, J. E., Branscum, A. J., Neese, S. L., Olson, D. A., Wagner, L., Wang, V. C., Schantz, S. L. & Helferich, W. G. Jun 2013 In : Menopause. 20, 6, p. 677-686 10 p.

Research output: Contribution to journalArticle

Postmenopausal Osteoporosis
Genistein
Tibia
Bone and Bones
Dietary Supplements

Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

Jiang, Y., Gong, P., Madak-Erdogan, Z., Martin, T., Jeyakumar, M., Carlson, K., Khan, I., Smillie, T. J., Chittiboyina, A. G., Rotte, S. C. K., Helferich, W. G., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. Nov 2013 In : FASEB Journal. 27, 11, p. 4406-4418 13 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Estrogens
Chromatin
Breast Neoplasms
Equol

Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

Xing, H., Tang, L., Yang, X., Hwang, K., Wang, W., Yin, Q., Wong, N. Y., Dobrucki, L. W., Yasui, N., Katzenellenbogen, J. A., Helferich, W. G., Cheng, J. & Lu, Y. Oct 21 2013 In : Journal of Materials Chemistry B. 1, 39, p. 5288-5297 10 p.

Research output: Contribution to journalArticle

Liposomes
Breast Neoplasms
Neoplasms
In Vitro Techniques
Cells
2012

Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats

Pisani, S. L., Neese, S. L., Doerge, D. R., Helferich, W. G., Schantz, S. L. & Korol, D. L. Sep 2012 In : Hormones and Behavior. 62, 4, p. 491-499 9 p.

Research output: Contribution to journalArticle

Genistein
Young Adult
Estradiol
Learning
Estrogen Receptors

Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

Tang, L., Yang, X., Dobrucki, L. W., Chaudhury, I., Yin, Q., Yao, C., Lezmi, S., Helferich, W. G., Fan, T. M. & Cheng, J. Dec 14 2012 In : Angewandte Chemie - International Edition. 51, 51, p. 12721-12726 6 p.

Research output: Contribution to journalArticle

Nanoconjugates
Silicon Dioxide
Lymph Nodes
Neoplasms
Imaging techniques

Effects of multiple daily genistein treatments on delayed alternation and a differential reinforcement of low rates of responding task in middle-aged rats

Neese, S. L., Bandara, S. B., Doerge, D. R., Helferich, W. G., Korol, D. L. & Schantz, S. L. Jan 2012 In : Neurotoxicology and Teratology. 34, 1, p. 187-195 9 p.

Research output: Contribution to journalArticle

Genistein
Reinforcement (Psychology)
Phytoestrogens
Long Evans Rats
Short-Term Memory

Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice

Du, M., Yang, X., Hartman, J. A., Cooke, P. S., Doerge, D. R., Ju, Y. H. & Helferich, W. G. 2012 In : Carcinogenesis. 33, 4, p. 895-901 7 p.

Research output: Contribution to journalArticle

Genistein
Tamoxifen
Nude Mice
Estrogens
Neoplasms
2011

Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression

De Assis, S., Warri, A., Benitez, C., Helferich, W. & Hilakivi-Clarke, L. Sep 2011 In : Cancer Prevention Research. 4, 9, p. 1436-1448 13 p.

Research output: Contribution to journalArticle

Genistein
Carcinogenesis
Breast
Diet
Progesterone Receptors
2010

Absolute bioavailability of isoflavones from soy protein isolate-containing food in female Balb/c mice

Andrade, J. E., Twaddle, N. C., Helferich, W. G. & Doerge, D. R. Apr 14 2010 In : Journal of Agricultural and Food Chemistry. 58, 7, p. 4529-4536 8 p.

Research output: Contribution to journalArticle

Soybean Proteins
Isoflavones
Biological Availability
Food
Genistein

Acute and chronic effects of oral genistein administration in neonatal mice

Cimafranca, M. A., Davila, J., Ekman, G. C., Andrews, R. N., Neese, S. L., Peretz, J., Woodling, K. A., Helferich, W. G., Sarkar, J., Flaws, J. A., Schantz, S. L., Doerge, D. R. & Cooke, P. S. 2010 In : Biology of Reproduction. 83, 1, p. 114-121 8 p.

Research output: Contribution to journalArticle

Genistein
Oral Administration
Serum
Infant Formula
Incidence

Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2 x Pten+/- preclinical mouse model

Vissapragada, S., Ghosh, A., Ringer, L., Salinas, P., Brophy, A., Peaceman, D., Kallakury, B., Banerjee, P. P., Fricke, S. T., Helfrich, W., Lee, Y. C., Pestell, R., Scherer, P., Tanowitz, H. B., Avantaggiati, M. L., Hilakivi-Clarke, L., Lisanti, M. P., Rodriguez, O. C. & Albanese, C. May 1 2010 In : Cell Cycle. 9, 9, p. 1824-1829 6 p.

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
Prostate
Carcinogenesis
Diet
Cyclin E

Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells

Hsu, A., Bray, T. M., Helferich, W. G., Doerge, D. R. & Ho, E. Jan 2010 In : Experimental Biology and Medicine. 235, 1, p. 90-97 8 p.

Research output: Contribution to journalArticle

Isoflavones
Prostatic Neoplasms
Apoptosis
Genistein
Food

Impact of dietary genistein and aging on executive function in rats

Neese, S. L., Wang, V. C., Doerge, D. R., Woodling, K. A., Andrade, J. E., Helferich, W. G., Korol, D. L. & Schantz, S. L. Mar 2010 In : Neurotoxicology and Teratology. 32, 2, p. 200-211 12 p.

Research output: Contribution to journalArticle

Genistein
Executive Function
Dopamine Plasma Membrane Transport Proteins
Age Groups
Reversal Learning

Is soy consumption good or bad for the breast?

Hilakivi-Clarke, L., Andrade, J. E. & Helferich, W. Dec 1 2010 In : Journal of Nutrition. 140, 12

Research output: Contribution to journalArticle

Breast
Breast Neoplasms
Genistein
Survivors
Recurrence
2009

Body mass influences cortical bone mass independent of leptin signaling

Iwaniec, U. T., Dube, M. G., Boghossian, S., Song, H., Helferich, W. G., Turner, R. T. & Kalra, S. P. Mar 2009 In : Bone. 44, 3, p. 404-412 9 p.

Research output: Contribution to journalArticle

Leptin
Bone and Bones
Femur
Dependovirus
Diet