Research Output 1979 2017

2017

Lifetime genistein intake increases the response of mammary tumors to tamoxifen in rats

Zhang, X., Cook, K. L., Warri, A., Cruz, I. M., Rosim, M., Riskin, J., Helferich, W., Doerge, D., Clarke, R. & Hilakivi-Clarke, L. Feb 1 2017 In : Clinical Cancer Research. 23, 3, p. 814-824 11 p.

Research output: Research - peer-reviewArticle

Genistein
Tamoxifen
Breast Neoplasms
Diet
Unfolded Protein Response

Low calcium diet increases 4T1 mammary tumor carcinoma cell burden and bone pathology in mice

Wang, W., Gordon, J. L., Philbrick, K. A., Yang, X., Branscum, A. J., Löhr, C. V., Haschek, W. M., Turner, R. T., Iwaniec, U. T. & Helferich, W. G. Jul 1 2017 In : PLoS ONE. 12, 7, e0180886

Research output: Research - peer-reviewArticle

mammary neoplasms (animal)
carcinoma
bones
calcium
mice

Preconception exposure to dietary levels of genistein affects female reproductive outcomes

Patel, S., Hartman, J. A., Helferich, W. G. & Flaws, J. A. Dec 1 2017 In : Reproductive Toxicology. 74, p. 174-180 7 p.

Research output: Research - peer-reviewArticle

2016

Effects of isoliquiritigenin on ovarian antral follicle growth and steroidogenesis

Mahalingam, S., Gao, L., Eisner, J., Helferich, W. & Flaws, J. A. Dec 1 2016 In : Reproductive Toxicology. 66, p. 107-114 8 p.

Research output: Research - peer-reviewArticle

Ovarian Follicle
Growth
isoliquiritigenin
Antral
Steroid 17-alpha-Hydroxylase

Effects of letrozole on breast cancer micro-metastatic tumor growth in bone and lung in mice inoculated with murine 4T1 cells

Wang, W., Belosay, A., Yang, X., Hartman, J. A., Song, H., Iwaniec, U. T., Turner, R. T., Churchwell, M. I., Doerge, D. R. & Helferich, W. G. Jun 1 2016 In : Clinical and Experimental Metastasis. 33, 5, p. 475-485 11 p.

Research output: Research - peer-reviewArticle

letrozole
Bone Development
Breast Neoplasms
Lung
Neoplasms

Equol inhibits growth, induces atresia, and inhibits steroidogenesis of mouse antral follicles in vitro

Mahalingam, S., Gao, L., Gonnering, M., Helferich, W. & Flaws, J. A. Mar 15 2016 In : Toxicology and Applied Pharmacology. 295, p. 47-55 9 p.

Research output: Research - peer-reviewArticle

Equol
Growth
In Vitro Techniques
Antral
Isoflavones

Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

Patel, S., Peretz, J., Pan, Y. X., Helferich, W. G. & Flaws, J. A. Feb 15 2016 In : Toxicology and Applied Pharmacology. 293, p. 53-62 10 p.

Research output: Research - peer-reviewArticle

Genistein
Growth
Antral
Cell Cycle
Enzymes

Interplay between steroid hormone activation of the unfolded protein response and nuclear receptor action

Zheng, X., Andruska, N., Yu, L., Mao, C., Kim, J. E., Livezey, M., Helferich, W. G. & Shapiro, D. J. Oct 1 2016 In : Steroids. 114, p. 2-6 5 p.

Research output: Research - peer-reviewReview article

Unfolded Protein Response
Cytoplasmic and Nuclear Receptors
Steroids
Hormones
Steroid hormones

Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities

Boonmuen, N., Gong, P., Ali, Z., Chittiboyina, A. G., Khan, I., Doerge, D. R., Helferich, W. G., Carlson, K. E., Martin, T., Piyachaturawat, P., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. Jan 1 2016 In : Steroids. 105, p. 42-49 8 p.

Research output: Research - peer-reviewArticle

Glycyrrhiza
Selective Estrogen Receptor Modulators
Dietary Supplements
liquiritigenin
isoliquiritigenin

Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer

Rendeiro, C., Sheriff, A., Bhattacharya, T. K., Gogola, J. V., Baxter, J. H., Chen, H., Helferich, W. G., Roy, E. J. & Rhodes, J. S. Dec 15 2016 In : Behavioural Brain Research. 315, p. 10-22 13 p.

Research output: Research - peer-reviewArticle

Neurogenesis
Breast Neoplasms
Drug Therapy
Spatial Learning
Spatial Memory

Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

Yin, Q., Tang, L., Cai, K., Tong, R., Sternberg, R., Yang, X., Dobrucki, L. W., Borst, L. B., Kamstock, D., Song, Z., Helferich, W. G., Cheng, J. & Fan, T. M. Aug 9 2016 In : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4601-E4609

Research output: Research - peer-reviewArticle

pamidronate
Nanoconjugates
Osteolysis
Nanoparticles
Therapeutics

Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys

Doerge, D. R., Woodling, K. A., Churchwell, M. I., Fleck, S. C. & Helferich, W. G. Jun 1 2016 In : Food and Chemical Toxicology. 92, p. 165-176 12 p.

Research output: Research - peer-reviewArticle

Infant Formula
Isoflavones
Macaca mulatta
Pharmacokinetics
infant formulas

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro

Aumsuwan, P., Khan, S. I., Khan, I. A., Ali, Z., Avula, B., Walker, L. A., Shariat-Madar, Z., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K. Feb 1 2016 In : Archives of Biochemistry and Biophysics. 591, p. 98-110 13 p.

Research output: Research - peer-reviewArticle

Dioscorea
Saponins
Breast Neoplasms
Cell Line
In Vitro Techniques
2015

A multi-targeted approach to suppress tumor-promoting inflammation

Samadi, A. K. , Bilsland, A. , Georgakilas, A. G. , Amedei, A. , Amin, A. , Bishayee, A. , Azmi, A. S. , Lokeshwar, B. L. , Grue, B. , Panis, C. , Boosani, C. S. , Poudyal, D. , Stafforini, D. M. , Bhakta, D. , Niccolai, E. , Guha, G. , Vasantha Rupasinghe, H. P. , Fujii, H. , Honoki, K. , Mehta, K. & 15 others Aquilano, K., Lowe, L., Hofseth, L. J., Ricciardiello, L., Ciriolo, M. R., Singh, N., Whelan, R. L., Chaturvedi, R., Ashraf, S. S., Shantha Kumara, H. M. C., Nowsheen, S., Mohammed, S. I., Keith, W. N., Helferich, W. G. & Yang, X. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S151-S184

Research output: Research - peer-reviewReview article

Inflammation
Neoplasms
Therapeutics
Anti-Inflammatory Agents
Macrophage Migration-Inhibitory Factors

Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer

Andruska, N., Zheng, X., Yang, X., Helferich, W. G. & Shapiro, D. J. Jul 21 2015 In : Oncogene. 34, 29, p. 3760-3769 10 p.

Research output: Research - peer-reviewArticle

Unfolded Protein Response
Estrogen Receptor alpha
Estrogens
Cell Proliferation
Breast Neoplasms

Broad targeting of resistance to apoptosis in cancer

Mohammad, R. M. , Muqbil, I. , Lowe, L. , Yedjou, C. , Hsu, H. Y. , Lin, L. T. , Siegelin, M. D. , Fimognari, C. , Kumar, N. B. , Dou, Q. P. , Yang, H. , Samadi, A. K. , Russo, G. L. , Spagnuolo, C. , Ray, S. K. , Chakrabarti, M. , Morre, J. D. , Coley, H. M. , Honoki, K. , Fujii, H. & 19 others Georgakilas, A. G., Amedei, A., Niccolai, E., Amin, A., Ashraf, S. S., Helferich, W. G., Yang, X., Boosani, C. S., Guha, G., Bhakta, D., Ciriolo, M. R., Aquilano, K., Chen, S., Mohammed, S. I., Keith, W. N., Bilsland, A., Halicka, D., Nowsheen, S. & Azmi, A. S. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S78-S103

Research output: Research - peer-reviewReview article

Apoptosis
Neoplasms
Therapeutics
Cell Death
Gossypol

Cancer prevention and therapy through the modulation of the tumor microenvironment

Casey, S. C. , Amedei, A. , Aquilano, K. , Azmi, A. S. , Benencia, F. , Bhakta, D. , Bilsland, A. E. , Boosani, C. S. , Chen, S. , Ciriolo, M. R. , Crawford, S. , Fujii, H. , Georgakilas, A. G. , Guha, G. , Halicka, D. , Helferich, W. G. , Heneberg, P. , Honoki, K. , Keith, W. N. , Kerkar, S. P. & 11 others Mohammed, S. I., Niccolai, E., Nowsheen, S., Vasantha Rupasinghe, H. P., Samadi, A., Singh, N., Talib, W. H., Venkateswaran, V., Whelan, R. L., Yang, X. & Felsher, D. W. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S199-S223

Research output: Research - peer-reviewReview article

Tumor Microenvironment
Neoplasms
Therapeutics
Carcinogenesis
Hypoxia

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Block, K. I. , Gyllenhaal, C. , Lowe, L. , Amedei, A. , Ruhul Amin, A. R. M. , Amin, A. , Aquilano, K. , Arbiser, J. , Arreola, A. , Arzumanyan, A. , Salman Ashraf, S. , Azmi, A. S. , Benencia, F. , Bhakta, D. , Bilsland, A. , Bishayee, A. , Blain, S. W. , Block, P. B. , Boosani, C. S. , Carey, T. E. & 160 others Carnero, A., Carotenuto, M., Casey, S. C., Chakrabarti, M., Chaturvedi, R., Chen, G. Z., Chen, H., Chen, S., Chen, Y. C., Choi, B. K., Ciriolo, M. R., Coley, H. M., Collins, A. R., Connell, M., Crawford, S., Curran, C. S., Dabrosin, C., Damia, G., Dasgupta, S., DeBerardinis, R. J., Decker, W. K., Dhawan, P., Diehl, A. M. E., Dong, J. T., Dou, Q. P., Drewa, J. E., Elkord, E., El-Rayes, B., Feitelson, M. A., Felsheru, D. W., Ferguson, L. R., Fimognari, C., Firestone, G. L., Frezza, C., Fujii, H., Fuster, M. M., Generali, D., Georgakilas, A. G., Gieseler, F., Gilbertson, M., Green, M. F., Grue, B., Guhal, G., Halicka, D., Helferich, W. G., Heneberg, P., Hentosh, P., Hirschey, M. D., Hofseth, L. J., Holcombe, R. F., Honoki, K., Hsu, H. Y., Huang, G. S., Jensen, L. D., Jiang, W. G., Jones, L. W., Karpowicz, P. A., Keith, W. N., Kerkar, S. P., Khan, G. N., Khatami, M., Ko, Y. H., Kucuk, O., Kulathinal, R. J., Kumar, N. B., Kwon, B. S., Leb, A., Leab, M. A., Lee, H. Y., Lichtor, T., Lin, L. T., Locasale, J. W., Lokeshwar, B. L., Longo, V. D., Lyssiotis, C. A., MacKenzie, K. L., Malhotra, M., Marino, M., Martinez-Chantar, M. L., Matheu, A., Maxwellx, C., McDonnell, E., Meeker, A. K., Mehrmohamadi, M., Mehta, K., Michelotti, G. A., Mohammad, R. M., Mohammed, S. I., Morre, D. J., Muqbil, I., Muralidharcq, V., Murphy, M. P., Nagaraju, G. P., Nahta, R., Niccolai, E., Nowsheen, S., Panis, C., Pantano, F., Parslow, V. R., Pawelec, G., Pedersen, P. L., Poore, B., Poudyal, D., Prakash, S., Prince, M., Raffaghello, L., Rathmell, J. C., Rathmell, W. K., Ray, S. K., Reichrath, J., Rezazadeh, S., Ribatti, D., Ricciardiello, L., Robeydf, R. B., Rodierdh, F., Rupasinghe, H. P. V., Russo, G. L., Ryan, E. P., Samadi, A. K., Sanchez-Garcia, I., Sanders, A. J., Santini, D., Sarkar, M., Sasada, T., Saxena, N. K., Shackelford, R. E., Shantha Kumara, H. M. C., Sharma, D., Shin, D. M., Sidransky, D., Siegelin, M. D., Signori, E., Singh, N., Sivanand, S., Sliva, D., Smythe, C., Spagnuolo, C., Stafforini, D. M., Stagg, J., Subbarayan, P. R., Sundin, T., Talib, W. H., Thompson, S. K., Tran, P. T., Ungefroren, H., Vander Heiden, M. G., Venkateswaran, V., Vinay, D. S., Vlachostergios, P. J., Wang, Z., Wellen, K. E., Whelan, R. L., Yang, E. S., Yang, H., Yang, X., Yaswen, P., Yedjou, C., Yin, X., Zhu, J. & Zollo, M. 2015 In : Seminars in Cancer Biology. 35, p. S276-S304

Research output: Research - peer-reviewReview article

Neoplasms
Therapeutics
Recurrence
Tumor Microenvironment
Genetic Heterogeneity
High Fat Diet
Parturition
Gene Expression
Liver
bisphenol A

Development of a point-of-use fortification technology for delivery of micronutrients in Honduras

Andrade, J. E., Rosales, E., Lopez, J. R., Carrillo, E. P., Engeseth, N. J. & Helferich, W. G. Jan 30 2015 In : Journal of the Science of Food and Agriculture. 95, 2, p. 393-400 8 p.

Research output: Research - peer-reviewArticle

Honduras
dietary minerals
Micronutrients
Technology
rice

Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland

Madak-Erdogan, Z., Gong, P., Zhao, Y. C., Xu, L., Wrobel, K. U., Hartman, J. A., Wang, M., Cam, A., Iwaniec, U. T., Turner, R. T., Twaddle, N. C., Doerge, D. R., Khan, I. A., Katzenellenbogen, J. A., Katzenellenbogen, B. S. & Helferich, W. G. 2015 (Accepted/In press) In : Molecular Nutrition and Food Research.

Research output: Research - peer-reviewArticle

Glycyrrhiza
Human Mammary Glands
Weight Gain
Diet
Lipids

Dietary soy isoflavones increase metastasis to lungs in an experimental model of breast cancer with bone micro-tumors

Yang, X., Belosay, A., Hartman, J. A., Song, H., Zhang, Y., Wang, W., Doerge, D. R. & Helferich, W. G. Apr 8 2015 In : Clinical and Experimental Metastasis. 32, 4, p. 323-333 11 p.

Research output: Research - peer-reviewArticle

Bone Neoplasms
Isoflavones
Theoretical Models
Breast Neoplasms
Neoplasm Metastasis

Estrogen receptor α inhibitor activates the unfolded protein response, blocks protein synthesis, and induces tumor regression

Andruska, N. D., Zheng, X., Yang, X., Mao, C., Cherian, M. M., Mahapatra, L., Helferich, W. G. & Shapiro, D. J. Apr 14 2015 In : Proceedings of the National Academy of Sciences of the United States of America. 112, 15, p. 4737-4742 6 p.

Research output: Research - peer-reviewArticle

Unfolded Protein Response
Estrogen Receptor alpha
Neoplasms
Proteins
Endoplasmic Reticulum

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

Ferguson, L. R. , Chen, H. , Collins, A. R. , Connell, M. , Damia, G. , Dasgupta, S. , Malhotra, M. , Meeker, A. K. , Amedei, A. , Amin, A. , Ashraf, S. S. , Aquilano, K. , Azmi, A. S. , Bhakta, D. , Bilsland, A. , Boosani, C. S. , Chen, S. , Ciriolo, M. R. , Fujii, H. , Guha, G. & 15 others Halicka, D., Helferich, W. G., Keith, W. N., Mohammed, S. I., Niccolai, E., Yang, X., Honoki, K., Parslow, V. R., Prakash, S., Rezazadeh, S., Shackelford, R. E., Sidransky, D., Tran, P. T., Yang, E. S. & Maxwell, C. A. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S5-S24

Research output: Research - peer-reviewReview article

Genomic Instability
Diet
Neoplasms
Therapeutics
DNA Damage

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

Vinay, D. S. , Ryan, E. P. , Pawelec, G. , Talib, W. H. , Stagg, J. , Elkord, E. , Lichtor, T. , Decker, W. K. , Whelan, R. L. , Kumara, H. M. C. S. , Signori, E. , Honoki, K. , Georgakilas, A. G. , Amin, A. , Helferich, W. G. , Boosani, C. S. , Guha, G. , Ciriolo, M. R. , Chen, S. , Mohammed, S. I. & 12 others Azmi, A. S., Keith, W. N., Bilsland, A., Bhakta, D., Halicka, D., Fujii, H., Aquilano, K., Ashraf, S. S., Nowsheen, S., Yang, X., Choi, B. K. & Kwon, B. S. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S185-S198

Research output: Research - peer-reviewReview article

Immune Evasion
Neoplasms
Therapeutics
Phytochemicals
Growth
Adipogenesis
Glucose Intolerance
Dietary Fats
Growth
phthalic acid

Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

Liu, Y., Hilakivi-Clarke, L., Zhang, Y., Wang, X., Pan, Y. X., Xuan, J., Fleck, S. C., Doerge, D. R. & Helferich, W. G. Aug 1 2015 In : Molecular Nutrition and Food Research. 59, 8, p. 1419-1430 12 p.

Research output: Research - peer-reviewArticle

soy flour
isoflavones
breast neoplasms
neoplasms
genome
Genistein
Heterografts
Estrogens
Breast Neoplasms
genistein

Redox-responsive self-assembled chain-shattering polymeric therapeutics

Cai, K., Yen, J., Yin, Q., Liu, Y., Song, Z., Lezmi, S., Zhang, Y., Yang, X., Helferich, W. G. & Cheng, J. Jul 1 2015 In : Biomaterials Science. 3, 7, p. 1061-1065 5 p.

Research output: Research - peer-reviewArticle

Polyethylene glycols
Nanoparticles
Pharmaceutical Preparations
Oxidation-Reduction
Polycondensation

Tissue invasion and metastasis: Molecular, biological and clinical perspectives

Jiang, W. G. , Sanders, A. J. , Katoh, M. , Ungefroren, H. , Gieseler, F. , Prince, M. , Thompson, S. K. , Zollo, M. , Spano, D. , Dhawan, P. , Sliva, D. , Subbarayan, P. R. , Sarkar, M. , Honoki, K. , Fujii, H. , Georgakilas, A. G. , Amedei, A. , Niccolai, E. , Amin, A. , Ashraf, S. S. & 16 others Ye, L., Helferich, W. G., Yang, X., Boosani, C. S., Guha, G., Ciriolo, M. R., Aquilano, K., Chen, S., Azmi, A. S., Keith, W. N., Bilsland, A., Bhakta, D., Halicka, D., Nowsheen, S., Pantano, F. & Santini, D. Dec 1 2015 In : Seminars in Cancer Biology. 35, p. S244-S275

Research output: Research - peer-reviewReview article

Neoplasm Metastasis
Neoplasms
Transforming Growth Factor beta
Mortality
Milk Thistle
2014

Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells

Aumsuwan, P., Khan, S. I., Khan, I. A., Avula, B., Walker, L. A., Helferich, W. G., Katzenellenbogen, B. S. & Dasmahapatra, A. K. 2014 In : In Vitro Cellular and Developmental Biology - Animal. 51, 1, p. 59-71 13 p.

Research output: Research - peer-reviewArticle

Dioscorea villosa
yams
epigenetics
breast neoplasms
extracts

Genistein exposure during the early postnatal period favors the development of obesity in female, but not male rats

Strakovsky, R. S., Lezmi, S., Flaws, J. A., Schantz, S. L., Pan, Y. X. & Helferich, W. G. Mar 2014 In : Toxicological Sciences. 138, 1, p. 161-174 14 p., kft331

Research output: Research - peer-reviewArticle

Genistein
Obesity
Rats
Fats
CCAAT-Enhancer-Binding Protein-alpha

Investigating the optimal size of anticancer nanomedicine

Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., Dobrucki, I. T., Dobrucki, L. W., Borst, L. B., Lezmi, S., Helferich, W. G., Ferguson, A. L., Fan, T. M. & Cheng, J. Oct 28 2014 In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15344-15349 6 p.

Research output: Research - peer-reviewArticle

Nanomedicine
Neoplasms
Pharmaceutical Preparations
Nanoconjugates
United States Food and Drug Administration

The effects of dietary treatment with S-equol on learning and memory processes in middle-aged ovariectomized rats

Neese, S. L., Pisani, S. L., Doerge, D. R., Helferich, W. G., Sepehr, E., Chittiboyina, A. G., Rotte, S. C. K., Smillie, T. J., Khan, I. A., Korol, D. L. & Schantz, S. L. Jan 2014 In : Neurotoxicology and Teratology. 41, p. 80-88 9 p.

Research output: Research - peer-reviewArticle

Equol
Learning
Therapeutics
Rats
Data storage equipment
Estrogen Receptor alpha
Gene Regulatory Networks
Estrogens
Genes
Gene Expression
2013

Association between Absolute Tumor Burden and Serum Bone-Specific Alkaline Phosphatase in Canine Appendicular Osteosarcoma

Sternberg, R. A., Pondenis, H. C., Yang, X., Mitchell, M. A., O'Brien, R. T., Garrett, L. D., Helferich, W. G., Hoffmann, W. E. & Fan, T. M. Jul 2013 In : Journal of Veterinary Internal Medicine. 27, 4, p. 955-963 9 p.

Research output: Research - peer-reviewArticle

Osteosarcoma
Tumor Burden
Alkaline Phosphatase
Canidae
Bone and Bones

Estradiol increases ER-negative breast cancer metastasis in an experimental model

Yang, X., Belosay, A., Du, M., Fan, T. M., Turner, R. T., Iwaniec, U. T. & Helferich, W. G. Aug 2013 In : Clinical and Experimental Metastasis. 30, 6, p. 711-721 11 p.

Research output: Research - peer-reviewArticle

Estradiol
Theoretical Models
Breast Neoplasms
Neoplasm Metastasis
Neoplasms

Genistein administered as a once-daily oral supplement had no beneficial effect on the tibia in rat models for postmenopausal bone loss

Turner, R. T., Iwaniec, U. T., Andrade, J. E., Branscum, A. J., Neese, S. L., Olson, D. A., Wagner, L., Wang, V. C., Schantz, S. L. & Helferich, W. G. Jun 2013 In : Menopause. 20, 6, p. 677-686 10 p.

Research output: Research - peer-reviewArticle

Postmenopausal Osteoporosis
Genistein
Tibia
Bone and Bones
Cancellous Bone

Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

Jiang, Y., Gong, P., Madak-Erdogan, Z., Martin, T., Jeyakumar, M., Carlson, K., Khan, I., Smillie, T. J., Chittiboyina, A. G., Rotte, S. C. K., Helferich, W. G., Katzenellenbogen, J. A. & Katzenellenbogen, B. S. Nov 2013 In : FASEB Journal. 27, 11, p. 4406-4418 13 p.

Research output: Research - peer-reviewArticle

Estrogen Receptor beta
Estrogens
Chromatin
Breast Neoplasms
Gene expression

Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

Xing, H., Tang, L., Yang, X., Hwang, K., Wang, W., Yin, Q., Wong, N. Y., Dobrucki, L. W., Yasui, N., Katzenellenbogen, J. A., Helferich, W. G., Cheng, J. & Lu, Y. Oct 21 2013 In : Journal of Materials Chemistry B. 1, 39, p. 5288-5297 10 p.

Research output: Research - peer-reviewArticle

Liposomes
Breast Neoplasms
Pharmaceutical Preparations
Neoplasms
In Vitro Techniques
2012

Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats

Pisani, S. L., Neese, S. L., Doerge, D. R., Helferich, W. G., Schantz, S. L. & Korol, D. L. Sep 2012 In : Hormones and Behavior. 62, 4, p. 491-499 9 p.

Research output: Research - peer-reviewArticle

Genistein
Young Adult
Estradiol
Learning
Therapeutics

Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

Tang, L., Yang, X., Dobrucki, L. W., Chaudhury, I., Yin, Q., Yao, C., Lezmi, S., Helferich, W. G., Fan, T. M. & Cheng, J. Dec 14 2012 In : Angewandte Chemie - International Edition. 51, 51, p. 12721-12726 6 p.

Research output: Research - peer-reviewArticle

Nanoconjugates
Silicon Dioxide
Tumors
Silica
Imaging techniques

Effects of multiple daily genistein treatments on delayed alternation and a differential reinforcement of low rates of responding task in middle-aged rats

Neese, S. L., Bandara, S. B., Doerge, D. R., Helferich, W. G., Korol, D. L. & Schantz, S. L. Jan 2012 In : Neurotoxicology and Teratology. 34, 1, p. 187-195 9 p.

Research output: Research - peer-reviewArticle

Genistein
Therapeutics
Reinforcement (Psychology)
Rats
Reinforcement

Low-dose dietary genistein negates the therapeutic effect of tamoxifen in athymic nude mice

Du, M., Yang, X., Hartman, J. A., Cooke, P. S., Doerge, D. R., Ju, Y. H. & Helferich, W. G. 2012 In : Carcinogenesis. 33, 4, p. 895-901 7 p.

Research output: Research - peer-reviewArticle

Genistein
Therapeutic Uses
Tamoxifen
Nude Mice
Estrogens
2011

Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression

De Assis, S., Warri, A., Benitez, C., Helferich, W. & Hilakivi-Clarke, L. Sep 2011 In : Cancer Prevention Research. 4, 9, p. 1436-1448 13 p.

Research output: Research - peer-reviewArticle

Genistein
Carcinogenesis
Breast
Diet
Human Mammary Glands
2010

Absolute bioavailability of isoflavones from soy protein isolate-containing food in female Balb/c mice

Andrade, J. E., Twaddle, N. C., Helferich, W. G. & Doerge, D. R. Apr 14 2010 In : Journal of Agricultural and Food Chemistry. 58, 7, p. 4529-4536 8 p.

Research output: Research - peer-reviewArticle

soy protein isolate
isoflavones
bioavailability
mice
Soybean Proteins

Acute and chronic effects of oral genistein administration in neonatal mice

Cimafranca, M. A., Davila, J., Ekman, G. C., Andrews, R. N., Neese, S. L., Peretz, J., Woodling, K. A., Helferich, W. G., Sarkar, J., Flaws, J. A., Schantz, S. L., Doerge, D. R. & Cooke, P. S. 2010 In : Biology of Reproduction. 83, 1, p. 114-121 8 p.

Research output: Research - peer-reviewArticle

Genistein
Oral Administration
Serum
Infant Formula
Weights and Measures

Dietary n-3 polyunsaturated fatty acids fail to reduce prostate tumorigenesis in the PB-ErbB-2 x Pten+/- preclinical mouse model

Vissapragada, S., Ghosh, A., Ringer, L., Salinas, P., Brophy, A., Peaceman, D., Kallakury, B., Banerjee, P. P., Fricke, S. T., Helfrich, W., Lee, Y. C., Pestell, R., Scherer, P., Tanowitz, H. B., Avantaggiati, M. L., Hilakivi-Clarke, L., Lisanti, M. P., Rodriguez, O. C. & Albanese, C. May 1 2010 In : Cell Cycle. 9, 9, p. 1824-1829 6 p.

Research output: Research - peer-reviewArticle

Omega-3 Fatty Acids
Prostate
Carcinogenesis
Diet
Cyclin E

Differential effects of whole soy extract and soy isoflavones on apoptosis in prostate cancer cells

Hsu, A., Bray, T. M., Helferich, W. G., Doerge, D. R. & Ho, E. Jan 2010 In : Experimental Biology and Medicine. 235, 1, p. 90-97 8 p.

Research output: Research - peer-reviewArticle

Isoflavones
Cells
Apoptosis
Prostatic Neoplasms
Genistein

Impact of dietary genistein and aging on executive function in rats

Neese, S. L., Wang, V. C., Doerge, D. R., Woodling, K. A., Andrade, J. E., Helferich, W. G., Korol, D. L. & Schantz, S. L. Mar 2010 In : Neurotoxicology and Teratology. 32, 2, p. 200-211 12 p.

Research output: Research - peer-reviewArticle

Genistein
Executive Function
Rats
Aging of materials
Dopamine Plasma Membrane Transport Proteins