Wilfred Adrianus van der Donk

1990 …2019
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Research Output 1990 2019

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Review article
2017

Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes

Peck, S. C. & van der Donk, W. A., Apr 1 2017, In : Journal of Biological Inorganic Chemistry. 22, 2-3, p. 381-394 14 p.

Research output: Contribution to journalReview article

Iron
Electrons
Oxidation
Enzymes
Biosynthesis

Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era

Hetrick, K. J. & van der Donk, W. A., Jun 1 2017, In : Current Opinion in Chemical Biology. 38, p. 36-44 9 p.

Research output: Contribution to journalReview article

Biological Products
Genes
Genome
Bacterial Genomes
Peptides
2016

Cameo appearances of aminoacyl-tRNA in natural product biosynthesis

Ulrich, E. C. & van der Donk, W. A., Dec 1 2016, In : Current Opinion in Chemical Biology. 35, p. 29-36 8 p.

Research output: Contribution to journalReview article

Biosynthesis
Transfer RNA
Biological Products
Genes
Enzymes

New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products

Ortega, M. A. & van der Donk, W. A., Jan 21 2016, In : Cell chemical biology. 23, 1, p. 31-44 14 p.

Research output: Contribution to journalReview article

Biosynthesis
Biological Products
Synthetic Biology
Peptides
Biosynthetic Pathways

The many roles of glutamate in metabolism

Walker, M. C. & van der Donk, W. A., Mar 1 2016, In : Journal of Industrial Microbiology and Biotechnology. 43, 2-3, p. 419-430 12 p.

Research output: Contribution to journalReview article

Metabolism
Amino acids
Glutamic Acid
Bioremediation
Biosynthesis
2015

Minimum Information about a Biosynthetic Gene cluster

Medema, M. H., Kottmann, R., Yilmaz, P., Cummings, M., Biggins, J. B., Blin, K., De Bruijn, I., Chooi, Y. H., Claesen, J., Coates, R. C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D. J., Fewer, D. P., Garg, N., Geiger, C., Gomez-Escribano, J. P., Greule, A., Hadjithomas, M. & 134 othersHaines, A. S., Helfrich, E. J. N., Hillwig, M. L., Ishida, K., Jones, A. C., Jones, C. S., Jungmann, K., Kegler, C., Kim, H. U., Kötter, P., Krug, D., Masschelein, J., Melnik, A. V., Mantovani, S. M., Monroe, E. A., Moore, M., Moss, N., Nützmann, H. W., Pan, G., Pati, A., Petras, D., Reen, F. J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N. J., Tsunematsu, Y., Wiemann, P., Wyckoff, E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C. J., Balskus, E. P., Barona-Gómez, F., Bechthold, A., Bode, H. B., Borriss, R., Brady, S. F., Brakhage, A. A., Caffrey, P., Cheng, Y. Q., Clardy, J., Cox, R. J., De Mot, R., Donadio, S., Donia, M. S., van der Donk, W. A., Dorrestein, P. C., Doyle, S., Driessen, A. J. M., Ehling-Schulz, M., Entian, K. D., Fischbach, M. A., Gerwick, L., Gerwick, W. H., Gross, H., Gust, B., Hertweck, C., Höfte, M., Jensen, S. E., Ju, J., Katz, L., Kaysser, L., Klassen, J. L., Keller, N. P., Kormanec, J., Kuipers, O. P., Kuzuyama, T., Kyrpides, N. C., Kwon, H. J., Lautru, S., Lavigne, R., Lee, C. Y., Linquan, B., Liu, X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D. A., Moore, B. S., Moreira, L. M., Müller, R., Neilan, B. A., Nett, M., Nielsen, J., O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M. S., Ostash, B., Payne, S. M., Pernodet, J. L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J. M., Salas, J. A., Schmitt, E. K., Scott, B., Seipke, R. F., Shen, B., Sherman, D. H., Sivonen, K., Smanski, M. J., Sosio, M., Stegmann, E., Süssmuth, R. D., Tahlan, K., Thomas, C. M., Tang, Y., Truman, A. W., Viaud, M., Walton, J. D., Walsh, C. T., Weber, T., Van Wezel, G. P., Wilkinson, B., Willey, J. M., Wohlleben, W., Wright, G. D., Ziemert, N., Zhang, C., Zotchev, S. B., Breitling, R., Takano, E. & Glöckner, F. O., Aug 18 2015, In : Nature chemical biology. 11, 9, p. 625-631 7 p.

Research output: Contribution to journalReview article

Multigene Family
Information Storage and Retrieval
Fungi
Bacteria
2014

Structure and mechanism of lanthipeptide biosynthetic enzymes

van der Donk, W. A. & Nair, S. K., Dec 1 2014, In : Current Opinion in Structural Biology. 29, p. 58-66 9 p.

Research output: Contribution to journalReview article

Peptides
Sulfides
Enzymes
Post Translational Protein Processing
Biological Products
2013

Insights into the evolution of lanthipeptide biosynthesis

Yu, Y., Zhang, Q. & van der Donk, W. A., Nov 1 2013, In : Protein Science. 22, 11, p. 1478-1489 12 p.

Research output: Contribution to journalReview article

Biosynthesis
Post Translational Protein Processing
Biological Products
Peptides
Sulfides

Phosphonate biosynthesis and catabolism: A treasure trove of unusual enzymology

Peck, S. C. & van der Donk, W. A., Aug 1 2013, In : Current Opinion in Chemical Biology. 17, 4, p. 580-588 9 p.

Research output: Contribution to journalReview article

Organophosphonates
Biosynthesis
Biochemistry
Phosphates
Biological Products

Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature

Arnison, P. G., Bibb, M. J., Bierbaum, G., Bowers, A. A., Bugni, T. S., Bulaj, G., Camarero, J. A., Campopiano, D. J., Challis, G. L., Clardy, J., Cotter, P. D., Craik, D. J., Dawson, M., Dittmann, E., Donadio, S., Dorrestein, P. C., Entian, K. D., Fischbach, M. A., Garavelli, J. S., Göransson, U. & 45 othersGruber, C. W., Haft, D. H., Hemscheidt, T. K., Hertweck, C., Hill, C., Horswill, A. R., Jaspars, M., Kelly, W. L., Klinman, J. P., Kuipers, O. P., Link, A. J., Liu, W., Marahiel, M. A., Mitchell, D. A., Moll, G. N., Moore, B. S., Müller, R., Nair, S. K., Nes, I. F., Norris, G. E., Olivera, B. M., Onaka, H., Patchett, M. L., Piel, J., Reaney, M. J. T., Rebuffat, S., Ross, R. P., Sahl, H. G., Schmidt, E. W., Selsted, M. E., Severinov, K., Shen, B., Sivonen, K., Smith, L., Stein, T., Süssmuth, R. D., Tagg, J. R., Tang, G. L., Truman, A. W., Vederas, J. C., Walsh, C. T., Walton, J. D., Wenzel, S. C., Willey, J. M. & van der Donk, W. A., Jan 1 2013, In : Natural Product Reports. 30, 1, p. 108-160 53 p.

Research output: Contribution to journalReview article

Biosynthesis
Terminology
Biological Products
Peptides
compound 20
2012

Discovery, biosynthesis, and engineering of lantipeptides

Knerr, P. J. & van der Donk, W. A., Jul 1 2012, In : Annual review of biochemistry. 81, p. 479-505 27 p.

Research output: Contribution to journalReview article

Bacterial Genomes
Biosynthesis
Gram-Positive Bacteria
Sulfides
Post Translational Protein Processing
2011

Genome mining for ribosomally synthesized natural products

Velásquez, J. E. & van der Donk, W. A., Feb 1 2011, In : Current Opinion in Chemical Biology. 15, 1, p. 11-21 11 p.

Research output: Contribution to journalReview article

Biological Products
Genes
Genome
Peptides
Cyclotides
Fosfomycin
Organophosphonates
Biosynthesis
Enzymes
Proteins
2010

Follow the leader: The use of leader peptides to guide natural product biosynthesis

Oman, T. J. & van der Donk, W. A., Jan 1 2010, In : Nature chemical biology. 6, 1, p. 9-18 10 p.

Research output: Contribution to journalReview article

Protein Sorting Signals
Biological Products
Avalanches
Peptides
Post Translational Protein Processing

Substrate activation by iron superoxo intermediates

van der Donk, W. A., Krebs, C. & Bollinger, J. M., Dec 1 2010, In : Current Opinion in Structural Biology. 20, 6, p. 673-683 11 p.

Research output: Contribution to journalReview article

Iron
Oxygenases
Superoxides
Hydrogen
Oxidoreductases
2009

Biosynthesis of phosphonic and phosphinic acid natural products

Metcalf, W. W. & van der Donk, W. A., Jul 27 2009, In : Annual review of biochemistry. 78, p. 65-94 30 p.

Research output: Contribution to journalReview article

Phosphinic Acids
Biosynthesis
Biological Products
Biochemistry
Phosphorous Acids
2007

Lantibiotics: Peptides of diverse structure and function

Willey, J. M. & van der Donk, W. A., Nov 14 2007, In : Annual review of microbiology. 61, p. 477-501 25 p.

Research output: Contribution to journalReview article

Bacteriocins
Peptides
Anti-Bacterial Agents
Protein Engineering
Gram-Positive Bacteria
2006

Lighting up the nascent cell wall.

van der Donk, W. A., Jan 1 2006, In : ACS chemical biology. 1, 7, p. 425-428 4 p.

Research output: Contribution to journalReview article

Lighting
Cell Wall
Cells
Peptidoglycan
Anti-Bacterial Agents

Rings, radicals, and regeneration: The early years of a bioorganic laboratory

van der Donk, W. A., Dec 22 2006, In : Journal of Organic Chemistry. 71, 26, p. 9561-9571 11 p.

Research output: Contribution to journalReview article

Nisin
Fosfomycin
Biosynthesis
Anti-Bacterial Agents
lacticin 481
2005

Biosynthesis and mode of action of lantibiotics

Chatterjee, C., Paul, M., Xie, L. & van der Donk, W. A., Feb 1 2005, In : Chemical reviews. 105, 2, p. 633-683 51 p.

Research output: Contribution to journalReview article

Bacteriocins
Biosynthesis
Nisin
Bioactivity
Genes

Chemical and enzymatic synthesis of lanthionines

Paul, M. & van der Donk, W. A., Jan 1 2005, In : Mini-Reviews in Organic Chemistry. 2, 1, p. 23-37 15 p.

Research output: Contribution to journalReview article

Bacteriocins
Nisin
Peptides
Food Preservatives
Sulfides

Mechanism and applications of phosphite dehydrogenase

Relyea, H. A. & van der Donk, W. A., Jan 1 2005, In : Bioorganic Chemistry. 33, 3, p. 171-189 19 p.

Research output: Contribution to journalReview article

NAD
Phosphites
Organophosphonates
Enzymes
Metabolism

New developments in lantibiotic biosynthesis and mode of action

Patton, G. C. & van der Donk, W. A., Oct 1 2005, In : Current Opinion in Microbiology. 8, 5, p. 543-551 9 p.

Research output: Contribution to journalReview article

Bacteriocins
Peptides
Peptidoglycan
Threonine
Post Translational Protein Processing
2004

Post-translational modifications during lantibiotic biosynthesis

Xie, L. & van der Donk, W. A., Oct 1 2004, In : Current Opinion in Chemical Biology. 8, 5, p. 498-507 10 p.

Research output: Contribution to journalReview article

Bacteriocins
Biosynthesis
Post Translational Protein Processing
Threonine
Substrate Specificity
2003

Comparison of the properties of prostaglandin H synthase-1 and -2

Kulmacz, R. J., van der Donk, W. A. & Tsai, A. L., Jan 1 2003, In : Progress in Lipid Research. 42, 5, p. 377-404 28 p.

Research output: Contribution to journalReview article

Cyclooxygenase 1
Cyclooxygenase 2
Protein Isoforms
Prostaglandin-Endoperoxide Synthases
Biosynthesis

Recent developments in pyridine nucleotide regeneration

van der Donk, W. A. & Zhao, H., Jan 1 2003, In : Current Opinion in Biotechnology. 14, 4, p. 421-426 6 p.

Research output: Contribution to journalReview article

Nucleotides
Pyridine
Regeneration
Oxidoreductases
Enzymes

Regeneration of cofactors for use in biocatalysis

Zhao, H. & van der Donk, W. A., Jan 1 2003, In : Current Opinion in Biotechnology. 14, 6, p. 583-589 7 p.

Research output: Contribution to journalReview article

Biocatalysis
Regeneration
Enzymes
Phosphoadenosine Phosphosulfate
Adenosinetriphosphate
2002

The cyclooxygenase reaction mechanism

van der Donk, W. A., Tsai, A. L. & Kulmacz, R. J., Dec 31 2002, In : Biochemistry. 41, 52, p. 15451-15458 8 p.

Research output: Contribution to journalReview article

Prostaglandins G
Molecular Conformation
Cyclooxygenase 1
Cyclooxygenase 2
Prostaglandin-Endoperoxide Synthases
2001

Tyrosyl radical cofactors

Pesavento, R. P. & van der Donk, W. A., Jan 1 2001, In : Advances in Protein Chemistry. 58, p. 317-385 69 p.

Research output: Contribution to journalReview article

2000

Novel cofactors via post-translational mocifications of enzyme active sites

Okeley, N. M. & van der Donk, W. A., Jul 1 2000, In : Chemistry and Biology. 7, 7

Research output: Contribution to journalReview article

Biosynthesis
Post Translational Protein Processing
Catalytic Domain
Enzymes
1995

Ribonucleotide reductases: radical enzymes with suicidal tendencies

Stubbe, J. A. & van der Donk, W. A., Jan 1 1995, In : Chemistry and Biology. 2, 12, p. 793-801 9 p.

Research output: Contribution to journalReview article

Ribonucleotide Reductases
Biochemistry
Biosynthesis
Antineoplastic Agents
Antiviral Agents