Wilfred Adrianus van der Donk

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Bacteroidetes can be a rich source of novel lanthipeptides: The case study of Pedobacter lusitanus

Caetano, T., van der Donk, W. & Mendo, S., May 2020, In : Microbiological Research. 235, 126441.

Research output: Contribution to journalArticle

Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae

Huo, L., Zhao, X., Acedo, J. Z., Estrada, P., Nair, S. K. & van der Donk, W. A., Jan 15 2020, In : ChemBioChem. 21, 1-2, p. 190-199 10 p.

Research output: Contribution to journalArticle

Discovery and Characterization of a Class IV Lanthipeptide with a Nonoverlapping Ring Pattern

Ren, H., Shi, C., Bothwell, I. R., Van Der Donk, W. A., Van Der Donk, W. A., Van Der Donk, W. A., Zhao, H., Zhao, H., Zhao, H., Zhao, H. & Zhao, H., Jun 19 2020, In : ACS chemical biology. 15, 6, p. 1642-1649 8 p.

Research output: Contribution to journalArticle

Nonribosomal peptide extension by a peptide amino-acyl tRNA ligase

Zhang, Z. & Van Der Donk, W. A., Jan 1 2020, In : Journal of the American Chemical Society. 141, 50, p. 19625-19633 9 p.

Research output: Contribution to journalArticle

Substrate Recognition by the Class II Lanthipeptide Synthetase HalM2

Rahman, I. R., Acedo, J. Z., Liu, X. R., Zhu, L., Arrington, J., Gross, M. L. & Van Der Donk, W. A., Jun 19 2020, In : ACS chemical biology. 15, 6, p. 1473-1486 14 p.

Research output: Contribution to journalArticle

2019

Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications

Hegemann, J. D., Bobeica, S. C., Walker, M. C., Bothwell, I. R. & Van Der Donk, W. A., May 17 2019, In : ACS synthetic biology. 8, 5, p. 1204-1214 11 p.

Research output: Contribution to journalArticle

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

Duan, Y., Llorente, C., Lang, S., Brandl, K., Chu, H., Jiang, L., White, R. C., Clarke, T. H., Nguyen, K., Torralba, M., Shao, Y., Liu, J., Hernandez-Morales, A., Lessor, L., Rahman, I. R., Miyamoto, Y., Ly, M., Gao, B., Sun, W., Kiesel, R. & 26 others, Hutmacher, F., Lee, S., Ventura-Cots, M., Bosques-Padilla, F., Verna, E. C., Abraldes, J. G., Brown, R. S., Vargas, V., Altamirano, J., Caballería, J., Shawcross, D. L., Ho, S. B., Louvet, A., Lucey, M. R., Mathurin, P., Garcia-Tsao, G., Bataller, R., Tu, X. M., Eckmann, L., van der Donk, W. A., Young, R., Lawley, T. D., Stärkel, P., Pride, D., Fouts, D. E. & Schnabl, B., Nov 21 2019, In : Nature. 575, 7783, p. 505-511 7 p.

Research output: Contribution to journalArticle

Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics

Bothwell, I. R., Cogan, D. P., Kim, T., Reinhardt, C. J., van der Donk, W. A. & Nair, S. K., Aug 27 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17245-17250 6 p.

Research output: Contribution to journalArticle

Open Access

CylA is a sequence-specific protease involved in toxin biosynthesis

Tang, W., Bobeica, S. C., Wang, L. & van der Donk, W. A., Mar 29 2019, In : Journal of Industrial Microbiology and Biotechnology. 46, 3-4, p. 537-549 13 p.

Research output: Contribution to journalArticle

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

Bobeica, S. C., Dong, S. H., Huo, L., Mazo, N., McLaughlin, M. I., Jiménez-Osés, G., Nair, S. K. & van der Donk, W. A., Jan 14 2019, In : eLife. 8, e42305.

Research output: Contribution to journalArticle

Investigations into the Mechanism of Action of Sublancin

Wu, C., Biswas, S., Garcia De Gonzalo, C. V. & Van Der Donk, W. A., Mar 8 2019, In : ACS Infectious Diseases. 5, 3, p. 454-459 6 p.

Research output: Contribution to journalArticle

Mechanistic Studies of the Kinase Domains of Class IV Lanthipeptide Synthetases

Hegemann, J. D., Shi, L., Gross, M. L. & Van Der Donk, W. A., Jun 5 2019, In : ACS chemical biology. 14, 7, p. 1583-1592 10 p.

Research output: Contribution to journalArticle

O-Methyltransferase-Mediated Incorporation of a β-Amino Acid in Lanthipeptides

Acedo, J. Z., Bothwell, I. R., An, L., Trouth, A., Frazier, C. & Van Der Donk, W. A., Jan 1 2019, In : Journal of the American Chemical Society. 141, 42, p. 16790-16801 12 p.

Research output: Contribution to journalArticle

Temperature-Independent Kinetic Isotope Effects as Evidence for a Marcus-like Model of Hydride Tunneling in Phosphite Dehydrogenase

Howe, G. W. & Van Der Donk, W. A., Oct 15 2019, In : Biochemistry. 58, 41, p. 4260-4268 9 p.

Research output: Contribution to journalArticle

Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products

Ting, C. P., Funk, M. A., Halaby, S. L., Zhang, Z., Gonen, T. & Van Der Donk, W. A., Jul 19 2019, In : Science. 365, 6450, p. 280-284 5 p.

Research output: Contribution to journalArticle

Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin

Bougioukou, D. J., Ting, C. P., Peck, S. C., Mukherjee, S. & Van Der Donk, W. A., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 4, p. 822-829 8 p.

Research output: Contribution to journalArticle

2018

A lanthipeptide library used to identify a protein-protein interaction inhibitor article

Yang, X., Lennard, K. R., He, C., Walker, M. C., Ball, A. T., Doigneaux, C., Tavassoli, A. & Van Der Donk, W. A., Apr 1 2018, In : Nature chemical biology. 14, 4, p. 375-380 6 p.

Research output: Contribution to journalArticle

Characterization of Leader Peptide Binding during Catalysis by the Nisin Dehydratase NisB

Repka, L. M., Hetrick, K. J., Chee, S. H. & Van Der Donk, W. A., Mar 28 2018, In : Journal of the American Chemical Society. 140, 12, p. 4200-4203 4 p.

Research output: Contribution to journalArticle

Development and Application of Yeast and Phage Display of Diverse Lanthipeptides

Hetrick, K. J., Walker, M. C. & Van Der Donk, W. A., Apr 25 2018, In : ACS Central Science. 4, 4, p. 458-467 10 p.

Research output: Contribution to journalArticle

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

Hegemann, J. D., Schwalen, C. J., Mitchell, D. A. & Van der Donk, W. A., Jan 1 2018, In : Chemical Communications. 54, 65, p. 9007-9010 4 p.

Research output: Contribution to journalArticle

Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin

Wang, K. K. A., Ng, T. L., Wang, P., Huang, Z., Balskus, E. P. & van der Donk, W. A., Dec 1 2018, In : Nature communications. 9, 1, 3687.

Research output: Contribution to journalArticle

Incorporation of Nonproteinogenic Amino Acids in Class i and II Lantibiotics

Kakkar, N., Perez, J. G., Liu, W. R., Jewett, M. C. & Van Der Donk, W. A., Apr 20 2018, In : ACS chemical biology. 13, 4, p. 951-957 7 p.

Research output: Contribution to journalArticle

Investigation of Amide Bond Formation during Dehydrophos Biosynthesis

Ulrich, E. C., Bougioukou, D. J. & Van Der Donk, W. A., Mar 16 2018, In : ACS chemical biology. 13, 3, p. 537-541 5 p.

Research output: Contribution to journalArticle

Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems

Hegemann, J. D. & Van Der Donk, W. A., May 2 2018, In : Journal of the American Chemical Society. 140, 17, p. 5743-5754 12 p.

Research output: Contribution to journalArticle

Lanthionine synthetase C-like protein 2 (LanCL2) is important for adipogenic differentiation

Dutta, D., Lai, K. Y., Reyes-Ordoñez, A., Chen, J. & van der Donk, W. A., Jan 1 2018, In : Journal of Lipid Research. 59, 8, p. 1433-1445 13 p.

Research output: Contribution to journalArticle

Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli

Ren, H., Biswas, S., Ho, S., Van Der Donk, W. A. & Zhao, H., Oct 19 2018, In : ACS chemical biology. 13, 10, p. 2966-2972 7 p.

Research output: Contribution to journalArticle

Rapid Screening of Lanthipeptide Analogs via In-Colony Removal of Leader Peptides in Escherichia coli

Si, T., Tian, Q., Min, Y., Zhang, L., Sweedler, J. V., Van Der Donk, W. A. & Zhao, H., Sep 26 2018, In : Journal of the American Chemical Society. 140, 38, p. 11884-11888 5 p.

Research output: Contribution to journalArticle

Stereospecific Radical-Mediated B12-Dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3

McLaughlin, M. I. & Van Der Donk, W. A., Aug 21 2018, In : Biochemistry. 57, 33, p. 4967-4971 5 p.

Research output: Contribution to journalArticle

Substrate-assisted enzymatic formation of lysinoalanine in duramycin

An, L., Cogan, D. P., Navo, C. D., Jiménez-Osés, G., Nair, S. K. & van der Donk, W. A., Oct 1 2018, In : Nature chemical biology. 14, 10, p. 928-933 6 p.

Research output: Contribution to journalArticle

2017

Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads

Olivares, P., Ulrich, E. C., Chekan, J. R., Van Der Donk, W. A. & Nair, S. K., Feb 17 2017, In : ACS chemical biology. 12, 2, p. 456-463 8 p.

Research output: Contribution to journalArticle

Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products

Burkhart, B. J., Kakkar, N., Hudson, G. A., Van Der Donk, W. A. & Mitchell, D. A., Jun 28 2017, In : ACS Central Science. 3, 6, p. 629-638 10 p.

Research output: Contribution to journalArticle

Evolutionary radiation of lanthipeptides in marine cyanobacteria

Cubillos-Ruiz, A., Berta-Thompson, J. W., Becker, J. W., Van Der Donk, W. A. & Chisholm, S. W., Jul 3 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 27, p. E5424-E5433

Research output: Contribution to journalArticle

Insights into the biosynthesis of duramycin

Huo, L., Ökesli, A., Zhao, M. & van der Donk, W. A., Jan 1 2017, In : Applied and environmental microbiology. 83, 3, e02698-16.

Research output: Contribution to journalArticle

LanCL proteins are not Involved in Lanthionine Synthesis in Mammals

He, C., Zeng, M., Dutta, D., Koh, T. H., Chen, J. & Van Der Donk, W. A., Jan 20 2017, In : Scientific reports. 7, 40980.

Research output: Contribution to journalArticle

Mechanism of a Class C Radical S-Adenosyl- l -methionine Thiazole Methyl Transferase

Zhang, Z., Mahanta, N., Hudson, G. A., Mitchell, D. A. & Van Der Donk, W. A., Dec 27 2017, In : Journal of the American Chemical Society. 139, 51, p. 18623-18631 9 p.

Research output: Contribution to journalArticle

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes

Repka, L. M., Chekan, J. R., Nair, S. K. & Van Der Donk, W. A., Apr 26 2017, In : Chemical reviews. 117, 8, p. 5457-5520 64 p.

Research output: Contribution to journalArticle

O-H activation by an unexpected ferryl intermediate during catalysis by 2-hydroxyethylphosphonate dioxygenase

Peck, S. C., Wang, C., Dassama, L. M. K., Zhang, B., Guo, Y., Rajakovich, L. J., Martin Bollinger, J., Krebs, C. & Van Der Donk, W. A., Feb 8 2017, In : Journal of the American Chemical Society. 139, 5, p. 2045-2052 8 p.

Research output: Contribution to journalArticle

Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis

Mahanta, N., Zhang, Z., Hudson, G. A., Van Der Donk, W. A. & Mitchell, D. A., Mar 29 2017, In : Journal of the American Chemical Society. 139, 12, p. 4310-4313 4 p.

Research output: Contribution to journalArticle

Ribosomal Natural Products, Tailored to Fit

Funk, M. A. & Van Der Donk, W. A., Jul 18 2017, In : Accounts of chemical research. 50, 7, p. 1577-1586 10 p.

Research output: Contribution to journalArticle

Structural basis for methylphosphonate biosynthesis

Born, D. A., Ulrich, E. C., Ju, K. S., Peck, S. C., Van Der Donk, W. A. & Drennan, C. L., Dec 8 2017, In : Science. 358, 6368, p. 1336-1339 4 p.

Research output: Contribution to journalArticle

Structure-Activity Relationships of the S-Linked Glycocin Sublancin

Biswas, S., Garcia De Gonzalo, C. V., Repka, L. M. & Van Der Donk, W. A., Dec 15 2017, In : ACS chemical biology. 12, 12, p. 2965-2969 5 p.

Research output: Contribution to journalArticle

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis

Ortega, M. A., Cogan, D. P., Mukherjee, S., Garg, N., Li, B., Thibodeaux, G. N., Maffioli, S. I., Donadio, S., Sosio, M., Escano, J., Smith, L., Nair, S. K. & Van Der Donk, W. A., Feb 17 2017, In : ACS chemical biology. 12, 2, p. 548-557 10 p.

Research output: Contribution to journalArticle

2016

Biosynthetic investigation of phomopsins reveals a widespread pathway for ribosomal natural products in Ascomycetes

Ding, W., Liu, W. Q., Jia, Y., Li, Y., Van Der Donk, W. A. & Zhang, Q., Mar 29 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 13, p. 3521-3526 6 p.

Research output: Contribution to journalArticle

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin

Zhang, Z., Hudson, G. A., Mahanta, N., Tietz, J. I., Van der Donk, W. A. & Mitchell, D. A., Dec 7 2016, In : Journal of the American Chemical Society. 138, 48, p. 15511-15514 4 p.

Research output: Contribution to journalArticle

Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM

Garg, N., Goto, Y., Chen, T. & van der Donk, W. A., Nov 1 2016, In : Biopolymers. 106, 6, p. 834-842 9 p.

Research output: Contribution to journalArticle

Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity during Lacticin 481 Biosynthesis

Thibodeaux, C. J., Wagoner, J., Yu, Y. & Van Der Donk, W. A., May 25 2016, In : Journal of the American Chemical Society. 138, 20, p. 6436-6444 9 p.

Research output: Contribution to journalArticle