Weiping Zhang

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Research Output

2020
Open Access

Development of effective vaccines for enterotoxigenic Escherichia coli

Seo, H. & Zhang, W., Feb 2020, In : The Lancet Infectious Diseases. 20, 2, p. 150-152 3 p.

Research output: Contribution to journalComment/debate

Open Access

Engineered recombinant escherichia coli probiotic strains integrated with f4 and f18 fimbriae cluster genes in the chromosome and their assessment of immunogenic efficacy in vivo

Ou, B., Jiang, B., Jin, D., Yang, Y., Zhang, M., Zhang, D., Zhao, H., Xu, M., Song, H., Wu, W., Chen, M., Lu, T., Huang, J., Seo, H., Garcia, C., Zheng, W., Guo, W., Lu, Y., Jiang, Y., Yang, S. & 4 others, Kaushik, R. S., Li, X., Zhang, W. & Zhu, G., Feb 21 2020, In : ACS synthetic biology. 9, 2, p. 412-426 15 p.

Research output: Contribution to journalArticle

2019

Antibodies induced by enterotoxigenic Escherichia coli (ETEC) adhesin major structural subunit and minor tip adhesin subunit equivalently inhibit bacteria adherence in vitro

Seo, H., Nandre, R. M., Nietfeld, J., Chen, Z., Duan, Q. & Zhang, W., May 2019, In : PloS one. 14, 5, e0216076.

Research output: Contribution to journalArticle

Open Access

Immunogenicity characterization of genetically fused or chemically conjugated heat-stable toxin toxoids of enterotoxigenic Escherichia coli in mice and pigs

Seo, H., Lu, T., Nandre, R. M., Duan, Q. & Zhang, W., Feb 25 2019, In : FEMS microbiology letters. 366, 4, fny037.

Research output: Contribution to journalArticle

Open Access

Mapping the neutralizing epitopes of enterotoxigenic Escherichia coli K88 (F4) fimbrial adhesin and major subunit FaeG

Lu, T., Moxley, R. A. & Zhang, W., Jun 1 2019, In : Applied and environmental microbiology. 85, 11, e00329-19.

Research output: Contribution to journalArticle

Mapping the neutralizing epitopes of F18 fimbrial adhesin subunit FedF of enterotoxigenic Escherichia coli (ETEC)

Lu, T., Seo, H., Moxley, R. A. & Zhang, W., Mar 2019, In : Veterinary Microbiology. 230, p. 171-177 7 p.

Research output: Contribution to journalArticle

Review of Newly Identified Functions Associated With the Heat-Labile Toxin of Enterotoxigenic Escherichia coli

Duan, Q., Xia, P., Nandre, R., Zhang, W. & Zhu, G., Aug 13 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 292.

Research output: Contribution to journalReview article

Open Access
2018
Open Access
Open Access
Open Access

Techniques for chromosomal integration and expression optimization in Escherichia coli

Ou, B., Garcia, C., Wang, Y., Zhang, W. & Zhu, G., Oct 2018, In : Biotechnology and bioengineering. 115, 10, p. 2467-2478 12 p.

Research output: Contribution to journalReview article

2017

Genetic fusion protein 3×STa-ovalbumin is an effective coating antigen in ELISA to titrate anti-STa antibodies

Duan, Q. & Zhang, W., Jul 2017, In : Microbiology and Immunology. 61, 7, p. 251-257 7 p.

Research output: Contribution to journalArticle

Improving chances for successful clinical outcomes with better preclinical models

Wenzel, H., Kaminski, R. W., Clarkson, K. A., Maciel, M., Smith, M. A., Zhang, W. & Oaks, E. V., Dec 14 2017, In : Vaccine. 35, 49, p. 6798-6802 5 p.

Research output: Contribution to journalArticle

Open Access

Passive antibodies derived from intramuscularly immunized toxoid fusion 3xSTaN12S-dmLT protect against STa+ enterotoxigenic Escherichia coli (ETEC) diarrhea in a pig model

Nandre, R. M., Duan, Q., Wang, Y. & Zhang, W., Jan 23 2017, In : Vaccine. 35, 4, p. 552-556 5 p.

Research output: Contribution to journalArticle

Pig BVDV-2 non-structural protein (Npro) links to cellular antiviral response in vitro

Tao, J., Liao, J., Wang, J., Zhang, X., Zhang, Q., Zhu, L., Zhang, W., Liu, H. & Zhu, G., Apr 1 2017, In : Virus Genes. 53, 2, p. 233-239 7 p.

Research output: Contribution to journalArticle

2016
Open Access
2015

Current progress in developing subunit vaccines against enterotoxigenic Escherichia coli-associated Diarrhea

Zhang, W. & Sack, D. A., Sep 1 2015, In : Clinical and Vaccine Immunology. 22, 9, p. 983-991 9 p.

Research output: Contribution to journalReview article

Open Access
Open Access
2014

Characterization of heat-stable (STa) toxoids of enterotoxigenic Escherichia coli fused to double mutant heat-labile toxin peptide in inducing neutralizing anti-STa antibodies

Ruan, X., Robertson, D. C., Nataro, J. P., Clements, J. D. & Zhang, W., May 2014, In : Infection and immunity. 82, 5, p. 1823-1832 10 p.

Research output: Contribution to journalArticle

Open Access

Multiepitope fusion antigen induces broadly protective antibodies that prevent adherence of Escherichia coli strains expressing colonization factor antigen I (CFA/I), CFA/II, and CFA/IV

Ruan, X., Knudsen, D. E., Wollenberg, K. M., Sack, D. A. & Zhang, W., Feb 1 2014, In : Clinical and Vaccine Immunology. 21, 2, p. 243-249 7 p.

Research output: Contribution to journalArticle

Open Access
2013

A multiepitope fusion antigen elicits neutralizing antibodies against enterotoxigenic Escherichia coli and homologous bovine viral diarrhea virus in Vitro

Hashish, E. A., Zhang, C., Ruan, X., Knudsen, D. E., Chase, C. C., Isaacson, R. E., Zhou, G. & Zhang, W., Jul 1 2013, In : Clinical and Vaccine Immunology. 20, 7, p. 1076-1083 8 p.

Research output: Contribution to journalArticle

Open Access

Both enzymatic and non-enzymatic properties of heat-labile enterotoxin are responsible for LT-enhanced adherence of enterotoxigenic Escherichia coli to porcine IPEC-J2 cells

Fekete, P. Z., Mateo, K. S., Zhang, W., Moxley, R. A., Kaushik, R. S. & Francis, D. H., Mar 19 2013, In : Veterinary Microbiology. 164, 3-4, p. 330-335 6 p.

Research output: Contribution to journalArticle

Construction and immunogenicity evaluation of an epitope-based antigen against swine influenza A virus using Escherichia coli heat-labile toxin B subunit as a carrier-adjuvant

Sun, Z., Lawson, S., Langenhorst, R., McCormick, K. L., Brunick, C., Opriessnig, T., Baker, R., Yoon, K. J., Zhang, W., Huber, V. C. & Fang, Y., Mar 14 2013, In : Veterinary Microbiology. 164, 3-4, p. 229-238 10 p.

Research output: Contribution to journalArticle

Flagella from F18+ Escherichia coli play a role in adhesion to pig epithelial cell lines

Duan, Q., Zhou, M., Zhu, X., Yang, Y., Zhu, J., Bao, W., Wu, S., Ruan, X., Zhang, W. & Zhu, G., Feb 1 2013, In : Microbial Pathogenesis. 55, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

Toxicity and Immunogenicity of Enterotoxigenic Escherichia coli Heat-Labile and Heat-Stable Toxoid Fusion 3xSTaA14Q-LTS63K/R192G/L211A in a Murine Model

Zhang, C., Knudsen, D. E., Liu, M., Robertson, D. C. & Zhang, W., Oct 11 2013, In : PloS one. 8, 10, e77386.

Research output: Contribution to journalArticle

Open Access
2012

Escherichia coli expressing EAST1 toxin did not cause an increase of cAMP or cGMP levels in cells, and no diarrhea in 5-day old gnotobiotic pigs

Ruan, X., Crupper, S. S., Schultz, B. D., Robertson, D. C. & Zhang, W., Aug 15 2012, In : PloS one. 7, 8, e43203.

Research output: Contribution to journalArticle

Open Access

Progress and hurdles in the development of vaccines against enterotoxigenic Escherichia coli in humans

Zhang, W. & Sack, D. A., Jun 1 2012, In : Expert review of vaccines. 11, 6, p. 677-694 18 p.

Research output: Contribution to journalReview article

The flagella of F18ab Escherichia coli is a virulence factor that contributes to infection in a IPEC-J2 cell model in vitro

Duan, Q., Zhou, M., Zhu, X., Bao, W., Wu, S., Ruan, X., Zhang, W., Yang, Y., Zhu, J. & Zhu, G., Nov 9 2012, In : Veterinary Microbiology. 160, 1-2, p. 132-140 9 p.

Research output: Contribution to journalArticle

2011
Open Access

Heat-labile- and Heat-stable-toxoid fusions (LTR192G-STaP13F) of human enterotoxigenic Escherichia coli elicit neutralizing antitoxin antibodies

Liu, M., Ruan, X., Zhang, C., Lawson, S. R., Knudsen, D. E., Nataro, J. P., Robertson, D. C. & Zhang, W., Oct 1 2011, In : Infection and immunity. 79, 10, p. 4002-4009 8 p.

Research output: Contribution to journalArticle

Open Access

Modified Heat-stable toxins (hSTa) of enterotoxigenic Escherichia coli lose toxicity but display antigenicity after being genetically fused to heat-labile toxoid LT(R192G)

Liu, M., Zhang, C., Mateo, K., Nataro, J. P., Robertson, D. C. & Zhang, W., Sep 2011, In : Toxins. 3, 9, p. 1146-1162 17 p.

Research output: Contribution to journalArticle

Open Access
2010
Open Access

Genetic fusions of heat-labile (LT) and heat-stable (ST) toxoids of porcine enterotoxigenic Escherichia coli elicit neutralizing anti-LT and anti-STa antibodies

Zhang, W., Zhang, C., Francis, D. H., Fang, Y., Knudsen, D., Nataro, J. P. & Robertson, D. C., Jan 1 2010, In : Infection and immunity. 78, 1, p. 316-325 10 p.

Research output: Contribution to journalArticle

Open Access
Open Access
2009
Open Access
Open Access
2008

Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model

Zhang, W., Robertson, D. C., Zhang, C., Bai, W., Zhao, M. & Francis, D. H., Sep 1 2008, In : Applied and environmental microbiology. 74, 18, p. 5832-5837 6 p.

Research output: Contribution to journalArticle

Open Access
2007

Diversity and evolution of a newly emerged North American Type 1 porcine arterivirus: Analysis of isolates collected between 1999 and 2004

Fang, Y., Schneider, P., Zhang, W. P., Faaberg, K. S., Nelson, E. A. & Rowland, R. R. R., May 1 2007, In : Archives of Virology. 152, 5, p. 1009-1017 9 p.

Research output: Contribution to journalArticle

Prevalence of virulence genes in Escherichia coli strains recently isolated from young pigs with diarrhea in the US

Zhang, W., Zhao, M., Ruesch, L., Omot, A. & Francis, D., Jul 20 2007, In : Veterinary Microbiology. 123, 1-3, p. 145-152 8 p.

Research output: Contribution to journalArticle

2006

Significance of heat-stable and heat-labile enterotoxins in porcine colibacillosis in an additive model for pathogenicity studies

Zhang, W., Berberov, E. M., Freeling, J., He, D., Moxley, R. A. & Francis, D. H., Jun 1 2006, In : Infection and immunity. 74, 6, p. 3107-3114 8 p.

Research output: Contribution to journalArticle

Open Access
2000

Phylogeny of the grass family (Poaceae) from rpl16 intron sequence data

Zhang, W., Apr 2000, In : Molecular Phylogenetics and Evolution. 15, 1, p. 135-146 12 p.

Research output: Contribution to journalArticle

1997

Bamboozled Again! Inadvertent Isolation of Fungal rDNA Sequences from Bamboos (Poaceae: Bambusoideae)

Zhang, W., Wendel, J. F. & Clark, L. G., Oct 1 1997, In : Molecular Phylogenetics and Evolution. 8, 2, p. 205-217 13 p.

Research output: Contribution to journalArticle