Wawrzyniec Dobrucki

2024

Biodistribution of PET radiotracers in tumor-bearing TRAMP mice administered by retroorbital or jugular vein injections

Applegate, C. C., Nelappana, M. B., Cui, Y., Okoro, G., Nielsen, E. A., Dovalovsky, N. P., Smith, A. M., Dobrucki, I. T. & Dobrucki, L. W., Dec 2024, In: Scientific reports. 14, 1, 20241.

Research output: Contribution to journal › Article › peer-review

Open Access

Power-Doppler Ultrasonic Imaging of Peripheral Perfusion in Diabetic Mice

Babaei, S., Dobrucki, L. W. & Insana, M. F., 2024, In: IEEE Transactions on Biomedical Engineering. 71, 8, p. 2421-2431 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The Impact of LY487379 or CDPPB on eNOS Expression in the Mouse Brain and the Effect of Joint Administration of Compounds with NO• Releasers on MK-801- or Scopolamine-Driven Cognitive Dysfunction in Mice

Płoska, A., Siekierzycka, A., Cieślik, P., Dobrucki, L. W., Kalinowski, L. & Wierońska, J. M., Feb 2024, In: Molecules. 29, 3, 627.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Amphiphilic Molecules Exhibiting Zwitterionic Excited-State Intramolecular Proton Transfer and Near-Infrared Emission for the Detection of Amyloid β Aggregates in Alzheimer's Disease**

Yu, Z., Moshood, Y., Wozniak, M. K., Patel, S., Terpstra, K., Llano, D. A., Dobrucki, L. W. & Mirica, L. M., Nov 16 2023, In: Chemistry - A European Journal. 29, 64, e202302408.

Research output: Contribution to journal › Article › peer-review

Open Access

Coordination Chemistry of Sulfur-Containing Bifunctional Chelators: Toward in Vivo Stabilization of ⁶⁴Cu PET Imaging Agents for Alzheimer’s Disease

Yu, Z., Blade, G., Bouley, B. S., Dobrucki, I. T., Dobrucki, L. W. & Mirica, L. M., Dec 18 2023, In: Inorganic Chemistry. 62, 50, p. 20820-20833 14 p.

Research output: Contribution to journal › Article › peer-review

Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

Janaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W. & Kalinowski, L., Dec 2023, In: Cellular and Molecular Biology Letters. 28, 1, 21.

Research output: Contribution to journal › Article › peer-review

Open Access

In Vitro and In Vivo Imaging-Based Evaluation of Doxorubicin Anticancer Treatment in Combination with the Herbal Medicine Black Cohosh

Płoska, A., Wozniak, M., Hedhli, J., Konopka, C. J., Skondras, A., Matatov, S., Stawarz, A., Schuh, S., Czerwinski, A., Dobrucki, L. W., Kalinowski, L. & Dobrucki, I. T., Dec 2023, In: International journal of molecular sciences. 24, 24, 17506.

Research output: Contribution to journal › Article › peer-review

Open Access

Monitoring Muscle Perfusion in Rodents During Short-Term Ischemia Using Power Doppler Ultrasound

Babaei, S., Dai, B., Abbey, C. K., Ambreen, Y., Dobrucki, W. L. & Insana, M. F., Jun 2023, In: Ultrasound in Medicine and Biology. 49, 6, p. 1465-1475 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Dextran-Mimetic Quantum Dots for Multimodal Macrophage Imaging In Vivo, Ex Vivo, and In Situ

Deng, H., Konopka, C. J., Prabhu, S., Sarkar, S., Medina, N. G., Fayyaz, M., Arogundade, O. H., Vidana Gamage, H. E., Shahoei, S. H., Nall, D., Youn, Y., Dobrucka, I. T., Audu, C. O., Joshi, A., Melvin, W. J., Gallagher, K. A., Selvin, P. R., Nelson, E. R., Dobrucki, L. W. & Swanson, K. S. & 1 others, Smith, A. M., Feb 22 2022, In: ACS Nano. 16, 2, p. 1999-2012 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Impact of administration route on nanocarrier biodistribution in a murine colitis model

Applegate, C. C., Deng, H., Kleszynski, B. L., Cross, T. W. L., Konopka, C. J., Dobrucki, L. W., Nelson, E. R., Wallig, M. A., Smith, A. M. & Swanson, K. S., 2022, In: Journal of Experimental Nanoscience. 17, 1, p. 599-616 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Hexachromatic bioinspired camera for image-guided cancer surgery

Blair, S., Garcia, M., Davis, T., Zhu, Z., Liang, Z., Konopka, C., Kauffman, K., Colanceski, R., Ferati, I., Kondov, B., Stojanoski, S., Todorovska, M. B., Dimitrovska, N. T., Jakupi, N., Miladinova, D., Petrusevska, G., Kondov, G., Dobrucki, W. L., Nie, S. & Gruev, V., May 5 2021, In: Science Translational Medicine. 13, 592, eaaw7067.

Research output: Contribution to journal › Article › peer-review

Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease

Woźniak, M., Konopka, C. J., Płoska, A., Hedhli, J., Siekierzycka, A., Banach, M., Bartoszewski, R., Dobrucki, L. W., Kalinowski, L. & Dobrucki, I. T., Dec 2021, In: Cellular and Molecular Biology Letters. 26, 1, 10.

Research output: Contribution to journal › Article › peer-review

Open Access

Nanocarriers targeting adipose macrophages increase glucocorticoid anti-inflammatory potency to ameliorate metabolic dysfunction

Prabhu, S., Deng, H., Cross, T. W. L., Shahoei, S. H., Konopka, C. J., Gonzalez Medina, N., Applegate, C. C., Wallig, M. A., Dobrucki, W., Nelson, E. R., Smith, A. M. & Swanson, K. S., Jan 21 2021, In: Biomaterials Science. 9, 2, p. 506-518 13 p.

Research output: Contribution to journal › Article › peer-review

2020

Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy

Misra, C., Bangru, S., Lin, F., Lam, K., Koenig, S. N., Lubbers, E. R., Hedhli, J., Murphy, N. P., Parker, D. J., Dobrucki, L. W., Cooper, T. A., Tajkhorshid, E., Mohler, P. J. & Kalsotra, A., Mar 23 2020, In: Developmental cell. 52, 6, p. 748-763.e6

Research output: Contribution to journal › Article › peer-review

Open Access

Imaging the landmarks of vascular recovery

Hedhli, J., Kim, M. W., Knox, H. J., Cole, J. A., Huynh, T., Schuelke, M., Dobrucki, I. T., Kalinowski, L., Chan, J., Sinusas, A. J., Insana, M. F. & Dobrucki, L. W., 2020, In: Theranostics. 10, 4, p. 1733-1745 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold

Schwartz-Duval, A. S., Konopka, C. J., Moitra, P., Daza, E. A., Srivastava, I., Johnson, E. V., Kampert, T. L., Fayn, S., Haran, A., Dobrucki, L. W. & Pan, D., Dec 1 2020, In: Nature communications. 11, 1, 4530.

Research output: Contribution to journal › Article › peer-review

Open Access

Modification of DNA structure by reactive nitrogen species as a result of 2-methoxyestradiol–induced neuronal nitric oxide synthase uncoupling in metastatic osteosarcoma cells

Gorska-Ponikowska, M., Ploska, A., Jacewicz, D., Szkatula, M., Barone, G., Lo Bosco, G., Lo Celso, F., Dabrowska, A. M., Kuban-Jankowska, A., Gorzynik-Debicka, M., Knap, N., Chmurzynski, L., Dobrucki, L. W., Kalinowski, L. & Wozniak, M., May 2020, In: Redox Biology. 32, 101522.

Research output: Contribution to journal › Article › peer-review

Open Access

Multimodal Nanocarrier Probes Reveal Superior Biodistribution Quantification by Isotopic Analysis over Fluorescence

Deng, H., Konopka, C. J., Cross, T. W. L., Swanson, K. S., Dobrucki, L. W. & Smith, A. M., Jan 28 2020, In: ACS Nano. 14, 1, p. 509-523 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Quantitative imaging of the receptor for advanced glycation end-products in prostate cancer

Konopka, C. J., Woźniak, M., Hedhli, J., Siekierzycka, A., Skokowski, J., Pęksa, R., Matuszewski, M., Munirathinam, G., Kajdacsy-Balla, A., Dobrucki, I. T., Kalinowski, L. & Dobrucki, L. W., Oct 1 2020, In: European Journal of Nuclear Medicine and Molecular Imaging. 47, 11, p. 2562-2576 15 p.

Research output: Contribution to journal › Article › peer-review

Streptococcus pneumoniae elaborates persistent and prolonged competent state during pneumonia-derived sepsis

Lin, J., Park, P., Li, H., Oh, M. W., Dobrucki, I. T., Dobrucki, W. & Lau, G. W., Mar 1 2020, In: Infection and immunity. 88, 4, e00919-19.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J., May 2018, In: Biomaterials Science. 6, 5, p. 1189-1200 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells

Janaszak-Jasiecka, A., Siekierzycka, A., Bartoszewska, S., Serocki, M., Dobrucki, L. W., Collawn, J. F., Kalinowski, L. & Bartoszewski, R., Nov 1 2018, In: Angiogenesis. 21, 4, p. 711-724 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Evaluation of a dimeric-cRGD peptide for targeted PET-CT imaging of peripheral angiogenesis in diabetic mice

Hedhli, J., Slania, S. L. L., Płoska, A., Czerwinski, A., Konopka, C. J., Wozniak, M., Banach, M., Dobrucki, I. T., Kalinowski, L. & Dobrucki, L. W., Dec 1 2018, In: Scientific reports. 8, 1, 5401.

Research output: Contribution to journal › Article › peer-review

Open Access

Multidimensional Clutter Filter Optimization for Ultrasonic Perfusion Imaging

Kim, M., Zhu, Y., Hedhli, J., Dobrucki, L. W. & Insana, M. F., Nov 2018, In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 65, 11, p. 2020-2029 10 p., 8453905.

Research output: Contribution to journal › Article › peer-review

Multimodal imaging of the receptor for advanced glycation end-products with molecularly targeted nanoparticles

Konopka, C. J., Wozniak, M., Hedhli, J., Ploska, A., Schwartz-Duval, A., Siekierzycka, A., Pan, D., Munirathinam, G., Dobrucki, I. T., Kalinowski, L. & Dobrucki, W., Jan 1 2018, In: Theranostics. 8, 18, p. 5012-5024 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Pixelated spatial gene expression analysis from tissue

Ganguli, A., Ornob, A., Spegazzini, N., Liu, Y., Damhorst, G., Ghonge, T., Thornton, B., Konopka, C. J., Dobrucki, W., Clare, S. E., Bhargava, R., Smith, A. M., Kosari, F. & Bashir, R., Dec 1 2018, In: Nature communications. 9, 1, 202.

Research output: Contribution to journal › Article › peer-review

Open Access

Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, L. W., Fan, T. M. & Chan, J., Aug 22 2018, In: ACS Central Science. 4, 8, p. 1045-1055 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The impact of mechanically stimulated muscle-derived stromal cells on aged skeletal muscle

Huntsman, H. D., Rendeiro, C., Merritt, J. R., Pincu, Y., Cobert, A., De Lisio, M., Kolyvas, E., Dvoretskiy, S., Dobrucki, I. T., Kemkemer, R., Jensen, T., Dobrucki, L. W., Rhodes, J. S. & Boppart, M. D., Mar 2018, In: Experimental Gerontology. 103, p. 35-46 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia

Knox, H. J., Hedhli, J., Kim, T. W., Khalili, K., Dobrucki, L. W. & Chan, J., Dec 1 2017, In: Nature communications. 8, 1, 1794.

Research output: Contribution to journal › Article › peer-review

Open Access

Expanding Acquisition and Clutter Filter Dimensions for Improved Perfusion Sensitivity

Kim, M., Abbey, C. K., Hedhli, J., Dobrucki, L. W. & Insana, M. F., Oct 2017, In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 64, 10, p. 1429-1438 10 p., 7959089.

Research output: Contribution to journal › Article › peer-review

Melanoma topology reveals a stem-like phenotype that promotes angiogenesis

Lee, J., Abdeen, A. A., Hedhli, J., Wycislo, K. L., Dobrucki, I. T., Fan, T. M., Dobrucki, L. W. & Kilian, K. A., 2017, In: Science Advances. 3, 10, e1701350.

Research output: Contribution to journal › Article › peer-review

Open Access

Multimodal assessment of mesenchymal stem cell therapy for diabetic vascular complications

Hedhli, J., Konopka, C. J., Schuh, S., Bouvin, H., Cole, J. A., Huntsman, H. D., Kilian, K. A., Dobrucki, I. T., Boppart, M. D. & Dobrucki, L. W., 2017, In: Theranostics. 7, 16, p. 3876-3888 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Selective in vivo metabolic cell-labeling-mediated cancer targeting

Wang, H., Wang, R., Cai, K., He, H., Liu, Y., Yen, J., Wang, Z., Xu, M., Sun, Y., Zhou, X., Yin, Q., Tang, L., Dobrucki, I. T., Dobrucki, L. W., Chaney, E. J., Boppart, S. A., Fan, T. M., Lezmi, S., Chen, X. & Yin, L. & 1 others, Cheng, J., Apr 1 2017, In: Nature chemical biology. 13, 4, p. 415-424 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a Dimeric-cRGD Peptide for Targeted Imaging of α _V β ₃ Integrin Activity

Hedhli, J., Czerwinski, A., Schuelke, M., Płoska, A., Sowinski, P., Hood, L. L., Mamer, S. B., Cole, J. A., Czaplewska, P., Banach, M., Dobrucki, I. T., Kalinowski, L., Imoukhuede, P. & Dobrucki, L. W., Dec 1 2017, In: Scientific reports. 7, 1, 3185.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Efficient Targeting of Adipose Tissue Macrophages in Obesity with Polysaccharide Nanocarriers

Ma, L., Liu, T. W., Wallig, M. A., Dobrucki, I. T., Dobrucki, L. W., Nelson, E. R., Swanson, K. S. & Smith, A. M., Jul 26 2016, In: ACS Nano. 10, 7, p. 6952-6962 11 p.

Research output: Contribution to journal › Article › peer-review

In vivo targeting of metabolically labeled cancers with ultra-small silica nanoconjugates

Wang, H., Tang, L., Liu, Y., Dobrucka, I. T., Dobrucki, L. W., Yin, L. & Cheng, J., 2016, In: Theranostics. 6, 9, p. 1467-1476 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

Yin, Q., Tang, L., Cai, K., Tong, R., Sternberg, R., Yang, X., Dobrucki, L. W., Borst, L. B., Kamstock, D., Song, Z., Helferich, W. G., Cheng, J. & Fan, T. M., Aug 9 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4601-E4609

Research output: Contribution to journal › Article › peer-review

Open Access

SPECT imaging of 2-D and 3-D distributed sources with near-field coded aperture collimation: Computer simulation and real data validation

Mu, Z., Dobrucki, L. W. & Liu, Y. H., Feb 1 2016, In: Journal of Medical and Biological Engineering. 36, 1, p. 32-43 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Bioorthogonal oxime ligation mediated in vivo cancer targeting

Tang, L., Yin, Q., Xu, Y., Zhou, Q., Cai, K., Yen, J., Dobrucki, L. W. & Cheng, J., Apr 1 2015, In: Chemical Science. 6, 4, p. 2182-2186 5 p.

Research output: Contribution to journal › Article › peer-review

Enhancement and wavelength-shifted emission of Cerenkov luminescence using multifunctional microspheres

Li, J., Dobrucki, L. W., Marjanovic, M., Chaney, E. J., Suslick, K. S. & Boppart, S. A., Jan 1 2015, In: Physics in medicine and biology. 60, 2, p. 727-739 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Multiscale imaging of nanoparticle drug delivery

Dobrucki, L. W., Pan, D. & Smith, A. M., Jul 1 2015, In: Current Drug Targets. 16, 6, p. 560-570 11 p.

Research output: Contribution to journal › Article › peer-review

2014

Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis

Mehra, V. C., Jackson, E., Zhang, X. M., Jiang, X. C., Dobrucki, L. W., Yu, J., Bernatchez, P., Sinusas, A. J., Shulman, G. I., Sessa, W. C., Yarovinsky, T. O. & Bender, J. R., May 2014, In: American Journal of Pathology. 184, 5, p. 1562-1576 15 p.

Research output: Contribution to journal › Article › peer-review

Investigating the optimal size of anticancer nanomedicine

Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., Dobrucki, I. T., Dobrucki, L. W., Borst, L. B., Lezmi, S., Helferich, W. G., Ferguson, A. L., Fan, T. M. & Cheng, J., Oct 28 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15344-15349 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2013

Drug-initiated ring-opening polymerization of O-carboxyanhydrides for the preparation of anticancer drug-poly(O-carboxyanhydride) nanoconjugates

Yin, Q., Tong, R., Xu, Y., Baek, K., Dobrucki, L. W., Fan, T. M. & Cheng, J., Mar 11 2013, In: Biomacromolecules. 14, 3, p. 920-929 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

New approach to quantification of molecularly targeted radiotracer uptake from hybrid cardiac SPECT/CT: Methodology and validation

Li, S., Sinusas, A. J., Dobrucki, L. W. & Liu, Y. H., Dec 1 2013, In: Journal of Nuclear Medicine. 54, 12, p. 2175-2181 7 p.

Research output: Contribution to journal › Article › peer-review

Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging

Yin, Q., Yap, F. Y., Yin, L., Ma, L., Zhou, Q., Dobrucki, L. W., Fan, T. M., Gaba, R. C. & Cheng, J., Sep 18 2013, In: Journal of the American Chemical Society. 135, 37, p. 13620-13623 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

Xing, H., Tang, L., Yang, X., Hwang, K., Wang, W., Yin, Q., Wong, N. Y., Dobrucki, L. W., Yasui, N., Katzenellenbogen, J. A., Helferich, W. G., Cheng, J. & Lu, Y., Oct 21 2013, In: Journal of Materials Chemistry B. 1, 39, p. 5288-5297 10 p.

Research output: Contribution to journal › Article › peer-review

2012

Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

Tang, L., Yang, X., Dobrucki, L. W., Chaudhury, I., Yin, Q., Yao, C., Lezmi, S., Helferich, W. G., Fan, T. M. & Cheng, J., Dec 14 2012, In: Angewandte Chemie - International Edition. 51, 51, p. 12721-12726 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis

Hedhli, N., Dobrucki, L. W., Kalinowski, A., Zhuang, Z. W., Wu, X., Russell, R. R., Sinusas, A. J. & Russell, K. S., Mar 1 2012, In: Cardiovascular research. 93, 3, p. 516-524 9 p.

Research output: Contribution to journal › Article › peer-review

Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N ¹-methylnicotinamide in human blood vessels

Domagala, T. B., Szeffler, A., Dobrucki, L. W., Dropinski, J., Polanski, S., Leszczynska-Wiloch, M., Kotula-Horowitz, K., Wojciechowski, J., Wojnowski, L., Szczeklik, A. & Kalinowski, L., Apr 2012, In: Hypertension. 59, 4, p. 825-832 8 p.

Research output: Contribution to journal › Article › peer-review

Wawrzyniec Dobrucki

Research output

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