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Research Output 1986 2019

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Review article
2019

Modulating anxiety and activity

Rudolph, U. & Moss, S. J., Oct 11 2019, In : Science. 366, 6462, p. 185-186 2 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Anxiety Disorders
Benzodiazepines
Anxiety
2018

An Emerging Circuit Pharmacology of GABAA Receptors

Engin, E., Benham, R. S. & Rudolph, U., Aug 2018, In : Trends in Pharmacological Sciences. 39, 8, p. 710-732 23 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Brain
Pharmacology
Networks (circuits)
Pharmaceutical Preparations
2017

Disinhibition, an emerging pharmacology of learning and memory

Möhler, H. & Rudolph, U., Jan 1 2017, In : F1000Research. 6, 101.

Research output: Contribution to journalReview article

Neurons
Learning
Pharmacology
Data storage equipment
GABA-A Receptors
2016
Aminobutyrates
General Anesthetics
GABA-A Receptors
Anesthesia
Interneurons
2015

Regulating anxiety with extrasynaptic inhibition

Botta, P., Demmou, L., Kasugai, Y., Markovic, M., Xu, C., Fadok, J. P., Lu, T., Poe, M. M., Xu, L., Cook, J. M., Rudolph, U., Sah, P., Ferraguti, F. & Lüthi, A., Oct 28 2015, In : Nature Neuroscience. 18, 10, p. 1493-1500 8 p.

Research output: Contribution to journalReview article

Anxiety
Fear
Neurons
Protein Kinase C
Optogenetics
2014

GABAA receptor subtypes: Therapeutic potential in down syndrome, affective disorders, schizophrenia, and autism

Rudolph, U. & Möhler, H., Jan 1 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 483-507 25 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Autistic Disorder
Down Syndrome
Mood Disorders
Schizophrenia
2012

α2-containing GABAA receptors: A target for the development of novel treatment strategies for CNS disorders

Engin, E., Liu, J. & Rudolph, U., Nov 1 2012, In : Pharmacology and Therapeutics. 136, 2, p. 142-152 11 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Chronic Pain
Schizophrenia
Therapeutics
Anti-Anxiety Agents
2011

Beyond classical benzodiazepines: Novel therapeutic potential of GABA A receptor subtypes

Rudolph, U. & Knoflach, F., Sep 1 2011, In : Nature Reviews Drug Discovery. 10, 9, p. 685-697 13 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Benzodiazepines
Ligand-Gated Ion Channels
Aminobutyrates
Sleep Initiation and Maintenance Disorders

Hooked on benzodiazepines: GABAA receptor subtypes and addiction

Tan, K. R., Rudolph, U. & Lüscher, C., Apr 1 2011, In : Trends in Neurosciences. 34, 4, p. 188-197 10 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Benzodiazepines
Muscle Relaxation
Amnesia
Dopaminergic Neurons

Identification and characterization of anesthetic targets by mouse molecular genetics approaches

Drexler, B., Antkowiak, B., Engin, E. & Rudolph, U., Feb 1 2011, In : Canadian Journal of Anesthesia. 58, 2, p. 178-190 13 p.

Research output: Contribution to journalReview article

General Anesthetics
Anesthetics
Molecular Biology
GABA-A Receptors
Ligand-Gated Ion Channels

Is there a way to curb benzodiazepine addiction?

Lalive, A. L., Rudolph, U., Lus̈cher, C. & Tan, K. R., Oct 1 2011, In : Swiss Medical Weekly. 141, OCTOBER, w13277.

Research output: Contribution to journalReview article

Benzodiazepines
Pharmaceutical Preparations
Muscle Relaxation
Amnesia
Dopaminergic Neurons
2008

Regulation of cognition and symptoms of psychosis: Focus on GABAA receptors and glycine transporter 1`

Möhler, H., Rudolph, U., Boison, D., Singer, P., Feldon, J. & Yee, B. K., Jul 1 2008, In : Pharmacology Biochemistry and Behavior. 90, 1, p. 58-64 7 p.

Research output: Contribution to journalReview article

Glycine Plasma Membrane Transport Proteins
GABA-A Receptors
N-Methyl-D-Aspartate Receptors
Psychotic Disorders
Cognition
2006

Anaesthetic drugs: Linking molecular actions to clinical effects

Grasshoff, C., Drexler, B., Rudolph, U. & Antkowiak, B., Oct 1 2006, In : Current Pharmaceutical Design. 12, 28, p. 3665-3679 15 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Anesthetics
Intravenous Anesthetics
General Anesthetics
Hypnosis

GABA-based therapeutic approaches: GABAA receptor subtype functions

Rudolph, U. & Möhler, H., Feb 2006, In : Current Opinion in Pharmacology. 6, 1 SPEC. ISS., p. 18-23 6 p.

Research output: Contribution to journalReview article

GABA-A Receptors
gamma-Aminobutyric Acid
Therapeutics
Pharmacology
Hypnotics and Sedatives
2005

Molecular and systemic mechanisms of general anaesthesia: The 'multi-site and multiple mechanisms' concept

Grasshoff, C., Rudolph, U. & Antkowiak, B., Aug 2005, In : Current Opinion in Anaesthesiology. 18, 4, p. 386-391 6 p.

Research output: Contribution to journalReview article

Etomidate
Amnesia
Hypnosis
General Anesthesia
Aminobutyrates
2004
Dissection
General Anesthetics
GABA-A Receptors
Benzodiazepines
Pharmacology

Molecular and neuronal substrates for general anaesthetics

Rudolph, U. & Antkowiak, B., Sep 1 2004, In : Nature Reviews Neuroscience. 5, 9, p. 709-720 12 p.

Research output: Contribution to journalReview article

General Anesthetics
GABA-A Receptors
General Anesthesia
Pharmaceutical Preparations

Selective GABAA circuits for novel CNS drugs

Möhler, H. & Rudolph, U., Sep 2004, In : Drug Discovery Today: Therapeutic Strategies. 1, 1, p. 117-123 7 p.

Research output: Contribution to journalReview article

Central Nervous System Agents
Interneurons
GABA-A Receptors
Pharmacology
Aminobutyrates
2002

A new benzodiazepine pharmacology

Möhler, H., Fritschy, J. M. & Rudolph, U., Jan 12 2002, In : Journal of Pharmacology and Experimental Therapeutics. 300, 1, p. 2-8 7 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Benzodiazepines
Pharmacology
Anti-Anxiety Agents
Anterograde Amnesia
2001

GABAA receptor subtypes: Dissecting their pharmacological functions

Rudolph, U., Crestani, F. & Möhler, H., Apr 1 2001, In : Trends in Pharmacological Sciences. 22, 4, p. 188-194 7 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Pharmacology
Drug therapy
Dissection
Nervous System Diseases

GABAA-receptor subtypes: A new pharmacology

Möhler, H., Crestani, F. & Rudolph, U., Feb 1 2001, In : Current Opinion in Pharmacology. 1, 1, p. 22-25 4 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Pharmacology
Pharmaceutical Preparations
Anti-Anxiety Agents
Hypnotics and Sedatives
Aminobutyrates
Anti-Anxiety Agents
Benzodiazepines
drug
Anxiety
1999

Genetically modified animals in pharmacological research: Future trends

Rudolph, U. & Möhler, H., Jun 30 1999, In : European Journal of Pharmacology. 375, 1-3, p. 327-337 11 p.

Research output: Contribution to journalReview article

Genetically Modified Animals
Pharmacology
Biological Phenomena
Gene Expression Regulation
Genomics
1996

The GABAA receptors. From subunits to diverse functions.

Mohler, H., Fritschy, J. M., Lüscher, B., Rudolph, U., Benson, J. & Benke, D., 1996, In : Ion channels. 4, p. 89-113 25 p.

Research output: Contribution to journalReview article

Angelman Syndrome
Protein Conformation
GABA Receptors
Huntington Disease
Gene Expression Regulation