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2019

Effects of Diazepam on Low-Frequency and High- Frequency Electrocortical -Power Mediated by α1- and α2-GABAA Receptors

Hofmann, J. I., Schwarz, C., Rudolph, U. & Antkowiak, B., Jul 2 2019, In : International journal of molecular sciences. 20, 14, 3486.

Research output: Contribution to journalArticle

Open Access

Targeted Treatment of Individuals With Psychosis Carrying a Copy Number Variant Containing a Genomic Triplication of the Glycine Decarboxylase Gene

Bodkin, J. A., Coleman, M. J., Godfrey, L. J., Carvalho, C. M. B., Morgan, C. J., Suckow, R. F., Anderson, T., Öngür, D., Kaufman, M. J., Lewandowski, K. E., Siegel, A. J., Waldstreicher, E., Grochowski, C. M., Javitt, D. C., Rujescu, D., Hebbring, S., Weinshilboum, R., Rodriguez, S. B., Kirchhoff, C., Visscher, T. & 11 others, Vuckovic, A., Fialkowski, A., McCarthy, S., Malhotra, D., Sebat, J., Goff, D. C., Hudson, J. I., Lupski, J. R., Coyle, J. T., Rudolph, U. & Levy, D. L., Oct 1 2019, In : Biological Psychiatry. 86, 7, p. 523-535 13 p.

Research output: Contribution to journalArticle

Zolpidem activation of alpha 1-containing GABAA receptors selectively inhibits high frequency action potential firing of cortical neurons

Neumann, E., Rudolph, U., Knutson, D. E., Li, G., Cook, J. M., Hentschke, H., Antkowiak, B. & Drexler, B., 2019, In : Frontiers in Pharmacology. 9, JAN, 1523.

Research output: Contribution to journalArticle

Open Access
2018

Astrocytes in primary cultures express serine racemase, synthesize D-serine and acquire A1 reactive astrocyte features

Li, S., Uno, Y., Rudolph, U., Cobb, J., Liu, J., Anderson, T., Levy, D., Balu, D. T. & Coyle, J. T., May 2018, In : Biochemical Pharmacology. 151, p. 245-251 7 p.

Research output: Contribution to journalArticle

GABAA Receptor Subtypes Regulate Stress-Induced Colon Inflammation in Mice

Seifi, M., Rodaway, S., Rudolph, U. & Swinny, J. D., Sep 2018, In : Gastroenterology. 155, 3, p. 852-864.e3

Research output: Contribution to journalArticle

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors

Ralvenius, W. T., Neumann, E., Pagani, M., Acuña, M. A., Wildner, H., Benke, D., Fischer, N., Rostaher, A., Schwager, S., Detmar, M., Frauenknecht, K., Aguzzi, A., Hubbs, J. L., Rudolph, U., Favrot, C. & Zeilhofer, H. U., Dec 1 2018, In : Nature communications. 9, 1, 3230.

Research output: Contribution to journalArticle

Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes

Grochowski, C. M., Gu, S., Yuan, B., Tcw, J., Brennand, K. J., Sebat, J., Malhotra, D., McCarthy, S., Rudolph, U., Lindstrand, A., Chong, Z., Levy, D. L., Lupski, J. R. & Carvalho, C. M. B., Jul 2018, In : Human mutation. 39, 7, p. 939-946 8 p.

Research output: Contribution to journalArticle

TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors

Neumann, E., Ralvenius, W. T., Acuña, M. A., Rudolph, U. & Zeilhofer, H. U., Dec 2018, In : Neuropharmacology. 143, p. 71-78 8 p.

Research output: Contribution to journalArticle

2017

Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices

Balk, M., Hentschke, H., Rudolph, U., Antkowiak, B. & Drexler, B., Dec 1 2017, In : Scientific reports. 7, 1, 3503.

Research output: Contribution to journalArticle

Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis

TCW, J., Carvalho, C. M. B., Yuan, B., Gu, S., Altheimer, A. N., McCarthy, S., Malhotra, D., Sebat, J., Siegel, A. J., Rudolph, U., Lupski, J. R., Levy, D. L. & Brennand, K. J., Mar 14 2017, In : Stem Cell Reports. 8, 3, p. 519-528 10 p.

Research output: Contribution to journalArticle

Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors

Benham, R. S., Hewage, N. B., Suckow, R. F., Engin, E. & Rudolph, U., Aug 14 2017, In : Behavioural Brain Research. 332, p. 172-179 8 p.

Research output: Contribution to journalArticle

2016

A Pharmacogenetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABA A Receptors in Mice

Behlke, L. M., Foster, R. A., Liu, J., Benke, D., Benham, R. S., Nathanson, A. J., Yee, B. K., Zeilhofer, H. U., Engin, E. & Rudolph, U., Sep 1 2016, In : Neuropsychopharmacology. 41, 10, p. 2492-2501 10 p.

Research output: Contribution to journalArticle

Early postnatal switch in GABAA receptor α-subunits in the reticular thalamic nucleus

Pangratz-Fuehrer, S., Sieghart, W., Rudolph, U., Parada, I. & Huguenard, J. R., Mar 1 2016, In : Journal of neurophysiology. 115, 3, p. 1183-1195 13 p.

Research output: Contribution to journalArticle

Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice

Newman, E. L., Gunner, G., Huynh, P., Gachette, D., Moss, S. J., Smart, T. G., Rudolph, U., DeBold, J. F. & Miczek, K. A., Nov 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 11, p. 2445-2455 11 p.

Research output: Contribution to journalArticle

Modulation of anxiety and fear via distinct intrahippocampal circuits

Engin, E., Smith, K. S., Gao, Y., Nagy, D., Foster, R. A., Tsvetkov, E., Keist, R., Crestani, F., Fritschy, J. M., Bolshakov, V. Y., Hajos, M., Heldt, S. A. & Rudolph, U., Mar 14 2016, In : eLife. 5, MARCH2016, e14120.

Research output: Contribution to journalArticle

Partial inactivation of GABAA receptors containing the α5 subunit affects the development of adult-born dentate gyrus granule cells

Deprez, F., Vogt, F., Floriou-Servou, A., Lafourcade, C., Rudolph, U., Tyagarajan, S. K. & Fritschy, J. M., Sep 1 2016, In : European Journal of Neuroscience. 44, 5, p. 2258-2271 14 p.

Research output: Contribution to journalArticle

The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia

Ralvenius, W. T., Acuña, M. A., Benke, D., Matthey, A., Daali, Y., Rudolph, U., Desmeules, J., Zeilhofer, H. U. & Besson, M., Oct 1 2016, In : Neuropharmacology. 109, p. 366-375 10 p.

Research output: Contribution to journalArticle

2015

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype

Ralvenius, W. T., Benke, D., Acuña, M. A., Rudolph, U. & Zeilhofer, H. U., Apr 13 2015, In : Nature communications. 6, 6803.

Research output: Contribution to journalArticle

Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders

Vien, T. N., Modgil, A., Abramian, A. M., Jurd, R., Walker, J., Brandon, N. J., Terunuma, M., Rudolph, U., Maguire, J., Davies, P. A. & Moss, S. J., Dec 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14805-14810 6 p.

Research output: Contribution to journalArticle

Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABAA receptor

Zarnowska, E. D., Rodgers, F. C., Oh, I., Rau, V., Lor, C., Laha, K. T., Jurd, R., Rudolph, U., Eger, E. I. & Pearce, R. A., Jun 2015, In : Neuropharmacology. 93, p. 171-178 8 p.

Research output: Contribution to journalArticle

Etomidate impairs long-term potentiation in vitro by targeting α5-subunit containing GABAA receptors on nonpyramidal cells

Rodgers, F. C., Zarnowska, E. D., Laha, K. T., Engin, E., Zeller, A., Keist, R., Rudolph, U. & Pearce, R. A., Jul 1 2015, In : Journal of Neuroscience. 35, 26, p. 9707-9716 10 p.

Research output: Contribution to journalArticle

Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus

Corteen, N. L., Carter, J. A., Rudolph, U., Belelli, D., Lambert, J. J. & Swinny, J. D., Sep 28 2015, In : Brain Structure and Function. 220, 5, p. 2739-2763 25 p.

Research output: Contribution to journalArticle

Propofol modulates phasic and tonic GABAergic currents in spinal ventral horn interneurones

Eckle, V. S., Rudolph, U., Antkowiak, B. & Grasshoff, C., Jan 1 2015, In : British Journal of Anaesthesia. 114, 3, p. 491-498 8 p.

Research output: Contribution to journalArticle

Tonic Inhibitory control of dentate gyrus granule cells by α5-containing GABAA receptors reduces memory interference

Engin, E., Zarnowska, E. D., Benke, D., Tsvetkov, E., Sigal, M., Keist, R., Bolshakov, V. Y., Pearce, R. A. & Rudolph, U., Oct 7 2015, In : Journal of Neuroscience. 35, 40, p. 13698-13712 15 p.

Research output: Contribution to journalArticle

α2-containing GABA(A) receptors: A requirement for midazolam-escalated aggression and social approach in mice

Newman, E. L., Smith, K. S., Takahashi, A., Chu, A., Hwa, L. S., Chen, Y., Debold, J. F., Rudolph, U. & Miczek, K. A., Dec 1 2015, In : Psychopharmacology. 232, 23, p. 4359-4369 11 p.

Research output: Contribution to journalArticle

2014

Antihyperalgesia by 2-GABA A receptors occurs via a genuine spinal action and does not involve supraspinal sites

Paul, J., Yévenes, G. E., Benke, D., Lio, A. D., Ralvenius, W. T., Witschi, R., Scheurer, L., Cook, J. M., Rudolph, U., Fritschy, J. M. & Zeilhofer, H. U., Jan 2014, In : Neuropsychopharmacology. 39, 2, p. 477-487 11 p.

Research output: Contribution to journalArticle

Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels

Riccio, A., Li, Y., Tsvetkov, E., Gapon, S., Yao, G. L., Smith, K. S., Engin, E., Rudolph, U., Bolshakov, V. Y. & Clapham, D. E., Mar 10 2014, In : Journal of Neuroscience. 34, 10, p. 3653-3667 15 p.

Research output: Contribution to journalArticle

Diversity of neuronal inhibition: A path to novel treatments for neuropsychiatric disorders

Benham, R. S., Engin, E. & Rudolph, U., Jan 2014, In : JAMA Psychiatry. 71, 1, p. 91-93 3 p.

Research output: Contribution to journalArticle

Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress

Martin, C. B. P., Gassmann, M., Chevarin, C., Hamon, M., Rudolph, U., Bettler, B., Lanfumey, L. & Mongeau, R., Dec 2014, In : Journal of Neurochemistry. 131, 5, p. 566-572 7 p.

Research output: Contribution to journalArticle

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon

Seifi, M., Brown, J. F., Mills, J., Bhandari, P., Belelli, D., Lambert, J. J., Rudolph, U. & Swinny, J. D., 2014, In : Journal of Neuroscience. 34, 31, p. 10361-10378 18 p.

Research output: Contribution to journalArticle

Neural basis of benzodiazepine reward: Requirement for α2 containing GABA a receptors in the nucleus accumbens

Engin, E., Bakhurin, K. I., Smith, K. S., Hines, R. M., Reynolds, L. M., Tang, W., Sprengel, R., Moss, S. J. & Rudolph, U., Jul 2014, In : Neuropsychopharmacology. 39, 8, p. 1805-1815 11 p.

Research output: Contribution to journalArticle

2013

Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity

Van'T Veer, A., Bechtholt, A. J., Onvani, S., Potter, D., Wang, Y., Liu-Chen, L. Y., Schütz, G., Chartoff, E. H., Rudolph, U., Cohen, B. M. & Carlezon, W. A., Jul 1 2013, In : Neuropsychopharmacology. 38, 8, p. 1585-1597 13 p.

Research output: Contribution to journalArticle

Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment

Licata, S. C., Shinday, N. M., Huizenga, M. N., Darnell, S. B., Sangrey, G. R., Rudolph, U., Rowlett, J. K. & Sadri-Vakili, G., Dec 19 2013, In : PloS one. 8, 12, e84806.

Research output: Contribution to journalArticle

Bidirectional regulation of intravenous general anesthetic actions by α3-containing γ-aminobutyric acida receptors

Straub, C. J., Lau, H. M., Parlato, R., Schuetz, G., Fritschy, J. M. & Rudolph, U., Mar 2013, In : Anesthesiology. 118, 3, p. 562-576 15 p.

Research output: Contribution to journalArticle

Dissecting the role of diazepam-sensitive γ-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat

Koester, C., Rudolph, U., Haenggi, T., Papilloud, A., Fritschy, J. M. & Crestani, F., Jan 1 2013, In : Pharmacology Biochemistry and Behavior. 103, 3, p. 541-549 9 p.

Research output: Contribution to journalArticle

Endogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor

Christian, C. A., Herbert, A. G., Holt, R. L., Peng, K., Sherwood, K. D., Pangratz-Fuehrer, S., Rudolph, U. & Huguenard, J. R., Jun 19 2013, In : Neuron. 78, 6, p. 1063-1074 12 p.

Research output: Contribution to journalArticle

Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states

Drexler, B., Zinser, S., Huang, S., Poe, M. M., Rudolph, U., Cook, J. M. & Antkowiak, B., Mar 5 2013, In : European Journal of Pharmacology. 703, 1-3, p. 18-24 7 p.

Research output: Contribution to journalArticle

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5

Ohtsuka, N., Badurek, S., Busslinger, M., Benes, F. M., Minichiello, L. & Rudolph, U., Apr 2013, In : Genesis. 51, 4, p. 234-245 12 p.

Research output: Contribution to journalArticle

Linking GABAA receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication

Blednov, Y. A., Benavidez, J. M., Black, M., Chandra, D., Homanics, G. E., Rudolph, U. & Harris, R. A., Apr 1 2013, In : Neuropharmacology. 67, p. 46-56 11 p.

Research output: Contribution to journalArticle

2012

Anxiety and depression: Mouse genetics and pharmacological approaches to the role of GABA A receptor subtypes

Smith, K. S. & Rudolph, U., Jan 1 2012, In : Neuropharmacology. 62, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in mice

Smith, K. S., Engin, E., Meloni, E. G. & Rudolph, U., Aug 2012, In : Neuropharmacology. 63, 2, p. 250-258 9 p.

Research output: Contribution to journalArticle

Differential roles of GABA a receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward

Reynolds, L. M., Engin, E., Tantillo, G., Lau, H. M., Muschamp, J. W., Carlezon, W. A. & Rudolph, U., Oct 1 2012, In : Neuropsychopharmacology. 37, 11, p. 2531-2540 10 p.

Research output: Contribution to journalArticle

Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb

Pallotto, M., Nissant, A., Fritschy, J. M., Rudolph, U. W. E., Sassoè-Pognett, M., Panzanelli, P. & Lledo, P. M., Jun 27 2012, In : Journal of Neuroscience. 32, 26, p. 9103-9115 13 p.

Research output: Contribution to journalArticle

GABA a receptors containing the α2 subunit are critical for direction-selective inhibition in the retina

Auferkorte, O. N., Baden, T., Kaushalya, S. K., Zabouri, N., Rudolph, U., Haverkamp, S. & Euler, T., Apr 10 2012, In : PloS one. 7, 4, e35109.

Research output: Contribution to journalArticle

GABA A receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies

Yanovsky, Y., Schubring, S., Fleischer, W., Gisselmann, G., Zhu, X. R., Lübbert, H., Hatt, H., Rudolph, U., Haas, H. L. & Sergeeva, O. A., Jan 1 2012, In : Pflugers Archiv European Journal of Physiology. 463, 1, p. 187-199 13 p.

Research output: Contribution to journalArticle

Tonic inhibition in principal cells of the amygdala: A central role for α3 subunit-containing GABA A receptors

Marowsky, A., Rudolph, U., Fritschy, J. M. & Arand, M., Jun 20 2012, In : Journal of Neuroscience. 32, 25, p. 8611-8619 9 p.

Research output: Contribution to journalArticle

2011

Antidepressant-like properties of α2-containing GABAA receptors

Vollenweider, I., Smith, K. S., Keist, R. & Rudolph, U., Feb 2 2011, In : Behavioural Brain Research. 217, 1, p. 77-80 4 p.

Research output: Contribution to journalArticle

Cellular correlate of assembly formation in oscillating hippocampal networks in vitro

Bähner, F., Weiss, E. K., Birke, G., Maier, N., Schmitz, D., Rudolph, U., Frotscher, M., Traub, R. D., Both, M. & Draguhn, A., Aug 30 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 35, p. E607-E616

Research output: Contribution to journalArticle

Distinct mechanisms regulate GABA A receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells

Panzanelli, P., Gunn, B. G., Schlatter, M. C., Benke, D., Tyagarajan, S. K., Scheiffele, P., Belelli, D., Lambert, J. J., Rudolph, U. & Fritschy, J. M., Oct 2011, In : Journal of Physiology. 589, 20, p. 4959-4980 22 p.

Research output: Contribution to journalArticle