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Research Output 1986 2019

2019

Effects of Diazepam on Low-Frequency and High- Frequency Electrocortical -Power Mediated by α1- and α2-GABAA Receptors

Hofmann, J. I., Schwarz, C., Rudolph, U. & Antkowiak, B., Jul 2 2019, In : International journal of molecular sciences. 20, 14, 3486.

Research output: Contribution to journalArticle

Open Access
Power spectral density
GABA-A Receptors
Diazepam
mice
low frequencies

Modulating anxiety and activity

Rudolph, U. & Moss, S. J., Oct 11 2019, In : Science. 366, 6462, p. 185-186 2 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Anxiety Disorders
Benzodiazepines
Anxiety

Zolpidem activation of alpha 1-containing GABAA receptors selectively inhibits high frequency action potential firing of cortical neurons

Neumann, E., Rudolph, U., Knutson, D. E., Li, G., Cook, J. M., Hentschke, H., Antkowiak, B. & Drexler, B., Jan 1 2019, In : Frontiers in Pharmacology. 9, JAN, 01523.

Research output: Contribution to journalArticle

Open Access
GABA-A Receptors
Action Potentials
Neurons
Benzodiazepines
Flumazenil
2018

An Emerging Circuit Pharmacology of GABAA Receptors

Engin, E., Benham, R. S. & Rudolph, U., Aug 2018, In : Trends in Pharmacological Sciences. 39, 8, p. 710-732 23 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Brain
Pharmacology
Networks (circuits)
Pharmaceutical Preparations

Astrocytes in primary cultures express serine racemase, synthesize D-serine and acquire A1 reactive astrocyte features

Li, S., Uno, Y., Rudolph, U., Cobb, J., Liu, J., Anderson, T., Levy, D., Balu, D. T. & Coyle, J. T., May 2018, In : Biochemical Pharmacology. 151, p. 245-251 7 p.

Research output: Contribution to journalArticle

Astrocytes
Serine
Glycine Dehydrogenase (Decarboxylating)
Glycine Dehydrogenase
Neuroglia
GABA-A Receptors
Antidepressive Agents
Serotonin
Norepinephrine
Emotions

GABAA Receptor Subtypes Regulate Stress-Induced Colon Inflammation in Mice

Seifi, M., Rodaway, S., Rudolph, U. & Swinny, J. D., Sep 2018, In : Gastroenterology. 155, 3, p. 852-864.e3

Research output: Contribution to journalArticle

GABA-A Receptors
Colon
Inflammation
Psychological Stress
Inflammatory Bowel Diseases

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA A receptors

Ralvenius, W. T., Neumann, E., Pagani, M., Acuña, M. A., Wildner, H., Benke, D., Fischer, N., Rostaher, A., Schwager, S., Detmar, M., Frauenknecht, K., Aguzzi, A., Hubbs, J. L., Rudolph, U., Favrot, C. & Zeilhofer, H. U., Dec 1 2018, In : Nature communications. 9, 1, 3230.

Research output: Contribution to journalArticle

Antipruritics
dogs
mice
Modulation
retarding

Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes

Grochowski, C. M., Gu, S., Yuan, B., Tcw, J., Brennand, K. J., Sebat, J., Malhotra, D., McCarthy, S., Rudolph, U., Lindstrand, A., Chong, Z., Levy, D. L., Lupski, J. R. & Carvalho, C. M. B., Jul 2018, In : Human mutation. 39, 7, p. 939-946 8 p.

Research output: Contribution to journalArticle

Chromosome Structures
Genetic Markers
Psychiatry
Phenotype
Mothers

TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors

Neumann, E., Ralvenius, W. T., Acuña, M. A., Rudolph, U. & Zeilhofer, H. U., Dec 2018, In : Neuropharmacology. 143, p. 71-78 8 p.

Research output: Contribution to journalArticle

Benzodiazepines
Pharmacology
GABA-A Receptors
Anxiety Disorders
gamma-Aminobutyric Acid
2017

Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices

Balk, M., Hentschke, H., Rudolph, U., Antkowiak, B. & Drexler, B., Dec 1 2017, In : Scientific reports. 7, 1, 3503.

Research output: Contribution to journalArticle

Midazolam
GABA-A Receptors
Benzodiazepines
1-hydroxymethylmidazolam
Critical Care

Disinhibition, an emerging pharmacology of learning and memory

Möhler, H. & Rudolph, U., Jan 1 2017, In : F1000Research. 6, 101.

Research output: Contribution to journalReview article

Neurons
Learning
Pharmacology
Data storage equipment
GABA-A Receptors

Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis

TCW, J., Carvalho, C. M. B., Yuan, B., Gu, S., Altheimer, A. N., McCarthy, S., Malhotra, D., Sebat, J., Siegel, A. J., Rudolph, U., Lupski, J. R., Levy, D. L. & Brennand, K. J., Mar 14 2017, In : Stem Cell Reports. 8, 3, p. 519-528 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Chromosomes
Stem cells
Genetic Markers
Cells

Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors

Benham, R. S., Hewage, N. B., Suckow, R. F., Engin, E. & Rudolph, U., Aug 14 2017, In : Behavioural Brain Research. 332, p. 172-179 8 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Antidepressive Agents
Serotonin
Norepinephrine
Fluoxetine
2016

A Pharmacogenetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABA A Receptors in Mice

Behlke, L. M., Foster, R. A., Liu, J., Benke, D., Benham, R. S., Nathanson, A. J., Yee, B. K., Zeilhofer, H. U., Engin, E. & Rudolph, U., Sep 1 2016, In : Neuropsychopharmacology. 41, 10, p. 2492-2501 10 p.

Research output: Contribution to journalArticle

Pharmacogenetics
Anti-Anxiety Agents
GABA-A Receptors
Diazepam
Light

Early postnatal switch in GABAA receptor α-subunits in the reticular thalamic nucleus

Pangratz-Fuehrer, S., Sieghart, W., Rudolph, U., Parada, I. & Huguenard, J. R., Mar 1 2016, In : Journal of neurophysiology. 115, 3, p. 1183-1195 13 p.

Research output: Contribution to journalArticle

Thalamic Nuclei
Inhibitory Postsynaptic Potentials
GABA-A Receptors
Neurons
L 655,708

Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice

Newman, E. L., Gunner, G., Huynh, P., Gachette, D., Moss, S. J., Smart, T. G., Rudolph, U., DeBold, J. F. & Miczek, K. A., Nov 1 2016, In : Alcoholism: Clinical and Experimental Research. 40, 11, p. 2445-2455 11 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Point Mutation
Drinking
Pregnanolone
Alcohols

Modulation of anxiety and fear via distinct intrahippocampal circuits

Engin, E., Smith, K. S., Gao, Y., Nagy, D., Foster, R. A., Tsvetkov, E., Keist, R., Crestani, F., Fritschy, J. M., Bolshakov, V. Y., Hajos, M., Heldt, S. A. & Rudolph, U., Mar 14 2016, In : eLife. 5, MARCH2016, e14120.

Research output: Contribution to journalArticle

GABA-A Receptors
Neurons
Fear
Anxiety
Modulation
Aminobutyrates
General Anesthetics
GABA-A Receptors
Anesthesia
Interneurons

Partial inactivation of GABAA receptors containing the α5 subunit affects the development of adult-born dentate gyrus granule cells

Deprez, F., Vogt, F., Floriou-Servou, A., Lafourcade, C., Rudolph, U., Tyagarajan, S. K. & Fritschy, J. M., Sep 1 2016, In : European Journal of Neuroscience. 44, 5, p. 2258-2271 14 p.

Research output: Contribution to journalArticle

Dentate Gyrus
GABA-A Receptors
Hippocampus
Neuronal Plasticity
Neurogenesis

Targeting Cognitive Deficits in Schizophrenia via GABAA Receptors: Focus on α2, α3, and α5 Receptor Subtypes

Rudolph, U. & Möhler, H., Jul 26 2016, The Neurobiology of Schizophrenia. Elsevier Inc., p. 149-164 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

GABA-A Receptors
Schizophrenia
Methylazoxymethanol Acetate
Memory Disorders
Ketamine

The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia

Ralvenius, W. T., Acuña, M. A., Benke, D., Matthey, A., Daali, Y., Rudolph, U., Desmeules, J., Zeilhofer, H. U. & Besson, M., Oct 1 2016, In : Neuropharmacology. 109, p. 366-375 10 p.

Research output: Contribution to journalArticle

Benzodiazepines
Diazepam
Therapeutics
clobazam
Neuralgia
2015

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype

Ralvenius, W. T., Benke, D., Acuña, M. A., Rudolph, U. & Zeilhofer, H. U., Apr 13 2015, In : Nature communications. 6, 6803.

Research output: Contribution to journalArticle

analgesia
GABA-A Receptors
Benzodiazepines
Analgesia
mice

A tribute to professor Hanns Möhler

Rudolph, U. & Enna, S. J., Jan 1 2015, In : Advances in Pharmacology. 72, p. 9-12 4 p.

Research output: Contribution to journalEditorial

Behavioral functions of GABAA receptor subtypes - The zurich experience

Crestani, F. & Rudolph, U., Jan 1 2015, Advances in Pharmacology. Academic Press Inc., p. 37-51 15 p. (Advances in Pharmacology; vol. 72).

Research output: Chapter in Book/Report/Conference proceedingChapter

GABA-A Receptors
Benzodiazepines
Neurotransmitter Receptor
Point Mutation
Toxicology

Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders

Vien, T. N., Modgil, A., Abramian, A. M., Jurd, R., Walker, J., Brandon, N. J., Terunuma, M., Rudolph, U., Maguire, J., Davies, P. A. & Moss, S. J., Dec 1 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 48, p. 14805-14810 6 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Phenotype
Phosphorylation
Alanine
Convulsants

Erratum: Regulating anxiety with extrasynaptic inhibition (Nature Neuroscience (2015) 18, (1493-1500))

Botta, P., Demmou, L., Kasugai, Y., Markovic, M., Xu, C., Fadok, J. P., Lu, T., Poe, M. M., Xu, L., Cook, J. M., Rudolph, U., Sah, P., Ferraguti, F. & Lüthi, A., Nov 25 2015, In : Nature Neuroscience. 18, 12, 1 p.

Research output: Contribution to journalComment/debate

Etomidate blocks LTP and impairs learning but does not enhance tonic inhibition in mice carrying the N265M point mutation in the beta3 subunit of the GABAA receptor

Zarnowska, E. D., Rodgers, F. C., Oh, I., Rau, V., Lor, C., Laha, K. T., Jurd, R., Rudolph, U., Eger, E. I. & Pearce, R. A., Jun 2015, In : Neuropharmacology. 93, p. 171-178 8 p.

Research output: Contribution to journalArticle

Etomidate
GABA-A Receptors
Point Mutation
Learning
Pyramidal Cells

Etomidate impairs long-term potentiation in vitro by targeting α5-subunit containing GABAA receptors on nonpyramidal cells

Rodgers, F. C., Zarnowska, E. D., Laha, K. T., Engin, E., Zeller, A., Keist, R., Rudolph, U. & Pearce, R. A., Jul 1 2015, In : Journal of Neuroscience. 35, 26, p. 9707-9716 10 p.

Research output: Contribution to journalArticle

Etomidate
Long-Term Potentiation
GABA-A Receptors
Pyramidal Cells
Aptitude

Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus

Corteen, N. L., Carter, J. A., Rudolph, U., Belelli, D., Lambert, J. J. & Swinny, J. D., Sep 28 2015, In : Brain Structure and Function. 220, 5, p. 2739-2763 25 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Serotonergic Neurons
Serotonin
Central Nervous System
Proteins

Preface: A Tribute to Professor Hanns Möhler

Rudolph, U. & Enna, S. J., Jan 1 2015, In : Advances in Pharmacology. 73, p. ix-xii

Research output: Contribution to journalEditorial

21st Century History
20th Century History
Neuropharmacology
GABA-A Receptors
gamma-Aminobutyric Acid

Propofol modulates phasic and tonic GABAergic currents in spinal ventral horn interneurones

Eckle, V. S., Rudolph, U., Antkowiak, B. & Grasshoff, C., Jan 1 2015, In : British Journal of Anaesthesia. 114, 3, p. 491-498 8 p.

Research output: Contribution to journalArticle

Interneurons
Propofol
Horns
GABA-A Receptors
Reflex

Regulating anxiety with extrasynaptic inhibition

Botta, P., Demmou, L., Kasugai, Y., Markovic, M., Xu, C., Fadok, J. P., Lu, T., Poe, M. M., Xu, L., Cook, J. M., Rudolph, U., Sah, P., Ferraguti, F. & Lüthi, A., Oct 28 2015, In : Nature Neuroscience. 18, 10, p. 1493-1500 8 p.

Research output: Contribution to journalReview article

Anxiety
Fear
Neurons
Protein Kinase C
Optogenetics

Tonic Inhibitory control of dentate gyrus granule cells by α5-containing GABAA receptors reduces memory interference

Engin, E., Zarnowska, E. D., Benke, D., Tsvetkov, E., Sigal, M., Keist, R., Bolshakov, V. Y., Pearce, R. A. & Rudolph, U., Oct 7 2015, In : Journal of Neuroscience. 35, 40, p. 13698-13712 15 p.

Research output: Contribution to journalArticle

Dentate Gyrus
GABA-A Receptors
Neurobehavioral Manifestations
Aptitude
Pharmacology

α2-containing GABA(A) receptors: A requirement for midazolam-escalated aggression and social approach in mice

Newman, E. L., Smith, K. S., Takahashi, A., Chu, A., Hwa, L. S., Chen, Y., Debold, J. F., Rudolph, U. & Miczek, K. A., Dec 1 2015, In : Psychopharmacology. 232, 23, p. 4359-4369 11 p.

Research output: Contribution to journalArticle

Midazolam
GABA-A Receptors
Aggression
Benzodiazepines
Hypnotics and Sedatives
2014

Antihyperalgesia by 2-GABA A receptors occurs via a genuine spinal action and does not involve supraspinal sites

Paul, J., Yévenes, G. E., Benke, D., Lio, A. D., Ralvenius, W. T., Witschi, R., Scheurer, L., Cook, J. M., Rudolph, U., Fritschy, J. M. & Zeilhofer, H. U., Jan 1 2014, In : Neuropsychopharmacology. 39, 2, p. 477-487 11 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Benzodiazepines
Neuralgia
gamma-Aminobutyric Acid
Spinal Cord

Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels

Riccio, A., Li, Y., Tsvetkov, E., Gapon, S., Yao, G. L., Smith, K. S., Engin, E., Rudolph, U., Bolshakov, V. Y. & Clapham, D. E., Mar 10 2014, In : Journal of Neuroscience. 34, 10, p. 3653-3667 15 p.

Research output: Contribution to journalArticle

Amygdala
Fear
Anxiety
Transient Receptor Potential Channels
Brain

Diversity of neuronal inhibition: A path to novel treatments for neuropsychiatric disorders

Benham, R. S., Engin, E. & Rudolph, U., Jan 2014, In : JAMA Psychiatry. 71, 1, p. 91-93 3 p.

Research output: Contribution to journalArticle

Effect of genetic and pharmacological blockade of GABA receptors on the 5-HT2C receptor function during stress

Martin, C. B. P., Gassmann, M., Chevarin, C., Hamon, M., Rudolph, U., Bettler, B., Lanfumey, L. & Mongeau, R., Dec 2014, In : Journal of Neurochemistry. 131, 5, p. 566-572 7 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2C
GABA Receptors
Serotonin
Pharmacology
gamma-Aminobutyric Acid

GABAA receptor subtypes: Therapeutic potential in down syndrome, affective disorders, schizophrenia, and autism

Rudolph, U. & Möhler, H., Jan 1 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 483-507 25 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Autistic Disorder
Down Syndrome
Mood Disorders
Schizophrenia

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon

Seifi, M., Brown, J. F., Mills, J., Bhandari, P., Belelli, D., Lambert, J. J., Rudolph, U. & Swinny, J. D., Jan 1 2014, In : Journal of Neuroscience. 34, 31, p. 10361-10378 18 p.

Research output: Contribution to journalArticle

Neurologic Mutant Mice
Enteric Nervous System
GABA-A Receptors
Colon
Myenteric Plexus

Neural basis of benzodiazepine reward: Requirement for α2 containing GABA a receptors in the nucleus accumbens

Engin, E., Bakhurin, K. I., Smith, K. S., Hines, R. M., Reynolds, L. M., Tang, W., Sprengel, R., Moss, S. J. & Rudolph, U., Jul 2014, In : Neuropsychopharmacology. 39, 8, p. 1805-1815 11 p.

Research output: Contribution to journalArticle

GABA Receptors
Nucleus Accumbens
Benzodiazepines
Reward
Midazolam
Substantia Gelatinosa
Interneurons
GABA-A Receptors
Synapses
Glycine Receptors
2013

Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity

Van'T Veer, A., Bechtholt, A. J., Onvani, S., Potter, D., Wang, Y., Liu-Chen, L. Y., Schütz, G., Chartoff, E. H., Rudolph, U., Cohen, B. M. & Carlezon, W. A., Jul 1 2013, In : Neuropsychopharmacology. 38, 8, p. 1585-1597 13 p.

Research output: Contribution to journalArticle

kappa Opioid Receptor
Dopaminergic Neurons
Anti-Anxiety Agents
Cocaine
Brain

Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment

Licata, S. C., Shinday, N. M., Huizenga, M. N., Darnell, S. B., Sangrey, G. R., Rudolph, U., Rowlett, J. K. & Sadri-Vakili, G., Dec 19 2013, In : PloS one. 8, 12, e84806.

Research output: Contribution to journalArticle

benzodiazepines
neurotrophins
Brain-Derived Neurotrophic Factor
hippocampus
Benzodiazepines

Bidirectional regulation of intravenous general anesthetic actions by α3-containing γ-aminobutyric acida receptors

Straub, C. J., Lau, H. M., Parlato, R., Schuetz, G., Fritschy, J. M. & Rudolph, U., Mar 1 2013, In : Anesthesiology. 118, 3, p. 562-576 15 p.

Research output: Contribution to journalArticle

Intravenous Anesthetics
General Anesthetics
GABA-A Receptors
Adrenergic Neurons
Hypnotics and Sedatives

Dissecting the role of diazepam-sensitive γ-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat

Koester, C., Rudolph, U., Haenggi, T., Papilloud, A., Fritschy, J. M. & Crestani, F., Jan 1 2013, In : Pharmacology Biochemistry and Behavior. 103, 3, p. 541-549 9 p.

Research output: Contribution to journalArticle

Aminobutyrates
Diazepam
Risk assessment
gamma-Aminobutyric Acid
Drug therapy

Endogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor

Christian, C. A., Herbert, A. G., Holt, R. L., Peng, K., Sherwood, K. D., Pangratz-Fuehrer, S., Rudolph, U. & Huguenard, J. R., Jun 19 2013, In : Neuron. 78, 6, p. 1063-1074 12 p.

Research output: Contribution to journalArticle

Diazepam Binding Inhibitor
GABA-A Receptors
Benzodiazepines
Aminobutyrates
Absence Epilepsy

Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states

Drexler, B., Zinser, S., Huang, S., Poe, M. M., Rudolph, U., Cook, J. M. & Antkowiak, B., Mar 5 2013, In : European Journal of Pharmacology. 703, 1-3, p. 18-24 7 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Benzodiazepines
Action Potentials
Diazepam
L 655,708

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5

Ohtsuka, N., Badurek, S., Busslinger, M., Benes, F. M., Minichiello, L. & Rudolph, U., Apr 1 2013, In : Genesis. 51, 4, p. 234-245 12 p.

Research output: Contribution to journalArticle

GABAergic Neurons
Transcription Factors
Quantitative Trait Loci
Phenotype
Chromosomes, Human, Pair 4