Timothy M Fan

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2020

Pharmacokinetics of platinum and safety evaluation of carboplatin-impregnated calcium sulfate hemihydrate beads after implantation in healthy cats

Maxwell, E. A., Phillips, H., Clark-Price, S. C., Vieson, M. D., Selmic, L. E., Schaeffer, D. J. & Fan, T. M., Jan 1 2020, (Accepted/In press) In : Veterinary Surgery.

Research output: Contribution to journalArticle

Rabacfosadine for naïve canine intermediate to large cell lymphoma: Efficacy and adverse event profile across three prospective clinical trials

Saba, C. F., Clifford, C., Burgess, K., Phillips, B., Vail, D., Wright, Z., Curran, K., Fan, T., Elmslie, R., Post, G. & Thamm, D., 2020, (Accepted/In press) In : Veterinary and comparative oncology.

Research output: Contribution to journalArticle

Open Access
2019

EVALUATING THE CLINICAL AND PHYSIOLOGICAL EFFECTS OF LONG-TERM ULTRAVIOLET B RADIATION ON RABBITS (ORYCTOLAGUS CUNICULUS)

Watson, M. K., Mitchell, M. A., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Cavaretta, M., Kohles, M. & Marshall, K., Jan 2019, In : Journal of Exotic Pet Medicine. 28, p. 43-55 13 p.

Research output: Contribution to journalArticle

Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells

Roy, J., Dibaeinia, P., Fan, T. M., Sinha, S. & Das, A., Jan 1 2019, In : Journal of Lipid Research. 60, 2, p. 375-387 13 p.

Research output: Contribution to journalArticle

Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. J. & Fan, T. M., Jan 1 2019, In : Frontiers in Oncology. 9, FEB, 96.

Research output: Contribution to journalArticle

Open Access
2018

Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J., May 2018, In : Biomaterials Science. 6, 5, p. 1189-1200 12 p.

Research output: Contribution to journalArticle

Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides

Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In : Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.

Research output: Contribution to journalArticle

In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin

Maxwell, E. A., Phillips, H., Schaeffer, D. J. & Fan, T. M., Feb 1 2018, In : Veterinary Surgery. 47, 2, p. 219-226 8 p.

Research output: Contribution to journalArticle

NCI comparative oncology program testing of non-camptothecin indenoisoquinoline topoisomerase I inhibitors in naturally occurring canine lymphoma

Burton, J. H., Mazcko, C., LeBlanc, A., Covey, J. M., Ji, J., Kinders, R. J., Parchment, R. E., Khanna, C., Paoloni, M., Lana, S., Weishaar, K., London, C., Kisseberth, W., Krick, E., Vail, D., Childress, M., Bryan, J. N., Barber, L., Ehrhart, E. J., Kent, M. & 11 others, Fan, T., Kow, K., Northup, N., Wilson-Robles, H., Tomaszewski, J., Holleran, J. L., Muzzio, M., Eiseman, J., Beumer, J. H., Doroshow, J. H. & Pommier, Y., Dec 1 2018, In : Clinical Cancer Research. 24, 23, p. 5830-5840 11 p.

Research output: Contribution to journalArticle

Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses

Saba, C. F., Vickery, K. R., Clifford, C. A., Burgess, K. E., Phillips, B., Vail, D. M., Wright, Z. M., Morges, M. A., Fan, T. M. & Thamm, D. H., Mar 2018, In : Veterinary and comparative oncology. 16, 1, p. E76-E82

Research output: Contribution to journalArticle

Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K., Dobrucki, L. W., Fan, T. M. & Chan, J., Aug 22 2018, In : ACS Central Science. 4, 8, p. 1045-1055 11 p.

Research output: Contribution to journalArticle

Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

Svec, R. L., Furiassi, L., Skibinski, C. G., Fan, T. M., Riggins, G. J. & Hergenrother, P. J., Nov 16 2018, In : ACS chemical biology. 13, 11, p. 3206-3216 11 p.

Research output: Contribution to journalArticle

2017

Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma

Thamm, D. H., Vail, D. M., Post, G. S., Fan, T. M., Phillips, B. S., Axiak-Bechtel, S., Elmslie, R. S., Klein, M. K. & Ruslander, D. A., May 1 2017, In : Journal of veterinary internal medicine. 31, 3, p. 872-878 7 p.

Research output: Contribution to journalArticle

Combinatorial Discovery of Defined Substrates That Promote a Stem Cell State in Malignant Melanoma

Zhang, D., Lee, J., Sun, M. B., Pei, Y., Chu, J., Gillette, M. U., Fan, T. M. & Kilian, K. A., May 24 2017, In : ACS Central Science. 3, 5, p. 381-393 13 p.

Research output: Contribution to journalArticle

Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin

Roy, J., Wycislo, K. L., Pondenis, H., Fan, T. M. & Das, A., Sep 2017, In : PloS one. 12, 9, e0183930.

Research output: Contribution to journalArticle

Melanoma topology reveals a stem-like phenotype that promotes angiogenesis

Lee, J., Abdeen, A. A., Hedhli, J., Wycislo, K. L., Dobrucki, I. T., Fan, T. M., Dobrucki, L. W. & Kilian, K. A., Jan 1 2017, In : Science Advances. 3, 10, e1701350.

Research output: Contribution to journalArticle

Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species

Lundberg, A. P., Francis, J. M., Pajak, M., Parkinson, E. I., Wycislo, K. L., Rosol, T. J., Brown, M. E., London, C. A., Dirikolu, L., Hergenrother, P. J. & Fan, T. M., Apr 1 2017, In : Investigational New Drugs. 35, 2, p. 134-144 11 p.

Research output: Contribution to journalArticle

Selective in vivo metabolic cell-labeling-mediated cancer targeting

Wang, H., Wang, R., Cai, K., He, H., Liu, Y., Yen, J., Wang, Z., Xu, M., Sun, Y., Zhou, X., Yin, Q., Tang, L., Dobrucki, I. T., Dobrucki, L. W., Chaney, E. J., Boppart, S. A., Fan, T. M., Lezmi, S., Chen, X., Yin, L. & 1 others, Cheng, J., Apr 1 2017, In : Nature chemical biology. 13, 4, p. 415-424 10 p.

Research output: Contribution to journalArticle

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

Joshi, A. D., Botham, R. C., Schlein, L. J., Roth, H. S., Mangraviti, A., Borodovsky, A., Tyler, B., Joslyn, S., Looper, J. S., Podell, M., Fan, T. M., Hergenrother, P. J. & Riggins, G. J., Jan 1 2017, In : Oncotarget. 8, 46, p. 80124-80138 15 p.

Research output: Contribution to journalArticle

2016

Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005-2013)

Cesario, L., Garrett, L. D., Barger, A. M., O'Brien, R. T. & Fan, T. M., May 1 2016, In : Australian veterinary journal. 94, 5, p. 160-165 6 p.

Research output: Contribution to journalArticle

Downregulation of CXCR4 Expression and Functionality After Zoledronate Exposure in Canine Osteosarcoma

Byrum, M. L., Pondenis, H. C., Fredrickson, R. L., Wycislo, K. L. & Fan, T. M., Jul 1 2016, In : Journal of veterinary internal medicine. 30, 4, p. 1187-1196 10 p.

Research output: Contribution to journalArticle

Interfacial geometry dictates cancer cell tumorigenicity

Lee, J., Abdeen, A. A., Wycislo, K. L., Fan, T. M. & Kilian, K. A., Aug 1 2016, In : Nature Materials. 15, 8, p. 856-862 7 p.

Research output: Contribution to journalArticle

mTOR inhibition mitigates enhanced mRNA translation associated with the metastatic phenotype of osteosarcoma cells in vivo

Morrow, J. J., Mendoza, A., Koyen, A., Lizardo, M. M., Ren, L., Waybright, T. J., Hansen, R. J., Gustafson, D. L., Zhou, M., Fan, T. M., Scacheri, P. C. & Khanna, C., Dec 15 2016, In : Clinical Cancer Research. 22, 24, p. 6129-6141 13 p.

Research output: Contribution to journalArticle

Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

Yin, Q., Tang, L., Cai, K., Tong, R., Sternberg, R., Yang, X., Dobrucki, L. W., Borst, L. B., Kamstock, D., Song, Z., Helferich, W. G., Cheng, J. & Fan, T. M., Aug 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4601-E4609

Research output: Contribution to journalArticle

Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs

Larson, J. C., Allstadt, S. D., Fan, T. M., Khanna, C., Lunghofer, P. J., Hansen, R. J., Gustafson, D. L. PHD., Legendre, A. M., Galyon, G. D., LeBlanc, A. K. & Martin-Jimenez, T., Jan 2016, In : American journal of veterinary research. 77, 1, p. 65-71 7 p.

Research output: Contribution to journalArticle

Small-molecule procaspase-3 activation sensitizes cancer to treatment with diverse chemotherapeutics

Botham, R. C., Roth, H. S., Book, A. P., Roady, P. J., Fan, T. M. & Hergenrother, P. J., Aug 24 2016, In : ACS Central Science. 2, 8, p. 545-559 15 p.

Research output: Contribution to journalArticle

The combination of vemurafenib and procaspase-3 activation is synergistic in mutant BRAF melanomas

Peh, J., Fan, T. M., Wycislo, K. L., Roth, H. S. & Hergenrother, P. J., Aug 2016, In : Molecular Cancer Therapeutics. 15, 8, p. 1859-1869 11 p.

Research output: Contribution to journalArticle

2015

Alkylation and carbamylation effects of lomustine and its major metabolites and MGMT expression in canine cells

Chakkath, T., Lavergne, S., Fan, T. M., Bunick, D. & Dirikolu, L., Jun 1 2015, In : Veterinary Sciences. 2, 2, p. 52-68 17 p.

Research output: Contribution to journalArticle

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

Palchaudhuri, R., Lambrecht, M. J., Botham, R. C., Partlow, K. C., van Ham, T. J., Putt, K. S., Nguyen, L. T., Kim, S. H., Peterson, R. T., Fan, T. M. & Hergenrother, P. J., Dec 1 2015, In : Cell Reports. 13, 9, p. 2027-2036 10 p.

Research output: Contribution to journalArticle

A summary of the osteosarcoma banking efforts: A report from the Children's Oncology Group and the QuadW Foundation

Glover, J., Krailo, M., Tello, T., Marina, N., Janeway, K., Barkauskas, D., Fan, T. M., Gorlick, R. & Khanna, C., Mar 1 2015, In : Pediatric Blood and Cancer. 62, 3, p. 450-455 6 p.

Research output: Contribution to journalArticle

Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007)

Coyle, V. J., Rassnick, K. M., Borst, L. B., Rodriguez, C. O., Northrup, N. C., Fan, T. M. & Garrett, L. D., Jun 1 2015, In : Veterinary and comparative oncology. 13, 2, p. 89-97 9 p.

Research output: Contribution to journalArticle

Canine osteosarcoma cell lines from patients with differing serum alkaline phosphatase concentrations display no behavioural differences in vitro

Holmes, K. E., Thompson, V., Piskun, C. M., Kohnken, R. A., Huelsmeyer, M. K., Fan, T. M. & Stein, T. J., Sep 1 2015, In : Veterinary and comparative oncology. 13, 3, p. 166-175 10 p.

Research output: Contribution to journalArticle

Direct Capture of Functional Proteins from Mammalian Plasma Membranes into Nanodiscs

Roy, J., Pondenis, H., Fan, T. M. & Das, A., Oct 20 2015, In : Biochemistry. 54, 41, p. 6299-6302 4 p.

Research output: Contribution to journalArticle

Expression of Nociceptive Ligands in Canine Osteosarcoma

Shor, S., Fadl-Alla, B. A., Pondenis, H. C., Zhang, X., Wycislo, K. L., Lezmi, S. & Fan, T. M., Jan 1 2015, In : Journal of veterinary internal medicine. 29, 1, p. 268-275 8 p.

Research output: Contribution to journalArticle

Removal of metabolic liabilities enables development of derivatives of procaspase-activating compound 1 (PAC-1) with improved pharmacokinetics

Roth, H. S., Botham, R. C., Schmid, S. C., Fan, T. M., Dirikolu, L. & Hergenrother, P. J., May 14 2015, In : Journal of Medicinal Chemistry. 58, 9, p. 4046-4065 20 p.

Research output: Contribution to journalArticle

Targeting tumor vasculature with aptamer-functionalized doxorubicin-polylactide nanoconjugates for enhanced cancer therapy

Tang, L., Tong, R., Coyle, V. J., Yin, Q., Pondenis, H., Borst, L. B., Cheng, J. & Fan, T. M., May 26 2015, In : ACS Nano. 9, 5, p. 5072-5081 10 p.

Research output: Contribution to journalArticle

The Association of Endothelin-1 Signaling with Bone Alkaline Phosphatase Expression and Protumorigenic Activities in Canine Osteosarcoma

Neumann, Z. L., Pondenis, H. C., Masyr, A., Byrum, M. L., Wycislo, K. L. & Fan, T. M., Nov 1 2015, In : Journal of veterinary internal medicine. 29, 6, p. 1584-1594 11 p.

Research output: Contribution to journalArticle

The Immunotherapy of Canine Osteosarcoma: A Historical and Systematic Review

Wycislo, K. L. & Fan, T. M., May 1 2015, In : Journal of veterinary internal medicine. 29, 3, p. 759-769 11 p.

Research output: Contribution to journalArticle

2014

Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

Yin, Q., Tong, R., Yin, L., Fan, T. M. & Cheng, J., Mar 7 2014, In : Polymer Chemistry. 5, 5, p. 1581-1585 5 p.

Research output: Contribution to journalArticle

Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity

Botham, R. C., Fan, T. M., Im, I., Borst, L. B., Dirikolu, L. & Hergenrother, P. J., Jan 29 2014, In : Journal of the American Chemical Society. 136, 4, p. 1312-1319 8 p.

Research output: Contribution to journalArticle

Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus)

Watson, M. K., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Leister, K., Kohles, M., Marshall, K. & Mitchell, M. A., Dec 17 2014, In : PloS one. 9, 12, e114413.

Research output: Contribution to journalArticle

Investigating the optimal size of anticancer nanomedicine

Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., Dobrucki, I. T., Dobrucki, L. W., Borst, L. B., Lezmi, S., Helferich, W. G., Ferguson, A. L., Fan, T. M. & Cheng, J., Oct 28 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15344-15349 6 p.

Research output: Contribution to journalArticle

Preliminary metabolism of lomustine in dogs and comparative cytotoxicity of lomustine and its major metabolites in canine cells

Chakkath, T., Lavergne, S., Fan, T. M., Bunick, D. & Dirikolu, L., Dec 1 2014, In : Veterinary Sciences. 1, 3, p. 159-173 15 p.

Research output: Contribution to journalArticle

Pro-tumorigenic effects of transforming growth factor beta 1 in canine osteosarcoma

Portela, R. F., Fadl-Alla, B. A., Pondenis, H. C., Byrum, M. L., Garrett, L. D., Wycislo, K. L., Borst, L. B. & Fan, T. M., Jan 1 2014, In : Journal of veterinary internal medicine. 28, 3, p. 894-904 11 p.

Research output: Contribution to journalArticle

2013

Association between Absolute Tumor Burden and Serum Bone-Specific Alkaline Phosphatase in Canine Appendicular Osteosarcoma

Sternberg, R. A., Pondenis, H. C., Yang, X., Mitchell, M. A., O'Brien, R. T., Garrett, L. D., Helferich, W. G., Hoffmann, W. E. & Fan, T. M., Jul 1 2013, In : Journal of veterinary internal medicine. 27, 4, p. 955-963 9 p.

Research output: Contribution to journalArticle

Drug-initiated ring-opening polymerization of O-carboxyanhydrides for the preparation of anticancer drug-poly(O-carboxyanhydride) nanoconjugates

Yin, Q., Tong, R., Xu, Y., Baek, K., Dobrucki, L. W., Fan, T. M. & Cheng, J., Mar 11 2013, In : Biomacromolecules. 14, 3, p. 920-929 10 p.

Research output: Contribution to journalArticle