Timothy M Fan

Search results

• 2022

  Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer

  Boudreau, M. W., Mulligan, M. P., Shapiro, D. J., Fan, T. M. & Hergenrother, P. J., Mar 10 2022, In: Journal of Medicinal Chemistry. 65, 5, p. 3894-3912 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Unfolded Protein Response 100%
  • Estrogen 86%
  • Estrogen Receptors 75%
  • Aromatase Inhibitor 59%
  • Breast Neoplasms 51%

• Acute phase protein concentrations following serial procaine penicillin G injections in horses

  Gordon, D. L., Foreman, J. H., Connolly, S. L., Schnelle, A. N., Fan, T. M. & Barger, A. M., Oct 6 2022, (E-pub ahead of print) In: Equine veterinary journal.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Penicillin G Procaine 100%
  • procaine 83%
  • acute phase proteins 80%
  • benzylpenicillin 74%
  • Acute-Phase Proteins 72%

• Characterization of Anti-Angiogenic Chemo-Sensitization via Longitudinal Ultrasound Localization Microscopy in Colorectal Carcinoma Tumor Xenografts

  Lowerison, M., Zhang, W., Chen, X., Fan, T. & Song, P., Apr 2022, In: IEEE Transactions on Biomedical Engineering. 69, 4, p. 1449 - 1460 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heterografts 100%
  • Microscopic examination 58%
  • Tumors 55%
  • Chemotherapy 48%
  • Ultrasonics 45%

• Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs

  LeBlanc, A. K., Mazcko, C. N., Fan, T. M., Vail, D. M., Flesner, B. K., Bryan, J. N., Li, S., Wang, F., Harris, S., Vargas, J. D., Govindharajulu, J. P., Jaganathan, S., Tomaino, F., Srivastava, A. K., Chou, T. F., Stott, G. M., Covey, J. M., Mroczkowski, B. & Doroshow, J. H., Oct 2022, In: Molecular Cancer Therapeutics. 21, 10, p. 1510-1523 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Valosin Containing Protein 100%
  • Dogs 44%
  • Multiple Myeloma 30%
  • Pets 23%
  • Neoplasms 19%

• Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

  Zhang, L., Dutta, S., Xiong, S., Chan, M., Chan, K. K., Fan, T. M., Bailey, K. L., Lindeblad, M., Cooper, L. M., Rong, L., Gugliuzza, A. F., Shukla, D., Procko, E., Rehman, J. & Malik, A. B., Mar 2022, In: Nature chemical biology. 18, 3, p. 342-351 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • angiotensin converting enzyme 2 100%
  • Severe Acute Respiratory Syndrome 86%
  • Coronavirus 84%
  • Lung Injury 70%
  • S protein, severe acute respiratory syndrome coronavirus 32%

• Investigating PSMA differential expression in canine uroepithelial carcinomas to aid disease-based stratification and guide therapeutic selection

  Berry, M. R., Fadl-Alla, B. A., Samuelson, J., Rosol, T. J. & Fan, T. M., Dec 2022, In: BMC Veterinary Research. 18, 1, 441.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • prostatic neoplasms 100%
  • carcinoma 77%
  • Prostate-Specific Antigen 74%
  • Canidae 63%
  • therapeutics 56%

• Mitigation of SARS-CoV-2 transmission at a large public university

  Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Fredrickson, R. L., Wang, T., Wong, G. N., Uelmen, J., Maslov, S., Weiner, Z. J., Tkachenko, A. V., Zhang, H., Liu, Z., Ibrahim, A., Patel, S. J., Paul, J. M., Vance, N. P., Gulick, J. G., Satheesan, S. P., & 129 othersGalvan, I. J., Miller, A., Grohens, J., Nelson, T. J., Stevens, M. P., Hennessy, P. M., Parker, R. C., Santos, E., Brackett, C., Steinman, J. D., Fenner, M. R., Dohrer, K., Delorenzo, M., Wilhelm-barr, L., Brauer, B. R., Best-popescu, C., Durack, G., Wetter, N., Kranz, D. M., Breitbarth, J., Simpson, C., Pryde, J. A., Kaler, R. N., Harris, C., Vance, A. C., Silotto, J. L., Johnson, M., Valera, E. A., Anton, P. K., Mwilambwe, L., Bryan, S. P., Stone, D. S., Young, D. B., Ward, W. E., Lantz, J., Vozenilek, J. A., Bashir, R., Moore, J. S., Garg, M., Cooper, J. C., Snyder, G., Lore, M. H., Yocum, D. L., Cohen, N. J., Novakofski, J. E., Loots, M. J., Ballard, R. L., Band, M., Banks, K. M., Barnes, J. D., Bentea, I., Black, J., Busch, J., Conte, A., Conte, M., Curry, M., Eardley, J., Edwards, A., Eggett, T., Fleurimont, J., Foster, D., Fouke, B. W., Gallagher, N., Gastala, N., Genung, S. A., Glueck, D., Gray, B., Greta, A., Healy, R. M., Hetrick, A., Holterman, A. A., Ismail, N., Jasenof, I., Kelly, P., Kielbasa, A., Kiesel, T., Kindle, L. M., Lipking, R. L., Manabe, Y. C., Mayes, J. ., Mcguffin, R., Mchenry, K. G., Mirza, A., Moseley, J., Mostafa, H. H., Mumford, M., Munoz, K., Murray, A. D., Nolan, M., Parikh, N. A., Pekosz, A., Pflugmacher, J., Phillips, J. M., Pitts, C., Potter, M. C., Quisenberry, J., Rear, J., Robinson, M. L., Rosillo, E., Rye, L. N., Sherwood, M., Simon, A., Singson, J. M., Skadden, C., Skelton, T. H., Smith, C., Stech, M., Thomas, R., Tomaszewski, M. A., Tyburski, E. A., Vanwingerden, S., Vlach, E., Watkins, R. S., Watson, K., White, K. C., Killeen, T. L., Jones, R. J., Cangellaris, A. C., Martinis, S. A., Vaid, A., Brooke, C. B., Walsh, J. T., Elbanna, A., Sullivan, W. C., Smith, R. L., Goldenfeld, N., Fan, T. M., Hergenrother, P. J. & Burke, M. D., Dec 2022, In: Nature communications. 13, 1, 3207.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Compliance 81%
  • Communication 61%
  • Accidental Falls 26%
  • saliva 20%

• Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture

  Svec, R. L., Mckee, S. A., Berry, M. R., Kelly, A. M., Fan, T. M. & Hergenrother, P. J., Feb 18 2022, In: ACS chemical biology. 17, 2, p. 299–313 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide 63%
  • Glioblastoma 50%
  • Brain Neoplasms 47%
  • Maximum Tolerated Dose 43%
  • Cell Culture Techniques 38%

• Osteosarcoma mechanobiology and therapeutic targets

  Shoaib, Z., Fan, T. M. & Irudayaraj, J. M. K., Jan 2022, In: British Journal of Pharmacology. 179, 2, p. 201-217 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biophysics 100%
  • Osteosarcoma 76%
  • Bone and Bones 26%
  • Osteitis Deformans 20%
  • Neoplasm Metastasis 18%

• Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies

  Danciu, O. C., Holdhoff, M., Peterson, R. A., Fischer, J. H., Liu, L. C., Wang, H., Venepalli, N. K., Chowdhery, R., Nicholas, M. K., Russell, M. J., Fan, T. M., Hergenrother, P. J., Tarasow, T. M. & Dudek, A. Z., 2022, (Accepted/In press) In: British Journal of Cancer.

  Research output: Contribution to journal › Article › peer-review

  • Nervous System 100%
  • Neuroendocrine Tumors 92%
  • Caspase 3 72%
  • Pharmacokinetics 61%
  • Clinical Trials 53%

• Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy

  Kelly, A. M., Berry, M. R., Tasker, S. Z., McKee, S. A., Fan, T. M. & Hergenrother, P. J., Jul 13 2022, In: Journal of the American Chemical Society. 144, 27, p. 12367-12380 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Dabrafenib 100%
  • Blood-Brain Barrier 90%
  • Glycoproteins 87%
  • Intracranial 81%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 56%

• The use of alkaline phosphatase and runx2 to distinguish osteosarcoma from other common malignant primary bone tumors in dogs

  Barger, A., Baker, K., Driskell, E., Sander, W., Roady, P., Berry, M., Schnelle, A. & Fan, T. M., May 2022, In: Veterinary pathology. 59, 3, p. 427-432 6 p.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma 100%
  • Osteosarcoma 72%
  • alkaline phosphatase 62%
  • Alkaline Phosphatase 61%
  • bones 58%
• 2021

  A 10% Tomato Diet Selectively Reduces Radiation-Induced Damage in TRAMP Mice

  Rowles, J. L., Wallig, M. A., Selting, K. A., Fan, T. M., Miller, R. J., O'Brien, W. D. & Erdman, J. W., Nov 1 2021, In: The Journal of nutrition. 151, 11, p. 3421-3430 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Lycopersicon esculentum 100%
  • Transgenic Mice 64%
  • Ointments 63%
  • Prostate 60%
  • Adenocarcinoma 56%

• A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice

  Boudreau, M. W., Duraki, D., Wang, L., Mao, C., Kim, J. E., Henn, M. A., Tang, B., Fanning, S. W., Kiefer, J., Tarasow, T. M., Bruckheimer, E. M., Moreno, R., Mousses, S., Greene, G. L., Roy, E. J., Park, B. H., Fan, T. M., Nelson, E. R., Hergenrother, P. J. & Shapiro, D. J., Jul 21 2021, In: Science Translational Medicine. 13, 603, eabf1383.

  Research output: Contribution to journal › Article › peer-review

  • Unfolded Protein Response 100%
  • Breast Neoplasms 51%
  • Estrogen Receptors 45%
  • Neoplasm Metastasis 39%
  • Heterografts 28%

• Evaluation of a Procaspase-3 Activator with Hydroxyurea or Temozolomide Against High-grade Meningioma in Cell Culture and Canine Cancer Patients

  Tonogai, E. J., Huang, S., Botham, R. C., Berry, M. R., Joslyn, S. K., Daniel, G. B., Chen, Z., Rao, J., Zhang, X., Basuli, F., Rossmeisl, J. H., Riggins, G. J., LeBlanc, A. K., Fan, T. M. & Hergenrother, P. J., Oct 1 2021, In: Neuro-Oncology. 23, 10, p. 1723-1735 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide 100%
  • Hydroxyurea 97%
  • Meningioma 87%
  • Caspase 3 71%
  • Canidae 70%

• Pharmacokinetics of a cytosine arabinoside subcutaneous protocol in dogs with meningoencephalomyelitis of unknown aetiology

  Levitin, H. A., Foss, K. D., Li, Z., Reinhart, J. M., Hague, D. W. & Fan, T. M., Sep 2021, In: Journal of Veterinary Pharmacology and Therapeutics. 44, 5, p. 696-704 9 p.

  Research output: Contribution to journal › Article › peer-review

  • meningoencephalitis 100%
  • Cytarabine 80%
  • cytosine 77%
  • etiology 73%
  • pharmacokinetics 69%

• Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy

  Lundberg, A. P., Boudreau, M. W., Selting, K. A., Chatkewitz, L. E., Samuelson, J., Francis, J. M., Parkinson, E. I., Barger, A. M., Hergenrother, P. J. & Fan, T. M., Aug 2021, In: Neoplasia (United States). 23, 8, p. 811-822 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Felidae 100%
  • Squamous Cell Carcinoma 73%
  • Squamous Cell Carcinoma of Head and Neck 48%
  • Oxidoreductases 26%
  • Radiotherapy 20%
• 2020

  Pharmacokinetics of platinum and safety evaluation of carboplatin-impregnated calcium sulfate hemihydrate beads after implantation in healthy cats

  Maxwell, E. A., Phillips, H., Clark-Price, S. C., Vieson, M. D., Selmic, L. E., Schaeffer, D. J. & Fan, T. M., May 1 2020, In: Veterinary Surgery. 49, 4, p. 748-757 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Sulfate 100%
  • calcium sulfate 97%
  • platinum 88%
  • Carboplatin 80%
  • Platinum 75%

• Rabacfosadine for naïve canine intermediate to large cell lymphoma: Efficacy and adverse event profile across three prospective clinical trials

  Saba, C. F., Clifford, C., Burgess, K., Phillips, B., Vail, D., Wright, Z., Curran, K., Fan, T., Elmslie, R., Post, G. & Thamm, D., Dec 2020, In: Veterinary and comparative oncology. 18, 4, p. 763-769 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • rabacfosadine 100%
  • prospective studies 58%
  • lymphoma 52%
  • Canidae 39%
  • Lymphoma 37%
• 2019

  EVALUATING THE CLINICAL AND PHYSIOLOGICAL EFFECTS OF LONG-TERM ULTRAVIOLET B RADIATION ON RABBITS (ORYCTOLAGUS CUNICULUS)

  Watson, M. K., Mitchell, M. A., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Cavaretta, M., Kohles, M. & Marshall, K., Jan 2019, In: Journal of Exotic Pet Medicine. 28, p. 43-55 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Oryctolagus cuniculus 100%
  • long term effects 77%
  • ultraviolet radiation 71%
  • Rabbits 56%
  • rabbits 53%

• Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells

  Roy, J., Dibaeinia, P., Fan, T. M., Sinha, S. & Das, A., 2019, In: Journal of Lipid Research. 60, 2, p. 375-387 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Lipidomics 100%
  • Osteosarcoma 76%
  • Lipid 50%
  • Lipids 48%
  • Diglycerides 25%

• Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

  Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. J. & Fan, T. M., 2019, In: Frontiers in Oncology. 9, FEB, 96.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Neoplasms 100%
  • Caspase 3 95%
  • Canidae 93%
  • Meningioma 19%
  • Comparative Histology 16%

• Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions

  Dowling, M., Samuelson, J., Fadl-Alla, B., Pondenis, H. C., Byrum, M., Barger, A. M. & Fan, T. M., Jan 2019, In: PloS one. 14, 1, e0210297.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • hemangiosarcoma 100%
  • burden of disease 83%
  • body cavities 73%
  • Hemangiosarcoma 71%
  • Prostate-Specific Antigen 58%
• 2018

  Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

  Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J., May 2018, In: Biomaterials Science. 6, 5, p. 1189-1200 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Nanoconjugates 100%
  • Nanoconjugate 58%
  • Tumors 40%
  • Heterografts 18%
  • Decoration 14%

• Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides

  Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In: Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Endocannabinoid 84%
  • Epoxy Compounds 75%
  • Cannabinoid 70%
  • Endocannabinoids 68%
  • Epoxide 49%

• In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin

  Maxwell, E. A., Phillips, H., Schaeffer, D. J. & Fan, T. M., Feb 1 2018, In: Veterinary Surgery. 47, 2, p. 219-226 8 p.

  Research output: Contribution to journal › Article › peer-review

  • injection site 100%
  • sarcoma 92%
  • Felidae 88%
  • Carboplatin 86%
  • calcium sulfate 83%

• NCI comparative oncology program testing of non-camptothecin indenoisoquinoline topoisomerase I inhibitors in naturally occurring canine lymphoma

  Burton, J. H., Mazcko, C., LeBlanc, A., Covey, J. M., Ji, J., Kinders, R. J., Parchment, R. E., Khanna, C., Paoloni, M., Lana, S., Weishaar, K., London, C., Kisseberth, W., Krick, E., Vail, D., Childress, M., Bryan, J. N., Barber, L., Ehrhart, E. J., Kent, M., & 11 othersFan, T., Kow, K., Northup, N., Wilson-Robles, H., Tomaszewski, J., Holleran, J. L., Muzzio, M., Eiseman, J., Beumer, J. H., Doroshow, J. H. & Pommier, Y., Dec 1 2018, In: Clinical Cancer Research. 24, 23, p. 5830-5840 11 p.

  Research output: Contribution to journal › Article › peer-review

  • NSC 724998 100%
  • Topoisomerase I Inhibitors 89%
  • indimitecan 72%
  • Canidae 54%
  • Lymphoma 51%

• Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses

  Saba, C. F., Vickery, K. R., Clifford, C. A., Burgess, K. E., Phillips, B., Vail, D. M., Wright, Z. M., Morges, M. A., Fan, T. M. & Thamm, D. H., Mar 2018, In: Veterinary and comparative oncology. 16, 1, p. E76-E82

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • rabacfosadine 100%
  • B-cell lymphoma 65%
  • B-Cell Lymphoma 46%
  • Canidae 39%
  • dogs 34%

• Simulation of spatial diffusion of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads by use of an agarose gelatin tissue phantom

  Phillips, H., Maxwell, E. A., Schaeffer, D. J. & Fan, T. M., Jun 2018, In: American journal of veterinary research. 79, 6, p. 592-599 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Sulfate 100%
  • calcium sulfate 97%
  • platinum 88%
  • Carboplatin 80%
  • Gelatin 77%

• Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

  Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, L. W., Fan, T. M. & Chan, J., Aug 22 2018, In: ACS Central Science. 4, 8, p. 1045-1055 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidoreductases 100%
  • Stem cells 93%
  • Plastic Property 76%
  • Plasticity 61%
  • Fluorescent Probe 61%

• Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

  Svec, R. L., Furiassi, L., Skibinski, C. G., Fan, T. M., Riggins, G. J. & Hergenrother, P. J., Nov 16 2018, In: ACS chemical biology. 13, 11, p. 3206-3216 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Temozolomide 81%
  • Glioblastoma 50%
  • Halogens 10%
  • Ketones 9%
  • Alkylating Agents 8%
• 2017

  Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma

  Thamm, D. H., Vail, D. M., Post, G. S., Fan, T. M., Phillips, B. S., Axiak-Bechtel, S., Elmslie, R. S., Klein, M. K. & Ruslander, D. A., May 1 2017, In: Journal of veterinary internal medicine. 31, 3, p. 872-878 7 p.

  Research output: Contribution to journal › Article › peer-review

  • rabacfosadine 100%
  • doxorubicin 55%
  • lymphoma 52%
  • Doxorubicin 41%
  • Canidae 39%

• Combinatorial Discovery of Defined Substrates That Promote a Stem Cell State in Malignant Melanoma

  Zhang, D., Lee, J., Sun, M. B., Pei, Y., Chu, J., Gillette, M. U., Fan, T. M. & Kilian, K. A., May 24 2017, In: ACS Central Science. 3, 5, p. 381-393 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stem cells 100%
  • Peptides 69%
  • Cells 68%
  • Proteoglycans 60%
  • Proteoglycan 58%

• Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin

  Roy, J., Wycislo, K. L., Pondenis, H., Fan, T. M. & Das, A., Sep 2017, In: PloS one. 12, 9, e0183930.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma 100%
  • Osteosarcoma 72%
  • Proteomics 63%
  • proteomics 61%
  • Canidae 60%

• Melanoma topology reveals a stem-like phenotype that promotes angiogenesis

  Lee, J., Abdeen, A. A., Hedhli, J., Wycislo, K. L., Dobrucki, I. T., Fan, T. M., Dobrucki, L. W. & Kilian, K. A., 2017, In: Science Advances. 3, 10, e1701350.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Melanoma 100%
  • Phenotype 72%
  • Integrins 32%
  • Cues 29%
  • Neoplasms 27%

• Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation

  for the COG Osteosarcoma Biology Group, Jul 2017, In: PloS one. 12, 7, e0181204.

  Research output: Contribution to journal › Article › peer-review

  • Osteosarcoma 100%
  • Sarcoma 90%
  • Computer Simulation 90%
  • Databases 57%
  • Child 41%

• Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species

  Lundberg, A. P., Francis, J. M., Pajak, M., Parkinson, E. I., Wycislo, K. L., Rosol, T. J., Brown, M. E., London, C. A., Dirikolu, L., Hergenrother, P. J. & Fan, T. M., Apr 1 2017, In: Investigational New Drugs. 35, 2, p. 134-144 11 p.

  Research output: Contribution to journal › Article › peer-review

  • deoxynyboquinone 100%
  • Pharmacokinetics 33%
  • Felidae 20%
  • Neoplasms 14%
  • Squamous Cell Carcinoma 11%

• Selective in vivo metabolic cell-labeling-mediated cancer targeting

  Wang, H., Wang, R., Cai, K., He, H., Liu, Y., Yen, J., Wang, Z., Xu, M., Sun, Y., Zhou, X., Yin, Q., Tang, L., Dobrucki, I. T., Dobrucki, L. W., Chaney, E. J., Boppart, S. A., Fan, T. M., Lezmi, S., Chen, X., Yin, L., & 1 othersCheng, J., Apr 1 2017, In: Nature chemical biology. 13, 4, p. 415-424 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Neoplasms 100%
  • N-azidoacetylmannosamine 88%
  • Cell Surface Receptors 83%
  • Sugars 75%
  • Click Chemistry 62%

• Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

  Joshi, A. D., Botham, R. C., Schlein, L. J., Roth, H. S., Mangraviti, A., Borodovsky, A., Tyler, B., Joslyn, S., Looper, J. S., Podell, M., Fan, T. M., Hergenrother, P. J. & Riggins, G. J., 2017, In: Oncotarget. 8, 46, p. 80124-80138 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Temozolomide 100%
  • Glioma 74%
  • Caspase 3 71%
  • Canidae 70%
  • Rodentia 66%
• 2016

  Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005-2013)

  Cesario, L., Garrett, L. D., Barger, A. M., O'Brien, R. T. & Fan, T. M., May 1 2016, In: Australian veterinary journal. 94, 5, p. 160-165 6 p.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma 100%
  • metastasis 88%
  • Osteosarcoma 72%
  • Canidae 60%
  • dogs 52%

• Downregulation of CXCR4 Expression and Functionality After Zoledronate Exposure in Canine Osteosarcoma

  Byrum, M. L., Pondenis, H. C., Fredrickson, R. L., Wycislo, K. L. & Fan, T. M., Jul 1 2016, In: Journal of veterinary internal medicine. 30, 4, p. 1187-1196 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • osteosarcoma 100%
  • Zoledronic Acid 90%
  • Osteosarcoma 72%
  • Canidae 60%
  • dogs 52%

• Interfacial geometry dictates cancer cell tumorigenicity

  Lee, J., Abdeen, A. A., Wycislo, K. L., Fan, T. M. & Kilian, K. A., Aug 1 2016, In: Nature Materials. 15, 8, p. 856-862 7 p.

  Research output: Contribution to journal › Article › peer-review

  • stem cells 100%
  • Tumors 98%
  • Cells 93%
  • tumors 92%
  • cancer 90%

• mTOR inhibition mitigates enhanced mRNA translation associated with the metastatic phenotype of osteosarcoma cells in vivo

  Morrow, J. J., Mendoza, A., Koyen, A., Lizardo, M. M., Ren, L., Waybright, T. J., Hansen, R. J., Gustafson, D. L., Zhou, M., Fan, T. M., Scacheri, P. C. & Khanna, C., Dec 15 2016, In: Clinical Cancer Research. 22, 24, p. 6129-6141 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein Biosynthesis 100%
  • Osteosarcoma 95%
  • Sirolimus 77%
  • Psychological Inhibition 74%
  • Phenotype 55%

• Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

  Yin, Q., Tang, L., Cai, K., Tong, R., Sternberg, R., Yang, X., Dobrucki, L. W., Borst, L. B., Kamstock, D., Song, Z., Helferich, W. G., Cheng, J. & Fan, T. M., Aug 9 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4601-E4609

  Research output: Contribution to journal › Article › peer-review

  • Nanoconjugates 100%
  • Pamidronate 81%
  • Osteolysis 70%
  • Nanoparticles 51%
  • Doxorubicin 40%

• Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs

  Larson, J. C., Allstadt, S. D., Fan, T. M., Khanna, C., Lunghofer, P. J., Hansen, R. J., Gustafson, D. L. PHD., Legendre, A. M., Galyon, G. D., LeBlanc, A. K. & Martin-Jimenez, T., Jan 2016, In: American journal of veterinary research. 77, 1, p. 65-71 7 p.

  Research output: Contribution to journal › Article › peer-review

  • rapamycin 100%
  • Sirolimus 81%
  • pharmacokinetics 75%
  • dogs 58%
  • Pharmacokinetics 57%

• Small-molecule procaspase-3 activation sensitizes cancer to treatment with diverse chemotherapeutics

  Botham, R. C., Roth, H. S., Book, A. P., Roady, P. J., Fan, T. M. & Hergenrother, P. J., Aug 24 2016, In: ACS Central Science. 2, 8, p. 545-559 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell death 100%
  • Toxicity 79%
  • Doxorubicin 70%
  • Tumors 69%
  • Molecules 65%

• The combination of vemurafenib and procaspase-3 activation is synergistic in mutant BRAF melanomas

  Peh, J., Fan, T. M., Wycislo, K. L., Roth, H. S. & Hergenrother, P. J., Aug 2016, In: Molecular Cancer Therapeutics. 15, 8, p. 1859-1869 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Vemurafenib 100%
  • Caspase 3 60%
  • Melanoma 56%
  • Cell Death 13%
  • Mutation 9%

• Zoledronate-Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma

  Lundberg, A. P., Roady, P. J., Somrak, A. J., Howes, M. E. & Fan, T. M., Jul 1 2016, In: Journal of veterinary internal medicine. 30, 4, p. 1235-1240 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2015

  Alkylation and carbamylation effects of lomustine and its major metabolites and MGMT expression in canine cells

  Chakkath, T., Lavergne, S., Fan, T. M., Bunick, D. & Dirikolu, L., Jun 1 2015, In: Veterinary Sciences. 2, 2, p. 52-68 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Carbamylation 100%
  • Lomustine 88%
  • Alkylation 80%
  • alkylation 75%
  • Methyltransferases 67%

• A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

  Palchaudhuri, R., Lambrecht, M. J., Botham, R. C., Partlow, K. C., van Ham, T. J., Putt, K. S., Nguyen, L. T., Kim, S. H., Peterson, R. T., Fan, T. M. & Hergenrother, P. J., Dec 1 2015, In: Cell Reports. 13, 9, p. 2027-2036 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Apoptotic 100%
  • raptinal 91%
  • Apoptosis Induction 63%
  • Apoptosis 53%
  • Inducer 50%