Research Output per year
Research Output 1998 2019
- 1 - 50 out of 98 results
- Publication Year, Title (descending)
2019
EVALUATING THE CLINICAL AND PHYSIOLOGICAL EFFECTS OF LONG-TERM ULTRAVIOLET B RADIATION ON RABBITS (ORYCTOLAGUS CUNICULUS)
Watson, M. K., Mitchell, M. A., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Cavaretta, M., Kohles, M. & Marshall, K., Jan 1 2019, In : Journal of Exotic Pet Medicine. 28, p. 43-55 13 p.Research output: Contribution to journal › Article
Oryctolagus cuniculus
ultraviolet radiation
long term effects
rabbits
Radiation
Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells
Roy, J., Dibaeinia, P., Fan, T. M., Sinha, S. & Das, A., Jan 1 2019, In : Journal of Lipid Research. 60, 2, p. 375-387 13 p.Research output: Contribution to journal › Article
Osteosarcoma
Lipids
Diglycerides
Bone Neoplasms
Sphingolipids
Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers
Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. & Fan, T. M., Jan 1 2019, In : Frontiers in Oncology. 9, FEB, 96.Research output: Contribution to journal › Article
Open Access
Brain Neoplasms
Caspase 3
Canidae
Meningioma
Glioma
Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions
Dowling, M., Samuelson, J. P., Fadl-Alla, B., Pondenis, H. C., Byrum, M., Barger, A. M. & Fan, T. M., Jan 1 2019, In : PloS one. 14, 1, e0210297.Research output: Contribution to journal › Article
hemangiosarcoma
Hemangiosarcoma
burden of disease
body cavities
Canidae
2018
Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting
Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, W., Helferich, W. G., Fan, T. M. & Cheng, J., May 1 2018, In : Biomaterials Science. 6, 5, p. 1189-1200 12 p.Research output: Contribution to journal › Article
Nanoconjugates
Tumors
Albumins
Bearings (structural)
Medical nanotechnology
Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides
Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In : Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.Research output: Contribution to journal › Article
Endocannabinoids
Epoxy Compounds
Cannabinoid Receptors
Docosahexaenoic Acids
Osteosarcoma
In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin
Maxwell, E. A., Phillips, H., Schaeffer, D. J. & Fan, T. M., Feb 1 2018, In : Veterinary Surgery. 47, 2, p. 219-226 8 p.Research output: Contribution to journal › Article
injection site
Carboplatin
Felidae
sarcoma
calcium sulfate
NCI comparative oncology program testing of non-camptothecin indenoisoquinoline topoisomerase I inhibitors in naturally occurring canine lymphoma
Burton, J. H., Mazcko, C., LeBlanc, A., Covey, J. M., Ji, J., Kinders, R. J., Parchment, R. E., Khanna, C., Paoloni, M., Lana, S., Weishaar, K., London, C., Kisseberth, W., Krick, E., Vail, D., Childress, M., Bryan, J. N., Barber, L., Ehrhart, E. J., Kent, M. & 11 others, , Dec 1 2018, In : Clinical Cancer Research. 24, 23, p. 5830-5840 11 p.Research output: Contribution to journal › Article
Topoisomerase I Inhibitors
Canidae
Lymphoma
Camptothecin
irinotecan
Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses
Saba, C. F., Vickery, K. R., Clifford, C. A., Burgess, K. E., Phillips, B., Vail, D. M., Wright, Z. M., Morges, M. A., Fan, T. M. & Thamm, D. H., Mar 1 2018, In : Veterinary and comparative oncology. 16, 1, p. E76-E82Research output: Contribution to journal › Article
B-Cell Lymphoma
lymphoma
B-lymphocytes
Canidae
Dogs
Simulation of spatial diffusion of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads by use of an agarose gelatin tissue phantom
Phillips, H., Maxwell, E. A., Schaeffer, D. J. & Fan, T. M., Jun 1 2018, In : American journal of veterinary research. 79, 6, p. 592-599 8 p.Research output: Contribution to journal › Article
Calcium Sulfate
calcium sulfate
platinum
Carboplatin
Gelatin
Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1
Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, W., Fan, T. M. & Chan, J. K. F., Aug 22 2018, In : ACS Central Science. 4, 8, p. 1045-1055 11 p.Research output: Contribution to journal › Article
Aldehyde Dehydrogenase
Stem cells
Aldehydes
Fluorescent Dyes
Plasticity
Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma
Svec, R. L., Furiassi, L., Skibinski, C. G., Fan, T. M., Riggins, G. J. & Hergenrother, P., Nov 16 2018, In : ACS chemical biology. 13, 11, p. 3206-3216 11 p.Research output: Contribution to journal › Article
temozolomide
Glioblastoma
Toxicity
Precision Medicine
Halogens
2017
Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma
Thamm, D. H., Vail, D. M., Post, G. S., Fan, T. M., Phillips, B. S., Axiak-Bechtel, S., Elmslie, R. S., Klein, M. K. & Ruslander, D. A., May 1 2017, In : Journal of veterinary internal medicine. 31, 3, p. 872-878 7 p.Research output: Contribution to journal › Article
doxorubicin
lymphoma
Doxorubicin
Canidae
Lymphoma
Combinatorial Discovery of Defined Substrates That Promote a Stem Cell State in Malignant Melanoma
Zhang, D., Lee, J., Sun, M. B., Pei, Y., Chu, J., Gillette, M. L., Fan, T. M. & Kilian, K., May 24 2017, In : ACS Central Science. 3, 5, p. 381-393 13 p.Research output: Contribution to journal › Article
Stem cells
Cells
Peptides
Proteoglycans
Substrates
Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin
Roy, J., Wycislo, K. L., Pondenis, H., Fan, T. M. & Das, A., Sep 1 2017, In : PloS one. 12, 9, e0183930.Research output: Contribution to journal › Article
osteosarcoma
Osteosarcoma
Proteomics
proteomics
Canidae
Melanoma topology reveals a stem-like phenotype that promotes angiogenesis
Lee, J., Abdeen, A. A., Hedhli, J., Wycislo, K. L., Dobrucki, I. T., Fan, T. M., Dobrucki, W. & Kilian, K., Jan 1 2017, In : Science Advances. 3, 10, e1701350.Research output: Contribution to journal › Article
Melanoma
Phenotype
Neoplasms
Integrins
Cues
Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation
for the COG Osteosarcoma Biology Group, Jul 1 2017, In : PloS one. 12, 7, e0181204.Research output: Contribution to journal › Article
Oncology
osteosarcoma
sarcoma
Osteosarcoma
Sarcoma
Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species
Lundberg, A. P., Francis, J. M., Pajak, M., Parkinson, E. I., Wycislo, K. L., Rosol, T. J., Brown, M. E., London, C. A., Dirikolu, L., Hergenrother, P. & Fan, T. M., Apr 1 2017, In : Investigational New Drugs. 35, 2, p. 134-144 11 p.Research output: Contribution to journal › Article
Pharmacokinetics
Felidae
Neoplasms
Squamous Cell Carcinoma
Antineoplastic Agents
Selective in vivo metabolic cell-labeling-mediated cancer targeting
Wang, H., Wang, R., Cai, K., He, H., Liu, Y., Yen, J., Wang, Z., Xu, M., Sun, Y., Zhou, X., Yin, Q., Tang, L., Dobrucki, I. T., Dobrucki, L. W., Chaney, E. J., Boppart, S. A., Fan, T. M., Lezmi, S., Chen, X., Yin, L. & 1 others, , Apr 1 2017, In : Nature chemical biology. 13, 4, p. 415-424 10 p.Research output: Contribution to journal › Article
Neoplasms
Cell Surface Receptors
Click Chemistry
Triple Negative Breast Neoplasms
Cathepsin L
Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients
Joshi, A. D., Botham, R. C., Schlein, L. J., Roth, H. S., Mangraviti, A., Borodovsky, A., Tyler, B., Joslyn, S., Looper, J. S., Podell, M., Fan, T. M., Hergenrother, P. & Riggins, G. J., Jan 1 2017, In : Oncotarget. 8, 46, p. 80124-80138 15 p.Research output: Contribution to journal › Article
temozolomide
Glioma
Caspase 3
Canidae
Rodentia
2016
Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005-2013)
Cesario, L., Garrett, L. D., Barger, A. M., O'Brien, R. T. & Fan, T. M., May 1 2016, In : Australian veterinary journal. 94, 5, p. 160-165 6 p.Research output: Contribution to journal › Article
osteosarcoma
Osteosarcoma
metastasis
Canidae
Neoplasm Metastasis
Downregulation of CXCR4 Expression and Functionality After Zoledronate Exposure in Canine Osteosarcoma
Byrum, M. L., Pondenis, H. C., Fredrickson, R. L., Wycislo, K. L. & Fan, T. M., Jul 1 2016, In : Journal of veterinary internal medicine. 30, 4, p. 1187-1196 10 p.Research output: Contribution to journal › Article
zoledronic acid
osteosarcoma
Osteosarcoma
Canidae
Down-Regulation
Interfacial geometry dictates cancer cell tumorigenicity
Lee, J., Abdeen, A. A., Wycislo, K. L., Fan, T. M. & Kilian, K. A., Aug 1 2016, In : Nature Materials. 15, 8, p. 856-862 7 p.Research output: Contribution to journal › Article
stem cells
Tumors
tumors
cancer
Cells
Protein Biosynthesis
Osteosarcoma
Sirolimus
Phenotype
Neoplasm Metastasis
mTOR inhibition mitigates enhanced mRNA translation associated with the metastatic phenotype of osteosarcoma cells in vivo
Morrow, J. J., Mendoza, A., Koyen, A., Lizardo, M. M., Ren, L., Waybright, T. J., Hansen, R. J., Gustafson, D. L., Zhou, M., Fan, T. M., Scacheri, P. C. & Khanna, C., Dec 15 2016, In : Clinical Cancer Research. 22, 24, p. 6129-6141 13 p.Research output: Contribution to journal › Article
Protein Biosynthesis
Osteosarcoma
Sirolimus
Phenotype
Neoplasm Metastasis
Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis
Yin, Q., Tang, L., Cai, K., Tong, R., Sternberg, R., Yang, X., Dobrucki, L. W., Borst, L. B., Kamstock, D., Song, Z., Helferich, W. G., Cheng, J. & Fan, T. M., Aug 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4601-E4609Research output: Contribution to journal › Article
pamidronate
Nanoconjugates
Osteolysis
Nanoparticles
Doxorubicin
Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs
Larson, J. C., Allstadt, S. D., Fan, T. M., Khanna, C., Lunghofer, P. J., Hansen, R. J., Gustafson, D. L. PHD., Legendre, A. M., Galyon, G. D., LeBlanc, A. K. & Martin-Jimenez, T., Jan 1 2016, In : American journal of veterinary research. 77, 1, p. 65-71 7 p.Research output: Contribution to journal › Article
Sirolimus
pharmacokinetics
Pharmacokinetics
Dogs
dogs
Small-molecule procaspase-3 activation sensitizes cancer to treatment with diverse chemotherapeutics
Botham, R. C., Roth, H. S., Book, A. P., Roady, P. J., Fan, T. M. & Hergenrother, P., Aug 24 2016, In : ACS Central Science. 2, 8, p. 545-559 15 p.Research output: Contribution to journal › Article
Cell death
Caspase 3
Doxorubicin
Toxicity
Tumors
The combination of vemurafenib and procaspase-3 activation is synergistic in mutant BRAF melanomas
Peh, J., Fan, T. M., Wycislo, K. L., Roth, H. S. & Hergenrother, P., Aug 1 2016, In : Molecular Cancer Therapeutics. 15, 8, p. 1859-1869 11 p.Research output: Contribution to journal › Article
Caspase 3
Melanoma
Cell Death
Caspase 1
Mutation
Zoledronate-Associated Osteonecrosis of the Jaw in a Dog with Appendicular Osteosarcoma
Lundberg, A. P., Roady, P. J., Somrak, A. J., Howes, M. E. & Fan, T. M., Jul 1 2016, In : Journal of veterinary internal medicine. 30, 4, p. 1235-1240 6 p.Research output: Contribution to journal › Article
zoledronic acid
Bisphosphonate-Associated Osteonecrosis of the Jaw
Bone Density Conservation Agents
Imidazoles
Dog Diseases
2015
Alkylation and carbamylation effects of lomustine and its major metabolites and MGMT expression in canine cells
Chakkath, T., Lavergne, S., Fan, T. M., Bunick, D. & Dirikolu, L., Jun 1 2015, In : Veterinary Sciences. 2, 2, p. 52-68 17 p.Research output: Contribution to journal › Article
Lomustine
alkylation
methyltransferases
Methyltransferases
Alkylation
A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed
Palchaudhuri, R., Lambrecht, M. J., Botham, R. C., Partlow, K. C., van Ham, T. J., Putt, K. S., Nguyen, L. T., Kim, S. H., Peterson, R. T., Fan, T. M. & Hergenrother, P., Dec 1 2015, In : Cell Reports. 13, 9, p. 2027-2036 10 p.Research output: Contribution to journal › Article
Apoptosis
Molecules
Voltage-Dependent Anion Channels
Mitochondrial Membrane Potential
Cell death
A summary of the osteosarcoma banking efforts: A report from the Children's Oncology Group and the QuadW Foundation
Glover, J., Krailo, M., Tello, T., Marina, N., Janeway, K., Barkauskas, D., Fan, T. M., Gorlick, R. & Khanna, C., Mar 1 2015, In : Pediatric Blood and Cancer. 62, 3, p. 450-455 6 p.Research output: Contribution to journal › Article
Osteosarcoma
Biostatistics
Sarcoma
Therapeutics
Research
Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007)
Coyle, V. J., Rassnick, K. M., Borst, L. B., Rodriguez, C. O., Northrup, N. C., Fan, T. M. & Garrett, L. D., Jun 1 2015, In : Veterinary and comparative oncology. 13, 2, p. 89-97 9 p.Research output: Contribution to journal › Article
osteosarcoma
Osteosarcoma
retrospective studies
Canidae
Retrospective Studies
Canine osteosarcoma cell lines from patients with differing serum alkaline phosphatase concentrations display no behavioural differences in vitro
Holmes, K. E., Thompson, V., Piskun, C. M., Kohnken, R. A., Huelsmeyer, M. K., Fan, T. M. & Stein, T. J., Sep 1 2015, In : Veterinary and comparative oncology. 13, 3, p. 166-175 10 p.Research output: Contribution to journal › Article
osteosarcoma
Osteosarcoma
Alkaline Phosphatase
alkaline phosphatase
Canidae
Direct Capture of Functional Proteins from Mammalian Plasma Membranes into Nanodiscs
Roy, J., Pondenis, H., Fan, T. M. & Das, A., Oct 20 2015, In : Biochemistry. 54, 41, p. 6299-6302 4 p.Research output: Contribution to journal › Article
Cell membranes
Membrane Proteins
Cell Membrane
Proteome
Blood Proteins
Expression of Nociceptive Ligands in Canine Osteosarcoma
Shor, S., Fadl-Alla, B. A., Pondenis, H. C., Zhang, X., Wycislo, K. L., Lezmi, S. & Fan, T. M., Jan 1 2015, In : Journal of veterinary internal medicine. 29, 1, p. 268-275 8 p.Research output: Contribution to journal › Article
osteosarcoma
Osteosarcoma
Canidae
Ligands
pain
Removal of metabolic liabilities enables development of derivatives of procaspase-activating compound 1 (PAC-1) with improved pharmacokinetics
Roth, H. S., Botham, R. C., Schmid, S. C., Fan, T. M., Dirikolu, L. & Hergenrother, P., May 14 2015, In : Journal of Medicinal Chemistry. 58, 9, p. 4046-4065 20 p.Research output: Contribution to journal › Article
Pharmacokinetics
Cell Culture Techniques
Neoplasms
Clinical Trials, Phase I
Liver Microsomes
Targeting tumor vasculature with aptamer-functionalized doxorubicin-polylactide nanoconjugates for enhanced cancer therapy
Tang, L., Tong, R., Coyle, V. J., Yin, Q., Pondenis, H., Borst, L. B., Cheng, J. & Fan, T. M., May 26 2015, In : ACS Nano. 9, 5, p. 5072-5081 10 p.Research output: Contribution to journal › Article
Nanoconjugates
Doxorubicin
Tumors
therapy
tumors
The Association of Endothelin-1 Signaling with Bone Alkaline Phosphatase Expression and Protumorigenic Activities in Canine Osteosarcoma
Neumann, Z. L., Pondenis, H. C., Masyr, A., Byrum, M. L., Wycislo, K. L. & Fan, T. M., Nov 1 2015, In : Journal of veterinary internal medicine. 29, 6, p. 1584-1594 11 p.Research output: Contribution to journal › Article
endothelins
osteosarcoma
Endothelin-1
Osteosarcoma
Alkaline Phosphatase
The Immunotherapy of Canine Osteosarcoma: A Historical and Systematic Review
Wycislo, K. L. & Fan, T. M., May 1 2015, In : Journal of veterinary internal medicine. 29, 3, p. 759-769 11 p.Research output: Contribution to journal › Article
osteosarcoma
immunotherapy
systematic review
Osteosarcoma
Immunotherapy
2014
Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker
Yin, Q., Tong, R., Yin, L., Fan, T. M. & Cheng, J., Mar 7 2014, In : Polymer Chemistry. 5, 5, p. 1581-1585 5 p.Research output: Contribution to journal › Article
Nanoconjugates
Camptothecin
Lactic acid
Esters
Polymerization
Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity
Botham, R. C., Fan, T. M., Im, I., Borst, L. B., Dirikolu, L. & Hergenrother, P., Jan 29 2014, In : Journal of the American Chemical Society. 136, 4, p. 1312-1319 8 p.Research output: Contribution to journal › Article
Enzyme Precursors
Caspase 3
targeting
cancer
Enzymes
Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus)
Watson, M. K., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Leister, K., Kohles, M., Marshall, K. & Mitchell, M. A., Dec 17 2014, In : PloS one. 9, 12, e114413.Research output: Contribution to journal › Article
guinea pigs
ultraviolet radiation
long term effects
Guinea Pigs
Animals
Investigating the optimal size of anticancer nanomedicine
Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., Dobrucki, I. T., Dobrucki, L. W., Borst, L. B., Lezmi, S., Helferich, W. G., Ferguson, A. L., Fan, T. M. & Cheng, J., Oct 28 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15344-15349 6 p.Research output: Contribution to journal › Article
Nanomedicine
Neoplasms
Nanoconjugates
United States Food and Drug Administration
Particle Size
Preliminary metabolism of lomustine in dogs and comparative cytotoxicity of lomustine and its major metabolites in canine cells
Chakkath, T., Lavergne, S. N., Fan, T. M., Bunick, D. & Dirikolu, L., Dec 1 2014, In : Veterinary Sciences. 1, 3, p. 159-173 15 p.Research output: Contribution to journal › Article
Lomustine
cytotoxicity
Canidae
Dogs
metabolites
Pro-tumorigenic effects of transforming growth factor beta 1 in canine osteosarcoma
Portela, R. F., Fadl-Alla, B. A., Pondenis, H. C., Byrum, M. L., Garrett, L. D., Wycislo, K. L., Borst, L. B. & Fan, T. M., Jan 1 2014, In : Journal of veterinary internal medicine. 28, 3, p. 894-904 11 p.Research output: Contribution to journal › Article
transforming growth factor beta 1
osteosarcoma
Osteosarcoma
Transforming Growth Factor beta
Canidae
2013
Association between Absolute Tumor Burden and Serum Bone-Specific Alkaline Phosphatase in Canine Appendicular Osteosarcoma
Sternberg, R. A., Pondenis, H. C., Yang, X., Mitchell, M. A., O'Brien, R. T., Garrett, L. D., Helferich, W. G., Hoffmann, W. E. & Fan, T. M., Jul 1 2013, In : Journal of veterinary internal medicine. 27, 4, p. 955-963 9 p.Research output: Contribution to journal › Article
osteosarcoma
Osteosarcoma
Tumor Burden
Alkaline Phosphatase
alkaline phosphatase
Drug-initiated ring-opening polymerization of O-carboxyanhydrides for the preparation of anticancer drug-poly(O-carboxyanhydride) nanoconjugates
Yin, Q., Tong, R., Xu, Y., Baek, K., Dobrucki, L. W., Fan, T. M. & Cheng, J., Mar 11 2013, In : Biomacromolecules. 14, 3, p. 920-929 10 p.Research output: Contribution to journal › Article
Nanoconjugates
Ring opening polymerization
Pharmaceutical Preparations
docetaxel
Polymers
Estradiol increases ER-negative breast cancer metastasis in an experimental model
Yang, X., Belosay, A., Du, M., Fan, T. M., Turner, R. T., Iwaniec, U. T. & Helferich, W. G., Aug 1 2013, In : Clinical and Experimental Metastasis. 30, 6, p. 711-721 11 p.Research output: Contribution to journal › Article
Estradiol
Theoretical Models
Breast Neoplasms
Neoplasm Metastasis
Neoplasms