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Research Output 1998 2019

2014
Nanoconjugates
Ring opening polymerization

Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus)

Watson, M. K., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Leister, K., Kohles, M., Marshall, K. & Mitchell, M. A., Dec 17 2014, In : PloS one. 9, 12, e114413.

Research output: Contribution to journalArticle

guinea pigs
ultraviolet radiation
long term effects
Guinea Pigs
Animals

Investigating the optimal size of anticancer nanomedicine

Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., Dobrucki, I. T., Dobrucki, L. W., Borst, L. B., Lezmi, S., Helferich, W. G., Ferguson, A. L., Fan, T. M. & Cheng, J., Oct 28 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15344-15349 6 p.

Research output: Contribution to journalArticle

Nanomedicine
Neoplasms
Nanoconjugates
United States Food and Drug Administration
Particle Size

Pain management in veterinary patients with cancer

Fan, T. M., Sep 1 2014, In : The Veterinary clinics of North America. Small animal practice. 44, 5, p. 989-1001 13 p.

Research output: Contribution to journalReview article

Pain Management
pain
Pets
neoplasms
pets

Preliminary metabolism of lomustine in dogs and comparative cytotoxicity of lomustine and its major metabolites in canine cells

Chakkath, T., Lavergne, S. N., Fan, T. M., Bunick, D. & Dirikolu, L., Dec 1 2014, In : Veterinary Sciences. 1, 3, p. 159-173 15 p.

Research output: Contribution to journalArticle

Lomustine
cytotoxicity
Canidae
Dogs
metabolites

Pro-tumorigenic effects of transforming growth factor beta 1 in canine osteosarcoma

Portela, R. F., Fadl-Alla, B. A., Pondenis, H. C., Byrum, M. L., Garrett, L. D., Wycislo, K. L., Borst, L. B. & Fan, T. M., Jan 1 2014, In : Journal of veterinary internal medicine. 28, 3, p. 894-904 11 p.

Research output: Contribution to journalArticle

transforming growth factor beta 1
osteosarcoma
Osteosarcoma
Transforming Growth Factor beta
Canidae

Toward a drug development path that targets metastatic progression in osteosarcoma

Khanna, C., Fan, T. M., Gorlick, R., Helman, L. J., Kleinerman, E. S., Adamson, P. C., Houghton, P. J., Tap, W. D., Welch, D. R., Steeg, P. S., Merlino, G., Sorensen, P. H. B., Meltzer, P., Kirsch, D. G., Janeway, K. A., Weigel, B., Randall, L., Withrow, S. J., Paoloni, M., Kaplan, R. & 12 others, Teicher, B. A., Seibel, N. L., Smith, M., Üren, A., Patel, S. R., Trent, J., Savage, S. A., Mirabello, L., Reinke, D., Barkaukas, D. A., Krailo, M. & Bernstein, M., Aug 15 2014, In : Clinical Cancer Research. 20, 16, p. 4200-4209 10 p.

Research output: Contribution to journalReview article

Osteosarcoma
Neoplasm Metastasis
Pharmaceutical Preparations
Expert Testimony
Neoplasms
2013

Association between Absolute Tumor Burden and Serum Bone-Specific Alkaline Phosphatase in Canine Appendicular Osteosarcoma

Sternberg, R. A., Pondenis, H. C., Yang, X., Mitchell, M. A., O'Brien, R. T., Garrett, L. D., Helferich, W. G., Hoffmann, W. E. & Fan, T. M., Jul 1 2013, In : Journal of veterinary internal medicine. 27, 4, p. 955-963 9 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Tumor Burden
Alkaline Phosphatase
alkaline phosphatase

Drug-initiated ring-opening polymerization of O-carboxyanhydrides for the preparation of anticancer drug-poly(O-carboxyanhydride) nanoconjugates

Yin, Q., Tong, R., Xu, Y., Baek, K., Dobrucki, L. W., Fan, T. M. & Cheng, J., Mar 11 2013, In : Biomacromolecules. 14, 3, p. 920-929 10 p.

Research output: Contribution to journalArticle

Nanoconjugates
Ring opening polymerization
Pharmaceutical Preparations
docetaxel
Polymers

Estradiol increases ER-negative breast cancer metastasis in an experimental model

Yang, X., Belosay, A., Du, M., Fan, T. M., Turner, R. T., Iwaniec, U. T. & Helferich, W. G., Aug 1 2013, In : Clinical and Experimental Metastasis. 30, 6, p. 711-721 11 p.

Research output: Contribution to journalArticle

Estradiol
Theoretical Models
Breast Neoplasms
Neoplasm Metastasis
Neoplasms

Evidence-based medicine: The design and interpretation of noninferiority clinical trials in veterinary medicine

Freise, K. J., Lin, T. L., Fan, T. M., Recta, V. & Clark, T. P., Nov 1 2013, In : Journal of veterinary internal medicine. 27, 6, p. 1305-1317 13 p.

Research output: Contribution to journalReview article

Veterinary Medicine
Evidence-Based Medicine
veterinary medicine
clinical trials
medicine

Feasibility and dose discovery analysis of zoledronic acid with concurrent chemotherapy in the treatment of newly diagnosed metastatic osteosarcoma: A report from the Children's Oncology Group

Goldsby, R. E., Fan, T. M., Villaluna, D., Wagner, L. M., Isakoff, M. S., Meyer, J., Lor Randall, R., Lee, S., Kim, G., Bernstein, M., Gorlick, R., Krailo, M. & Marina, N., Jul 1 2013, In : European Journal of Cancer. 49, 10, p. 2384-2391 8 p.

Research output: Contribution to journalArticle

zoledronic acid
Osteosarcoma
Drug Therapy
Maximum Tolerated Dose
Therapeutics

Just Ask the Expert: Are intact dogs less likely to get cancer?

Fan, T. M., Jun 1 2013, In : Veterinary Medicine. 108, 6

Research output: Contribution to journalComment/debate

Dogs
neoplasms
dogs
Neoplasms

Poly(iohexol) nanoparticles as contrast agents for in vivo X-ray computed tomography imaging

Yin, Q., Yap, F. Y., Yin, L., Ma, L., Zhou, Q., Dobrucki, L. W., Fan, T. M., Gaba, R. C. & Cheng, J., Sep 18 2013, In : Journal of the American Chemical Society. 135, 37, p. 13620-13623 4 p.

Research output: Contribution to journalArticle

Iohexol
X Ray Computed Tomography
Nanoparticles
Contrast Media
tomography

Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates

Tang, L., Gabrielson, N. P., Uckun, F. M., Fan, T. M. & Cheng, J., Mar 11 2013, In : Molecular Pharmaceutics. 10, 3, p. 883-892 10 p.

Research output: Contribution to journalArticle

Nanoconjugates
Nanomedicine
Silicon Dioxide
Pharmaceutical Preparations
Camptothecin
2012

Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

Tang, L., Yang, X., Dobrucki, L. W., Chaudhury, I., Yin, Q., Yao, C., Lezmi, S., Helferich, W. G., Fan, T. M. & Cheng, J., Dec 14 2012, In : Angewandte Chemie - International Edition. 51, 51, p. 12721-12726 6 p.

Research output: Contribution to journalArticle

Nanoconjugates
Silicon Dioxide
Tumors
Silica
Imaging techniques

Bone Resorption Markers and Dual-Energy X-Ray Absorptiometry in Dogs with Avascular Necrosis, Degenerative Joint Disease, and Trauma of the Coxofemoral Joint

Youkhanna, D., Griffon, D. J., Fredericks, P., Schaeffer, D., Fan, T. M. & Jasiuk, I. M., Jul 1 2012, In : Veterinary Surgery. 41, 5, p. 551-558 8 p.

Research output: Contribution to journalArticle

bone resorption
dual-energy X-ray absorptiometry
osteoarthritis
Photon Absorptiometry
Bone Resorption

Cathepsin K expression and activity in Canine osteosarcoma

Schmit, J. M., Pondenis, H. C., Barger, A. M., Borst, L. B., Garrett, L. D., Wypij, J. M., Neumann, Z. L. & Fan, T. M., Jan 1 2012, In : Journal of veterinary internal medicine. 26, 1, p. 126-134 9 p.

Research output: Contribution to journalArticle

cathepsin K
Cathepsin K
osteosarcoma
Osteosarcoma
Canidae

Differential effects of procaspase-3 activating compounds in the induction of cancer cell death

West, D. C., Qin, Y., Peterson, Q. P., Thomas, D. L., Palchaudhuri, R., Morrison, K. C., Lucas, P. W., Palmer, A. E., Fan, T. M. & Hergenrother, P. J., May 7 2012, In : Molecular Pharmaceutics. 9, 5, p. 1425-1434 10 p.

Research output: Contribution to journalArticle

Caspase 3
Cell Death
Neoplasms
Apoptosis
2-carboxyarabinitol 1-phosphate

Polymeric nanomedicines based on poly(lactide) and poly(lactide-co- glycolide)

Tong, R., Gabrielson, N. P., Fan, T. M. & Cheng, J., Dec 2012, In : Current Opinion in Solid State and Materials Science. 16, 6, p. 323-332 10 p.

Research output: Contribution to journalReview article

Nanoconjugates
Medical nanotechnology
Polyglactin 910
Drug delivery
Polyesters

Synthesis and biological response of size-specific, monodisperse drug-silica nanoconjugates

Tang, L., Fan, T. M., Borst, L. B. & Cheng, J., May 22 2012, In : ACS Nano. 6, 5, p. 3954-3966 13 p.

Research output: Contribution to journalArticle

Nanoconjugates
Silicon Dioxide
drugs
Silica
Nanoparticles

Tumors of the Skeletal System

Ehrhart, N. P., Ryan, S. D. & Fan, T. M., Nov 1 2012, Withrow and MacEwen's Small Animal Clinical Oncology: Fifth Edition. Elsevier Inc., p. 463-503 41 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

musculoskeletal system
neoplasms
Neoplasms

Will pamidronate help manage osteosarcoma pain?

Fan, T. M., Jul 2012, In : Veterinary Medicine. 107, 7, p. 299 1 p.

Research output: Contribution to journalComment/debate

pamidronate
osteosarcoma
Osteosarcoma
pain
Pain
2011

An herbal treatment for cancer?

Fan, T. M., May 2011, In : Veterinary Medicine. 106, 5, p. 230 1 p.

Research output: Contribution to journalComment/debate

neoplasms
Neoplasms

Canine and feline nasal tumors

Neumann, Z. L., Fan, T. M. & Looper, J., Aug 2011, In : Veterinary Medicine. 106, 8, p. 402-416 15 p.

Research output: Contribution to journalReview article

Felidae
Nose
Canidae
Cats
Dogs

Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs

Lucas, P. W., Schmit, J. M., Peterson, Q. P., West, D. C., Hsu, D. C., Novotny, C. J., Dirikolu, L., Churchwell, M. I., Doerge, D. R., Garrett, L. D., Hergenrother, P. & Fan, T. M., Oct 1 2011, In : Investigational New Drugs. 29, 5, p. 901-911 11 p.

Research output: Contribution to journalArticle

Caspase 3
Pharmacokinetics
Dogs
Lymphoma
2-carboxyarabinitol 1-phosphate
2010

Animal models of osteosarcoma

Fan, T. M., Aug 1 2010, In : Expert Review of Anticancer Therapy. 10, 8, p. 1327-1338 12 p.

Research output: Contribution to journalReview article

Osteosarcoma
Animal Models
Neoplasms
Osteoblasts
Sarcoma

Biological behavior of oral and perioral mast cell tumors in dogs: 44 cases (1996-2006)

Hillman, L. A., Garrett, L. D., De Lorimier, L. P., Charney, S. C., Borst, L. B. & Fan, T. M., Oct 15 2010, In : Journal of the American Veterinary Medical Association. 237, 8, p. 936-942 7 p.

Research output: Contribution to journalArticle

mast cells
Mast Cells
metastasis
mouth
lymph nodes

Delayed diagnosis of fungal osteomyelitis with early scintigraphic lesions in a dog

De Lorimier, L. P. & Fan, T. M., Dec 1 2010, In : Canadian Veterinary Journal. 51, 12, p. 1394-1396 3 p.

Research output: Contribution to journalArticle

osteomyelitis
Forelimb
Delayed Diagnosis
Osteomyelitis
forelimbs

Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound

Peterson, Q. P., Hsu, D. C., Novotny, C. J., West, D. C., Kim, D., Schmit, J. M., Dirikolu, L., Hergenrother, P. & Fan, T. M., Sep 15 2010, In : Cancer Research. 70, 18, p. 7232-7241 10 p.

Research output: Contribution to journalArticle

Caspase 3
Canidae
Dogs
Caspases
Neoplasms

Effect of leukoreduction on transfusion-induced inflammation in dogs

McMichael, M. A., Smith, S. A., Galligan, A., Swanson, K. S. & Fan, T. M., Sep 1 2010, In : Journal of veterinary internal medicine. 24, 5, p. 1131-1137 7 p.

Research output: Contribution to journalArticle

erythrocytes
Erythrocytes
inflammation
Dogs
Inflammation

In vitro expression of receptor activator of nuclear factor-κB ligand and osteoprotegerin in cultured equine articular cells

Byron, C. R., Barger, A. M., Stewart, A. A., Pondenis, H. C. & Fan, T. M., Jun 1 2010, In : American journal of veterinary research. 71, 6, p. 615-622 8 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteoprotegerin
chondrocytes
Cytoplasmic and Nuclear Receptors
Horses

Polylactide nanoparticles containing stably incorporated cyanine dyes for in vitro and in vivo imaging applications

Tong, R., Coyle, V. J., Tang, L., Barger, A. M., Fan, T. M. & Cheng, J., Sep 1 2010, In : Microscopy research and technique. 73, 9, p. 901-909 9 p.

Research output: Contribution to journalArticle

Nanoparticles
Coloring Agents
Dyes
dyes
Imaging techniques

Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: A comparative oncology study in dogs

Paoloni, M. C., Mazcko, C., Fox, E., Fan, T., Lana, S., Kisseberth, W., Vail, D. M., Nuckolls, K., Osborne, T., Yalkowsy, S., Gustafson, D., Yu, Y., Cao, L. & Khanna, C., Aug 9 2010, In : PloS one. 5, 6, e11013.

Research output: Contribution to journalArticle

Pharmacodynamics
Pharmacokinetics
Oncology
osteosarcoma
pharmacology

The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells

Tong, R., Yala, L., Fan, T. M. & Cheng, J., Apr 1 2010, In : Biomaterials. 31, 11, p. 3043-3053 11 p.

Research output: Contribution to journalArticle

Nanoconjugates
Paclitaxel
Cells
Neoplasms
Polyethylene glycols

Transitional cell carcinoma of the bladder and piroxicam

Fan, T. M., May 1 2010, In : Veterinary Medicine. 105, 5, 1 p.

Research output: Contribution to journalComment/debate

Piroxicam
Transitional Cell Carcinoma
bladder
carcinoma
Urinary Bladder
2009

Double-blind placebo-controlled trial of adjuvant pamidronate with palliative radiotherapy and intravenous doxorubicin for canine appendicular osteosarcoma bone pain

Fan, T. M., Charney, S. C., De Lorimier, L. P., Garrett, L. D., Griffon, D. J., Gordon-Evans, W. J. & Wypij, J. M., Jan 1 2009, In : Journal of veterinary internal medicine. 23, 1, p. 152-160 9 p.

Research output: Contribution to journalArticle

pamidronate
doxorubicin
osteosarcoma
radiotherapy
Osteosarcoma
Osteolysis
Pets
pets
Cats
bones
Lomustine
Canidae
analytical method
Plasmas
High performance liquid chromatography
2008

A comparison of five different bone resorption markers in osteosarcoma-bearing dogs, normal dogs, and dogs with orthopedic diseases

Lucas, P. W., Fan, T. M., Garrett, L. D., Griffon, D. J. & Wypij, J. M., Jul 1 2008, In : Journal of veterinary internal medicine. 22, 4, p. 1008-1013 6 p.

Research output: Contribution to journalArticle

bone resorption
osteosarcoma
orthopedics
Osteosarcoma
Bone Resorption

An update on diagnosing and treating primary lung tumors

Rissetto, K. C., Lucas, P. W. & Fan, T. M., Mar 1 2008, In : Veterinary Medicine. 103, 3

Research output: Contribution to journalReview article

lung neoplasms
Lung
Cats
Dogs
cats
Transforming Growth Factors
Regulatory T-Lymphocytes
T-Lymphocytes
Lymphocytes
Cytokines

Investigating CXCR4 expression in canine appendicular osteosarcoma

Fan, T. M., Barger, A. M., Fredrickson, R. L., Fitzsimmons, D. & Garrett, L. D., May 1 2008, In : Journal of veterinary internal medicine. 22, 3, p. 602-608 7 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Canidae
dogs
metastasis

Investigating TrkA expression in canine appendicular osteosarcoma

Fan, T. M., Barger, A. M., Sprandel, I. T. & Fredrickson, R. L., Sep 1 2008, In : Journal of veterinary internal medicine. 22, 5, p. 1181-1188 8 p.

Research output: Contribution to journalArticle

tropomyosins
osteosarcoma
Osteosarcoma
Canidae
phosphotransferases (kinases)

In vivo and in vitro efficacy of zoledronate for treating oral squamous cell carcinoma in cats

Wypij, J. M., Fan, T. M., Fredrickson, R. L., Barger, A. M., De Lorimier, L. P. & Charney, S. C., Jan 1 2008, In : Journal of veterinary internal medicine. 22, 1, p. 158-163 6 p.

Research output: Contribution to journalArticle

zoledronic acid
squamous cell carcinoma
Squamous Cell Carcinoma
mouth
Cats

The bone biologic effects of zoledronate in healthy dogs and dogs with malignant osteolysis

Fan, T. M., De Lorimier, L. P., Garrett, L. D. & Lacoste, H. I., Mar 1 2008, In : Journal of veterinary internal medicine. 22, 2, p. 380-387 8 p.

Research output: Contribution to journalArticle

zoledronic acid
Osteolysis
bones
Dogs
Bone and Bones
2007

A veterinary medicine interview

Fan, T. M., Apr 2007, In : Veterinary Medicine. 102, 4, p. 224-226 3 p.

Research output: Contribution to journalComment/debate

Veterinary Medicine
veterinary medicine
interviews
Interviews

Enhancing antitumor immunity: Combining IL-12 with TGFβ1 antagonism

Fan, T. M., Kranz, D. M. & Roy, E. J., Jul 1 2007, In : Journal of Immunotherapy. 30, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Interleukin-12
Immunity
T-Lymphocytes
Interferons

Expression of receptor activator of nuclear factor κ-B ligand (RANKL) in neoplasms of dogs and cats

Barger, A. M., Fan, T. M., De Lorimier, L. P., Sprandel, I. T. & O'Dell-Anderson, K., Jan 1 2007, In : Journal of veterinary internal medicine. 21, 1, p. 133-140 8 p.

Research output: Contribution to journalArticle

RANK Ligand
Cytoplasmic and Nuclear Receptors
Cats
Dogs
cats

In vitro cyclooxygenase-2 protein expression and enzymatic activity in neoplastic cells

Heller, D. A., Fan, T. M., De Lorimier, L. P., Charney, S. C., Barger, A. M., Tannehill-Gregg, S. H., Rosol, T. J. & Wallig, M. A., Sep 1 2007, In : Journal of veterinary internal medicine. 21, 5, p. 1048-1055 8 p.

Research output: Contribution to journalArticle

prostaglandin synthase
Cyclooxygenase 2
protein synthesis
Proteins
cell lines