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Research Output 1998 2019

Article

A comparison of five different bone resorption markers in osteosarcoma-bearing dogs, normal dogs, and dogs with orthopedic diseases

Lucas, P. W., Fan, T. M., Garrett, L. D., Griffon, D. J. & Wypij, J. M., Jul 1 2008, In : Journal of veterinary internal medicine. 22, 4, p. 1008-1013 6 p.

Research output: Contribution to journalArticle

bone resorption
osteosarcoma
orthopedics
Osteosarcoma
Bone Resorption

Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J., May 2018, In : Biomaterials Science. 6, 5, p. 1189-1200 12 p.

Research output: Contribution to journalArticle

Nanoconjugates
Tumors
Albumins
Bearings (structural)
Medical nanotechnology

Alkylation and carbamylation effects of lomustine and its major metabolites and MGMT expression in canine cells

Chakkath, T., Lavergne, S., Fan, T. M., Bunick, D. & Dirikolu, L., Jun 1 2015, In : Veterinary Sciences. 2, 2, p. 52-68 17 p.

Research output: Contribution to journalArticle

Lomustine
alkylation
methyltransferases
Methyltransferases
Alkylation

Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma

Thamm, D. H., Vail, D. M., Post, G. S., Fan, T. M., Phillips, B. S., Axiak-Bechtel, S., Elmslie, R. S., Klein, M. K. & Ruslander, D. A., May 1 2017, In : Journal of veterinary internal medicine. 31, 3, p. 872-878 7 p.

Research output: Contribution to journalArticle

doxorubicin
lymphoma
Doxorubicin
Canidae
Lymphoma

Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

Yin, Q., Tong, R., Yin, L., Fan, T. M. & Cheng, J., Mar 7 2014, In : Polymer Chemistry. 5, 5, p. 1581-1585 5 p.

Research output: Contribution to journalArticle

Nanoconjugates
Camptothecin
Lactic acid
Esters
Polymerization

Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides

Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In : Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.

Research output: Contribution to journalArticle

Endocannabinoids
Epoxy Compounds
Cannabinoid Receptors
Docosahexaenoic Acids
Osteosarcoma

An update on diagnosing and treating urinary bladder transitional cell carcinoma in dogs

Heller, D. A., De Lorimier, L. P. & Fan, T. M., Jun 2006, In : Veterinary Medicine. 101, 6, p. 369-380 12 p.

Research output: Contribution to journalArticle

Transitional Cell Carcinoma
bladder
carcinoma
Urinary Bladder
Dogs

Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

Tang, L., Yang, X., Dobrucki, L. W., Chaudhury, I., Yin, Q., Yao, C., Lezmi, S., Helferich, W. G., Fan, T. M. & Cheng, J., Dec 14 2012, In : Angewandte Chemie - International Edition. 51, 51, p. 12721-12726 6 p.

Research output: Contribution to journalArticle

Nanoconjugates
Silicon Dioxide
Tumors
Silica
Imaging techniques

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

Palchaudhuri, R., Lambrecht, M. J., Botham, R. C., Partlow, K. C., van Ham, T. J., Putt, K. S., Nguyen, L. T., Kim, S. H., Peterson, R. T., Fan, T. M. & Hergenrother, P. J., Dec 1 2015, In : Cell Reports. 13, 9, p. 2027-2036 10 p.

Research output: Contribution to journalArticle

Apoptosis
Molecules
Voltage-Dependent Anion Channels
Mitochondrial Membrane Potential
Cell death

Association between Absolute Tumor Burden and Serum Bone-Specific Alkaline Phosphatase in Canine Appendicular Osteosarcoma

Sternberg, R. A., Pondenis, H. C., Yang, X., Mitchell, M. A., O'Brien, R. T., Garrett, L. D., Helferich, W. G., Hoffmann, W. E. & Fan, T. M., Jul 1 2013, In : Journal of veterinary internal medicine. 27, 4, p. 955-963 9 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Tumor Burden
Alkaline Phosphatase
alkaline phosphatase

A summary of the osteosarcoma banking efforts: A report from the Children's Oncology Group and the QuadW Foundation

Glover, J., Krailo, M., Tello, T., Marina, N., Janeway, K., Barkauskas, D., Fan, T. M., Gorlick, R. & Khanna, C., Mar 1 2015, In : Pediatric Blood and Cancer. 62, 3, p. 450-455 6 p.

Research output: Contribution to journalArticle

Osteosarcoma
Biostatistics
Sarcoma
Therapeutics
Research

Biological behavior of oral and perioral mast cell tumors in dogs: 44 cases (1996-2006)

Hillman, L. A., Garrett, L. D., De Lorimier, L. P., Charney, S. C., Borst, L. B. & Fan, T. M., Oct 15 2010, In : Journal of the American Veterinary Medical Association. 237, 8, p. 936-942 7 p.

Research output: Contribution to journalArticle

mast cells
Mast Cells
metastasis
mouth
lymph nodes

Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007)

Coyle, V. J., Rassnick, K. M., Borst, L. B., Rodriguez, C. O., Northrup, N. C., Fan, T. M. & Garrett, L. D., Jun 1 2015, In : Veterinary and comparative oncology. 13, 2, p. 89-97 9 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
retrospective studies
Canidae
Retrospective Studies

Bone metabolic effects of single-dose zoledronate in healthy dogs

De Lorimier, L. P. & Fan, T. M., Nov 1 2005, In : Journal of veterinary internal medicine. 19, 6, p. 924-927 4 p.

Research output: Contribution to journalArticle

zoledronic acid
bones
Dogs
Bone and Bones
dogs

Bone Resorption Markers and Dual-Energy X-Ray Absorptiometry in Dogs with Avascular Necrosis, Degenerative Joint Disease, and Trauma of the Coxofemoral Joint

Youkhanna, D., Griffon, D. J., Fredericks, P., Schaeffer, D., Fan, T. M. & Jasiuk, I. M., Jul 1 2012, In : Veterinary Surgery. 41, 5, p. 551-558 8 p.

Research output: Contribution to journalArticle

bone resorption
dual-energy X-ray absorptiometry
osteoarthritis
Photon Absorptiometry
Bone Resorption

Calcipotriol toxicity in a dog

Fan, T. M., Simpson, K. W., Trasti, S., Birnbaum, N., Center, S. A. & Yeager, A., Dec 1998, In : Journal of Small Animal Practice. 39, 12, p. 581-586 6 p.

Research output: Contribution to journalArticle

Hematemesis
Vitamin D
mineralization
hypervitaminosis D
Dogs

Canine osteosarcoma cell lines from patients with differing serum alkaline phosphatase concentrations display no behavioural differences in vitro

Holmes, K. E., Thompson, V., Piskun, C. M., Kohnken, R. A., Huelsmeyer, M. K., Fan, T. M. & Stein, T. J., Sep 1 2015, In : Veterinary and comparative oncology. 13, 3, p. 166-175 10 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Alkaline Phosphatase
alkaline phosphatase
Canidae

Cathepsin K expression and activity in Canine osteosarcoma

Schmit, J. M., Pondenis, H. C., Barger, A. M., Borst, L. B., Garrett, L. D., Wypij, J. M., Neumann, Z. L. & Fan, T. M., Jan 1 2012, In : Journal of veterinary internal medicine. 26, 1, p. 126-134 9 p.

Research output: Contribution to journalArticle

cathepsin K
Cathepsin K
osteosarcoma
Osteosarcoma
Canidae

Combinatorial Discovery of Defined Substrates That Promote a Stem Cell State in Malignant Melanoma

Zhang, D., Lee, J., Sun, M. B., Pei, Y., Chu, J., Gillette, M. U., Fan, T. M. & Kilian, K. A., May 24 2017, In : ACS Central Science. 3, 5, p. 381-393 13 p.

Research output: Contribution to journalArticle

Stem cells
Cells
Peptides
Proteoglycans
Substrates

Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin

Roy, J., Wycislo, K. L., Pondenis, H., Fan, T. M. & Das, A., Sep 2017, In : PloS one. 12, 9, e0183930.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Proteomics
proteomics
Canidae
Transforming Growth Factors
Regulatory T-Lymphocytes
T-Lymphocytes
Lymphocytes
Cytokines

Delayed diagnosis of fungal osteomyelitis with early scintigraphic lesions in a dog

De Lorimier, L. P. & Fan, T. M., Dec 1 2010, In : Canadian Veterinary Journal. 51, 12, p. 1394-1396 3 p.

Research output: Contribution to journalArticle

osteomyelitis
Forelimb
Delayed Diagnosis
Osteomyelitis
forelimbs

Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005-2013)

Cesario, L., Garrett, L. D., Barger, A. M., O'Brien, R. T. & Fan, T. M., May 1 2016, In : Australian veterinary journal. 94, 5, p. 160-165 6 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
metastasis
Canidae
Neoplasm Metastasis

Differential effects of procaspase-3 activating compounds in the induction of cancer cell death

West, D. C., Qin, Y., Peterson, Q. P., Thomas, D. L., Palchaudhuri, R., Morrison, K. C., Lucas, P. W., Palmer, A. E., Fan, T. M. & Hergenrother, P. J., May 7 2012, In : Molecular Pharmaceutics. 9, 5, p. 1425-1434 10 p.

Research output: Contribution to journalArticle

Caspase 3
Cell Death
Neoplasms
Apoptosis
2-carboxyarabinitol 1-phosphate

Direct Capture of Functional Proteins from Mammalian Plasma Membranes into Nanodiscs

Roy, J., Pondenis, H., Fan, T. M. & Das, A., Oct 20 2015, In : Biochemistry. 54, 41, p. 6299-6302 4 p.

Research output: Contribution to journalArticle

Cell membranes
Membrane Proteins
Cell Membrane
Proteome
Blood Proteins

Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound

Peterson, Q. P., Hsu, D. C., Novotny, C. J., West, D. C., Kim, D., Schmit, J. M., Dirikolu, L., Hergenrother, P. & Fan, T. M., Sep 15 2010, In : Cancer Research. 70, 18, p. 7232-7241 10 p.

Research output: Contribution to journalArticle

Caspase 3
Canidae
Dogs
Caspases
Neoplasms

Double-blind placebo-controlled trial of adjuvant pamidronate with palliative radiotherapy and intravenous doxorubicin for canine appendicular osteosarcoma bone pain

Fan, T. M., Charney, S. C., De Lorimier, L. P., Garrett, L. D., Griffon, D. J., Gordon-Evans, W. J. & Wypij, J. M., Jan 1 2009, In : Journal of veterinary internal medicine. 23, 1, p. 152-160 9 p.

Research output: Contribution to journalArticle

pamidronate
doxorubicin
osteosarcoma
radiotherapy
Osteosarcoma

Downregulation of CXCR4 Expression and Functionality After Zoledronate Exposure in Canine Osteosarcoma

Byrum, M. L., Pondenis, H. C., Fredrickson, R. L., Wycislo, K. L. & Fan, T. M., Jul 1 2016, In : Journal of veterinary internal medicine. 30, 4, p. 1187-1196 10 p.

Research output: Contribution to journalArticle

zoledronic acid
osteosarcoma
Osteosarcoma
Canidae
Down-Regulation

Drug-initiated ring-opening polymerization of O-carboxyanhydrides for the preparation of anticancer drug-poly(O-carboxyanhydride) nanoconjugates

Yin, Q., Tong, R., Xu, Y., Baek, K., Dobrucki, L. W., Fan, T. M. & Cheng, J., Mar 11 2013, In : Biomacromolecules. 14, 3, p. 920-929 10 p.

Research output: Contribution to journalArticle

Nanoconjugates
Ring opening polymerization
Pharmaceutical Preparations
docetaxel
Polymers

Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity

Botham, R. C., Fan, T. M., Im, I., Borst, L. B., Dirikolu, L. & Hergenrother, P. J., Jan 29 2014, In : Journal of the American Chemical Society. 136, 4, p. 1312-1319 8 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Caspase 3
targeting
cancer
Enzymes

Effect of leukoreduction on transfusion-induced inflammation in dogs

McMichael, M. A., Smith, S. A., Galligan, A., Swanson, K. S. & Fan, T. M., Sep 1 2010, In : Journal of veterinary internal medicine. 24, 5, p. 1131-1137 7 p.

Research output: Contribution to journalArticle

erythrocytes
Erythrocytes
inflammation
Dogs
Inflammation

Enhancing antitumor immunity: Combining IL-12 with TGFβ1 antagonism

Fan, T. M., Kranz, D. M. & Roy, E. J., Jul 1 2007, In : Journal of Immunotherapy. 30, 5, p. 479-489 11 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Interleukin-12
Immunity
T-Lymphocytes
Interferons

Estradiol increases ER-negative breast cancer metastasis in an experimental model

Yang, X., Belosay, A., Du, M., Fan, T. M., Turner, R. T., Iwaniec, U. T. & Helferich, W. G., Aug 1 2013, In : Clinical and Experimental Metastasis. 30, 6, p. 711-721 11 p.

Research output: Contribution to journalArticle

Estradiol
Theoretical Models
Breast Neoplasms
Neoplasm Metastasis
Neoplasms

Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus)

Watson, M. K., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Leister, K., Kohles, M., Marshall, K. & Mitchell, M. A., Dec 17 2014, In : PloS one. 9, 12, e114413.

Research output: Contribution to journalArticle

guinea pigs
ultraviolet radiation
long term effects
Guinea Pigs
Animals

EVALUATING THE CLINICAL AND PHYSIOLOGICAL EFFECTS OF LONG-TERM ULTRAVIOLET B RADIATION ON RABBITS (ORYCTOLAGUS CUNICULUS)

Watson, M. K., Mitchell, M. A., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Cavaretta, M., Kohles, M. & Marshall, K., Jan 2019, In : Journal of Exotic Pet Medicine. 28, p. 43-55 13 p.

Research output: Contribution to journalArticle

Oryctolagus cuniculus
ultraviolet radiation
long term effects
rabbits
Radiation

Evaluation of intravenous pamidronate administration in 33 cancer-bearing dogs with primary or secondary bone involvement

Fan, T. M., De Lorimier, L. P., Charney, S. C. & Hintermeister, J. G., Jan 1 2005, In : Journal of veterinary internal medicine. 19, 1, p. 74-80 7 p.

Research output: Contribution to journalArticle

pamidronate
intravenous injection
Intravenous Administration
bones
Dogs

Expression of Nociceptive Ligands in Canine Osteosarcoma

Shor, S., Fadl-Alla, B. A., Pondenis, H. C., Zhang, X., Wycislo, K. L., Lezmi, S. & Fan, T. M., Jan 1 2015, In : Journal of veterinary internal medicine. 29, 1, p. 268-275 8 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Canidae
Ligands
pain

Expression of receptor activator of nuclear factor κ-B ligand (RANKL) in neoplasms of dogs and cats

Barger, A. M., Fan, T. M., De Lorimier, L. P., Sprandel, I. T. & O'Dell-Anderson, K., Jan 1 2007, In : Journal of veterinary internal medicine. 21, 1, p. 133-140 8 p.

Research output: Contribution to journalArticle

RANK Ligand
Cytoplasmic and Nuclear Receptors
Cats
Dogs
cats

Feasibility and dose discovery analysis of zoledronic acid with concurrent chemotherapy in the treatment of newly diagnosed metastatic osteosarcoma: A report from the Children's Oncology Group

Goldsby, R. E., Fan, T. M., Villaluna, D., Wagner, L. M., Isakoff, M. S., Meyer, J., Lor Randall, R., Lee, S., Kim, G., Bernstein, M., Gorlick, R., Krailo, M. & Marina, N., Jul 1 2013, In : European Journal of Cancer. 49, 10, p. 2384-2391 8 p.

Research output: Contribution to journalArticle

zoledronic acid
Osteosarcoma
Drug Therapy
Maximum Tolerated Dose
Therapeutics

Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells

Roy, J., Dibaeinia, P., Fan, T. M., Sinha, S. & Das, A., Jan 1 2019, In : Journal of Lipid Research. 60, 2, p. 375-387 13 p.

Research output: Contribution to journalArticle

Osteosarcoma
Lipids
Diglycerides
Bone Neoplasms
Sphingolipids

Hematological toxicity and therapeutic efficacy of lomustine in 20 tumor-bearing cats: Critical assessment of a practical dosing regimen

Fan, T. M., Kitchell, B. E., Dhaliwal, R. S., Jones, P. D., Hintermeister, J. G. & Paria, B. C., Jan 1 2002, In : Journal of the American Animal Hospital Association. 38, 4, p. 357-363 7 p.

Research output: Contribution to journalArticle

Lomustine
Cats
cats
toxicity
therapeutics

Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. & Fan, T. M., Jan 1 2019, In : Frontiers in Oncology. 9, FEB, 96.

Research output: Contribution to journalArticle

Open Access
Brain Neoplasms
Caspase 3
Canidae
Meningioma
Glioma

Interfacial geometry dictates cancer cell tumorigenicity

Lee, J., Abdeen, A. A., Wycislo, K. L., Fan, T. M. & Kilian, K. A., Aug 1 2016, In : Nature Materials. 15, 8, p. 856-862 7 p.

Research output: Contribution to journalArticle

stem cells
Tumors
tumors
cancer
Cells

Intestinal haemorrhage associated with colonic vascular ectasia (angiodysplasia) in a dog

Fan, T. M., Simpson, K. W., Polack, E., Dykes, N. & Harvey, J., Jan 1999, In : Journal of Small Animal Practice. 40, 1, p. 25-30 6 p.

Research output: Contribution to journalArticle

Angiodysplasia
Pathologic Dilatations
blood vessels
hemorrhage
Blood Vessels
Osteolysis
Pets
pets
Cats
bones

Investigating CXCR4 expression in canine appendicular osteosarcoma

Fan, T. M., Barger, A. M., Fredrickson, R. L., Fitzsimmons, D. & Garrett, L. D., May 1 2008, In : Journal of veterinary internal medicine. 22, 3, p. 602-608 7 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Canidae
dogs
metastasis

Investigating the optimal size of anticancer nanomedicine

Tang, L., Yang, X., Yin, Q., Cai, K., Wang, H., Chaudhury, I., Yao, C., Zhou, Q., Kwon, M., Hartman, J. A., Dobrucki, I. T., Dobrucki, L. W., Borst, L. B., Lezmi, S., Helferich, W. G., Ferguson, A. L., Fan, T. M. & Cheng, J., Oct 28 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 43, p. 15344-15349 6 p.

Research output: Contribution to journalArticle

Nanomedicine
Neoplasms
Nanoconjugates
United States Food and Drug Administration
Particle Size

Investigating TrkA expression in canine appendicular osteosarcoma

Fan, T. M., Barger, A. M., Sprandel, I. T. & Fredrickson, R. L., Sep 1 2008, In : Journal of veterinary internal medicine. 22, 5, p. 1181-1188 8 p.

Research output: Contribution to journalArticle

tropomyosins
osteosarcoma
Osteosarcoma
Canidae
phosphotransferases (kinases)

In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin

Maxwell, E. A., Phillips, H., Schaeffer, D. J. & Fan, T. M., Feb 1 2018, In : Veterinary Surgery. 47, 2, p. 219-226 8 p.

Research output: Contribution to journalArticle

injection site
Carboplatin
Felidae
sarcoma
calcium sulfate

In vitro cyclooxygenase-2 protein expression and enzymatic activity in neoplastic cells

Heller, D. A., Fan, T. M., De Lorimier, L. P., Charney, S. C., Barger, A. M., Tannehill-Gregg, S. H., Rosol, T. J. & Wallig, M. A., Sep 1 2007, In : Journal of veterinary internal medicine. 21, 5, p. 1048-1055 8 p.

Research output: Contribution to journalArticle

prostaglandin synthase
Cyclooxygenase 2
protein synthesis
Proteins
cell lines