Timothy M Fan

Search results

• 2022

  Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer

  Boudreau, M. W., Mulligan, M. P., Shapiro, D. J., Fan, T. M. & Hergenrother, P. J., Mar 10 2022, In: Journal of Medicinal Chemistry. 65, 5, p. 3894-3912 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Unfolded Protein Response 100%
  • Estrogen 86%
  • Estrogen Receptors 75%
  • Aromatase Inhibitor 59%
  • Breast Neoplasms 51%

• Acute phase protein concentrations following serial procaine penicillin G injections in horses

  Gordon, D. L., Foreman, J. H., Connolly, S. L., Schnelle, A. N., Fan, T. M. & Barger, A. M., Oct 6 2022, (E-pub ahead of print) In: Equine veterinary journal.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Penicillin G Procaine 100%
  • procaine 83%
  • acute phase proteins 80%
  • benzylpenicillin 74%
  • Acute-Phase Proteins 72%

• Characterization of Anti-Angiogenic Chemo-Sensitization via Longitudinal Ultrasound Localization Microscopy in Colorectal Carcinoma Tumor Xenografts

  Lowerison, M., Zhang, W., Chen, X., Fan, T. & Song, P., Apr 2022, In: IEEE Transactions on Biomedical Engineering. 69, 4, p. 1449 - 1460 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Heterografts 100%
  • Microscopic examination 58%
  • Tumors 55%
  • Chemotherapy 48%
  • Ultrasonics 45%

• Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs

  LeBlanc, A. K., Mazcko, C. N., Fan, T. M., Vail, D. M., Flesner, B. K., Bryan, J. N., Li, S., Wang, F., Harris, S., Vargas, J. D., Govindharajulu, J. P., Jaganathan, S., Tomaino, F., Srivastava, A. K., Chou, T. F., Stott, G. M., Covey, J. M., Mroczkowski, B. & Doroshow, J. H., Oct 2022, In: Molecular Cancer Therapeutics. 21, 10, p. 1510-1523 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Valosin Containing Protein 100%
  • Dogs 44%
  • Multiple Myeloma 30%
  • Pets 23%
  • Neoplasms 19%

• Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants

  Zhang, L., Dutta, S., Xiong, S., Chan, M., Chan, K. K., Fan, T. M., Bailey, K. L., Lindeblad, M., Cooper, L. M., Rong, L., Gugliuzza, A. F., Shukla, D., Procko, E., Rehman, J. & Malik, A. B., Mar 2022, In: Nature chemical biology. 18, 3, p. 342-351 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • angiotensin converting enzyme 2 100%
  • Severe Acute Respiratory Syndrome 86%
  • Coronavirus 84%
  • Lung Injury 70%
  • S protein, severe acute respiratory syndrome coronavirus 32%

• Investigating PSMA differential expression in canine uroepithelial carcinomas to aid disease-based stratification and guide therapeutic selection

  Berry, M. R., Fadl-Alla, B. A., Samuelson, J., Rosol, T. J. & Fan, T. M., Dec 2022, In: BMC Veterinary Research. 18, 1, 441.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • prostatic neoplasms 100%
  • carcinoma 77%
  • Prostate-Specific Antigen 74%
  • Canidae 63%
  • therapeutics 56%

• Mitigation of SARS-CoV-2 transmission at a large public university

  Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Fredrickson, R. L., Wang, T., Wong, G. N., Uelmen, J., Maslov, S., Weiner, Z. J., Tkachenko, A. V., Zhang, H., Liu, Z., Ibrahim, A., Patel, S. J., Paul, J. M., Vance, N. P., Gulick, J. G., Satheesan, S. P., & 129 othersGalvan, I. J., Miller, A., Grohens, J., Nelson, T. J., Stevens, M. P., Hennessy, P. M., Parker, R. C., Santos, E., Brackett, C., Steinman, J. D., Fenner, M. R., Dohrer, K., Delorenzo, M., Wilhelm-barr, L., Brauer, B. R., Best-popescu, C., Durack, G., Wetter, N., Kranz, D. M., Breitbarth, J., Simpson, C., Pryde, J. A., Kaler, R. N., Harris, C., Vance, A. C., Silotto, J. L., Johnson, M., Valera, E. A., Anton, P. K., Mwilambwe, L., Bryan, S. P., Stone, D. S., Young, D. B., Ward, W. E., Lantz, J., Vozenilek, J. A., Bashir, R., Moore, J. S., Garg, M., Cooper, J. C., Snyder, G., Lore, M. H., Yocum, D. L., Cohen, N. J., Novakofski, J. E., Loots, M. J., Ballard, R. L., Band, M., Banks, K. M., Barnes, J. D., Bentea, I., Black, J., Busch, J., Conte, A., Conte, M., Curry, M., Eardley, J., Edwards, A., Eggett, T., Fleurimont, J., Foster, D., Fouke, B. W., Gallagher, N., Gastala, N., Genung, S. A., Glueck, D., Gray, B., Greta, A., Healy, R. M., Hetrick, A., Holterman, A. A., Ismail, N., Jasenof, I., Kelly, P., Kielbasa, A., Kiesel, T., Kindle, L. M., Lipking, R. L., Manabe, Y. C., Mayes, J. ., Mcguffin, R., Mchenry, K. G., Mirza, A., Moseley, J., Mostafa, H. H., Mumford, M., Munoz, K., Murray, A. D., Nolan, M., Parikh, N. A., Pekosz, A., Pflugmacher, J., Phillips, J. M., Pitts, C., Potter, M. C., Quisenberry, J., Rear, J., Robinson, M. L., Rosillo, E., Rye, L. N., Sherwood, M., Simon, A., Singson, J. M., Skadden, C., Skelton, T. H., Smith, C., Stech, M., Thomas, R., Tomaszewski, M. A., Tyburski, E. A., Vanwingerden, S., Vlach, E., Watkins, R. S., Watson, K., White, K. C., Killeen, T. L., Jones, R. J., Cangellaris, A. C., Martinis, S. A., Vaid, A., Brooke, C. B., Walsh, J. T., Elbanna, A., Sullivan, W. C., Smith, R. L., Goldenfeld, N., Fan, T. M., Hergenrother, P. J. & Burke, M. D., Dec 2022, In: Nature communications. 13, 1, 3207.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Compliance 81%
  • Communication 61%
  • Accidental Falls 26%
  • saliva 20%

• Novel Imidazotetrazine Evades Known Resistance Mechanisms and Is Effective against Temozolomide-Resistant Brain Cancer in Cell Culture

  Svec, R. L., Mckee, S. A., Berry, M. R., Kelly, A. M., Fan, T. M. & Hergenrother, P. J., Feb 18 2022, In: ACS chemical biology. 17, 2, p. 299–313 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide 63%
  • Glioblastoma 50%
  • Brain Neoplasms 47%
  • Maximum Tolerated Dose 43%
  • Cell Culture Techniques 38%

• Novel immunotherapy offers promising weapon against canine melanoma

  Fan, T. M., Garrett, L. D., Selting, K. A. & Constable, P. D., Oct 2022, In: American journal of veterinary research. 83, 10

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

• Osteosarcoma mechanobiology and therapeutic targets

  Shoaib, Z., Fan, T. M. & Irudayaraj, J. M. K., Jan 2022, In: British Journal of Pharmacology. 179, 2, p. 201-217 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Biophysics 100%
  • Osteosarcoma 76%
  • Bone and Bones 26%
  • Osteitis Deformans 20%
  • Neoplasm Metastasis 18%

• Phase I study of procaspase-activating compound-1 (PAC-1) in the treatment of advanced malignancies

  Danciu, O. C., Holdhoff, M., Peterson, R. A., Fischer, J. H., Liu, L. C., Wang, H., Venepalli, N. K., Chowdhery, R., Nicholas, M. K., Russell, M. J., Fan, T. M., Hergenrother, P. J., Tarasow, T. M. & Dudek, A. Z., 2022, (Accepted/In press) In: British Journal of Cancer.

  Research output: Contribution to journal › Article › peer-review

  • Nervous System 100%
  • Neuroendocrine Tumors 92%
  • Caspase 3 72%
  • Pharmacokinetics 61%
  • Clinical Trials 53%

• Saliva-based Molecular Testing For SARS-CoV-2

  Burke, M. D., Fan, T. M., Hergenrother, P. J., Brooke, C. B., Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J. & Wang, L., Dec 20 2022, U.S. Patent No. 11530457

  Research output: Patent

• Target-Agnostic P-Glycoprotein Assessment Yields Strategies to Evade Efflux, Leading to a BRAF Inhibitor with Intracranial Efficacy

  Kelly, A. M., Berry, M. R., Tasker, S. Z., McKee, S. A., Fan, T. M. & Hergenrother, P. J., Jul 13 2022, In: Journal of the American Chemical Society. 144, 27, p. 12367-12380 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Dabrafenib 100%
  • Blood-Brain Barrier 90%
  • Glycoproteins 87%
  • Intracranial 81%
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 56%

• The use of alkaline phosphatase and runx2 to distinguish osteosarcoma from other common malignant primary bone tumors in dogs

  Barger, A., Baker, K., Driskell, E., Sander, W., Roady, P., Berry, M., Schnelle, A. & Fan, T. M., May 2022, In: Veterinary pathology. 59, 3, p. 427-432 6 p.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma 100%
  • Osteosarcoma 72%
  • alkaline phosphatase 62%
  • Alkaline Phosphatase 61%
  • bones 58%

• Three-dimensional hydrogel culture systems support growth and determination of chemosensitivity of feline sarcoma and carcinoma cell lines

  Cavalcanti, J. V. J., Selting, K. A., Ngo, M. T., Hoang, C. K. T., Schaeffer, D. J., Fan, T. M., Harley, B. A. C. & Phillips, H., 2022, In: American journal of veterinary research. 83, 6

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • support systems 100%
  • sarcoma 95%
  • Felidae 91%
  • hydrogels 90%
  • Carboplatin 89%
• 2021

  A 10% Tomato Diet Selectively Reduces Radiation-Induced Damage in TRAMP Mice

  Rowles, J. L., Wallig, M. A., Selting, K. A., Fan, T. M., Miller, R. J., O'Brien, W. D. & Erdman, J. W., Nov 1 2021, In: The Journal of nutrition. 151, 11, p. 3421-3430 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Lycopersicon esculentum 100%
  • Transgenic Mice 64%
  • Ointments 63%
  • Prostate 60%
  • Adenocarcinoma 56%

• Adjuvant sirolimus does not improve outcome in pet dogs receiving standard-of-care therapy for appendicular osteosarcoma: A prospective, randomized trial of 324 dogs

  LeBlanc, A. K., Mazcko, C. N., Cherukuri, A., Berger, E. P., Kisseberth, W. C., Brown, M. E., Lana, S. E., Weishaar, K., Flesner, B. K., Bryan, J. N., Vail, D. M., Burton, J. H., Willcox, J. L., Mutsaers, A. J., Woods, J. P., Northrup, N. C., Saba, C., Curran, K. M., Leeper, H., Wilson-Robles, H., & 24 othersWustefeld-Janssens, B. G., Lindley, S., Smith, A. N., Dervisis, N., Klahn, S., Higginbotham, M. L., Wouda, R. M., Krick, E., Mahoney, J. A., London, C. A., Barber, L. G., Balkman, C. E., McCleary-Wheeler, A. L., Suter, S. E., Martin, O., Borgatti, A., Burgess, K., Childress, M. O., Fidel, J. L., Allstadt, S. D., Gustafson, D. L., Selmic, L. E., Khanna, C. & Fan, T. M., Jun 1 2021, In: Clinical Cancer Research. 27, 11, p. 3005-3016 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Pets 100%
  • Sirolimus 92%
  • Osteosarcoma 91%
  • Standard of Care 84%
  • Dogs 63%

• A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice

  Boudreau, M. W., Duraki, D., Wang, L., Mao, C., Kim, J. E., Henn, M. A., Tang, B., Fanning, S. W., Kiefer, J., Tarasow, T. M., Bruckheimer, E. M., Moreno, R., Mousses, S., Greene, G. L., Roy, E. J., Park, B. H., Fan, T. M., Nelson, E. R., Hergenrother, P. J. & Shapiro, D. J., Jul 21 2021, In: Science Translational Medicine. 13, 603, eabf1383.

  Research output: Contribution to journal › Article › peer-review

  • Unfolded Protein Response 100%
  • Breast Neoplasms 51%
  • Estrogen Receptors 45%
  • Neoplasm Metastasis 39%
  • Heterografts 28%

• Cancer-Immunity Cycle and Therapeutic Interventions- Opportunities for Including Pet Dogs With Cancer

  Von Rueden, S. K. & Fan, T. M., Nov 19 2021, In: Frontiers in Oncology. 11, 773420.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Immunity 100%
  • Dogs 88%
  • Neoplasms 39%
  • Therapeutics 20%
  • Tumor Microenvironment 16%

• Evaluation of a Procaspase-3 Activator with Hydroxyurea or Temozolomide Against High-grade Meningioma in Cell Culture and Canine Cancer Patients

  Tonogai, E. J., Huang, S., Botham, R. C., Berry, M. R., Joslyn, S. K., Daniel, G. B., Chen, Z., Rao, J., Zhang, X., Basuli, F., Rossmeisl, J. H., Riggins, G. J., LeBlanc, A. K., Fan, T. M. & Hergenrother, P. J., Oct 1 2021, In: Neuro-Oncology. 23, 10, p. 1723-1735 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Temozolomide 100%
  • Hydroxyurea 97%
  • Meningioma 87%
  • Caspase 3 71%
  • Canidae 70%

• Pharmacokinetics of a cytosine arabinoside subcutaneous protocol in dogs with meningoencephalomyelitis of unknown aetiology

  Levitin, H. A., Foss, K. D., Li, Z., Reinhart, J. M., Hague, D. W. & Fan, T. M., Sep 2021, In: Journal of Veterinary Pharmacology and Therapeutics. 44, 5, p. 696-704 9 p.

  Research output: Contribution to journal › Article › peer-review

  • meningoencephalitis 100%
  • Cytarabine 80%
  • cytosine 77%
  • etiology 73%
  • pharmacokinetics 69%

• Procaspase 3 activation by combination therapy

  Handley, M. K., Joshi, A., Fan, T. M., Hergenrother, P. J., Roth, H. S., Gilbert, M. J., Botham, R. C., Riggins, G. J. & Deering, A., Jan 12 2021, U.S. Patent No. 10888560, Oct 1 2018

  Research output: Patent

  • Neurotoxicity 58%

• Target-Based Radiosensitization Strategies: Concepts and Companion Animal Model Outlook

  Berry, M. R. & Fan, T. M., Oct 20 2021, In: Frontiers in Oncology. 11, 768692.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Pets 100%
  • Animal Models 62%
  • Radiotherapy 37%
  • Neoplasms 28%
  • Ionizing Radiation 22%

• Utilizing feline oral squamous cell carcinoma patients to develop NQO1-targeted therapy

  Lundberg, A. P., Boudreau, M. W., Selting, K. A., Chatkewitz, L. E., Samuelson, J., Francis, J. M., Parkinson, E. I., Barger, A. M., Hergenrother, P. J. & Fan, T. M., Aug 2021, In: Neoplasia (United States). 23, 8, p. 811-822 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Felidae 100%
  • Squamous Cell Carcinoma 73%
  • Squamous Cell Carcinoma of Head and Neck 48%
  • Oxidoreductases 26%
  • Radiotherapy 20%
• 2020

  Pharmacokinetics of platinum and safety evaluation of carboplatin-impregnated calcium sulfate hemihydrate beads after implantation in healthy cats

  Maxwell, E. A., Phillips, H., Clark-Price, S. C., Vieson, M. D., Selmic, L. E., Schaeffer, D. J. & Fan, T. M., May 1 2020, In: Veterinary Surgery. 49, 4, p. 748-757 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Sulfate 100%
  • calcium sulfate 97%
  • platinum 88%
  • Carboplatin 80%
  • Platinum 75%

• Procaspase combination therapy for glioblastoma

  Handley, M. K., Joshi, A., Fan, T. M., Hergenrother, P. J., Roth, H. S., Gilbert, M. J., Botham, R. C., Riggins, G. J. & Deering, A., Dec 29 2020, U.S. Patent No. 10874666, Oct 1 2018

  Research output: Patent

  • Neurotoxicity 58%

• Rabacfosadine for naïve canine intermediate to large cell lymphoma: Efficacy and adverse event profile across three prospective clinical trials

  Saba, C. F., Clifford, C., Burgess, K., Phillips, B., Vail, D., Wright, Z., Curran, K., Fan, T., Elmslie, R., Post, G. & Thamm, D., Dec 2020, In: Veterinary and comparative oncology. 18, 4, p. 763-769 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • rabacfosadine 100%
  • prospective studies 58%
  • lymphoma 52%
  • Canidae 39%
  • Lymphoma 37%

• Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction

  Ranoa, D. R. E., Holland, R. L., Alnaji, F. G., Green, K. J., Wang, L., Brooke, C. B., Burke, M., Fan, T. M. & Hergenrother, P., Jun 18 2020, (In preparation) Cold Spring Harbor Laboratory Press, 35 p. (bioRxiv).

  Research output: Working paper

  • SARS Virus 100%
  • Saliva 66%
  • RNA 47%
  • Pandemics 28%
  • Personal Protective Equipment 18%

• Understanding and Modeling Metastasis Biology to Improve Therapeutic Strategies for Combating Osteosarcoma Progression

  Fan, T. M., Roberts, R. D. & Lizardo, M. M., Jan 31 2020, In: Frontiers in Oncology. 10, 13.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Osteosarcoma 100%
  • Neoplasm Metastasis 59%
  • Pets 48%
  • Dogs 30%
  • Cues 18%
• 2019

  EVALUATING THE CLINICAL AND PHYSIOLOGICAL EFFECTS OF LONG-TERM ULTRAVIOLET B RADIATION ON RABBITS (ORYCTOLAGUS CUNICULUS)

  Watson, M. K., Mitchell, M. A., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Cavaretta, M., Kohles, M. & Marshall, K., Jan 2019, In: Journal of Exotic Pet Medicine. 28, p. 43-55 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Oryctolagus cuniculus 100%
  • long term effects 77%
  • ultraviolet radiation 71%
  • Rabbits 56%
  • rabbits 53%

• Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells

  Roy, J., Dibaeinia, P., Fan, T. M., Sinha, S. & Das, A., 2019, In: Journal of Lipid Research. 60, 2, p. 375-387 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Lipidomics 100%
  • Osteosarcoma 76%
  • Lipid 50%
  • Lipids 48%
  • Diglycerides 25%

• Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

  Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. J. & Fan, T. M., 2019, In: Frontiers in Oncology. 9, FEB, 96.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Neoplasms 100%
  • Caspase 3 95%
  • Canidae 93%
  • Meningioma 19%
  • Comparative Histology 16%

• Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions

  Dowling, M., Samuelson, J., Fadl-Alla, B., Pondenis, H. C., Byrum, M., Barger, A. M. & Fan, T. M., Jan 2019, In: PloS one. 14, 1, e0210297.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • hemangiosarcoma 100%
  • burden of disease 83%
  • body cavities 73%
  • Hemangiosarcoma 71%
  • Prostate-Specific Antigen 58%

• Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group

  Roberts, R. D., Lizardo, M. M., Reed, D. R., Hingorani, P., Glover, J., Allen-Rhoades, W., Fan, T., Khanna, C., Sweet-Cordero, E. A., Cash, T., Bishop, M. W., Hegde, M., Sertil, A. R., Koelsche, C., Mirabello, L., Malkin, D., Sorensen, P. H., Meltzer, P. S., Janeway, K. A., Gorlick, R., & 1 othersCrompton, B. D., Oct 15 2019, In: Cancer. 125, 20, p. 3514-3525 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Osteosarcoma 100%
  • Child 41%
  • Lung Diseases 28%
  • Epigenomics 27%
  • Organizations 26%
• 2018

  Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

  Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, L. W., Helferich, W. G., Fan, T. M. & Cheng, J., May 2018, In: Biomaterials Science. 6, 5, p. 1189-1200 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Nanoconjugates 100%
  • Nanoconjugate 58%
  • Tumors 40%
  • Heterografts 18%
  • Decoration 14%

• Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides

  Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In: Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Endocannabinoid 84%
  • Epoxy Compounds 75%
  • Cannabinoid 70%
  • Endocannabinoids 68%
  • Epoxide 49%

• Exploring the Potential Utility of Pet Dogs With Cancer for Studying Radiation-Induced Immunogenic Cell Death Strategies

  Fan, T. M. & Selting, K. A., 2018, In: Frontiers in Oncology. 8, p. 680

  Research output: Contribution to journal › Review article › peer-review

  • Immunogenic Cell Death 100%
  • Radiation-Induced Neoplasms 95%
  • Pets 72%
  • Dogs 45%
  • Radiotherapy 37%

• In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin

  Maxwell, E. A., Phillips, H., Schaeffer, D. J. & Fan, T. M., Feb 1 2018, In: Veterinary Surgery. 47, 2, p. 219-226 8 p.

  Research output: Contribution to journal › Article › peer-review

  • injection site 100%
  • sarcoma 92%
  • Felidae 88%
  • Carboplatin 86%
  • calcium sulfate 83%

• NCI comparative oncology program testing of non-camptothecin indenoisoquinoline topoisomerase I inhibitors in naturally occurring canine lymphoma

  Burton, J. H., Mazcko, C., LeBlanc, A., Covey, J. M., Ji, J., Kinders, R. J., Parchment, R. E., Khanna, C., Paoloni, M., Lana, S., Weishaar, K., London, C., Kisseberth, W., Krick, E., Vail, D., Childress, M., Bryan, J. N., Barber, L., Ehrhart, E. J., Kent, M., & 11 othersFan, T., Kow, K., Northup, N., Wilson-Robles, H., Tomaszewski, J., Holleran, J. L., Muzzio, M., Eiseman, J., Beumer, J. H., Doroshow, J. H. & Pommier, Y., Dec 1 2018, In: Clinical Cancer Research. 24, 23, p. 5830-5840 11 p.

  Research output: Contribution to journal › Article › peer-review

  • NSC 724998 100%
  • Topoisomerase I Inhibitors 89%
  • indimitecan 72%
  • Canidae 54%
  • Lymphoma 51%

• Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research

  Overgaard, N. H., Fan, T. M., Schachtschneider, K. M., Principe, D. R., Schook, L. B. & Jungersen, G., Dec 31 2018, In: ILAR Journal. 59, 3, p. 247-262 16 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Swine 100%
  • neoplasms 96%
  • dogs 96%
  • Dogs 91%
  • swine 81%

• Procaspase 3 activation by combination therapy

  Handley, M. K., Joshi, A., Fan, T. M., Hergenrother, P. J., Roth, H. S., Gilbert, M. J., Botham, R. C., Riggins, G. J. & Deering, A., Oct 2 2018, U.S. Patent No. 10085977, Jul 26 2016

  Research output: Patent

  • Neurotoxicity 58%

• Procaspase combination therapy for glioblastoma

  Handley, M. K., Joshi, A., Fan, T. M., Hergenrother, P. J., Roth, H. S., Gilbert, M. J., Botham, R. C., Riggins, G. J. & Deering, A., Oct 2 2018, U.S. Patent No. 10085978, Aug 22 2016

  Research output: Patent

  • Neurotoxicity 58%

• Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses

  Saba, C. F., Vickery, K. R., Clifford, C. A., Burgess, K. E., Phillips, B., Vail, D. M., Wright, Z. M., Morges, M. A., Fan, T. M. & Thamm, D. H., Mar 2018, In: Veterinary and comparative oncology. 16, 1, p. E76-E82

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • rabacfosadine 100%
  • B-cell lymphoma 65%
  • B-Cell Lymphoma 46%
  • Canidae 39%
  • dogs 34%

• Simulation of spatial diffusion of platinum from carboplatin-impregnated calcium sulfate hemihydrate beads by use of an agarose gelatin tissue phantom

  Phillips, H., Maxwell, E. A., Schaeffer, D. J. & Fan, T. M., Jun 2018, In: American journal of veterinary research. 79, 6, p. 592-599 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Sulfate 100%
  • calcium sulfate 97%
  • platinum 88%
  • Carboplatin 80%
  • Gelatin 77%

• Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

  Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, L. W., Fan, T. M. & Chan, J., Aug 22 2018, In: ACS Central Science. 4, 8, p. 1045-1055 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidoreductases 100%
  • Stem cells 93%
  • Plastic Property 76%
  • Plasticity 61%
  • Fluorescent Probe 61%

• Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

  Svec, R. L., Furiassi, L., Skibinski, C. G., Fan, T. M., Riggins, G. J. & Hergenrother, P. J., Nov 16 2018, In: ACS chemical biology. 13, 11, p. 3206-3216 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Temozolomide 81%
  • Glioblastoma 50%
  • Halogens 10%
  • Ketones 9%
  • Alkylating Agents 8%
• 2017

  Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma

  Thamm, D. H., Vail, D. M., Post, G. S., Fan, T. M., Phillips, B. S., Axiak-Bechtel, S., Elmslie, R. S., Klein, M. K. & Ruslander, D. A., May 1 2017, In: Journal of veterinary internal medicine. 31, 3, p. 872-878 7 p.

  Research output: Contribution to journal › Article › peer-review

  • rabacfosadine 100%
  • doxorubicin 55%
  • lymphoma 52%
  • Doxorubicin 41%
  • Canidae 39%

• Cancer Patients

  Fan, T. M., Apr 28 2017, Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. Wiley, p. 993-1003 11 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • pain 100%
  • neoplasms 72%
  • Cancer Pain 67%
  • bones 53%
  • Nociceptive Pain 49%

• Combinatorial Discovery of Defined Substrates That Promote a Stem Cell State in Malignant Melanoma

  Zhang, D., Lee, J., Sun, M. B., Pei, Y., Chu, J., Gillette, M. U., Fan, T. M. & Kilian, K. A., May 24 2017, In: ACS Central Science. 3, 5, p. 381-393 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stem cells 100%
  • Peptides 69%
  • Cells 68%
  • Proteoglycans 60%
  • Proteoglycan 58%

• Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin

  Roy, J., Wycislo, K. L., Pondenis, H., Fan, T. M. & Das, A., Sep 2017, In: PloS one. 12, 9, e0183930.

  Research output: Contribution to journal › Article › peer-review

  • osteosarcoma 100%
  • Osteosarcoma 72%
  • Proteomics 63%
  • proteomics 61%
  • Canidae 60%