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Research Output 1998 2019

2019

EVALUATING THE CLINICAL AND PHYSIOLOGICAL EFFECTS OF LONG-TERM ULTRAVIOLET B RADIATION ON RABBITS (ORYCTOLAGUS CUNICULUS)

Watson, M. K., Mitchell, M. A., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Cavaretta, M., Kohles, M. & Marshall, K., Jan 1 2019, In : Journal of Exotic Pet Medicine. 28, p. 43-55 13 p.

Research output: Contribution to journalArticle

Oryctolagus cuniculus
ultraviolet radiation
long term effects
rabbits
Radiation

Global analysis of osteosarcoma lipidomes reveal altered lipid profiles in metastatic versus nonmetastatic cells

Roy, J., Dibaeinia, P., Fan, T. M., Sinha, S. & Das, A., Jan 1 2019, In : Journal of Lipid Research. 60, 2, p. 375-387 13 p.

Research output: Contribution to journalArticle

Osteosarcoma
Lipids
Diglycerides
Bone Neoplasms
Sphingolipids

Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. & Fan, T. M., Jan 1 2019, In : Frontiers in Oncology. 9, FEB, 96.

Research output: Contribution to journalArticle

Open Access
Brain Neoplasms
Caspase 3
Canidae
Meningioma
Glioma
hemangiosarcoma
Hemangiosarcoma
burden of disease
body cavities
Canidae
2018

Albumin as a "trojan Horse" for polymeric nanoconjugate transendothelial transport across tumor vasculatures for improved cancer targeting

Yin, Q., Tang, L., Cai, K., Yang, X., Yin, L., Zhang, Y., Dobrucki, W., Helferich, W. G., Fan, T. M. & Cheng, J., May 1 2018, In : Biomaterials Science. 6, 5, p. 1189-1200 12 p.

Research output: Contribution to journalArticle

Nanoconjugates
Tumors
Albumins
Bearings (structural)
Medical nanotechnology

Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides

Roy, J., Watson, J. E., Hong, I. S., Fan, T. M. & Das, A., Jul 12 2018, In : Journal of Medicinal Chemistry. 61, 13, p. 5569-5579 11 p.

Research output: Contribution to journalArticle

Endocannabinoids
Epoxy Compounds
Cannabinoid Receptors
Docosahexaenoic Acids
Osteosarcoma

In vitro chemosensitivity of feline injection site-associated sarcoma cell lines to carboplatin

Maxwell, E. A., Phillips, H., Schaeffer, D. J. & Fan, T. M., Feb 1 2018, In : Veterinary Surgery. 47, 2, p. 219-226 8 p.

Research output: Contribution to journalArticle

injection site
Carboplatin
Felidae
sarcoma
calcium sulfate

NCI comparative oncology program testing of non-camptothecin indenoisoquinoline topoisomerase I inhibitors in naturally occurring canine lymphoma

Burton, J. H., Mazcko, C., LeBlanc, A., Covey, J. M., Ji, J., Kinders, R. J., Parchment, R. E., Khanna, C., Paoloni, M., Lana, S., Weishaar, K., London, C., Kisseberth, W., Krick, E., Vail, D., Childress, M., Bryan, J. N., Barber, L., Ehrhart, E. J., Kent, M. & 11 othersFan, T. M., Kow, K., Northup, N., Wilson-Robles, H., Tomaszewski, J., Holleran, J. L., Muzzio, M., Eiseman, J., Beumer, J. H., Doroshow, J. H. & Pommier, Y., Dec 1 2018, In : Clinical Cancer Research. 24, 23, p. 5830-5840 11 p.

Research output: Contribution to journalArticle

Topoisomerase I Inhibitors
Canidae
Lymphoma
Camptothecin
irinotecan

Rabacfosadine for relapsed canine B-cell lymphoma: Efficacy and adverse event profiles of 2 different doses

Saba, C. F., Vickery, K. R., Clifford, C. A., Burgess, K. E., Phillips, B., Vail, D. M., Wright, Z. M., Morges, M. A., Fan, T. M. & Thamm, D. H., Mar 1 2018, In : Veterinary and comparative oncology. 16, 1, p. E76-E82

Research output: Contribution to journalArticle

B-Cell Lymphoma
lymphoma
B-lymphocytes
Canidae
Dogs
Calcium Sulfate
calcium sulfate
platinum
Carboplatin
Gelatin

Surveillance of Cancer Stem Cell Plasticity Using an Isoform-Selective Fluorescent Probe for Aldehyde Dehydrogenase 1A1

Anorma, C., Hedhli, J., Bearrood, T. E., Pino, N. W., Gardner, S. H., Inaba, H., Zhang, P., Li, Y., Feng, D., Dibrell, S. E., Kilian, K. A., Dobrucki, W., Fan, T. M. & Chan, J. K. F., Aug 22 2018, In : ACS Central Science. 4, 8, p. 1045-1055 11 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Stem cells
Aldehydes
Fluorescent Dyes
Plasticity

Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma

Svec, R. L., Furiassi, L., Skibinski, C. G., Fan, T. M., Riggins, G. J. & Hergenrother, P., Nov 16 2018, In : ACS chemical biology. 13, 11, p. 3206-3216 11 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Toxicity
Precision Medicine
Halogens
2017

Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma

Thamm, D. H., Vail, D. M., Post, G. S., Fan, T. M., Phillips, B. S., Axiak-Bechtel, S., Elmslie, R. S., Klein, M. K. & Ruslander, D. A., May 1 2017, In : Journal of veterinary internal medicine. 31, 3, p. 872-878 7 p.

Research output: Contribution to journalArticle

doxorubicin
lymphoma
Doxorubicin
Canidae
Lymphoma

Cancer Patients

Fan, T. M., Apr 28 2017, Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. Wiley, p. 993-1003 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

pain
neoplasms
Nociceptive Pain
bones
Pets

Combinatorial Discovery of Defined Substrates That Promote a Stem Cell State in Malignant Melanoma

Zhang, D., Lee, J., Sun, M. B., Pei, Y., Chu, J., Gillette, M. L., Fan, T. M. & Kilian, K., May 24 2017, In : ACS Central Science. 3, 5, p. 381-393 13 p.

Research output: Contribution to journalArticle

Stem cells
Cells
Peptides
Proteoglycans
Substrates

Comparative proteomic investigation of metastatic and non-metastatic osteosarcoma cells of human and canine origin

Roy, J., Wycislo, K. L., Pondenis, H., Fan, T. M. & Das, A., Sep 1 2017, In : PloS one. 12, 9, e0183930.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Proteomics
proteomics
Canidae

Melanoma topology reveals a stem-like phenotype that promotes angiogenesis

Lee, J., Abdeen, A. A., Hedhli, J., Wycislo, K. L., Dobrucki, I. T., Fan, T. M., Dobrucki, W. & Kilian, K., Jan 1 2017, In : Science Advances. 3, 10, e1701350.

Research output: Contribution to journalArticle

Melanoma
Phenotype
Neoplasms
Integrins
Cues
Oncology
osteosarcoma
sarcoma
Osteosarcoma
Sarcoma

Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ), a NQO1 bioactivatable molecule, in the domestic felid species

Lundberg, A. P., Francis, J. M., Pajak, M., Parkinson, E. I., Wycislo, K. L., Rosol, T. J., Brown, M. E., London, C. A., Dirikolu, L., Hergenrother, P. & Fan, T. M., Apr 1 2017, In : Investigational New Drugs. 35, 2, p. 134-144 11 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Felidae
Neoplasms
Squamous Cell Carcinoma
Antineoplastic Agents

Selective in vivo metabolic cell-labeling-mediated cancer targeting

Wang, H., Wang, R., Cai, K., He, H., Liu, Y., Yen, J., Wang, Z., Xu, M., Sun, Y., Zhou, X., Yin, Q., Tang, L., Dobrucki, I. T., Dobrucki, L. W., Chaney, E. J., Boppart, S. A., Fan, T. M., Lezmi, S., Chen, X., Yin, L. & 1 othersCheng, J., Apr 1 2017, In : Nature chemical biology. 13, 4, p. 415-424 10 p.

Research output: Contribution to journalArticle

Neoplasms
Cell Surface Receptors
Click Chemistry
Triple Negative Breast Neoplasms
Cathepsin L

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

Joshi, A. D., Botham, R. C., Schlein, L. J., Roth, H. S., Mangraviti, A., Borodovsky, A., Tyler, B., Joslyn, S., Looper, J. S., Podell, M., Fan, T. M., Hergenrother, P. & Riggins, G. J., Jan 1 2017, In : Oncotarget. 8, 46, p. 80124-80138 15 p.

Research output: Contribution to journalArticle

temozolomide
Glioma
Caspase 3
Canidae
Rodentia
2016

Cancer biology

Fan, T. M., Aug 19 2016, Small Animal Cytologic Diagnosis. CRC Press, p. 47-58 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biological Sciences
neoplasms
Neoplasms

Creation of an NCI comparative brain tumor consortium: Informing the translation of new knowledge from canine to human brain tumor patients

Leblanc, A. K., Mazcko, C., Brown, D. E., Koehler, J. W., Miller, A. D., Miller, C. R., Bentley, R. T., Packer, R. A., Breen, M., Boudreau, C. E., Levine, J. M., Simpson, R. M., Halsey, C., Kisseberth, W., Rossmeisl, J. H., Dickinson, P. J., Fan, T. M., Corps, K., Aldape, K., Puduvalli, V. & 2 othersPluhar, G. E. & Gilbert, M. R., Sep 1 2016, In : Neuro-Oncology. 18, 9, p. 1209-1218 10 p.

Research output: Contribution to journalReview article

Translational Medical Research
Brain Neoplasms
Canidae
National Institutes of Health (U.S.)
Glioma

Diagnosis and ultrasonographic appearance of hepatic metastasis in six cases of canine appendicular osteosarcoma (2005-2013)

Cesario, L., Garrett, L. D., Barger, A. M., O'Brien, R. T. & Fan, T. M., May 1 2016, In : Australian veterinary journal. 94, 5, p. 160-165 6 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
metastasis
Canidae
Neoplasm Metastasis

Downregulation of CXCR4 Expression and Functionality After Zoledronate Exposure in Canine Osteosarcoma

Byrum, M. L., Pondenis, H. C., Fredrickson, R. L., Wycislo, K. L. & Fan, T. M., Jul 1 2016, In : Journal of veterinary internal medicine. 30, 4, p. 1187-1196 10 p.

Research output: Contribution to journalArticle

zoledronic acid
osteosarcoma
Osteosarcoma
Canidae
Down-Regulation

Interfacial geometry dictates cancer cell tumorigenicity

Lee, J., Abdeen, A. A., Wycislo, K. L., Fan, T. M. & Kilian, K. A., Aug 1 2016, In : Nature Materials. 15, 8, p. 856-862 7 p.

Research output: Contribution to journalArticle

stem cells
Tumors
tumors
cancer
Cells

mTOR inhibition mitigates enhanced mRNA translation associated with the metastatic phenotype of osteosarcoma cells in vivo

Morrow, J. J., Mendoza, A., Koyen, A., Lizardo, M. M., Ren, L., Waybright, T. J., Hansen, R. J., Gustafson, D. L., Zhou, M., Fan, T. M., Scacheri, P. C. & Khanna, C., Dec 15 2016, In : Clinical Cancer Research. 22, 24, p. 6129-6141 13 p.

Research output: Contribution to journalArticle

Protein Biosynthesis
Osteosarcoma
Sirolimus
Phenotype
Neoplasm Metastasis

Pamidronate functionalized nanoconjugates for targeted therapy of focal skeletal malignant osteolysis

Yin, Q., Tang, L., Cai, K., Tong, R., Sternberg, R., Yang, X., Dobrucki, L. W., Borst, L. B., Kamstock, D., Song, Z., Helferich, W. G., Cheng, J. & Fan, T. M., Aug 9 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. E4601-E4609

Research output: Contribution to journalArticle

pamidronate
Nanoconjugates
Osteolysis
Nanoparticles
Doxorubicin

Perspectives from man's best friend: National academy of medicine's workshop on comparative oncology

Leblanc, A. K., Breen, M., Choyke, P., Dewhirst, M., Fan, T. M., Gustafson, D. L., Helman, L. J., Kastan, M. B., Knapp, D. W., Levin, W. J., London, C., Mason, N., Mazcko, C., Olson, P. N., Page, R., Teicher, B. A., Thamm, D. H., Trent, J. M., Vail, D. M. & Khanna, C., Feb 3 2016, In : Science Translational Medicine. 8, 324, 324ps5.

Research output: Contribution to journalReview article

Medicine
Education
Research
Therapeutics
Surveys and Questionnaires

Pet scans

Fan, T. M., Le Blanc, A. K. & Mason, N., Apr 1 2016, In : Scientist. 30, 4

Research output: Contribution to journalComment/debate

Pharmacokinetics of orally administered low-dose rapamycin in healthy dogs

Larson, J. C., Allstadt, S. D., Fan, T. M., Khanna, C., Lunghofer, P. J., Hansen, R. J., Gustafson, D. L. PHD., Legendre, A. M., Galyon, G. D., LeBlanc, A. K. & Martin-Jimenez, T., Jan 1 2016, In : American journal of veterinary research. 77, 1, p. 65-71 7 p.

Research output: Contribution to journalArticle

Sirolimus
pharmacokinetics
Pharmacokinetics
Dogs
dogs

Small-molecule procaspase-3 activation sensitizes cancer to treatment with diverse chemotherapeutics

Botham, R. C., Roth, H. S., Book, A. P., Roady, P. J., Fan, T. M. & Hergenrother, P., Aug 24 2016, In : ACS Central Science. 2, 8, p. 545-559 15 p.

Research output: Contribution to journalArticle

Cell death
Caspase 3
Doxorubicin
Toxicity
Tumors

The combination of vemurafenib and procaspase-3 activation is synergistic in mutant BRAF melanomas

Peh, J., Fan, T. M., Wycislo, K. L., Roth, H. S. & Hergenrother, P., Aug 1 2016, In : Molecular Cancer Therapeutics. 15, 8, p. 1859-1869 11 p.

Research output: Contribution to journalArticle

Caspase 3
Melanoma
Cell Death
Caspase 1
Mutation
zoledronic acid
Bisphosphonate-Associated Osteonecrosis of the Jaw
Bone Density Conservation Agents
Imidazoles
Dog Diseases
2015

Alkylation and carbamylation effects of lomustine and its major metabolites and MGMT expression in canine cells

Chakkath, T., Lavergne, S., Fan, T. M., Bunick, D. & Dirikolu, L., Jun 1 2015, In : Veterinary Sciences. 2, 2, p. 52-68 17 p.

Research output: Contribution to journalArticle

Lomustine
alkylation
methyltransferases
Methyltransferases
Alkylation

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

Palchaudhuri, R., Lambrecht, M. J., Botham, R. C., Partlow, K. C., van Ham, T. J., Putt, K. S., Nguyen, L. T., Kim, S. H., Peterson, R. T., Fan, T. M. & Hergenrother, P., Dec 1 2015, In : Cell Reports. 13, 9, p. 2027-2036 10 p.

Research output: Contribution to journalArticle

Apoptosis
Molecules
Voltage-Dependent Anion Channels
Mitochondrial Membrane Potential
Cell death

A summary of the osteosarcoma banking efforts: A report from the Children's Oncology Group and the QuadW Foundation

Glover, J., Krailo, M., Tello, T., Marina, N., Janeway, K., Barkauskas, D., Fan, T. M., Gorlick, R. & Khanna, C., Mar 1 2015, In : Pediatric Blood and Cancer. 62, 3, p. 450-455 6 p.

Research output: Contribution to journalArticle

Osteosarcoma
Biostatistics
Sarcoma
Therapeutics
Research

Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007)

Coyle, V. J., Rassnick, K. M., Borst, L. B., Rodriguez, C. O., Northrup, N. C., Fan, T. M. & Garrett, L. D., Jun 1 2015, In : Veterinary and comparative oncology. 13, 2, p. 89-97 9 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
retrospective studies
Canidae
Retrospective Studies

Canine osteosarcoma cell lines from patients with differing serum alkaline phosphatase concentrations display no behavioural differences in vitro

Holmes, K. E., Thompson, V., Piskun, C. M., Kohnken, R. A., Huelsmeyer, M. K., Fan, T. M. & Stein, T. J., Sep 1 2015, In : Veterinary and comparative oncology. 13, 3, p. 166-175 10 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Alkaline Phosphatase
alkaline phosphatase
Canidae

Comparative aspects of osteosarcoma pathogenesis in humans and dogs

Fan, T. M. & Khanna, C., Sep 1 2015, In : Veterinary Sciences. 2, 3, p. 210-230 21 p.

Research output: Contribution to journalReview article

osteosarcoma
Osteosarcoma
pathogenesis
Dogs
dogs

Direct Capture of Functional Proteins from Mammalian Plasma Membranes into Nanodiscs

Roy, J., Pondenis, H., Fan, T. M. & Das, A., Oct 20 2015, In : Biochemistry. 54, 41, p. 6299-6302 4 p.

Research output: Contribution to journalArticle

Cell membranes
Membrane Proteins
Cell Membrane
Proteome
Blood Proteins

Expression of Nociceptive Ligands in Canine Osteosarcoma

Shor, S., Fadl-Alla, B. A., Pondenis, H. C., Zhang, X., Wycislo, K. L., Lezmi, S. & Fan, T. M., Jan 1 2015, In : Journal of veterinary internal medicine. 29, 1, p. 268-275 8 p.

Research output: Contribution to journalArticle

osteosarcoma
Osteosarcoma
Canidae
Ligands
pain

Removal of metabolic liabilities enables development of derivatives of procaspase-activating compound 1 (PAC-1) with improved pharmacokinetics

Roth, H. S., Botham, R. C., Schmid, S. C., Fan, T. M., Dirikolu, L. & Hergenrother, P., May 14 2015, In : Journal of Medicinal Chemistry. 58, 9, p. 4046-4065 20 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Cell Culture Techniques
Neoplasms
Clinical Trials, Phase I
Liver Microsomes

Targeting tumor vasculature with aptamer-functionalized doxorubicin-polylactide nanoconjugates for enhanced cancer therapy

Tang, L., Tong, R., Coyle, V. J., Yin, Q., Pondenis, H., Borst, L. B., Cheng, J. & Fan, T. M., May 26 2015, In : ACS Nano. 9, 5, p. 5072-5081 10 p.

Research output: Contribution to journalArticle

Nanoconjugates
Doxorubicin
Tumors
therapy
tumors

The Association of Endothelin-1 Signaling with Bone Alkaline Phosphatase Expression and Protumorigenic Activities in Canine Osteosarcoma

Neumann, Z. L., Pondenis, H. C., Masyr, A., Byrum, M. L., Wycislo, K. L. & Fan, T. M., Nov 1 2015, In : Journal of veterinary internal medicine. 29, 6, p. 1584-1594 11 p.

Research output: Contribution to journalArticle

endothelins
osteosarcoma
Endothelin-1
Osteosarcoma
Alkaline Phosphatase

The Immunotherapy of Canine Osteosarcoma: A Historical and Systematic Review

Wycislo, K. L. & Fan, T. M., May 1 2015, In : Journal of veterinary internal medicine. 29, 3, p. 759-769 11 p.

Research output: Contribution to journalArticle

osteosarcoma
immunotherapy
systematic review
Osteosarcoma
Immunotherapy
2014

Anticancer camptothecin-N-poly(lactic acid) nanoconjugates with facile hydrolysable linker

Yin, Q., Tong, R., Yin, L., Fan, T. M. & Cheng, J., Mar 7 2014, In : Polymer Chemistry. 5, 5, p. 1581-1585 5 p.

Research output: Contribution to journalArticle

Nanoconjugates
Camptothecin
Lactic acid
Esters
Polymerization

Dual small-molecule targeting of procaspase-3 dramatically enhances zymogen activation and anticancer activity

Botham, R. C., Fan, T. M., Im, I., Borst, L. B., Dirikolu, L. & Hergenrother, P., Jan 29 2014, In : Journal of the American Chemical Society. 136, 4, p. 1312-1319 8 p.

Research output: Contribution to journalArticle

Enzyme Precursors
Caspase 3
targeting
cancer
Enzymes
Nanoconjugates
Ring opening polymerization

Evaluating the clinical and physiological effects of long term ultraviolet B radiation on guinea pigs (Cavia porcellus)

Watson, M. K., Stern, A. W., Labelle, A. L., Joslyn, S., Fan, T. M., Leister, K., Kohles, M., Marshall, K. & Mitchell, M. A., Dec 17 2014, In : PloS one. 9, 12, e114413.

Research output: Contribution to journalArticle

guinea pigs
ultraviolet radiation
long term effects
Guinea Pigs
Animals