20042019
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Research Output 2004 2019

2019

Disruption of glycolysis by nutritional immunity activates a two-component system that coordinates a metabolic and antihost response by staphylococcus aureus

Párraga Solórzano, P. K., Yao, J., Rock, C. O. & Kehl-Fiea, T. E., Jan 1 2019, In : mBio. 10, 4, e01321-19.

Research output: Contribution to journalArticle

Open Access
Leukocyte L1 Antigen Complex
Glycolysis
Manganese
Starvation
Staphylococcus aureus

Metal-independent variants of phosphoglycerate mutase promote resistance to nutritional immunity and retention of glycolysis during infection

Radin, J. N., Kelliher, J. L., Solórzano, P. K. P., Grim, K. P., Ramezanifard, R., Slauch, J. M. & Kehl-Fie, T. E., Jul 2019, In : PLoS pathogens. 15, 7, e1007971.

Research output: Contribution to journalArticle

Open Access
Phosphoglycerate Mutase
Glycolysis
Manganese
Immunity
Metals

Synergy between nutritional immunity and independent host defenses contributes to the importance of the MntABC manganese transporter during staphylococcus aureus infection

Radin, J. N., Zhu, J., Brazel, E. B., McDevitt, C. A. & Kehl-Fiea, T. E., Jan 1 2019, In : Infection and immunity. 87, 1, e00642.

Research output: Contribution to journalArticle

Manganese
Staphylococcus aureus
Immunity
Leukocyte L1 Antigen Complex
Infection
2018

Acquisition of the phosphate transporter NptA enhances Staphylococcus aureus pathogenesis by improving phosphate uptake in divergent environments

Kelliher, J. L., Radin, J. N., Grim, K. P., Solórzano, P. K. P., Degnan, P. H. & Kehl-Fie, T. E., Jan 1 2018, In : Infection and immunity. 86, 1, e00631-17.

Research output: Contribution to journalArticle

Phosphate Transport Proteins
Staphylococcus aureus
Phosphates
Infection
Bacteria

PhoPR contributes to staphylococcus aureus Growth during phosphate starvation and pathogenesis in an environment- specific manner

Kelliher, J. L., Radin, J. N. & Kehl-Fie, T., Oct 1 2018, In : Infection and immunity. 86, 10, e00371-18.

Research output: Contribution to journalArticle

Starvation
Staphylococcus aureus
Phosphates
Growth
Virulence

Role of calprotectin in withholding zinc and copper from Candida albicans

Besold, A. N., Gilston, B. A., Radin, J. N., Ramsoomair, C., Culbertson, E. M., Li, C. X., Cormack, B. P., Chazin, W. J., Kehl-Fie, T. & Culotta, V. C., Feb 1 2018, In : Infection and immunity. 86, 2, e00779-17.

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
Candida albicans
Zinc
Copper
Metals
2017

A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity

Garcia, Y. M., Barwinska-Sendra, A., Tarrant, E., Skaar, E. P., Waldron, K. J. & Kehl-Fie, T. E., Jan 2017, In : PLoS pathogens. 13, 1, e1006125.

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
Manganese
Superoxide Dismutase
Staphylococcus aureus
Immunity

Dietary Manganese Promotes Staphylococcal Infection of the Heart

Juttukonda, L. J., Berends, E. T. M., Zackular, J. P., Moore, J. L., Stier, M. T., Zhang, Y., Schmitz, J. E., Beavers, W. N., Wijers, C. D., Gilston, B. A., Kehl-Fie, T., Atkinson, J., Washington, M. K., Peebles, R. S., Chazin, W. J., Torres, V. J., Caprioli, R. M. & Skaar, E. P., Oct 11 2017, In : Cell Host and Microbe. 22, 4, p. 531-542.e8

Research output: Contribution to journalArticle

Staphylococcal Infections
Manganese
Staphylococcus aureus
Leukocyte L1 Antigen Complex
Infection

Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus

Peng, H., Zhang, Y., Palmer, L. D., Kehl-Fie, T., Skaar, E. P., Trinidad, J. C. & Giedroc, D. P., Oct 13 2017, In : ACS Infectious Diseases. 3, 10, p. 744-755 12 p.

Research output: Contribution to journalArticle

Hydrogen Sulfide
Proteome
Sulfur
Virulence
Staphylococcus aureus

Sulfide homeostasis and nitroxyl intersect via formation of reactive sulfur species in Staphylococcus aureus

Peng, H., Shen, J., Edmonds, K. A., Luebke, J. L., Hickey, A. K., Palmer, L. D., Chang, F. M. J., Bruce, K. A., Kehl-Fie, T. E., Skaar, E. P. & Giedroc, D. P., May 1 2017, In : mSphere. 2, 3, e00082-17.

Research output: Contribution to journalArticle

Sulfides
Sulfur
Staphylococcus aureus
Homeostasis
Regulon

The metallophore staphylopine enables staphylococcus aureus to compete with the host for zinc and overcome nutritional immunity

Grim, K. P., San Francisco, B., Radin, J. N., Brazel, E. B., Kelliher, J. L., Párraga Solórzano, P. K., Kim, P. C., McDevitt, C. A. & Kehl-Fie, T. E., Sep 1 2017, In : mBio. 8, 5, e01281-17.

Research output: Contribution to journalArticle

Staphylococcus aureus
Zinc
Immunity
Leukocyte L1 Antigen Complex
Infection
2016

Competition for Manganese at the Host–Pathogen Interface

Kelliher, J. L. & Kehl-Fie, T., Jan 1 2016, Host-Microbe Interactions, 2016. San Francisco, B. & San Francisco, M. (eds.). Elsevier B.V., p. 1-25 25 p. (Progress in Molecular Biology and Translational Science; vol. 142).

Research output: Chapter in Book/Report/Conference proceedingChapter

Manganese
Metals
Starvation
Immunity
Bacteria

Metal Sequestration: An Important Contribution of Antimicrobial Peptides to Nutritional Immunity

Damo, S. & Kehl-Fie, T., Jan 1 2016, Birkhauser Advances in Infectious Diseases. 9783319241975 ed. Springer Basel, p. 89-100 12 p. (Birkhauser Advances in Infectious Diseases; no. 9783319241975).

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunity
Metals
Peptides
Manganese
Infection

The Two-Component System ArlRS and Alterations in Metabolism Enable Staphylococcus aureus to Resist Calprotectin-Induced Manganese Starvation

Radin, J. N., Kelliher, J. L., Párraga Solórzano, P. K. & Kehl-Fie, T. E., Nov 1 2016, In : PLoS pathogens. 12, 11, e1006040.

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
Manganese
Starvation
Staphylococcus aureus
Metals
2015

Copper intoxication inhibits aerobic nucleotide synthesis in Streptococcus pneumoniae

Johnson, M. D. L., Kehl-Fie, T. & Rosch, J. W., May 1 2015, In : Metallomics. 7, 5, p. 786-794 9 p.

Research output: Contribution to journalArticle

Nucleotides
Streptococcus pneumoniae
Copper
Toxicity
Oxidative stress

Host-imposed manganese starvation of invading pathogens: Two routes to the same destination

Morey, J. R., McDevitt, C. A. & Kehl-Fie, T. E., Jun 1 2015, In : BioMetals. 28, 3, p. 509-519 11 p.

Research output: Contribution to journalArticle

Pathogens
Manganese
Starvation
starvation
manganese

Role of copper efflux in pneumococcal pathogenesis and resistance to macrophage-mediated immune clearance

Johnson, M. D. L., Kehl-Fie, T. E., Klein, R., Kelly, J., Burnham, C., Mann, B. & Rosch, J. W., Jan 1 2015, In : Infection and immunity. 83, 4, p. 1684-1694 11 p.

Research output: Contribution to journalArticle

Copper
Macrophages
Poisons
Operon
Virulence
2014

The CsoR-like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus

Luebke, J. L., Shen, J., Bruce, K. E., Kehl-Fie, T. E., Peng, H., Skaar, E. P. & Giedroc, D. P., Dec 1 2014, In : Molecular Microbiology. 94, 6, p. 1343-1360 18 p.

Research output: Contribution to journalArticle

Operon
Staphylococcus aureus
Copper
Sulfides
Thiosulfates

The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration

Gaddy, J. A., Radin, J. N., Loh, J. T., Piazuelo, M. B., Kehl-Fie, T. E., Delgado, A. G., Ilca, F. T., Peek, R. M., Cover, T. L., Chazin, W. J., Skaar, E. P. & Scott Algood, H. M., Oct 1 2014, In : PLoS pathogens. 10, 10

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
Helicobacter pylori
Zinc
Metals
Proteins
2013

Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus

Mike, L. A., Dutter, B. F., Stauff, D. L., Moore, J. L., Vitko, N. P., Aranmolate, O., Kehl-Fie, T. E., Sullivan, S., Reid, P. R., DuBois, J. L., Richardson, A. R., Caprioli, R. M., Sulikowski, G. A. & Skaar, E. P., May 14 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 20, p. 8206-8211 6 p.

Research output: Contribution to journalArticle

Poisons
Heme
Staphylococcus aureus
Bacteria
Phagocytes

Cdc42 promotes host defenses against fatal infection

Lee, K., Boyd, K. L., Parekh, D. V., Kehl-Fie, T. E., Scott Baldwin, H., Brakebusch, C., Skaar, E. P., Boothby, M. & Zent, R., Aug 1 2013, In : Infection and immunity. 81, 8, p. 2714-2713 2 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Fibroblasts
Infection
rho GTP-Binding Proteins
Lymphopenia

MntABC and MntH contribute to systemic staphylococcus aureus infection by competing with calprotectin for nutrient manganese

Kehl-Fie, T. E., Zhang, Y., Moore, J. L., Farrand, A. J., Hood, M. I., Rathi, S., Chazin, W. J., Caprioli, R. M. & Skaar, E. P., Sep 23 2013, In : Infection and immunity. 81, 9, p. 3395-3405 11 p.

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
Manganese
Staphylococcus aureus
Food
Infection

Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

Damo, S. M., Kehl-Fie, T. E., Sugitani, N., Holt, M. E., Rathi, S., Murphy, W. J., Zhang, Y., Betz, C., Hench, L., Fritz, G., Skaar, E. P. & Chazin, W. J., Mar 5 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 10, p. 3841-3846 6 p.

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
Manganese
Innate Immunity
Metals
S100 Proteins
2012

Identification of an Acinetobacter baumannii Zinc Acquisition System that Facilitates Resistance to Calprotectin-mediated Zinc Sequestration

Hood, M. I., Mortensen, B. L., Moore, J. L., Zhang, Y., Kehl-Fie, T. E., Sugitani, N., Chazin, W. J., Caprioli, R. M. & Skaar, E. P., Dec 1 2012, In : PLoS pathogens. 8, 12, e1003068.

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
Acinetobacter baumannii
Zinc
Metals
Manganese

Inhibition of bacterial superoxide defense: A new front in the struggle between host and pathogen

Damo, S., Chazin, W. J., Skaar, E. P. & Kehl-Fie, T., Jan 1 2012, In : Virulence. 3, 3, 1 p.

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
S100 Proteins
Manganese
Superoxides
Superoxide Dismutase

Inhibition of bacterial superoxide defense: a new front in the struggle between host and pathogen.

Damo, S., Chazin, W. J., Skaar, E. P. & Kehl-Fie, T. E., Jan 1 2012, In : Virulence. 3, 3, p. 325-328 4 p.

Research output: Contribution to journalReview article

Leukocyte L1 Antigen Complex
Staphylococcal Infections
Biological Models
Superoxides
Superoxide Dismutase

Modulation of kingella kingae adherence to human epithelial cells by type IV Pili, capsule, and a novel trimeric autotransporter

St. Geme, J. W., Porsch, E. A. & Kehl-Fie, T. E., Nov 9 2012, In : mBio. 3, 5

Research output: Contribution to journalArticle

Kingella kingae
Capsules
Epithelial Cells
Kingella
Respiratory Mucosa

Zinc sequestration by the neutrophil protein calprotectin enhances salmonella growth in the inflamed gut

Liu, J. Z., Jellbauer, S., Poe, A. J., Ton, V., Pesciaroli, M., Kehl-Fie, T. E., Restrepo, N. A., Hosking, M. P., Edwards, R. A., Battistoni, A., Pasquali, P., Lane, T. E., Chazin, W. J., Vogl, T., Roth, J., Skaar, E. P. & Raffatellu, M., Mar 15 2012, In : Cell Host and Microbe. 11, 3, p. 227-239 13 p.

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
Salmonella
Zinc
Neutrophils
Salmonella typhimurium
2011

Control of Copper Resistance and Inorganic Sulfur Metabolism by Paralogous Regulators in Staphylococcus aureus

Grossoehme, N., Kehl-Fie, T. E., Ma, Z., Adams, K. W., Cowart, D. M., Scott, R. A., Skaar, E. P. & Giedroc, D. P., Apr 15 2011, In : Journal of Biological Chemistry. 286, 15, p. 13522-13531 10 p.

Research output: Contribution to journalArticle

Operon
Sulfur
Metabolism
Staphylococcus aureus
Copper

Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus

Kehl-Fie, T. E., Chitayat, S., Hood, M. I., Damo, S., Restrepo, N., Garcia, C., Munro, K. A., Chazin, W. J. & Skaar, E. P., Aug 18 2011, In : Cell Host and Microbe. 10, 2, p. 158-164 7 p.

Research output: Contribution to journalArticle

Leukocyte L1 Antigen Complex
Superoxides
Staphylococcus aureus
Neutrophils
Metals
2010

Examination of Type IV Pilus Expression and Pilus-Associated Phenotypes in Kingella kingae Clinical Isolates

Kehl-Fie, T. E., Porsch, E. A., Yagupsky, P., Grass, E. A., Obert, C., Benjamin, D. K. & St Geme, J. W., Apr 1 2010, In : Infection and immunity. 78, 4, p. 1692-1699 8 p.

Research output: Contribution to journalArticle

Kingella kingae
Phenotype
Antigenic Variation
Infectious Arthritis
Osteomyelitis

Nutritional immunity beyond iron: a role for manganese and zinc

Kehl-Fie, T. E. & Skaar, E. P., Apr 1 2010, In : Current Opinion in Chemical Biology. 14, 2, p. 218-224 7 p.

Research output: Contribution to journalReview article

Manganese
Zinc
Immunity
Iron
Vertebrates
2009

Expression of Kingella kingae type IV pili is regulated by σ54, PilS, and PilR

Kehl-Fie, T. E., Porsch, E. A., Miller, S. E. & St. Geme, J. W., Aug 1 2009, In : Journal of bacteriology. 191, 15, p. 4976-4986 11 p.

Research output: Contribution to journalArticle

Kingella kingae
Neisseriaceae
Neisseria
Essential Genes
Electrophoretic Mobility Shift Assay
2008

Kingella kingae expresses type IV pili that mediate adherence to respiratory epithelial and synovial cells

Kehl-Fie, T. E., Miller, S. E. & St. Geme, J. W., Nov 1 2008, In : Journal of bacteriology. 190, 21, p. 7157-7163 7 p.

Research output: Contribution to journalArticle

Kingella kingae
Epithelial Cells
Fimbriae Proteins
Chromosomes
Genes
2007

Identification and characterization of an RTX toxin in the emerging pathogen Kingella kingae

Kehl-Fie, T. E. & St. Geme, J. W., Jan 1 2007, In : Journal of bacteriology. 189, 2, p. 430-436 7 p.

Research output: Contribution to journalArticle

Kingella kingae
Kingella
Lactic Acid
Oxidoreductases
Macrophages
2006

Translocator proteins in the two-partner secretion family have multiple domains

Surana, N. K., Buscher, A. Z., Hardy, G. G., Grass, S., Kehl-Fie, T. & St. Geme, J. W., Jun 30 2006, In : Journal of Biological Chemistry. 281, 26, p. 18051-18058 8 p.

Research output: Contribution to journalArticle

Haemophilus influenzae
Proteins
Membranes
Epitopes
Anchors
2005

SCAN1 mutant Tdp1 accumulates the enzyme-DNA intermediate and causes camptothecin hypersensitivity

Interthal, H., Chen, H. J., Kehl-Fie, T., Zotzmann, J., Leppard, J. B. & Champoux, J. J., Jun 15 2005, In : EMBO Journal. 24, 12, p. 2224-2233 10 p.

Research output: Contribution to journalArticle

Camptothecin
Type I DNA Topoisomerase
Hypersensitivity
DNA
Enzymes
2004

Legionella pneumophila dotU and icmF are required for stability of the Dot/Icm complex

Sexton, J. A., Miller, J. L., Yoneda, A., Kehl-Fie, T. E. & Vogel, J. P., Oct 1 2004, In : Infection and immunity. 72, 10, p. 5983-5992 10 p.

Research output: Contribution to journalArticle

Legionella pneumophila
Proteins
Genetic Linkage
Growth
Gram-Negative Bacteria