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Research Output

2018

Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

Kim, I. J., Lee, J., Oh, S. J., Yoon, M. S., Jang, S. S., Holland, R. L., Reno, M. L., Hamad, M. N., Maeda, T., Chung, H. J., Chen, J. & Blanke, S. R., May 9 2018, In : Cell Host and Microbe. 23, 5, p. 583-593.e8

Research output: Contribution to journalArticle

2016

AOAC SMPR(®) 2016.006

Hadfield, T. L., Jackson, P. J., Appler, J., Baillie, L., Bailor, E., Ballin, J., Beck, L., Blanke, S. R., Cahall, R., Damer, K., Dragon, D., Forsman, M., Jaing, C., Johns, M., Lin, N., Maple, L., Morse, S. A., New, D., Retford, M., Shah, S. & 4 others, Sozhamannan, S., Trudil, D., Welkos, S. & Coates, S. G., Jul 1 2016, In : Journal of AOAC International. 99, 4, p. 1084-1089 6 p.

Research output: Contribution to journalArticle

Helicobacter pylori vacuolating toxin

Cover, T. L., Holland, R. L. & Blanke, S. R., Jan 1 2016, Helicobacter pylori Research: From Bench to Bedside. Springer Japan, p. 113-142 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Distinct roles for CdtA and CdtC during intoxication by cytolethal distending toxins

Dixon, S. D., Huynh, M. M., Tamilselvam, B., Spiegelman, L. M., Son, S. B., Eshraghi, A., Blanke, S. R. & Bradley, K. A., Nov 1 2015, In : PloS one. 10, 11, 0143977.

Research output: Contribution to journalArticle

2014

Cytolethal Distending Toxins Require Components of the ER-Associated Degradation Pathway for Host Cell Entry

Eshraghi, A., Dixon, S. D., Tamilselvam, B., Kim, E. J. K., Gargi, A., Kulik, J. C., Damoiseaux, R., Blanke, S. R. & Bradley, K. A., Jul 2014, In : PLoS pathogens. 10, 7, e1004295.

Research output: Contribution to journalArticle

Dynamic intervention: Pathogen disarmament of mitochondrial-based immune surveillance

Holland, R. L. & Blanke, S. R., Nov 12 2014, In : Cell Host and Microbe. 16, 5, p. 555-557 3 p.

Research output: Contribution to journalShort survey

2013

Cellular interactions of the cytolethal distending toxins from Escherichia coli and Haemophilus ducreyi

Gargi, A., Tamilselvam, B., Powers, B., Prouty, M. G., Lincecum, T., Eshraghi, A., Maldonado-Arocho, F. J., Wilson, B. A., Bradley, K. A. & Blanke, S. R., Mar 15 2013, In : Journal of Biological Chemistry. 288, 11, p. 7492-7505 14 p.

Research output: Contribution to journalArticle

Helicobacter pylori activates NF-κB by inducing Ubc13-mediated ubiquitination of lysine 158 of TAK1

Lamb, A., Chen, J., Blanke, S. R. & Chen, L. F., Oct 1 2013, In : Journal of Cellular Biochemistry. 114, 10, p. 2284-2292 9 p.

Research output: Contribution to journalArticle

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

Gillespie, E. J., Ho, C. L. C., Balaji, K., Clemens, D. L., Deng, G., Wang, Y. E., Elsaesser, H. J., Tamilselvam, B., Gargi, A., Dixon, S. D., France, B., Chamberlain, B. T., Blanke, S. R., Cheng, G., De La Torre, J. C., Brooks, D. G., Jung, M. E., Colicelli, J., Damoiseaux, R. & Bradley, K. A., Dec 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 50, p. E4904-E4912

Research output: Contribution to journalArticle

2012

Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote helicobacter pylori infection in humans

Raju, D., Hussey, S., Ang, M., Terebiznik, M. R., Sibony, M., Galindo-Mata, E., Gupta, V., Blanke, S. R., Delgado, A., Romero-Gallo, J., Ramjeet, M. S., Mascarenhas, H., Peek, R. M., Correa, P., Streutker, C., Hold, G., Kunstmann, E., Yoshimori, T., Silverberg, M. S., Girardin, S. E. & 3 others, Philpott, D. J., El Omar, E. & Jones, N. L., May 2012, In : Gastroenterology. 142, 5, p. 1160-1171 12 p.

Research output: Contribution to journalArticle

2011

Adaptation of aerobic respiration to low O2 environments

Han, H., Hemp, J., Pace, L. A., Ouyang, H., Ganesan, K., Roh, J. H., Daldal, F., Blanke, S. R. & Gennis, R. B., Aug 23 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 34, p. 14109-14114 6 p.

Research output: Contribution to journalArticle

Bacillus anthracis spore interactions with mammalian cells: Relationship between germination state and the outcome of in vitro

Gut, I. M., Tamilselvam, B., Prouty, A. M., Stojkovic, B., Czeschin, S., Van Der Donk, W. A. & Blanke, S. R., Mar 2 2011, In : BMC microbiology. 11, 46.

Research output: Contribution to journalArticle

Mechanism of inhibition of bacillus anthracis spore outgrowth by the Lantibiotic Nisin

Gut, I. M., Blanke, S. R. & Van Der Donk, W. A., Jul 15 2011, In : ACS chemical biology. 6, 7, p. 744-752 9 p.

Research output: Contribution to journalArticle

Membrane interaction of Pasteurella multocida toxin involves sphingomyelin

Brothers, M. C., Ho, M., Maharjan, R., Clemons, N. C., Bannai, Y., Waites, M. A., Faulkner, M. J., Kuhlenschmidt, T. B., Kuhlenschmidt, M. S., Blanke, S. R., Rienstra, C. M. & Wilson, B. A., Dec 1 2011, In : FEBS Journal. 278, 23, p. 4633-4648 16 p.

Research output: Contribution to journalArticle

Nature of allosteric inhibition in glutamate racemase: Discovery and characterization of a cryptic inhibitory pocket using atomistic MD simulations and p Ka calculations

Whalen, K. L., Tussey, K. B., Blanke, S. R. & Spies, M. A., Apr 7 2011, In : Journal of Physical Chemistry B. 115, 13, p. 3416-3424 9 p.

Research output: Contribution to journalArticle

2010

Cytolethal distending toxin family members are differentially affected by alterations in host glycans and membrane cholesterol

Eshraghi, A., Maldonado-Arocho, F. J., Gargi, A., Cardwell, M. M., Prouty, M. G., Blanke, S. R. & Bradley, K. A., Jun 11 2010, In : Journal of Biological Chemistry. 285, 24, p. 18199-18207 9 p.

Research output: Contribution to journalArticle

Exploiting enzyme plasticity in virtual screening: High efficiency inhibitors of glutamate racemase

Whalen, K. L., Pankow, K. L., Blanke, S. R. & Spies, M. A., Apr 8 2010, In : ACS Medicinal Chemistry Letters. 1, 1, p. 9-13 5 p.

Research output: Contribution to journalArticle

Helicobacter pylori activation of PARP-1 usurping a versatile regulator of host cellular health

Nossa, C. W. & Blanke, S. R., Nov 1 2010, In : Gut Microbes. 1, 6

Research output: Contribution to journalArticle

Response: Strain-specific activation of NF-B by Helicobacter pylori CagA

Lamb, A., Li, J. D., Hatakeyama, M., Peek, R. M., Blanke, S. R. & Chen, L. F., Jan 1 2010, In : EMBO Reports. 11, 1, p. 11-12 2 p.

Research output: Contribution to journalLetter

Sphingomyelin is important for the cellular entry and intracellular localization of Helicobacter pylori VacA

Gupta, V. R., Wilson, B. A. & Blanke, S. R., Oct 1 2010, In : Cellular Microbiology. 12, 10, p. 1517-1533 17 p.

Research output: Contribution to journalArticle

2009

Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori

Nossa, C. W., Jain, P., Tamilselvam, B., Gupta, V. R., Chen, L. F., Schreiber, V., Desnoyers, S. & Blanke, S. R., Nov 24 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 47, p. 19998-20003 6 p.

Research output: Contribution to journalArticle

Determinants of catalytic power and ligand binding in glutamate racemase

Spies, M. A., Reese, J. G., Dodd, D., Pankow, K. L., Blanke, S. R. & Baudry, J., Apr 15 2009, In : Journal of the American Chemical Society. 131, 14, p. 5274-5284 11 p.

Research output: Contribution to journalArticle

Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells

Terebiznik, M. R., Raju, D., Vázquez, C. L., Torbricki, K., Kulkarni, R., Blanke, S. R., Yoshimori, T., Colombo, M. I. & Jones, N. L., Apr 1 2009, In : Autophagy. 5, 3, p. 370-379 10 p.

Research output: Contribution to journalArticle

Expanding functionality within the looking-glass universe

Blanke, S. R., Sep 28 2009, In : Science. 325, 5947, p. 1505-1506 2 p.

Research output: Contribution to journalShort survey

Helicobacter pylori CagA activates NF-κB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination

Lamb, A., Yang, X. D., Tsang, Y. H. N., Li, J. D., Higashi, H., Hatakeyama, M., Peek, R. M., Blanke, S. R. & Chen, L. F., Oct 15 2009, In : EMBO Reports. 10, 11, p. 1242-1249 8 p.

Research output: Contribution to journalArticle

Heterogeneity of vaginal microbial communities within individuals

Kim, T. K., Thomas, S. M., Ho, M., Sharma, S., Reich, C. I., Frank, J. A., Yeater, K. M., Biggs, D. R., Nakamura, N., Stumpf, R., Leigh, S. R., Tapping, R. I., Blanke, S. R., Slauch, J. M., Gaskins, H. R., Weisbaum, J. S., Olsen, G. J., Hoyer, L. L. & Wilson, B. A., Apr 1 2009, In : Journal of Clinical Microbiology. 47, 4, p. 1181-1189 9 p.

Research output: Contribution to journalArticle

The mechanism of Bacillus anthracis intracellular germination requires multiple and highly diverse genetic loci

Barua, S., McKevitt, M., DeGiusti, K., Hamm, E. E., Larabee, J., Shakir, S., Bryant, K., Koehler, T. M., Blanke, S. R., Dyer, D., Gillaspy, A. & Ballard, J. D., Jan 1 2009, In : Infection and immunity. 77, 1, p. 23-31 9 p.

Research output: Contribution to journalArticle

2008

Helicobacter pylori VacA subdomain required for intracellular toxin activity and assembly of functional oligomeric complexes

Ivie, S. E., McClain, M. S., Torres, V. J., Scott Algood, H. M., Lacy, D. B., Yang, R., Blanke, S. R. & Cover, T. L., Jul 1 2008, In : Infection and immunity. 76, 7, p. 2843-2851 9 p.

Research output: Contribution to journalArticle

High-throughput, single-cell analysis of macrophage interactions with fluorescently labeled Bacillus anthracis spores

Stojkovic, B., Torres, E. M., Prouty, A. M., Patel, H. K., Zhuang, L., Koehler, T. M., Ballard, J. D. & Blanke, S. R., Aug 1 2008, In : Applied and environmental microbiology. 74, 16, p. 5201-5210 10 p.

Research output: Contribution to journalArticle

Inhibition of Bacillus anthracis spore outgrowth by nisin

Gut, I. M., Prouty, A. M., Ballard, J. D., Van Der Donk, W. A. & Blanke, S. R., Dec 1 2008, In : Antimicrobial Agents and Chemotherapy. 52, 12, p. 4281-4288 8 p.

Research output: Contribution to journalArticle

Order-Disorder-Order Transitions Mediate the Activation of Cholera Toxin

Ampapathi, R. S., Creath, A. L., Lou, D. I., Craft, J. W., Blanke, S. R. & Legge, G. B., Mar 28 2008, In : Journal of Molecular Biology. 377, 3, p. 748-760 13 p.

Research output: Contribution to journalArticle

Sphingomyelin functions as a novel receptor for Helicobacter pylori VacA

Gupta, V. R., Patel, H. K., Kostolansky, S. S., Ballivian, R. A., Eichberg, J. & Blanke, S. R., May 1 2008, In : PLoS pathogens. 4, 5, e1000073.

Research output: Contribution to journalArticle

2007

Effects of endogenous D-alanine synthesis and autoinhibition of Bacillus anthracis germination on in vitro and in vivo infections

McKevitt, M. T., Bryant, K. M., Shakir, S. M., Larabee, J. L., Blanke, S. R., Lovchik, J., Lyons, C. R. & Ballard, J. D., Dec 1 2007, In : Infection and immunity. 75, 12, p. 5726-5734 9 p.

Research output: Contribution to journalArticle

Functional comparison of the two Bacillus anthracis glutamate racemases

Dodd, D., Reese, J. G., Louer, C. R., Ballard, J. D., Spies, M. A. & Blanke, S. R., Jul 1 2007, In : Journal of bacteriology. 189, 14, p. 5265-5275 11 p.

Research output: Contribution to journalArticle

2006

Helicobacter pylori VacA toxin promotes bacterial intracellular survival in gastric epithelial cells

Terebiznik, M. R., Vazquez, C. L., Torbicki, K., Banks, D., Wang, T., Hong, W., Blanke, S. R., Colombo, M. I. & Jones, N. L., Dec 1 2006, In : Infection and immunity. 74, 12, p. 6599-6614 16 p.

Research output: Contribution to journalArticle

Portals and pathways: Principles of bacterial toxin entry into host cells

Blanke, S. R., Jan 1 2006, In : Microbe. 1, 1, p. 26-32 7 p.

Research output: Contribution to journalReview article

2005

Helicobacter pylori VacA, a paradigm for toxin multifunctionality

Cover, T. L. & Blanke, S. R., Apr 1 2005, In : Nature Reviews Microbiology. 3, 4, p. 320-332 13 p.

Research output: Contribution to journalReview article

Micro-managing the executioner: Pathogen targeting of mitochondria

Blanke, S. R., Feb 1 2005, In : Trends in Microbiology. 13, 2, p. 64-71 8 p.

Research output: Contribution to journalReview article

2004
2003
2002

Characterization of a cytotoxic factor in culture filtrates of Serratia marcescens

Marty, K. B., Williams, C. L., Guynn, L. J., Benedik, M. J. & Blanke, S. R., Mar 4 2002, In : Infection and immunity. 70, 3, p. 1121-1128 8 p.

Research output: Contribution to journalArticle

Fluorescence resonance energy transfer microscopy of the Helicobacter pylori vacuolating cytotoxin within mammalian cells

Willhite, D. C., Ye, D. & Blanke, S. R., Jul 2 2002, In : Infection and immunity. 70, 7, p. 3824-3832 9 p.

Research output: Contribution to journalArticle

Plasma membrane cholesterol modulates cellular vacuolation induced by the Helicobacter pylori vacuolating cytotoxin

Patel, H. K., Willhite, D. C., Patel, R. M., Ye, D., Williams, C. L., Torres, E. M., Marty, K. B., MacDonald, R. A. & Blanke, S. R., Jul 30 2002, In : Infection and immunity. 70, 8, p. 4112-4123 12 p.

Research output: Contribution to journalArticle

2000
1999

A dominant negative mutant of Helicobacter pylori vacuolating toxin (VacA) inhibits VacA-induced cell vacuolation

Vinion-Dubiel, A. D., McClain, M. S., Czajkowsky, D. M., Iwamoto, H., Ye, D., Cao, P., Schraw, W., Szabo, G., Blanke, S. R., Shao, Z. & Cover, T. L., Dec 31 1999, In : Journal of Biological Chemistry. 274, 53, p. 37736-37742 7 p.

Research output: Contribution to journalArticle