Steven C Zimmerman

2024

Goals, challenges, and perspectives in chemical transformations within living systems

Wu, T., Chen, Y., Zimmerman, S. C., Xing, H. & Bai, Y., Apr 17 2024, In: Cell Reports Physical Science. 5, 4, 101896.

Research output: Contribution to journal › Review article › peer-review

Open Access

Inducing Microstrain in Electrodeposited Pt through Polymer Addition for Highly Active Oxygen Reduction Catalysis

Hua, Q., Chen, X., Chen, J., Alghoraibi, N. M., Lee, Y., Woods, T. J., Haasch, R. T., Zimmerman, S. C. & Gewirth, A. A., May 17 2024, In: ACS Catalysis. 14, 10, p. 7526-7535 10 p.

Research output: Contribution to journal › Article › peer-review

2023

Capturing students' identification of the relevance of organic chemistry in writing

Milne, S. L., Finkenstaedt-Quinn, S. A., Garza, N. F., Zimmerman, S. C. & Shultz, G. V., Nov 16 2023, (E-pub ahead of print) In: Chemistry Education Research and Practice.

Research output: Contribution to journal › Article › peer-review

End-of-life upcycling of polyurethanes using a room temperature, mechanism-based degradation

Morado, E. G., Paterson, M. L., Ivanoff, D. G., Wang, H. C., Johnson, A., Daniels, D., Rizvi, A., Sottos, N. R. & Zimmerman, S. C., Apr 2023, In: Nature Chemistry. 15, 4, p. 569-577 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Acid-Responsive Anticorrosion Microcapsules for Self-Protecting Coatings

Thakare, D. R., Xiong, T. M., Flueck, I. L., Morado, E. G., Zimmerman, S. C. & Sottos, N. R., Mar 2022, In: Macromolecular Chemistry and Physics. 223, 5, 2100382.

Research output: Contribution to journal › Article › peer-review

Open Access

A Selective Alkylating Agent for CTG Repeats in Myotonic Dystrophy Type 1

Lee, J. Y., Li, K. & Zimmerman, S. C., May 20 2022, In: ACS chemical biology. 17, 5, p. 1103-1110 8 p.

Research output: Contribution to journal › Article › peer-review

Building Personal Connections to Organic Chemistry through Writing

Garza, N. F., Finkenstaedt-Quinn, S. A., Shultz, G. V. & Zimmerman, S. C., Apr 12 2022, In: Journal of Chemical Education. 99, 4, p. 1802-1807 6 p.

Research output: Contribution to journal › Article › peer-review

Dynamic Covalent Template-Guided Screen for Nucleic Acid-Targeting Agents

Krueger, S. B. & Zimmerman, S. C., Sep 22 2022, In: Journal of Medicinal Chemistry. 65, 18, p. 12417-12426 10 p.

Research output: Contribution to journal › Article › peer-review

Enzyme-like catalysis by single chain nanoparticles that use transition metal cofactors

Xiong, T. M., Garcia, E. S., Chen, J., Zhu, L., Alzona, A. J. & Zimmerman, S. C., Jan 21 2022, In: Chemical Communications. 58, 7, p. 985-988 4 p.

Research output: Contribution to journal › Article › peer-review

Multivalent ligand for myotonic dystrophy

Zimmerman, S. C. (Inventor), Bai, Y. (Inventor) & Kalsotra, A. (Inventor), Feb 8 2022, U.S. Patent No. 11242326, Aug 23 2018

Research output: Patent

Selective and Reversible Ligand Assembly on the DNA and RNA Repeat Sequences in Myotonic Dystrophy

Krueger, S. B., Lanzendorf, A. N., Jeon, H. & Zimmerman, S. C., Sep 5 2022, In: ChemBioChem. 23, 17, e202200260.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

A Novel Minor Groove Binder as a Potential Therapeutic Agent for Myotonic Dystrophy Type 1

Li, K., Krueger, S. B. & Zimmerman, S. C., Sep 6 2021, In: ChemMedChem. 16, 17, p. 2638-2644 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A polymeric approach toward resistance-resistant antimicrobial agent with dual-selective mechanisms of action

Bai, S., Wang, J., Yang, K., Zhou, C., Xu, Y., Song, J., Gu, Y., Chen, Z., Wang, M., Shoen, C., Andrade, B., Cynamon, M., Zhou, K., Wang, H., Cai, Q., Oldfield, E., Zimmerman, S. C., Bai, Y. & Feng, X., Jan 27 2021, In: Science Advances. 7, 5, eabc9917.

Research output: Contribution to journal › Article › peer-review

Open Access

Cag rnas induce dna damage and apoptosis by silencing nudt16 expression in polyglutamine degeneration

Peng, S., Guo, P., Lin, X., An, Y., Sze, K. H., Lau, M. H. Y., Chen, Z. S., Wang, Q., Li, W., Sun, J. K. L., Ma, S. Y., Chan, T. F., Lau, K. F., Ngo, J. C. K., Kwan, K. M., Wong, C. H., Lam, S. L., Zimmerman, S. C., Tuccinardi, T. & Zuo, Z. & 3 others, Au-Yeung, H. Y., Chow, H. M. & Chan, H. Y. E., May 11 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 19, e2022940118.

Research output: Contribution to journal › Article › peer-review

Open Access

Electrochemical CO₂-to-ethylene conversion on polyamine-incorporated Cu electrodes

Chen, X., Chen, J., Alghoraibi, N. M., Henckel, D. A., Zhang, R., Nwabara, U. O., Madsen, K. E., Kenis, P. J. A., Zimmerman, S. C. & Gewirth, A. A., Jan 2021, In: Nature Catalysis. 4, 1, p. 20-27 8 p.

Research output: Contribution to journal › Article › peer-review

Tandem catalysis using an enzyme and a polymeric ruthenium-based artificial metalloenzyme

Garcia, E. S., Xiong, T. M., Lifschitz, A. & Zimmerman, S. C., Dec 14 2021, In: Polymer Chemistry. 12, 46, p. 6755-6760 6 p.

Research output: Contribution to journal › Article › peer-review

Versatile Target-Guided Screen for Discovering Bidirectional Transcription Inhibitors of a Trinucleotide Repeat Disease

Hagler, L. D., Krueger, S. B., Luu, L. M., Lanzendorf, A. N., Mitchell, N. L., Vergara, J. I., Curet, L. D. & Zimmerman, S. C., Jun 10 2021, In: ACS Medicinal Chemistry Letters. 12, 6, p. 935-940 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

A Bioorthogonal Small Molecule Selective Polymeric "clickase"

Chen, J., Li, K., Bonson, S. E. & Zimmerman, S. C., Aug 12 2020, In: Journal of the American Chemical Society. 142, 32, p. 13966-13973 8 p.

Research output: Contribution to journal › Article › peer-review

Assessing the feasibility and stability of uracil base flipping in RNA–small molecule complexes using molecular dynamics simulations

Hagler, L. D., Bonson, S. E., Kocheril, P. A. & Zimmerman, S. C., 2020, In: Canadian Journal of Chemistry. 98, 6, p. 261-269 9 p.

Research output: Contribution to journal › Article › peer-review

Base-triggered self-amplifying degradable polyurethanes with the ability to translate local stimulation to continuous long-range degradation

Xu, Y., Sen, S., Wu, Q., Zhong, X., Ewoldt, R. H. & Zimmerman, S. C., Mar 28 2020, In: Chemical Science. 11, 12, p. 3326-3331 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Construction from destruction using a photo-triggered self-propagating degradable polyurethane as a one-pot epoxy

Xu, Y., Morado, E. G. & Zimmerman, S. C., Oct 14 2020, In: Polymer Chemistry. 11, 38, p. 6215-6220 6 p.

Research output: Contribution to journal › Article › peer-review

Expanded DNA and RNA Trinucleotide Repeats in Myotonic Dystrophy Type 1 Select Their Own Multitarget, Sequence-Selective Inhibitors

Hagler, L. D., Luu, L. M., Tonelli, M., Lee, J., Hayes, S. M., Bonson, S. E., Vergara, J. I., Butcher, S. E. & Zimmerman, S. C., Sep 22 2020, In: Biochemistry. 59, 37, p. 3463-3472 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Independent control over size, valence, and elemental composition in the synthesis of DNA-nanoparticle conjugates

Bai, Y., Xing, H., Bai, Y., Tan, L. H., Hwang, K., Li, J., Lu, Y. & Zimmerman, S. C., Feb 14 2020, In: Chemical Science. 11, 6, p. 1564-1572 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Intramolecularly Cross-Linked Polymers: From Structure to Function with Applications as Artificial Antibodies and Artificial Enzymes

Chen, J., Garcia, E. S. & Zimmerman, S. C., Jun 16 2020, In: Accounts of chemical research. 53, 6, p. 1244-1256 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Nonionic Surfactant Properties of Amphiphilic Hyperbranched Polyglycerols

Andrade, B., Knewstub, S. N., Harris, K., Tucker, C. J., Katz, J. S. & Zimmerman, S. C., Sep 1 2020, In: Langmuir. 36, 34, p. 10103-10109 7 p.

Research output: Contribution to journal › Article › peer-review

Single-Chain Nanoparticle Delivers a Partner Enzyme for Concurrent and Tandem Catalysis in Cells

Chen, J., Li, K., Shon, J. S. & Zimmerman, S. C., Mar 11 2020, In: Journal of the American Chemical Society. 142, 10, p. 4565-4569 5 p.

Research output: Contribution to journal › Article › peer-review

Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA

Chien, C. M., Wu, P. C., Satange, R., Chang, C. C., Lai, Z. L., Hagler, L. D., Zimmerman, S. C. & Hou, M. H., Jun 24 2020, In: Journal of the American Chemical Society. 142, 25, p. 11165-11172 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers

Miller, K. A., Morado, E. G., Samanta, S. R., Walker, B. A., Nelson, A. Z., Sen, S., Tran, D. T., Whitaker, D. J., Ewoldt, R. H., Braun, P. V. & Zimmerman, S. C., Feb 20 2019, In: Journal of the American Chemical Society. 141, 7, p. 2838-2842 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models

Hong, H., Koon, A. C., Chen, Z. S., Wei, Y., An, Y., Li, W., Lau, M. H. Y., Lau, K. F., Ngo, J. C. K., Wong, C. H., Au-Yeung, H. Y., Zimmerman, S. C. & Chan, H. Y. E., Feb 22 2019, In: Journal of Biological Chemistry. 294, 8, p. 2757-2770 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Bisamidinium-based inhibitors for the treatment of myotonic dystrophy

Zimmerman, S. C. (Inventor), Luu, L. M. (Inventor) & Nguyen, L. T. T. (Inventor), Apr 23 2019, U.S. Patent No. 10266520, Aug 10 2015

Research output: Patent

Development of novel macrocyclic small molecules that target CTG trinucleotide repeats

Serrano, J. F., Lee, J. Y., Daniel Curet, L., Hagler, L. D., Bonson, S. E., Schuster, E. J. & Zimmerman, S. C., Jul 1 2019, In: Bioorganic and Medicinal Chemistry. 27, 13, p. 2978-2984 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1

Lee, J. Y., Bai, Y., Chembazhi, U. V., Peng, S., Yum, K., Luu, L. M., Hagler, L. D., Serrano, J. F., Edwin Chan, H. Y., Kalsotra, A. & Zimmerman, S. C., Apr 30 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 18, p. 8709-8714 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Designed transition metal catalysts for intracellular organic synthesis

Bai, Y., Chen, J. & Zimmerman, S. C., Mar 7 2018, In: Chemical Society Reviews. 47, 5, p. 1811-1821 11 p.

Research output: Contribution to journal › Review article › peer-review

Engineering the Surface of Therapeutic "living" Cells

Park, J., Andrade, B., Seo, Y., Kim, M. J., Zimmerman, S. C. & Kong, H., Feb 28 2018, In: Chemical reviews. 118, 4, p. 1664-1690 27 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Enzyme-like Click Catalysis by a Copper-Containing Single-Chain Nanoparticle

Chen, J., Wang, J., Bai, Y., Li, K., Garcia, E. S., Ferguson, A. L. & Zimmerman, S. C., Oct 24 2018, In: Journal of the American Chemical Society. 140, 42, p. 13695-13702 8 p.

Research output: Contribution to journal › Article › peer-review

Linear dendronized polyols as a multifunctional platform for a versatile and efficient fluorophore design

Li, Y., Huth, K., Garcia, E. S., Pedretti, B. J., Bai, Y., Vincil, G. A., Haag, R. & Zimmerman, S. C., Apr 21 2018, In: Polymer Chemistry. 9, 15, p. 2040-2047 8 p.

Research output: Contribution to journal › Article › peer-review

2017

Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand

Xing, H., Bai, Y., Bai, Y., Tan, L. H., Tao, J., Pedretti, B., Vincil, G. A., Lu, Y. & Zimmerman, S. C., Mar 15 2017, In: Journal of the American Chemical Society. 139, 10, p. 3623-3626 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Patterning Three-Dimensional Hydrogel Microenvironments Using Hyperbranched Polyglycerols for Independent Control of Mesh Size and Stiffness

Pedron, S., Pritchard, A. M., Vincil, G. A., Andrade, B., Zimmerman, S. C. & Harley, B. A. C., Apr 10 2017, In: Biomacromolecules. 18, 4, p. 1393-1400 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "click" Reactions in Water and in Cells

Bai, Y., Feng, X., Xing, H., Xu, Y., Kim, B. K., Baig, N., Zhou, T., Gewirth, A. A., Lu, Y., Oldfield, E. & Zimmerman, S. C., Sep 7 2016, In: Journal of the American Chemical Society. 138, 35, p. 11077-11080 4 p.

Research output: Contribution to journal › Article › peer-review

A Journey in bioinspired supramolecular chemistry: From molecular tweezers to small molecules that target myotonic dystrophy

Zimmerman, S. C., Jan 25 2016, In: Beilstein Journal of Organic Chemistry. 12, p. 125-138 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy

Luu, L. M., Nguyen, L., Peng, S., Lee, J. Y., Lee, H. Y., Wong, C. H., Hergenrother, P. J., Chan, H. Y. E. & Zimmerman, S. C., Jul 5 2016, In: ChemMedChem. 11, 13, p. 1428-1435 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Compounds and methods for myotonic dystrophy therapy

Zimmerman, S. C. (Inventor), Luu, L. M. (Inventor) & Nguyen, L. T. T. (Inventor), Jun 28 2016, U.S. Patent No. 9376421, Aug 10 2015

Research output: Patent

Crosslinked dendronized polyols as a general approach to brighter and more stable fluorophores

Li, Y., Bai, Y., Zheng, N., Liu, Y., Vincil, G. A., Pedretti, B. J., Cheng, J. & Zimmerman, S. C., 2016, In: Chemical Communications. 52, 19, p. 3781-3784 4 p.

Research output: Contribution to journal › Article › peer-review

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting

Bai, Y., Nguyen, L., Song, Z., Peng, S., Lee, J., Zheng, N., Kapoor, I., Hagler, L. D., Cai, K., Cheng, J., Chan, H. Y. E. & Zimmerman, S. C., Aug 3 2016, In: Journal of the American Chemical Society. 138, 30, p. 9498-9507 10 p.

Research output: Contribution to journal › Article › peer-review

Steven C Zimmerman

Research output

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