Steven C Zimmerman

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Research Output

2020

Assessing the feasibility and stability of uracil base flipping in RNA–small molecule complexes using molecular dynamics simulations

Hagler, L. D., Bonson, S. E., Kocheril, P. A. & Zimmerman, S. C., Jan 1 2020, In : Canadian Journal of Chemistry. 98, 6, p. 261-269 9 p.

Research output: Contribution to journalArticle

Base-triggered self-amplifying degradable polyurethanes with the ability to translate local stimulation to continuous long-range degradation

Xu, Y., Sen, S., Wu, Q., Zhong, X., Ewoldt, R. H. & Zimmerman, S. C., Mar 28 2020, In : Chemical Science. 11, 12, p. 3326-3331 6 p.

Research output: Contribution to journalArticle

Open Access

Independent control over size, valence, and elemental composition in the synthesis of DNA-nanoparticle conjugates

Bai, Y., Xing, H., Bai, Y., Tan, L. H., Hwang, K., Li, J., Lu, Y. & Zimmerman, S. C., Feb 14 2020, In : Chemical Science. 11, 6, p. 1564-1572 9 p.

Research output: Contribution to journalArticle

Open Access
Open Access

Single-Chain Nanoparticle Delivers a Partner Enzyme for Concurrent and Tandem Catalysis in Cells

Chen, J., Li, K., Shon, J. S. & Zimmerman, S. C., Mar 11 2020, In : Journal of the American Chemical Society. 142, 10, p. 4565-4569 5 p.

Research output: Contribution to journalArticle

2019

Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers

Miller, K. A., Morado, E. G., Samanta, S. R., Walker, B. A., Nelson, A. Z., Sen, S., Tran, D. T., Whitaker, D. J., Ewoldt, R. H., Braun, P. V. & Zimmerman, S. C., Feb 20 2019, In : Journal of the American Chemical Society. 141, 7, p. 2838-2842 5 p.

Research output: Contribution to journalArticle

AQAMAN, a bisamidine-based inhibitor of toxic protein inclusions in neurons, ameliorates cytotoxicity in polyglutamine disease models

Hong, H., Koon, A. C., Chen, Z. S., Wei, Y., An, Y., Li, W., Lau, M. H. Y., Lau, K. F., Ngo, J. C. K., Wong, C. H., Au-Yeung, H. Y., Zimmerman, S. C. & Chan, H. Y. E., Feb 22 2019, In : Journal of Biological Chemistry. 294, 8, p. 2757-2770 14 p.

Research output: Contribution to journalArticle

Development of novel macrocyclic small molecules that target CTG trinucleotide repeats

Serrano, J. F., Lee, J. Y., Daniel Curet, L., Hagler, L. D., Bonson, S. E., Schuster, E. J. & Zimmerman, S. C., Jul 1 2019, In : Bioorganic and Medicinal Chemistry. 27, 13, p. 2978-2984 7 p.

Research output: Contribution to journalArticle

Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1

Lee, J. Y., Bai, Y., Chembazhi, U. V., Peng, S., Yum, K., Luu, L. M., Hagler, L. D., Serrano, J. F., Edwin Chan, H. Y., Kalsotra, A. & Zimmerman, S. C., Apr 30 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 18, p. 8709-8714 6 p.

Research output: Contribution to journalArticle

Polymeric "clickase" Accelerates the Copper Click Reaction of Small Molecules, Proteins, and Cells

Chen, J., Wang, J., Li, K., Wang, Y., Gruebele, M., Ferguson, A. L. & Zimmerman, S. C., Jun 19 2019, In : Journal of the American Chemical Society. 141, 24, p. 9693-9700 8 p.

Research output: Contribution to journalArticle

Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking

Montemayor, E. J., Virta, J. M., Hagler, L. D., Zimmerman, S. C. & Butcher, S. E., Oct 1 2019, In : Acta Crystallographica Section F: Structural Biology Communications. 75, p. 652-656 5 p.

Research output: Contribution to journalArticle

Open Access
2018

Designed transition metal catalysts for intracellular organic synthesis

Bai, Y., Chen, J. & Zimmerman, S. C., Mar 7 2018, In : Chemical Society Reviews. 47, 5, p. 1811-1821 11 p.

Research output: Contribution to journalReview article

Engineering the Surface of Therapeutic "living" Cells

Park, J., Andrade, B., Seo, Y., Kim, M. J., Zimmerman, S. C. & Kong, H., Feb 28 2018, In : Chemical reviews. 118, 4, p. 1664-1690 27 p.

Research output: Contribution to journalReview article

Enzyme-like Click Catalysis by a Copper-Containing Single-Chain Nanoparticle

Chen, J., Wang, J., Bai, Y., Li, K., Garcia, E. S., Ferguson, A. L. & Zimmerman, S. C., Oct 24 2018, In : Journal of the American Chemical Society. 140, 42, p. 13695-13702 8 p.

Research output: Contribution to journalArticle

Linear dendronized polyols as a multifunctional platform for a versatile and efficient fluorophore design

Li, Y., Huth, K., Garcia, E. S., Pedretti, B. J., Bai, Y., Vincil, G. A., Haag, R. & Zimmerman, S. C., Apr 21 2018, In : Polymer Chemistry. 9, 15, p. 2040-2047 8 p.

Research output: Contribution to journalArticle

2017

Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand

Xing, H., Bai, Y., Bai, Y., Tan, L. H., Tao, J., Pedretti, B., Vincil, G. A., Lu, Y. & Zimmerman, S. C., Mar 15 2017, In : Journal of the American Chemical Society. 139, 10, p. 3623-3626 4 p.

Research output: Contribution to journalArticle

Patterning Three-Dimensional Hydrogel Microenvironments Using Hyperbranched Polyglycerols for Independent Control of Mesh Size and Stiffness

Pedron, S., Pritchard, A. M., Vincil, G. A., Andrade, B., Zimmerman, S. C. & Harley, B. A. C., Apr 10 2017, In : Biomacromolecules. 18, 4, p. 1393-1400 8 p.

Research output: Contribution to journalArticle

PH-Triggered release from polyamide microcapsules prepared by interfacial polymerization of a simple diester monomer

Wang, H. C., Grolman, J. M., Rizvi, A., Hisao, G. S., Rienstra, C. M. & Zimmerman, S. C., Jan 1 2017, In : ACS Macro Letters. 6, 3, p. 321-325 5 p.

Research output: Contribution to journalArticle

Proton transfer dynamics dictate quinone speciation at lipid-modified electrodes

Tse, E. C. M., Barile, C. J., Li, Y., Zimmerman, S. C., Hosseini, A. & Gewirth, A. A., Jan 1 2017, In : Physical Chemistry Chemical Physics. 19, 10, p. 7086-7093 8 p.

Research output: Contribution to journalArticle

Worm-like superparamagnetic nanoparticle clusters for enhanced adhesion and magnetic resonance relaxivity

Smith, C. E., Lee, J. Y., Seo, Y., Clay, N., Park, J., Shkumatov, A., Ernenwein, D., Lai, M. H., Misra, S., Sing, C. E., Andrade, B., Zimmerman, S. C. & Kong, H., Jan 1 2017, In : ACS Applied Materials and Interfaces. 9, 2, p. 1219-1225 7 p.

Research output: Contribution to journalArticle

2016

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "click" Reactions in Water and in Cells

Bai, Y., Feng, X., Xing, H., Xu, Y., Kim, B. K., Baig, N., Zhou, T., Gewirth, A. A., Lu, Y., Oldfield, E. & Zimmerman, S. C., Sep 7 2016, In : Journal of the American Chemical Society. 138, 35, p. 11077-11080 4 p.

Research output: Contribution to journalArticle

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy

Luu, L. M., Nguyen, L., Peng, S., Lee, J. Y., Lee, H. Y., Wong, C. H., Hergenrother, P. J., Chan, H. Y. E. & Zimmerman, S. C., Jan 1 2016, In : ChemMedChem. 11, 13, p. 1428-1435 8 p.

Research output: Contribution to journalArticle

Crosslinked dendronized polyols as a general approach to brighter and more stable fluorophores

Li, Y., Bai, Y., Zheng, N., Liu, Y., Vincil, G. A., Pedretti, B. J., Cheng, J. & Zimmerman, S. C., Jan 1 2016, In : Chemical Communications. 52, 19, p. 3781-3784 4 p.

Research output: Contribution to journalArticle

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting

Bai, Y., Nguyen, L., Song, Z., Peng, S., Lee, J., Zheng, N., Kapoor, I., Hagler, L. D., Cai, K., Cheng, J., Chan, H. Y. E. & Zimmerman, S. C., Aug 3 2016, In : Journal of the American Chemical Society. 138, 30, p. 9498-9507 10 p.

Research output: Contribution to journalArticle

Proton transfer dynamics control the mechanism of O2 reduction by a non-precious metal electrocatalyst

Tse, E. C. M., Barile, C. J., Kirchschlager, N. A., Li, Y., Gewargis, J. P., Zimmerman, S. C., Hosseini, A. & Gewirth, A. A., Jul 1 2016, In : Nature Materials. 15, 7, p. 754-759 6 p.

Research output: Contribution to journalArticle

Supramolecular chemistry at the interface of biology, materials and medicine

Anslyn, E. V. & Zimmerman, S. C., May 31 2016, In : Beilstein Journal of Organic Chemistry. 12, p. 1101-1102 2 p.

Research output: Contribution to journalEditorial

Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

Moore, E., Zill, A. T., Anderson, C. A., Jochem, A. R., Zimmerman, S. C., Bonder, C. S., Kraus, T., Thissen, H. & Voelcker, N. H., Oct 1 2016, In : Macromolecular Chemistry and Physics. 217, 20, p. 2252-2261 10 p.

Research output: Contribution to journalArticle

The Flip-Flop Diffusion Mechanism across Lipids in a Hybrid Bilayer Membrane

Barile, C. J., Tse, E. C. M., Li, Y., Gewargis, J. P., Kirchschlager, N. A., Zimmerman, S. C. & Gewirth, A. A., Jun 7 2016, In : Biophysical journal. 110, 11, p. 2451-2462 12 p.

Research output: Contribution to journalArticle

2015

A double supramolecular crosslinked polymer gel exhibiting macroscale expansion and contraction behavior and multistimuli responsiveness

Ji, X., Jie, K., Zimmerman, S. C. & Huang, F., Mar 21 2015, In : Polymer Chemistry. 6, 11, p. 1912-1917 6 p.

Research output: Contribution to journalArticle

Anion transport through lipids in a hybrid bilayer membrane

Tse, E. C. M., Barile, C. J., Gewargis, J. P., Li, Y., Zimmerman, S. C. & Gewirth, A. A., Feb 17 2015, In : Analytical chemistry. 87, 4, p. 2403-2409 7 p.

Research output: Contribution to journalArticle

Chemical Control over Cellular Uptake of Organic Nanoparticles by Fine Tuning Surface Functional Groups

Bai, Y., Xing, H., Wu, P., Feng, X., Hwang, K., Lee, J. M., Phang, X. Y., Lu, Y. & Zimmerman, S. C., Sep 1 2015, In : ACS Nano. 9, 10, p. 10227-10236 10 p.

Research output: Contribution to journalArticle

Hydrophilic packaging of iron oxide nanoclusters for highly sensitive imaging

Smith, C. E., Ernenwein, D., Shkumatov, A., Clay, N. E., Lee, J. Y., Melhem, M., Misra, S., Zimmerman, S. C. & Kong, H., Nov 1 2015, In : Biomaterials. 69, p. 184-190 7 p.

Research output: Contribution to journalArticle

New frontiers for encapsulation in the chemical industry

Andrade, B., Song, Z., Li, J., Zimmerman, S. C., Cheng, J., Moore, J. S., Harris, K. & Katz, J. S., Apr 1 2015, In : ACS Applied Materials and Interfaces. 7, 12, p. 6359-6368 10 p.

Research output: Contribution to journalArticle

Photoresponsive Molecular Switch for Regulating Transmembrane Proton-Transfer Kinetics

Li, Y., Tse, E. C. M., Barile, C. J., Gewirth, A. A. & Zimmerman, S. C., Nov 11 2015, In : Journal of the American Chemical Society. 137, 44, p. 14059-14062 4 p.

Research output: Contribution to journalArticle

Rationally Designed Small Molecules That Target Both the DNA and RNA Causing Myotonic Dystrophy Type 1

Nguyen, L., Luu, L. M., Peng, S., Serrano, J. F., Chan, H. Y. E. & Zimmerman, S. C., Nov 11 2015, In : Journal of the American Chemical Society. 137, 44, p. 14180-14189 10 p.

Research output: Contribution to journalArticle

Self-Assembling Amphiphilic Hyperbranched Polyglycerol-Polystyrene Copolymers for Encapsulation

Ernenwein, D., Vartanian, A. M. & Zimmerman, S. C., Aug 1 2015, In : Macromolecular Chemistry and Physics. 216, 16, p. 1729-1736 8 p.

Research output: Contribution to journalArticle

Trigger chemistries for better industrial formulations

Wang, H. C., Zhang, Y., Possanza, C. M., Zimmerman, S. C., Cheng, J., Moore, J. S., Harris, K. & Katz, J. S., Apr 1 2015, In : ACS Applied Materials and Interfaces. 7, 12, p. 6369-6382 14 p.

Research output: Contribution to journalReview article

Water-soluble polyglycerol dendrimers with two orthogonally reactive core functional groups for one-pot functionalization

Yang, S. K. & Zimmerman, S. C., Apr 28 2015, In : Macromolecules. 48, 8, p. 2504-2508 5 p.

Research output: Contribution to journalArticle

2014

Isaiah Shavitt: Computational chemistry pioneer

Zimmerman, S. C. & Pitzer, R. M., Jan 1 2014, In : Theoretical Chemistry Accounts. 133, 6, p. 1-7 7 p.

Research output: Contribution to journalArticle

Polymer self-assembly: A web themed issue

Huang, F., O’reilly, R. & Zimmerman, S. C., Oct 9 2014, In : Chemical Communications. 50, 88, p. 13415-13416 2 p.

Research output: Contribution to journalArticle

Practical synthesis of water-soluble organic nanoparticles with a single reactive group and a functional carrier scaffold

Bai, Y., Xing, H., Vincil, G. A., Lee, J., Henderson, E. J., Lu, Y., Lemcoff, N. G. & Zimmerman, S. C., Jul 2014, In : Chemical Science. 5, 7, p. 2862-2868 7 p.

Research output: Contribution to journalArticle

Proton switch for modulating oxygen reduction by a copper electrocatalyst embedded in a hybrid bilayer membrane

Barile, C. J., Tse, E. C. M., Li, Y., Sobyra, T. B., Zimmerman, S. C., Hosseini, A. & Gewirth, A. A., Jun 2014, In : Nature Materials. 13, 6, p. 619-623 5 p.

Research output: Contribution to journalArticle

Small Molecules that Target the Toxic RNA in Myotonic Dystrophy Type 2

Nguyen, L., Lee, J. Y., Wong, C. H. & Zimmerman, S. C., Aug 17 2014, In : ChemMedChem. 9, 11, p. 2455-2462 8 p.

Research output: Contribution to journalArticle

Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor

Wong, C. H., Nguyen, L., Peh, J., Luu, L. M., Sanchez, J. S., Richardson, S. L., Tuccinardi, T., Tsoi, H., Chan, W. Y., Chan, H. Y. E., Baranger, A. M., Hergenrother, P. J. & Zimmerman, S. C., Apr 30 2014, In : Journal of the American Chemical Society. 136, 17, p. 6355-6361 7 p.

Research output: Contribution to journalArticle

2013

A dendritic single-molecule fluorescent probe that is monovalent, photostable and minimally blinking

Yang, S. K., Shi, X., Park, S., Ha, T. & Zimmerman, S. C., Aug 1 2013, In : Nature Chemistry. 5, 8, p. 692-697 6 p.

Research output: Contribution to journalArticle

A novel CUGexp·MBNL1 inhibitor with therapeutic potential for myotonic dystrophy type 1

Jahromi, A. H., Nguyen, L., Fu, Y., Miller, K. A., Baranger, A. M. & Zimmerman, S. C., May 17 2013, In : ACS chemical biology. 8, 5, p. 1037-1043 7 p.

Research output: Contribution to journalArticle

A polymeric fastener can easily functionalize liposome surfaces with gadolinium for enhanced magnetic resonance imaging

Smith, C. E., Shkumatov, A., Withers, S. G., Yang, B., Glockner, J. F., Misra, S., Roy, E. J., Wong, C. H., Zimmerman, S. C. & Kong, H., Nov 26 2013, In : ACS Nano. 7, 11, p. 9599-9610 12 p.

Research output: Contribution to journalArticle

Developing bivalent ligands to target CUG triplet repeats, the causative agent of myotonic dystrophy type 1

Jahromi, A. H., Fu, Y., Miller, K. A., Nguyen, L., Luu, L. M., Baranger, A. M. & Zimmerman, S. C., Dec 12 2013, In : Journal of Medicinal Chemistry. 56, 23, p. 9471-9481 11 p.

Research output: Contribution to journalArticle

High-affinity DNA base analogs as supramolecular, nanoscale promoters of macroscopic adhesion

Anderson, C. A., Jones, A. R., Briggs, E. M., Novitsky, E. J., Kuykendall, D. W., Sottos, N. R. & Zimmerman, S. C., May 15 2013, In : Journal of the American Chemical Society. 135, 19, p. 7288-7295 8 p.

Research output: Contribution to journalArticle