Stanislav Rubakhin

2025

Neurochemical and Morphological Comparisons of Motor Nerve Organoids and Spinal-Cord Explants

Murphy, S. E., Sullivan-Weiss, A. C., Sirois, C. H., Rubakhin, S. S., Kong, H., Gillette, M. U. & Sweedler, J. V., Jan 2025, In: ACS Chemical Neuroscience. 16, 1, p. 30-39 10 p.

Research output: Contribution to journal › Article › peer-review

Single-Cell Peptide Profiling to Distinguish Stickleback Ecotypes with Divergent Breeding Behavior

Bell, S. E., Xie, Y. R., Maciejewski, M. F., Rubakhin, S. S., Romanova, E. V., Bell, A. M. & Sweedler, J. V., 2025, (Accepted/In press) In: Journal of Proteome Research.

Research output: Contribution to journal › Article › peer-review

2024

1-Octanol-assisted ultra-small volume droplet microfluidics with nanoelectrospray ionization mass spectrometry

Zhao, Y., Park, I., Rubakhin, S. S., Bashir, R., Vlasov, Y. & Sweedler, J. V., Sep 8 2024, In: Analytica Chimica Acta. 1321, 342998.

Research output: Contribution to journal › Article › peer-review

Open Access

A novel series of metazoan L/D peptide isomerases

Andersen, H. M., Tai, H. C., Rubakhin, S. S., Yau, P. M. & Sweedler, J. V., Jul 2024, In: Journal of Biological Chemistry. 300, 7, 107458.

Research output: Contribution to journal › Article › peer-review

Open Access

High-resolution ¹H-MRSI at 9.4 T by integrating relaxation enhancement and subspace imaging

Wang, Y., Saha, U., Rubakhin, S. S., Roy, E. J., Smith, A. M., Sweedler, J. V. & Lam, F., Oct 2024, In: NMR in Biomedicine. 37, 10, e5161.

Research output: Contribution to journal › Article › peer-review

Open Access

Multiscale biochemical mapping of the brain through deep-learning-enhanced high-throughput mass spectrometry

Xie, Y. R., Castro, D. C., Rubakhin, S. S., Trinklein, T. J., Sweedler, J. V. & Lam, F., Mar 2024, In: Nature Methods. 21, 3, p. 521-530 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

NanoLC-timsTOF-Assisted Analysis of Glycated Albumin in Diabetes-Affected Plasma and Tears

Tan, Y., De La Toba, E., Rubakhin, S. S., Labriola, L. T., Canfield, C., Pan, D. & Sweedler, J. V., Jan 3 2024, In: Journal of the American Society for Mass Spectrometry. 35, 1, p. 106-113 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Single Cell Analysis of Proteoforms

Su, P., Hollas, M. A. R., Butun, F. A., Kanchustambham, V. L., Rubakhin, S., Ramani, N., Greer, J. B., Early, B. P., Fellers, R. T., Caldwell, M. A., Sweedler, J. V., Kafader, J. O. & Kelleher, N. L., Jun 7 2024, In: Journal of Proteome Research. 23, 6, p. 1883-1893 11 p.

Research output: Contribution to journal › Article › peer-review

2023

Biodistribution and racemization of gut-absorbed l/d-alanine in germ-free mice

Qiu, T., Lee, C. J., Huang, C., Lee, D. K., Rubakhin, S. S., Romanova, E. V. & Sweedler, J. V., Dec 2023, In: Communications biology. 6, 1, 851.

Research output: Contribution to journal › Article › peer-review

Open Access

Chemical Decrosslinking-Based Peptide Characterization of Formaldehyde-Fixed Rat Pancreas Using Fluorescence-Guided Single-Cell Mass Spectrometry

Lee, D. K., Rubakhin, S. S. & Sweedler, J. V., Apr 25 2023, In: Analytical Chemistry. 95, 16, p. 6732-6739 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Data-Driven and Machine Learning-Based Framework for Image-Guided Single-Cell Mass Spectrometry

Xie, Y. R., Chari, V. K., Castro, D. C., Grant, R., Rubakhin, S. S. & Sweedler, J. V., Feb 3 2023, In: Journal of Proteome Research. 22, 2, p. 491-500 10 p.

Research output: Contribution to journal › Article › peer-review

Relations between Glucose and d-Amino Acids in the Modulation of Biochemical and Functional Properties of Rodent Islets of Langerhans

Lee, C. J., Lee, D. K., Wei, I. A., Qiu, T. A., Rubakhin, S. S., Roper, M. G. & Sweedler, J. V., Dec 19 2023, In: ACS Omega. 8, 50, p. 47723-47734 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Single-Cell and Subcellular Analysis Using Ultrahigh Resolution 21 T MALDI FTICR Mass Spectrometry

Castro, D. C., Smith, K. W., Norsworthy, M. D., Rubakhin, S. S., Weisbrod, C. R., Hendrickson, C. L. & Sweedler, J. V., May 2 2023, In: Analytical Chemistry. 95, 17, p. 6980-6988 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Characterizing RNA Modifications in Single Neurons using Mass Spectrometry

Clark, K. D., Rubakhin, S. S. & Sweedler, J. V., Apr 2022, In: Journal of Visualized Experiments. 2022, 182, e63940.

Research output: Contribution to journal › Article › peer-review

Open Access

d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans

Lee, C. J., Schnieders, J. H., Rubakhin, S. S., Patel, A. V., Liu, C., Naji, A. & Sweedler, J. V., Sep 2022, In: Metabolites. 12, 9, 799.

Research output: Contribution to journal › Article › peer-review

Open Access

Enhancing the Throughput of FT Mass Spectrometry Imaging Using Joint Compressed Sensing and Subspace Modeling

Xie, Y. R., Castro, D. C., Rubakhin, S. S., Sweedler, J. V. & Lam, F., Apr 5 2022, In: Analytical Chemistry. 94, 13, p. 5335-5343 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Profiling 26,000 Aplysia californica neurons by single cell mass spectrometry reveals neuronal populations with distinct neuropeptide profiles

Chan-Andersen, P. C., Romanova, E. V., Rubakhin, S. S. & Sweedler, J. V., Aug 2022, In: Journal of Biological Chemistry. 298, 8, 102254.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

3D Particle-Free Printing of Biocompatible Conductive Hydrogel Platforms for Neuron Growth and Electrophysiological Recording

Wang, C., Rubakhin, S. S., Enright, M. J., Sweedler, J. V. & Nuzzo, R. G., Apr 1 2021, In: Advanced Functional Materials. 31, 14, 2010246.

Research output: Contribution to journal › Article › peer-review

Open Access

Droplet Microfluidics with MALDI-MS Detection: The Effects of Oil Phases in GABA Analysis

Bell, S. E., Park, I., Rubakhin, S. S., Bashir, R., Vlasov, Y. & Sweedler, J. V., Dec 15 2021, In: ACS Measurement Science Au. 1, 3, p. 147-156 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Image-guided MALDI mass spectrometry for high-throughput single-organelle characterization

Castro, D. C., Xie, Y. R., Rubakhin, S. S., Romanova, E. V. & Sweedler, J. V., Oct 2021, In: Nature Methods. 18, 10, p. 1233-1238 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Single-Neuron RNA Modification Analysis by Mass Spectrometry: Characterizing RNA Modification Patterns and Dynamics with Single-Cell Resolution

Clark, K. D., Rubakhin, S. S. & Sweedler, J. V., Nov 2 2021, In: Analytical Chemistry. 93, 43, p. 14537-14544 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Spatiotemporal biodistribution of α-tocopherol is impacted by the source of ¹³C-labeled α-tocopherol in mice following a single oral dose

Jeon, S., Li, Q., Ranard, K. M., Rubakhin, S. S., Sweedler, J. V., Kuchan, M. J. & Erdman, J. W., Sep 2021, In: Nutrition Research. 93, p. 79-86 8 p.

Research output: Contribution to journal › Article › peer-review

2020

Enhanced single-cell metabolomics by capillary electrophoresis electrospray ionization-mass spectrometry with field amplified sample injection

Liao, H. W., Rubakhin, S., Philip, M. C. & Sweedler, J. V., Jun 29 2020, In: Analytica Chimica Acta. 1118, p. 36-43 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Quantitative Imprint Mass Spectrometry Imaging of Endogenous Ceramides in Rat Brain Tissue with Kinetic Calibration

Wu, Q., Rubakhin, S. S. & Sweedler, J. V., May 5 2020, In: Analytical Chemistry. 92, 9, p. 6613-6621 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Removing Formaldehyde-Induced Peptidyl Crosslinks Enables Mass Spectrometry Imaging of Peptide Hormone Distributions from Formalin-Fixed Paraffin-Embedded Tissues

Lee, D. K., Rubakhin, S. S., Kusmartseva, I., Wasserfall, C., Atkinson, M. A. & Sweedler, J. V., Dec 7 2020, In: Angewandte Chemie - International Edition. 59, 50, p. 22584-22590 7 p.

Research output: Contribution to journal › Article › peer-review

Single-Cell Classification Using Mass Spectrometry through Interpretable Machine Learning

Xie, Y. R., Castro, D. C., Bell, S. E., Rubakhin, S. & Sweedler, J. V., Jul 7 2020, In: Analytical Chemistry. 92, 13, p. 9338-9347 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

¹³C-lutein is differentially distributed in tissues of an adult female rhesus macaque following a single oral administration: a pilot study

Jeon, S., Li, Q., Rubakhin, S. S., Sweedler, J. V., Smith, J. W., Neuringer, M., Kuchan, M. & Erdman, J. W., Jan 2019, In: Nutrition Research. 61, p. 102-108 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Lipid Analysis of 30 000 Individual Rodent Cerebellar Cells Using High-Resolution Mass Spectrometry

Neumann, E. K., Ellis, J. F., Triplett, A. E., Rubakhin, S. S. & Sweedler, J. V., Jun 18 2019, In: Analytical Chemistry. 91, 12, p. 7871-7878 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Lipid Heterogeneity between Astrocytes and Neurons Revealed by Single-Cell MALDI-MS Combined with Immunocytochemical Classification

Neumann, E. K., Comi, T. J., Rubakhin, S. S. & Sweedler, J. V., Apr 23 2019, In: Angewandte Chemie - International Edition. 58, 18, p. 5910-5914 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol

Park, H. M., Satta, R., Davis, R. G., Goo, Y. A., Leduc, R. D., Fellers, R. T., Greer, J. B., Romanova, E. V., Rubakhin, S. S., Tai, R., Thomas, P. M., Sweedler, J. V., Kelleher, N. L., Patrie, S. M. & Lasek, A. W., Nov 1 2019, In: Journal of Proteome Research. 18, 11, p. 3999-4012 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

PACAP and other neuropeptide targets link chronic migraine and opioid-induced hyperalgesia in mouse models

Anapindi, K. D. B., Yang, N., Romanova, E. V., Rubakhin, S. S., Tipton, A., Dripps, I., Sheets, Z., Sweedler, J. V. & Pradhan, A. A., 2019, In: Molecular and Cellular Proteomics. 18, 12, p. 2447-2458 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Expired Epinephrine Maintains Chemical Concentration and Sterility

Weir, W. B., Fred, L. Y., Pike, M., Rubakhin, S. S., Ludwig, T. J., Shar, A. M., Zhu, L., Frederick, A., Uzoaru, I., Wang, L. & Sweedler, J. V., Jul 4 2018, In: Prehospital Emergency Care. 22, 4, p. 414-418 5 p.

Research output: Contribution to journal › Article › peer-review

Gene network dysregulation in the trigeminal ganglia and nucleus accumbens of a model of chronic migraine-associated hyperalgesia

Jeong, H., Moye, L. S., Southey, B. R., Hernandez, A. G., Dripps, I., Romanova, E. V., Rubakhin, S. S., Sweedler, J. V., Pradhan, A. A. & Rodriguez-Zas, S. L., Dec 18 2018, In: Frontiers in Systems Neuroscience. 12, 63.

Research output: Contribution to journal › Article › peer-review

Open Access

Multimodal Chemical Analysis of the Brain by High Mass Resolution Mass Spectrometry and Infrared Spectroscopic Imaging

Neumann, E. K., Comi, T. J., Spegazzini, N., Mitchell, J. W., Rubakhin, S. S., Gillette, M. U., Bhargava, R. & Sweedler, J. V., Oct 2 2018, In: Analytical Chemistry. 90, 19, p. 11572-11580 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Neuropeptidomics of the Rat Habenular Nuclei

Yang, N., Anapindi, K. D. B., Rubakhin, S. S., Wei, P., Yu, Q., Li, L., Kenny, P. J. & Sweedler, J. V., Apr 6 2018, In: Journal of Proteome Research. 17, 4, p. 1463-1473 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Optically Guided Single Cell Mass Spectrometry of Rat Dorsal Root Ganglia to Profile Lipids, Peptides and Proteins

Do, T. D., Ellis, J. F., Neumann, E. K., Comi, T. J., Tillmaand, E. G., Lenhart, A. E., Rubakhin, S. S. & Sweedler, J. V., May 22 2018, In: ChemPhysChem. 19, 10, p. 1180-1191 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms between Mouse Strains

Davis, R. G., Park, H. M., Kim, K., Greer, J. B., Fellers, R. T., Leduc, R. D., Romanova, E. V., Rubakhin, S. S., Zombeck, J. A., Wu, C., Yau, P. M., Gao, P., Van Nispen, A. J., Patrie, S. M., Thomas, P. M., Sweedler, J. V., Rhodes, J. S. & Kelleher, N. L., Mar 20 2018, In: Analytical Chemistry. 90, 6, p. 3802-3810 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

3D-Printed pHEMA Materials for Topographical and Biochemical Modulation of Dorsal Root Ganglion Cell Response

Badea, A., McCracken, J. M., Tillmaand, E. G., Kandel, M. E., Oraham, A. W., Mevis, M. B., Rubakhin, S. S., Popescu, G., Sweedler, J. V. & Nuzzo, R. G., Sep 13 2017, In: ACS Applied Materials and Interfaces. 9, 36, p. 30318-30328 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A unique combination of micronutrients rejuvenates cognitive performance in aged mice

Perez, S. D., Du, K., Rendeiro, C., Wang, L., Wu, Q., Rubakhin, S. S., Vazhappilly, R., Baxter, J. H., Sweedler, J. V. & Rhodes, J. S., Mar 1 2017, In: Behavioural Brain Research. 320, p. 97-112 16 p.

Research output: Contribution to journal › Article › peer-review

Carrot solution culture bioproduction of uniformly labeled ¹³C-lutein and in vivo dosing in non-human primates

Smith, J. W., Rogers, R. B., Jeon, S., Rubakhin, S. S., Wang, L., Sweedler, J. V., Neuringer, M., Kuchan, M. J. & Erdman, J. W., Feb 1 2017, In: Experimental Biology and Medicine. 242, 3, p. 305-315 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Chiral Measurement of Aspartate and Glutamate in Single Neurons by Large-Volume Sample Stacking Capillary Electrophoresis

Patel, A. V., Kawai, T., Wang, L., Rubakhin, S. S. & Sweedler, J. V., Nov 21 2017, In: Analytical Chemistry. 89, 22, p. 12375-12382 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks

McCracken, J. M., Xu, S., Badea, A., Jang, K. I., Yan, Z., Wetzel, D. J., Nan, K., Lin, Q., Han, M., Anderson, M. A., Lee, J. W., Wei, Z., Pharr, M., Wang, R., Su, J., Rubakhin, S. S., Sweedler, J. V., Rogers, J. A. & Nuzzo, R. G., Sep 2017, In: Advanced Biosystems. 1, 9, 1700068.

Research output: Contribution to journal › Article › peer-review

Open Access

Dopamine-modified TiO₂ monolith-assisted LDI MS imaging for simultaneous localization of small metabolites and lipids in mouse brain tissue with enhanced detection selectivity and sensitivity

Wu, Q., Chu, J. L., Rubakhin, S. S., Gillette, M. U. & Sweedler, J. V., 2017, In: Chemical Science. 8, 5, p. 3926-3938 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Improved identification and quantitation of mature endogenous peptides in the rodent hypothalamus using a rapid conductive sample heating system

Yang, N., Anapindi, K. D. B., Romanova, E. V., Rubakhin, S. S. & Sweedler, J. V., Dec 7 2017, In: Analyst. 142, 23, p. 4476-4485 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

MALDI MS Guided Liquid Microjunction Extraction for Capillary Electrophoresis-Electrospray Ionization MS Analysis of Single Pancreatic Islet Cells

Comi, T. J., Makurath, M. A., Philip, M. C., Rubakhin, S. S. & Sweedler, J. V., Jul 18 2017, In: Analytical Chemistry. 89, 14, p. 7765-7772 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Quantitative Reflection Imaging for the Morphology and Dynamics of Live Aplysia californica Pedal Ganglion Neurons Cultured on Nanostructured Plasmonic Crystals

Kang, S., Badea, A., Rubakhin, S. S., Sweedler, J. V., Rogers, J. A. & Nuzzo, R. G., Sep 5 2017, In: Langmuir. 33, 35, p. 8640-8650 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Single Cell Profiling Using Ionic Liquid Matrix-Enhanced Secondary Ion Mass Spectrometry for Neuronal Cell Type Differentiation

Do, T. D., Comi, T. J., Dunham, S. J. B., Rubakhin, S. S. & Sweedler, J. V., Mar 7 2017, In: Analytical Chemistry. 89, 5, p. 3078-3086 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Three-dimensional mesostructures as high-temperature growth templates, electronic cellular scaffolds, and self-propelled microrobots

Yan, Z., Han, M., Shi, Y., Badea, A., Yang, Y., Kulkarni, A., Hanson, E., Kandel, M. E., Wen, X., Zhang, F., Luo, Y., Lin, Q., Zhang, H., Guo, X., Huang, Y., Nan, K., Jia, S., Oraham, A. W., Mevis, M. B. & Lim, J. & 19 others, Guo, X., Gao, M., Ryu, W., Yu, K. J., Nicolau, B. G., Petronico, A., Rubakhin, S. S., Lou, J., Ajayan, P. M., Thornton, K., Popescu, G., Fang, D., Sweedler, J. V., Braun, P. V., Zhang, H., Nuzzo, R. G., Huang, Y., Zhang, Y. & Rogers, J. A., Nov 7 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 45, p. E9455-E9464

Research output: Contribution to journal › Article › peer-review

Open Access

2016

A neuron-in-capillary platform for facile collection and mass spectrometric characterization of a secreted neuropeptide

Lee, C. Y., Fan, Y., Rubakhin, S. S., Yoon, S. & Sweedler, J. V., Jun 1 2016, In: Scientific reports. 6, 26940.

Research output: Contribution to journal › Article › peer-review

Open Access

On-Tissue Derivatization via Electrospray Deposition for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Endogenous Fatty Acids in Rat Brain Tissues

Wu, Q., Comi, T. J., Li, B., Rubakhin, S. S. & Sweedler, J. V., Jun 7 2016, In: Analytical Chemistry. 88, 11, p. 5988-5995 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Stanislav Rubakhin

Research output

Search results