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2019

A clinical trial of intraoperative near-infrared imaging to assess tumor extent and identify residual disease during anterior mediastinal tumor resection

Predina, J. D., Keating, J., Newton, A., Corbett, C., Xia, L., Shin, M., Frenzel Sulyok, L., Deshpande, C., Litzky, L., Nie, S., Kucharczuk, J. C. & Singhal, S., Mar 1 2019, In : Cancer. 125, 5, p. 807-817 11 p.

Research output: Contribution to journalArticle

Aqueous acid-based synthesis of lead-free tin halide perovskites with near-unity photoluminescence quantum efficiency

Wang, A., Guo, Y., Zhou, Z., Niu, X., Wang, Y., Muhammad, F., Li, H., Zhang, T., Wang, J., Nie, S. & Deng, Z., Jan 1 2019, In : Chemical Science. 10, 17, p. 4573-4579 7 p.

Research output: Contribution to journalArticle

Open Access

Cherenkov excited luminescence imaging induced by megavolt X-ray beams in the second near-infrared window

Meng, X., Du, Y., Wang, R., Li, Z., Zhu, S., Wu, H., Li, C., Chen, W., Nie, S., Ren, Q. & Lu, Y., Dec 1 2019, In : Optics Communications. 452, p. 417-421 5 p.

Research output: Contribution to journalArticle

Direct Hot-Injection Synthesis of Lead Halide Perovskite Nanocubes in Acrylic Monomers for Ultrastable and Bright Nanocrystal-Polymer Composite Films

Tong, J., Wu, J., Shen, W., Zhang, Y., Liu, Y., Zhang, T., Nie, S. & Deng, Z., Mar 6 2019, In : ACS Applied Materials and Interfaces. 11, 9, p. 9317-9325 9 p.

Research output: Contribution to journalArticle

Encapsulating maytansinoid in pH-sensitive nanocarriers: The importance of using extremely potent cytotoxic agents and fast release for nanomedicine to achieve tumor elimination

Dai, B., Wu, X., Butch, C. J., Wang, J., Wang, Z., Wang, Y., Nie, S., Lu, Q., Wang, Y. & Ding, Y., Aug 1 2019, In : Nano Research. 12, 8, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

Evaluation of Aminolevulinic Acid-Derived Tumor Fluorescence Yields Disparate Results in Murine and Spontaneous Large Animal Models of Lung Cancer

Predina, J. D., Runge, J., Newton, A., Mison, M., Xia, L., Corbett, C., Shin, M., Sulyok, L. F., Durham, A., Nie, S., Singhal, S. & Holt, D., Dec 1 2019, In : Scientific reports. 9, 1, 7629.

Research output: Contribution to journalArticle

Open Access

Influence of Electron Acceptor and Electron Donor on the Photophysical Properties of Carbon Dots: A Comparative Investigation at the Bulk-State and Single-Particle Level

Srivastava, I., Khamo, J. S., Pandit, S., Fathi, P., Huang, X., Cao, A., Haasch, R. T., Nie, S., Zhang, K. & Pan, D., Jul 4 2019, In : Advanced Functional Materials. 29, 37, 1902466.

Research output: Contribution to journalArticle

Machine Learning-Assisted Array-Based Biomolecular Sensing Using Surface-Functionalized Carbon Dots

Pandit, S., Banerjee, T., Srivastava, I., Nie, S. & Pan, D., Jan 1 2019, In : ACS Sensors. 4, 10, p. 2730-2737 8 p.

Research output: Contribution to journalArticle

Measurement of circulating tumor cells in squamous cell carcinoma of the head and neck and patient outcomes

Morgan, T. M., Wang, X., Qian, X., Switchenko, J. M., Nie, S., Patel, K. R., Cassidy, R. J., Shin, D. M. & Beitler, J. J., Mar 8 2019, In : Clinical and Translational Oncology. 21, 3, p. 342-347 6 p.

Research output: Contribution to journalArticle

Near-infrared intraoperative imaging for minimally invasive pulmonary metastasectomy for sarcomas

Predina, J. D., Newton, A. D., Corbett, C., Shin, M., Sulfyok, L. F., Okusanya, O. T., Delikatny, E. J., Nie, S., Gaughan, C., Jarrar, D., Pechet, T., Kucharczuk, J. C. & Singhal, S., May 2019, In : Journal of Thoracic and Cardiovascular Surgery. 157, 5, p. 2061-2069 9 p.

Research output: Contribution to journalArticle

Optimization of Second Window Indocyanine Green for Intraoperative Near-Infrared Imaging of Thoracic Malignancy

Newton, A. D., Predina, J. D., Corbett, C. J., Frenzel-Sulyok, L. G., Xia, L., Petersson, E. J., Tsourkas, A., Nie, S., Delikatny, E. J. & Singhal, S., Feb 2019, In : Journal of the American College of Surgeons. 228, 2, p. 188-197 10 p.

Research output: Contribution to journalArticle

Succinylated heparin monolayer coating vastly increases superparamagnetic iron oxide nanoparticle: T 2 proton relaxivity

Xie, M., Liu, S., Butch, C. J., Liu, S., Wang, Z., Wang, J., Zhang, X., Nie, S., Lu, Q. & Wang, Y., Jul 21 2019, In : Nanoscale. 11, 27, p. 12905-12914 10 p.

Research output: Contribution to journalArticle

Targeted drug delivery and image-guided therapy of heterogeneous ovarian cancer using HER2-targeted theranostic nanoparticles

Satpathy, M., Wang, L., Zielinski, R. J., Qian, W., Wang, Y. A., Mohs, A. M., Kairdolf, B. A., Ji, X., Capala, J., Lipowska, M., Nie, S., Mao, H. & Yang, L., Jan 1 2019, In : Theranostics. 9, 3, p. 778-795 18 p.

Research output: Contribution to journalArticle

Open Access
2018

An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas

Predina, J. D., Newton, A. D., Xia, L., Corbett, C., Connolly, C., Shin, M., Sulyok, L. F., Litzky, L., Deshpande, C., Nie, S., Kularatne, S. A., Low, P. S. & Singhal, S., Jan 1 2018, In : Oncotarget. 9, 17, p. 13517-13529 13 p.

Research output: Contribution to journalArticle

Dual functional asymmetric plasmonic structures for solar water purification and pollution detection

Chen, C., Zhou, L., Yu, J., Wang, Y., Nie, S., Zhu, S. & Zhu, J., Sep 2018, In : Nano Energy. 51, p. 451-456 6 p.

Research output: Contribution to journalArticle

Near-infrared fluorescent image-guided surgery for intracranial meningioma

Lee, J. Y. K., Pierce, J. T., Thawani, J. P., Zeh, R., Nie, S., Martinez-Lage, M. & Singhal, S., Feb 2018, In : Journal of Neurosurgery. 128, 2, p. 380-390 11 p.

Research output: Contribution to journalArticle

2017

Diverse Applications of Nanomedicine

Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., Bosi, S., Carril, M., Chan, W. C. W., Chen, C., Chen, X., Chen, X., Cheng, Z., Cui, D., Du, J., Dullin, C. & 66 others, Escudero, A., Feliu, N., Gao, M., George, M., Gogotsi, Y., Grünweller, A., Gu, Z., Halas, N. J., Hampp, N., Hartmann, R. K., Hersam, M. C., Hunziker, P., Jian, J., Jiang, X., Jungebluth, P., Kadhiresan, P., Kataoka, K., Khademhosseini, A., Kopeček, J., Kotov, N. A., Krug, H. F., Lee, D. S., Lehr, C. M., Leong, K. W., Liang, X. J., Lim, M. L., Liz-Marzán, L. M., Ma, X., Macchiarini, P., Meng, H., Möhwald, H., Mulvaney, P., Nel, A. E., Nie, S., Nordlander, P., Okano, T., Oliveira, J., Park, T. H., Penner, R. M., Prato, M., Puntes, V., Rotello, V. M., Samarakoon, A., Schaak, R. E., Shen, Y., Sjöqvist, S., Skirtach, A. G., Soliman, M. G., Stevens, M. M., Sung, H. W., Tang, B. Z., Tietze, R., Udugama, B. N., Scott VanEpps, J., Weil, T., Weiss, P. S., Willner, I., Wu, Y., Yang, L., Yue, Z., Zhang, Q., Zhang, Q., Zhang, X. E., Zhao, Y., Zhou, X. & Parak, W. J., Mar 28 2017, In : ACS Nano. 11, 3, p. 2313-2381 69 p.

Research output: Contribution to journalArticle

Functionalized, long-circulating, and ultrasmall gold nanocarriers for overcoming the barriers of low nanoparticle delivery efficiency and poor tumor penetration

Lee, K. Y. J., Lee, G. Y., Lane, L. A., Li, B., Wang, J., Lu, Q., Wang, Y. & Nie, S., Jan 1 2017, In : Bioconjugate Chemistry. 28, 1, p. 244-252 9 p.

Research output: Contribution to journalArticle

Intraoperative molecular imaging can identify sub-centimeter peritoneal implants during ovarian cancer cytoreductive surgery

Tanyi, J. L., Cory, L., DeJesus, E., Keating, J., Predina, J., Nie, S., Deshpande, C., Low, P. & Singhal, S., Jan 1 2017, In : European Journal of Gynaecological Oncology. 38, 4, p. 589-595 7 p.

Research output: Contribution to journalArticle

Intraoperative near-infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large-animal model

Keating, J. J., Runge, J. J., Singhal, S., Nims, S., Venegas, O., Durham, A. C., Swain, G., Nie, S., Low, P. S. & Holt, D. E., Mar 15 2017, In : Cancer. 123, 6, p. 1051-1060 10 p.

Research output: Contribution to journalArticle

Intraoperative Near-Infrared Optical Contrast Can Localize Brain Metastases

Lee, J. Y. K., Pierce, J. T., Zeh, R., Cho, S. S., Salinas, R., Nie, S. & Singhal, S., Oct 2017, In : World Neurosurgery. 106, p. 120-130 11 p.

Research output: Contribution to journalArticle

Near-infrared Intraoperative Molecular Imaging Can Identify Metastatic Lymph Nodes in Prostate Cancer

Xia, L., Zeh, R., Mizelle, J., Newton, A., Predina, J., Nie, S., Singhal, S. & Guzzo, T. J., Aug 2017, In : Urology. 106, p. 133-138 6 p.

Research output: Contribution to journalArticle

Near-Infrared Intraoperative Molecular Imaging Can Locate Metastases to the Lung

Keating, J., Newton, A., Venegas, O., Nims, S., Zeh, R., Predina, J., Deshpande, C., Kucharczuk, J., Nie, S., Delikatny, E. J. & Singhal, S., Feb 1 2017, In : Annals of Thoracic Surgery. 103, 2, p. 390-398 9 p.

Research output: Contribution to journalArticle

Quantitative Examination of the Active Targeting Effect: The Key Factor for Maximal Tumor Accumulation and Retention of Short-Circulated Biopolymeric Nanocarriers

Wang, J., Lee, G. Y., Lu, Q., Peng, X., Wu, J., Wu, S., Kairdolf, B. A., Nie, S., Wang, Y. & Lane, L. A., May 17 2017, In : Bioconjugate Chemistry. 28, 5, p. 1351-1355 5 p.

Research output: Contribution to journalArticle

Surface-Enhanced Raman Scattering Active Gold Nanoparticles with Enzyme-Mimicking Activities for Measuring Glucose and Lactate in Living Tissues

Hu, Y., Cheng, H., Zhao, X., Wu, J., Muhammad, F., Lin, S., He, J., Zhou, L., Zhang, C., Deng, Y., Wang, P., Zhou, Z., Nie, S. & Wei, H., Jun 27 2017, In : ACS Nano. 11, 6, p. 5558-5566 9 p.

Research output: Contribution to journalArticle

2016

Identification of breast cancer margins using intraoperative near-infrared imaging

Keating, J., Tchou, J., Okusanya, O., Fisher, C., Batiste, R., Jiang, J., Kennedy, G., Nie, S. & Singhal, S., Apr 1 2016, In : Journal of Surgical Oncology. 113, 5, p. 508-514 7 p.

Research output: Contribution to journalArticle

Integrated Nanozymes with Nanoscale Proximity for in Vivo Neurochemical Monitoring in Living Brains

Cheng, H., Zhang, L., He, J., Guo, W., Zhou, Z., Zhang, X., Nie, S. & Wei, H., May 17 2016, In : Analytical chemistry. 88, 10, p. 5489-5497 9 p.

Research output: Contribution to journalArticle

Intraoperative Molecular Diagnostic Imaging Can Identify Renal Cell Carcinoma

Guzzo, T. J., Jiang, J., Keating, J., DeJesus, E., Judy, R., Nie, S., Low, P., Lal, P. & Singhal, S., Jan 1 2016, In : Journal of Urology. 195, 3, p. 748-755 8 p.

Research output: Contribution to journalArticle

Intraoperative Molecular Imaging of Lung Adenocarcinoma Can Identify Residual Tumor Cells at the Surgical Margins

Keating, J. J., Okusanya, O. T., De Jesus, E., Judy, R., Jiang, J., Deshpande, C., Nie, S., Low, P. & Singhal, S., Apr 1 2016, In : Molecular Imaging and Biology. 18, 2, p. 209-218 10 p.

Research output: Contribution to journalArticle

Intraoperative Spectroscopy with Ultrahigh Sensitivity for Image-Guided Surgery of Malignant Brain Tumors

Kairdolf, B. A., Bouras, A., Kaluzova, M., Sharma, A. K., Wang, M. D., Hadjipanayis, C. G. & Nie, S., Jan 5 2016, In : Analytical chemistry. 88, 1, p. 858-867 10 p.

Research output: Contribution to journalArticle

Novel surface-enhanced Raman scattering-based assays for ultra-sensitive detection of human pluripotent stem cells

Han, J., Qian, X., Wu, Q., Jha, R., Duan, J., Yang, Z., Maher, K. O., Nie, S. & Xu, C., Oct 1 2016, In : Biomaterials. 105, p. 66-76 11 p.

Research output: Contribution to journalArticle

Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration

Li, H. J., Du, J. Z., Liu, J., Du, X. J., Shen, S., Zhu, Y. H., Wang, X., Ye, X., Nie, S. & Wang, J., Jul 26 2016, In : ACS Nano. 10, 7, p. 6753-6761 9 p.

Research output: Contribution to journalArticle

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

Li, H. J., Du, J. Z., Du, X. J., Xu, C. F., Sun, C. Y., Wang, H. X., Cao, Z. T., Yang, X. Z., Zhu, Y. H., Nie, S. & Wang, J., Apr 12 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 15, p. 4164-4169 6 p.

Research output: Contribution to journalArticle

2015

An integrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors

Mohs, A. M., Mancini, M. C., Provenzale, J. M., Saba, C. F., Cornell, K. K., Howerth, E. W. & Nie, S., May 1 2015, In : IEEE Transactions on Biomedical Engineering. 62, 5, p. 1416-1424 9 p., 7005462.

Research output: Contribution to journalArticle

An unusual role of folate in the self-assembly of heparin-folate conjugates into nanoparticles

Wang, J., Ma, D., Lu, Q., Wu, S., Lee, G. Y., Lane, L. A., Li, B., Quan, L., Wang, Y. & Nie, S., Oct 7 2015, In : Nanoscale. 7, 37, p. 15185-15190 6 p.

Research output: Contribution to journalArticle

Intraoperative molecular imaging can identify lung adenocarcinomas during pulmonary resection

Okusanya, O. T., Dejesus, E. M., Jiang, J. X., Judy, R. P., Venegas, O. G., Deshpande, C. G., Heitjan, D. F., Nie, S., Low, P. S. & Singhal, S., Jan 1 2015, In : Journal of Thoracic and Cardiovascular Surgery. 150, 1, p. 28-35.e1

Research output: Contribution to journalArticle

Intraoperative near-infrared fluorescence imaging and spectroscopy identifies residual tumor cells in wounds

Holt, D., Parthasarathy, A. B., Okusanya, O., Keating, J., Venegas, O., Deshpande, C., Karakousis, G., Madajewski, B., Durham, A., Nie, S., Yodh, A. G. & Singhal, S., Jul 1 2015, In : Journal of biomedical optics. 20, 7, 076002.

Research output: Contribution to journalArticle

In vitro study of a pH-sensitive multifunctional doxorubicin-gold nanoparticle system: therapeutic effect and surface enhanced Raman scattering

Lee, K. Y. J., Wang, Y. & Nie, S., Jul 21 2015, In : RSC Advances. 5, 81, p. 65651-65659 9 p.

Research output: Contribution to journalArticle

Physical chemistry of nanomedicine: Understanding the complex behaviors of nanoparticles in vivo

Lane, L. A., Qian, X., Smith, A. M. & Nie, S., Apr 1 2015, In : Annual Review of Physical Chemistry. 66, p. 521-547 27 p.

Research output: Contribution to journalArticle

Quantification of tumor fluorescence during intraoperative optical cancer imaging

Judy, R. P., Keating, J. J., DeJesus, E. M., Jiang, J. X., Okusanya, O. T., Nie, S., Holt, D. E., Arlauckas, S. P., Low, P. S., Delikatny, E. J. & Singhal, S., Nov 2015, In : Scientific reports. 5, 16208.

Research output: Contribution to journalArticle

Small Portable Interchangeable Imager of Fluorescence for Fluorescence Guided Surgery and Research

Okusanya, O. T., Madajewski, B., Segal, E., Judy, B. F., Venegas, O. G., Judy, R. P., Quatromoni, J. G., Wang, M. D., Nie, S. & Singhal, S., Apr 1 2015, In : Technology in Cancer Research and Treatment. 14, 2, p. 213-220 8 p.

Research output: Contribution to journalArticle

Stimuli-responsive nanoparticles for targeting the tumor microenvironment

Du, J., Lane, L. A. & Nie, S., Dec 10 2015, In : Journal of Controlled Release. 219, p. 205-214 10 p.

Research output: Contribution to journalArticle

The optical biopsy: A novel technique for rapid intraoperative diagnosis of primary pulmonary adenocarcinomas

Kennedy, G. T., Okusanya, O. T., Keating, J. J., Heitjan, D. F., Deshpande, C., Litzky, L. A., Albelda, S. M., Drebin, J. A., Nie, S., Low, P. S. & Singhal, S., Oct 1 2015, In : Annals of Surgery. 262, 4, p. 602-609 8 p.

Research output: Contribution to journalArticle

2014

Biocompatible hyaluronic acid polymer-coated quantum dots for CD44+ cancer cell-targeted imaging

Wang, H., Sun, H., Wei, H., Xi, P., Nie, S. & Ren, Q., Jan 1 2014, In : Journal of Nanoparticle Research. 16, 10, 2621.

Research output: Contribution to journalArticle

Compact and blinking-suppressed quantum dots for single-particle tracking in live cells

Lane, L. A., Smith, A. M., Lian, T. & Nie, S., Dec 11 2014, In : Journal of Physical Chemistry B. 118, 49, p. 14140-14147 8 p.

Research output: Contribution to journalArticle

Intraoperative near-infrared imaging can distinguish cancer from normal tissue but not inflammation

Holt, D., Okusanya, O., Judy, R., Venegas, O., Jiang, J., DeJesus, E., Eruslanov, E., Quatromoni, J., Bhojnagarwala, P., Deshpande, C., Albelda, S., Nie, S. & Singhal, S., Jul 29 2014, In : PloS one. 9, 7, e103342.

Research output: Contribution to journalArticle

Intraoperative near-infrared imaging can identify pulmonary nodules

Okusanya, O. T., Holt, D., Heitjan, D., Deshpande, C., Venegas, O., Jiang, J., Judy, R., Dejesus, E., Madajewski, B., Oh, K., Wang, M., Albelda, S. M., Nie, S. & Singhal, S., Oct 1 2014, In : Annals of Thoracic Surgery. 98, 4, p. 1223-1230 8 p.

Research output: Contribution to journalArticle

Mapping the spatial distribution of charge carriers in quantum-confined heterostructures

Smith, A. M., Lane, L. A. & Nie, S., Jul 31 2014, In : Nature communications. 5, 4506.

Research output: Contribution to journalArticle

Molecular imaging to identify tumor recurrence following chemoradiation in a hostile surgical environment

Okusanya, O. T., Deshpande, C., Barbosa, E. M., Aggarwal, C., Simone, C. B., Jiang, J., Judy, R., DeJesus, E., Albelda, S., Nie, S., Low, P. S. & Singhal, S., Jan 1 2014, In : Molecular imaging. 13

Research output: Contribution to journalArticle

2013

Semiconductor quantum dots for bioimaging and biodiagnostic applications

Kairdolf, B. A., Smith, A. M., Stokes, T. H., Wang, M. D., Young, A. N. & Nie, S., Jun 1 2013, In : Annual Review of Analytical Chemistry. 6, p. 143-162 20 p.

Research output: Contribution to journalArticle