Shannon Sirk

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Research Output

2020

A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont

Liou, C. S., Sirk, S. J., Diaz, C. A. C., Klein, A. P., Fischer, C. R., Higginbottom, S. K., Erez, A., Donia, M. S., Sonnenburg, J. L. & Sattely, E. S., Feb 20 2020, In : Cell. 180, 4, p. 717-728.e19

Research output: Contribution to journalArticle

2018

Directed evolution of targeted recombinases for genome engineering

Sirk, S. J., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 89-102 14 p. (Methods in Molecular Biology; vol. 1867).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Genome-editing technologies: Principles and applications

Gaj, T., Sirk, S. J., Shui, S. L. & Liu, J., Jan 1 2016, In : Cold Spring Harbor Perspectives in Biology. 8, 12, a023754.

Research output: Contribution to journalArticle

2014

Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering

Liu, J., Gaj, T., Patterson, J. T., Sirk, S. J. & Barbas, C. F., Jan 20 2014, In : PloS one. 9, 1, e85755.

Research output: Contribution to journalArticle

Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign

Gaj, T., Sirk, S. J., Tingle, R. D., Mercer, A. C., Wallen, M. C. & Barbas, C. F., Apr 2 2014, In : Journal of the American Chemical Society. 136, 13, p. 5047-5056 10 p.

Research output: Contribution to journalArticle

Expanding the scope of site-specific recombinases for genetic and metabolic engineering

Gaj, T., Sirk, S. J. & Barbas, C. F., Jan 1 2014, In : Biotechnology and bioengineering. 111, 1, p. 1-15 15 p.

Research output: Contribution to journalReview article

Expanding the zinc-finger recombinase repertoire: Directed evolution and mutational analysis of serine recombinase specificity determinants

Sirk, S. J., Gaj, T., Jonsson, A., Mercer, A. C. & Barbas, C. F., Apr 2014, In : Nucleic acids research. 42, 7, p. 4755-4766 12 p.

Research output: Contribution to journalArticle

Protein delivery using Cys2-His2 zinc-finger domains

Gaj, T., Liu, J., Anderson, K. E., Sirk, S. J. & Barbas, C. F., Aug 15 2014, In : ACS chemical biology. 9, 8, p. 1662-1667 6 p.

Research output: Contribution to journalArticle

Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors

Mercer, A. C., Gaj, T., Sirk, S. J., Lamb, B. M. & Barbas, C. F., Oct 17 2014, In : ACS synthetic biology. 3, 10, p. 723-730 8 p.

Research output: Contribution to journalArticle

2013

A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells

Gaj, T., Mercer, A. C., Sirk, S. J., Smith, H. L. & Barbas, C. F., Apr 1 2013, In : Nucleic acids research. 41, 6, p. 3937-3946 10 p.

Research output: Contribution to journalArticle

Antibody conjugation approach enhances breadth and potency of neutralization of Anti-HIV-1 antibodies and CD4-IgG

Gavrilyuk, J., Ban, H., Uehara, H., Sirk, S. J., Saye-Francisco, K., Cuevas, A., Zablowsky, E., Oza, A., Seaman, M. S., Burton, D. R. & Barbas, C. F., May 1 2013, In : Journal of virology. 87, 9, p. 4985-4993 9 p.

Research output: Contribution to journalArticle

2012

ImmunoPET Using engineered antibody fragments: Fluorine-18 labeled diabodies for same-day imaging

Olafsen, T., Sirk, S. J., Olma, S., Shen, C. K. F. & Wu, A. M., Jun 1 2012, In : Tumor Biology. 33, 3, p. 669-677 9 p.

Research output: Contribution to journalArticle

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

Gaj, T., Guo, J., Kato, Y., Sirk, S. J. & Barbas, C. F., Aug 1 2012, In : Nature Methods. 9, 8, p. 805-807 3 p.

Research output: Contribution to journalArticle

2011

Microfluidic-based 18F-labeling of biomolecules for immuno-positron emission tomography

Liu, K., Lepin, E. J., Wang, M. W., Guo, F., Lin, W. Y., Chen, Y. C., Sirk, S. J., Olma, S., Phelps, M. E., Zhao, X. Z., Tseng, H. R., Van Dam, R. M., Wu, A. M. & Shen, C. K. F., Jun 1 2011, In : Molecular imaging. 10, 3, p. 168-176 9 p.

Research output: Contribution to journalArticle

2010

ImmunoPET imaging of B-cell lymphoma using 124I-anti-CD20 scFv dimers (diabodies)

Olafsen, T., Sirk, S. J., Betting, D. J., Kenanova, V. E., Bauer, K. B., Ladno, W., Raubitschek, A. A., Timmerman, J. M. & Wu, A. M., Apr 2010, In : Protein Engineering, Design and Selection. 23, 4, p. 243-249 7 p.

Research output: Contribution to journalArticle

2009

Cys-diabody quantum dot conjugates (ImmunoQdots) for cancer marker detection

Barat, B., Sirk, S. J., McCabe, K. E., Li, J., Lepin, E. J., Remenyi, R., Ai, L. K., Olafsen, T., Gambhir, S. S., Weiss, S. & Wu, A. M., Sep 21 2009, In : Bioconjugate Chemistry. 20, 8, p. 1474-1481 8 p.

Research output: Contribution to journalArticle

2008

Site-specific, thiol-mediated conjugation of fluorescent probes to cysteine-modified diabodies targeting CD20 or HER2

Sirk, S. J., Olafsen, T., Barat, B., Bauer, K. B. & Wu, A. M., Dec 17 2008, In : Bioconjugate Chemistry. 19, 12, p. 2527-2534 8 p.

Research output: Contribution to journalArticle

2006

Measurement of Amphotericin B concentration by Resonant Raman Spectroscopy - A novel technique that may be useful for non-invasive monitoring

La Via, W. V., Lambert, J. L., Pelletier, M. J., Morookian, J. M., Sirk, S. J., Mickiene, D., Walsh, T. J. & Borchert, M. S., Mar 1 2006, In : Medical Mycology. 44, 2, p. 169-174 6 p.

Research output: Contribution to journalArticle

2002

Measurement of aqueous glucose in a model anterior chamber using Raman spectroscopy

Lambert, J. L., Morookian, J. M., Sirk, S. J. & Borchert, M. S., Aug 13 2002, In : Journal of Raman Spectroscopy. 33, 7, p. 524-529 6 p.

Research output: Contribution to journalArticle