Shannon Sirk

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Zinc Fingers Medicine & Life Sciences
Recombinases Medicine & Life Sciences
Genes Chemical Compounds
Genome Medicine & Life Sciences
Immunoglobulin Fragments Medicine & Life Sciences
Transcription Chemical Compounds
Dimers Chemical Compounds
Zinc Chemical Compounds

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Research Output 2002 2018

Directed evolution of targeted recombinases for genome engineering

Sirk, S., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 89-102 14 p. (Methods in Molecular Biology; vol. 1867).

Research output: Chapter in Book/Report/Conference proceedingChapter

Catalytic Domain
Zinc Fingers

Genome-editing technologies: Principles and applications

Gaj, T., Sirk, S., Shui, S. L. & Liu, J., Jan 1 2016, In : Cold Spring Harbor Perspectives in Biology. 8, 12, a023754.

Research output: Contribution to journalArticle

Gene therapy
CRISPR-Associated Proteins
Genetic Therapy
Clustered Regularly Interspaced Short Palindromic Repeats

Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering

Liu, J., Gaj, T., Patterson, J. T., Sirk, S. J. & Barbas, C. F., Jan 20 2014, In : PloS one. 9, 1, e85755.

Research output: Contribution to journalArticle

Cell-Penetrating Peptides

Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign

Gaj, T., Sirk, S. J., Tingle, R. D., Mercer, A. C., Wallen, M. C. & Barbas, C. F., Apr 2 2014, In : Journal of the American Chemical Society. 136, 13, p. 5047-5056 10 p.

Research output: Contribution to journalArticle


Expanding the scope of site-specific recombinases for genetic and metabolic engineering

Gaj, T., Sirk, S. & Barbas, C. F., Jan 1 2014, In : Biotechnology and bioengineering. 111, 1, p. 1-15 15 p.

Research output: Contribution to journalReview article

Metabolic engineering
Metabolic Engineering
Genetic engineering
Genetic Engineering
Genetic Recombination