Sepideh Sadaghiani

20092019
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Distant brain regions are in constant communication with each other. This communication, also called functional connectivity, is foundational to all cognition. Functional connectivity is spatially organized into many large brain networks. But how this network organization is maintained and modulated in the service of flexible cognition is poorly understood. Sepideh Sadaghiani’s lab is studying connectivity and cognitive functions of large-scale brain networks. Her lab is most interested in networks involved in cognitive control functions such as alertness and attention (cognitive control networks).

One research line of the lab seeks to delineate the function of different cognitive control networks. This research investigates how cognitive control networks modulate processes in “lower-order” brain areas such as perception in sensory cortices.

Another research line focuses on the functional role of intrinsic (spontaneous) network activity. Neural activity and communication across brain networks are continuously ongoing independent of external stimuli or tasks. Sadaghiani’s research aims at understanding why this intrinsic activity and functional connectivity exists and how it affects behavior.

Sepideh Sadaghiani’s lab combines various techniques to address these questions in the human brain including functional magnetic resonance imaging (fMRI), electroencephalography (EEG), simultaneous EEG-fMRI and genetic analyses in healthy participants and neurological patients.

Education

Postdoc - Stanford University 2015

Postdoc - University of California at Berkeley 2010-2014

Ph.D - Max-Planck International Research School, Germany & NeuroSpin, France 2007-2010

Research Interests

Large-scale neurocognitive networks, functional connectivity, cognitive control

Education/Academic qualification

Neural and Behavioral Sciences, Ph.D., International Max Planck Research School of Neural and Behavioural Sciences

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Research Output 2009 2019

Lesions to the Fronto-Parietal Network Impact Alpha-Band Phase Synchrony and Cognitive Control

Friberg, S. S., Dombert, P. L., Løvstad, M., Funderud, I., Meling, T. R., Endestad, T., Knight, R. T., Solbakk, A. K. & D'Esposito, M., Sep 13 2019, In : Cerebral Cortex. 29, 10, p. 4143-4153 11 p., bhy296.

Research output: Contribution to journalArticle

Prefrontal Cortex
Electroencephalography
Trail Making Test
Frontal Lobe
Cognition

Concurrent EEG- and fMRI-derived functional connectomes exhibit linked dynamics

Wirsich, J., Giraud, A. L. & Sadaghiani, S., Nov 7 2018, Cold Spring Harbor Laboratory Press, 23 p. (bioRxiv; no. 464438).

Research output: Working paper

Open Access
Connectome
Electroencephalography
Magnetic Resonance Imaging
Brain
Hemodynamics

Impact of Zika Virus on adult human brain structure and functional organization

Bido-Medina, R., Wirsich, J., Rodríguez, M., Oviedo, J., Miches, I., Bido, P., Tusen, L., Stoeter, P. & Friberg, S. S., Jan 1 2018, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Peripheral Nervous System
Motor Cortex
Brain
Temporal Lobe
Central Nervous System

Spontaneous cognitive processes and the behavioral validation of time-varying brain connectivity

Kucyi, A., Tambini, A., Sadaghiani, S., Keilholz, S. & Cohen, J. R., Oct 1 2018, In : Network Neuroscience. 2, 4, p. 397-417

Research output: Contribution to journalArticle

Open Access
Brain
Functional Neuroimaging
Behavior Control
Practice Guidelines
Neuroimaging

Overdominant effect of a CHRNA4 polymorphism on cingulo-opercular network activity and cognitive control

Friberg, S. S., Ng, B., Altmann, A., Poline, J. B., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., Conrod, P., Desrivières, S., Flor, H., Frouin, V., Garavan, H., Gowland, P., Gallinat, J., Heinz, A., Ittermann, B., Martinot, J. L., Martinot, M. L. P. & 13 others, Lemaitre, H., Nees, F., Orfanos, D. P., Paus, T., Poustka, L., Millenet, S., Fröhner, J. H., Smolka, M. N., Walter, H., Whelan, R., Schumann, G., Napolioni, V. & Greicius, M., Oct 4 2017, In : Journal of Neuroscience. 37, 40, p. 9657-9666 10 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Heterozygote
Neuroimaging
Quantitative Trait Loci
Medical Genetics