Scott K Silverman

1991 …2017
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Research Output 1991 2017

Adenosine is inherently favored as the branch-site RNA nucleotide in a structural context that resembles natural RNA splicing

Zelin, E., Wang, Y. & Silverman, S. K., Mar 7 2006, In : Biochemistry. 45, 9, p. 2767-2771 5 p.

Research output: Contribution to journalArticle

RNA Splicing
Adenosine
Nucleotides
RNA
Catalytic DNA
Catalytic DNA
RNA
substrate
Nucleotides
Substrates

A deoxyribozyme that synthesizes 2′,5′-branched RNA with any branch-site nucleotide

Pratico, E. D., Wang, Y. & Silverman, S. K., Oct 18 2005, In : Nucleic acids research. 33, 11, p. 3503-3512 10 p.

Research output: Contribution to journalArticle

Catalytic DNA
Nucleotides
RNA
Ligation
Biochemical Phenomena

A DNA enzyme that mimics the first step of RNA splicing

Coppins, R. L. & Silverman, S. K., Mar 1 2004, In : Nature Structural and Molecular Biology. 11, 3, p. 270-274 5 p.

Research output: Contribution to journalArticle

RNA Splicing
DNA
Enzymes
Hydroxyl Radical
Catalytic RNA

A Forced March across an RNA Folding Landscape

Silverman, S. K., Mar 21 2008, In : Chemistry and Biology. 15, 3, p. 211-213 3 p.

Research output: Contribution to journalShort survey

Riboswitch
RNA Folding
Adenine
RNA
Molecules

A generalizable DNA-catalyzed approach to peptide-nucleic acid conjugation

Chu, C. C., Wong, O. Y. I. & Silverman, S. K., Sep 5 2014, In : Chembiochem : a European journal of chemical biology. 15, 13, p. 1905-1910 6 p.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
Peptides
Catalytic DNA
DNA
Nucleic Acids

A general two-step strategy to synthesize lariat RNAs

Wang, Y. & Silverman, S. K., Feb 1 2006, In : RNA. 12, 2, p. 313-321 9 p.

Research output: Contribution to journalArticle

RNA
Catalytic DNA
Ligases

Allosteric control of ribozyme catalysis by using DNA constraints

Zelin, E. & Silverman, S. K., Nov 5 2007, In : ChemBioChem. 8, 16, p. 1907-1911 5 p.

Research output: Contribution to journalArticle

Catalytic RNA
Catalysis
RNA
DNA
hammerhead ribozyme

A modular tyrosine kinase deoxyribozyme with discrete aptamer and catalyst domains

Dokukin, V. & Silverman, S. K., Aug 25 2014, In : Chemical Communications. 50, 66, p. 9317-9320 4 p.

Research output: Contribution to journalArticle

Catalytic DNA
Protein-Tyrosine Kinases
Catalysts
DNA
Nucleotide Aptamers

An early transition state for folding of the P4-P6 RNA domain

Silverman, S. K. & Cech, T. R., Feb 1 2001, In : RNA. 7, 2, p. 161-166 6 p.

Research output: Contribution to journalArticle

RNA
Thermodynamics
RNA Folding
Ions
Tetrahymena

A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation

Silverman, S. K., Kofuji, P., Dougherty, D. A., Davidson, N. & Lester, H. A., Dec 24 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 26, p. 15429-15434 6 p.

Research output: Contribution to journalArticle

Potassium Channels
GTP-Binding Proteins
Mutation
Neurologic Mutant Mice
Inwardly Rectifying Potassium Channel

A simple molecular model for thermophilic adaptation of functional nucleic acids

Blose, J. M., Silverman, S. K. & Bevilacqua, P. C., Apr 10 2007, In : Biochemistry. 46, 14, p. 4232-4240 9 p.

Research output: Contribution to journalArticle

Molecular Models
Nucleic Acids
RNA
Free energy
Base Pairing

Assessing histidine tags for recruiting deoxyribozymes to catalyze peptide and protein modification reactions

Chu, C. C. & Silverman, S. K., Jan 1 2016, In : Organic and Biomolecular Chemistry. 14, 20, p. 4697-4703 7 p.

Research output: Contribution to journalArticle

His-His-His-His-His-His
Catalytic DNA
histidine
Histidine
peptides

Asymmetrical contributions of subunit pore regions to ion selectivity in an inward rectifier K+ channel

Silverman, S. K., Lester, H. A. & Dougherty, D. A., Sep 1998, In : Biophysical journal. 75, 3, p. 1330-1339 10 p.

Research output: Contribution to journalArticle

Inwardly Rectifying Potassium Channel
Tyrosine
Ions
Oocytes
Voltage-Gated Potassium Channels

Breaking Up Is Easy to Do (If You're a DNA Enzyme that Cleaves RNA)

Silverman, S. K., Jan 2004, In : Chemistry and Biology. 11, 1, p. 7-8 2 p.

Research output: Contribution to journalReview article

Catalytic DNA
RNA
DNA
Enzymes
RNA-cleaving DNA 8-17

Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes

Silverman, S. K., Jul 1 2016, In : Trends in Biochemical Sciences. 41, 7, p. 595-609 15 p.

Research output: Contribution to journalReview article

Catalytic DNA
Biochemistry
RNA
DNA
Enzymes

Catalytic DNA (deoxyribozymes) for synthetic applications-current abilities and future prospects

Silverman, S. K., Jul 30 2008, In : Chemical Communications. 30, p. 3467-3485 19 p.

Research output: Contribution to journalReview article

Catalytic DNA
DNA
Catalytic RNA
Enzymes
RNA

Catalytic DNA with phosphatase activity

Chandrasekar, J. & Silverman, S. K., Apr 2 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 14, p. 5315-5320 6 p.

Research output: Contribution to journalArticle

Catalytic DNA
Phosphoric Monoester Hydrolases
DNA
Hydrolysis
Phosphoserine

Characterization of Deoxyribozymes That Synthesize Branched RNA

Wang, Y. & Silverman, S. K., Dec 30 2003, In : Biochemistry. 42, 51, p. 15252-15263 12 p.

Research output: Contribution to journalArticle

Catalytic DNA
Ligation
RNA
Substrates
Nucleotides

Conformational effects on high-spin organic molecules

Silverman, S. K. & Dougherty, D. A., Jan 1 1993, In : Journal of physical chemistry. 97, 50, p. 13273-13283 11 p.

Research output: Contribution to journalArticle

twisting
Ground state
Spin polarization
Molecules
Paramagnetic resonance

Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn2+-dependent deoxyribozymes that use 2′,3′-cyclic phosphate RNA substrates

Kost, D. M., Gerdt, J. P., Pradeepkumar, P. I. & Silverman, S. K., Nov 24 2008, In : Organic and Biomolecular Chemistry. 6, 23, p. 4391-4398 8 p.

Research output: Contribution to journalArticle

Catalytic DNA
Regioselectivity
linkages
Ligation
phosphates

Control of macromolecular structure and function using covalently attached double-stranded DNA constraints

Silverman, S. K., Jan 1 2007, In : Molecular BioSystems. 3, 1, p. 24-29 6 p.

Research output: Contribution to journalReview article

DNA
Nanotechnology
Sensors
Macromolecules
Rigidity

Convergent and general one-step DNA-catalyzed synthesis of multiply branched DNA

Mui, T. P. & Silverman, S. K., Dec 1 2008, In : Organic Letters. 10, 20, p. 4417-4420 4 p.

Research output: Contribution to journalArticle

deoxyribonucleic acid
Catalytic DNA
DNA
synthesis
Ribonucleotides

Covalent Tagging of Phosphorylated Peptides by Phosphate-Specific Deoxyribozymes

Sachdeva, A., Chandra, M., Chandrasekar, J. & Silverman, S. K., Mar 1 2012, In : ChemBioChem. 13, 5, p. 654-657 4 p.

Research output: Contribution to journalArticle

Catalytic DNA
Phosphopeptides
Phosphorylation
Phosphates
Peptides

Deoxyribozyme-catalyzed labeling of RNA

Baum, D. A. & Silverman, S. K., Jun 29 2007, In : Angewandte Chemie - International Edition. 46, 19, p. 3502-3504 3 p.

Research output: Contribution to journalArticle

Catalytic DNA
RNA
Labeling
Energy transfer
Fluorescence

Deoxyribozymes: DNA catalysts for bioorganic chemistry

Silverman, S. K., Oct 7 2004, In : Organic and Biomolecular Chemistry. 2, 19, p. 2701-2706 6 p.

Research output: Contribution to journalReview article

Catalytic DNA
nucleic acids
deoxyribonucleic acid
chemistry
catalysts

Deoxyribozymes: Useful DNA catalysts in vitro and in vivo

Baum, D. A. & Silverman, S. K., Jul 1 2008, In : Cellular and Molecular Life Sciences. 65, 14, p. 2156-2174 19 p.

Research output: Contribution to journalReview article

Catalytic DNA
Catalysts
DNA
RNA
RNA Cleavage

Deoxyribozymes: selection design and serendipity in the development of DNA catalysts.

Silverman, S. K., Oct 20 2009, In : Accounts of chemical research. 42, 10, p. 1521-1531 11 p.

Research output: Contribution to journalReview article

Catalytic DNA
Catalysts
RNA
DNA
DNA sequences

Deoxyribozymes that synthesize branched and lariat RNA

Wang, Y. & Silverman, S. K., Jun 11 2003, In : Journal of the American Chemical Society. 125, 23, p. 6880-6881 2 p.

Research output: Contribution to journalArticle

Catalytic DNA
RNA
Enzymes
enzyme
Introns

Deoxyribozymes with 2′-5′ RNA ligase activity

Flynn-Charlebois, A., Wang, Y., Prior, T. K., Rashid, I., Hoadley, K. A., Coppins, R. L., Wolf, A. C. & Silverman, S. K., Mar 5 2003, In : Journal of the American Chemical Society. 125, 9, p. 2444-2454 11 p.

Research output: Contribution to journalArticle

Catalytic DNA
Ligases
RNA
Ligation
Nucleotides

Directing the outcome of deoxyribozyme selections to favor native 3′-5′ RNA ligation

Wang, Y. & Silverman, S. K., Mar 1 2005, In : Biochemistry. 44, 8, p. 3017-3023 7 p.

Research output: Contribution to journalArticle

Catalytic DNA
Ligation
RNA
Substrates
Hydroxyl Radical

DNA and RNA can be equally efficient catalysts for carbon-carbon bond formation

Chandra, M. & Silverman, S. K., Mar 12 2008, In : Journal of the American Chemical Society. 130, 10, p. 2936-2937 2 p.

Research output: Contribution to journalArticle

Catalytic DNA
RNA
Catalytic RNA
DNA
Carbon

DNA as a versatile chemical component for catalysis, encoding, and stereocontrol

Silverman, S. K., Sep 24 2010, In : Angewandte Chemie - International Edition. 49, 40, p. 7180-7201 22 p.

Research output: Contribution to journalReview article

Catalysis
DNA
Chemical elements
Catalysts

DNA catalysis of a normally disfavored RNA hydrolysis reaction

Parker, D. J., Xiao, Y., Aguilar, J. M. & Silverman, S. K., Jun 12 2013, In : Journal of the American Chemical Society. 135, 23, p. 8472-8475 4 p.

Research output: Contribution to journalArticle

catalysis
RNA
Catalysis
hydrolysis
Hydrolysis

DNA catalysts with tyrosine kinase activity

Walsh, S. M., Sachdeva, A. & Silverman, S. K., Oct 21 2013, In : Journal of the American Chemical Society. 135, 40, p. 14928-14931 4 p.

Research output: Contribution to journalArticle

Catalytic DNA
Protein-Tyrosine Kinases
Tyrosine
Catalyst activity
DNA

DNA-Catalyzed Amide Hydrolysis

Zhou, C., Avins, J. L., Klauser, P. C., Brandsen, B. M., Lee, Y. & Silverman, S. K., Mar 2 2016, In : Journal of the American Chemical Society. 138, 7, p. 2106-2109 4 p.

Research output: Contribution to journalArticle

Catalytic DNA
Amides
hydrolysis
Hydrolysis
DNA

DNA-catalyzed covalent modification of amino acid side chains in tethered and free peptide substrates

Wong, O. Y., Pradeepkumar, P. I. & Silverman, S. K., May 31 2011, In : Biochemistry. 50, 21, p. 4741-4749 9 p.

Research output: Contribution to journalArticle

Catalytic DNA
Amino Acids
Peptides
Tyrosine
DNA

DNA-catalyzed DNA cleavage by a radical pathway with well-defined products

Lee, Y., Klauser, P. C., Brandsen, B. M., Zhou, C., Li, X. & Silverman, S. K., Jan 11 2017, In : Journal of the American Chemical Society. 139, 1, p. 255-261 7 p.

Research output: Contribution to journalArticle

Catalytic DNA
DNA Cleavage
cleavage
DNA
Catalysis

DNA-catalyzed formation of nucleopeptide linkages

Pradeepkumar, P. I., Höbartner, C., Baum, D. A. & Silverman, S. K., Feb 15 2008, In : Angewandte Chemie - International Edition. 47, 9, p. 1753-1757 5 p.

Research output: Contribution to journalArticle

RNA
Tyrosine
DNA
Catalytic DNA
Oligonucleotides

DNA-catalyzed glycosylation using aryl glycoside donors

Hesser, A. R., Brandsen, B. M., Walsh, S. M., Wang, P. & Silverman, S. K., Jan 1 2016, In : Chemical Communications. 52, 59, p. 9259-9262 4 p.

Research output: Contribution to journalArticle

Catalytic DNA
Glycosylation
Glycosides
DNA
Oligonucleotides

DNA-catalyzed hydrolysis of esters and aromatic amides

Brandsen, B. M., Hesser, A. R., Castner, M. A., Chandra, M. & Silverman, S. K., Oct 30 2013, In : Journal of the American Chemical Society. 135, 43, p. 16014-16017 4 p.

Research output: Contribution to journalArticle

Amides
ester
hydrolysis
Hydrolysis
Esters

DNA-Catalyzed Introduction of Azide at Tyrosine for Peptide Modification

Wang, P. & Silverman, S. K., Jan 1 2016, In : Angewandte Chemie - International Edition. 55, 34, p. 10052-10056 5 p.

Research output: Contribution to journalArticle

Catalytic DNA
Azides
Peptides
Tyrosine
DNA

DNA-catalyzed lysine side chain modification

Brandsen, B. M., Velez, T. E., Sachdeva, A., Ibrahim, N. A. & Silverman, S. K., Aug 18 2014, In : Angewandte Chemie - International Edition. 53, 34, p. 9045-9050 6 p.

Research output: Contribution to journalArticle

Lysine
DNA
Catalysis
Substrates
Proteins
Catalytic DNA
lysine
nucleic acids
linkages
Nucleic Acids

DNA-catalyzed reductive amination

Wong, O. Y., Mulcrone, A. E. & Silverman, S. K., Dec 2 2011, In : Angewandte Chemie - International Edition. 50, 49, p. 11679-11684 6 p.

Research output: Contribution to journalArticle

Amination
DNA
Guanosine
Nucleic acids
Nucleic Acids

DNA-catalyzed sequence-specific hydrolysis of DNA

Chandra, M., Sachdeva, A. & Silverman, S. K., Oct 2009, In : Nature chemical biology. 5, 10, p. 718-720 3 p.

Research output: Contribution to journalArticle

Hydrolysis
Catalytic DNA
DNA
RNA Cleavage
Deoxyribonucleases

DNA-catalyzed serine side chain reactivity and selectivity

Sachdeva, A. & Silverman, S. K., Mar 25 2010, In : Chemical Communications. 46, 13, p. 2215-2217 3 p.

Research output: Contribution to journalArticle

Serine
DNA
Catalytic DNA
Tyrosine

DNA constraints allow rational control of macromolecular conformation

Miduturu, C. V. & Silverman, S. K., Jul 27 2005, In : Journal of the American Chemical Society. 127, 29, p. 10144-10145 2 p.

Research output: Contribution to journalArticle

Conformations
DNA
RNA
nanotechnology
Nanotechnology

DNA Oligonucleotide 3′-Phosphorylation by a DNA Enzyme

Camden, A. J., Walsh, S. M., Suk, S. H. & Silverman, S. K., May 10 2016, In : Biochemistry. 55, 18, p. 2671-2676 6 p.

Research output: Contribution to journalArticle

Phosphorylation
Oligonucleotides
DNA
Enzymes
Catalytic DNA