Scott E Denmark

2025

Catalytic allylation of native hexoses and pentoses in water with indium

Adak, T., Menard, T., Albritton, M., Florit, F., Burke, M., Jensen, K. F. & Denmark, S. E., Apr 3 2025, In: Nature. 640, 8057, p. 94-99 6 p.

Research output: Contribution to journal › Article › peer-review

2024

Chemoinformatic Catalyst Selection Methods for the Optimization of Copper-Bis(oxazoline)-Mediated, Asymmetric, Vinylogous Mukaiyama Aldol Reactions

Olen, C. L., Zahrt, A. F., Reilly, S. W., Schultz, D., Emerson, K., Candito, D., Wang, X., Strotman, N. A. & Denmark, S. E., Feb 16 2024, In: ACS Catalysis. 14, 4, p. 2642-2655 14 p.

Research output: Contribution to journal › Article › peer-review

ChemScraper: leveraging PDF graphics instructions for molecular diagram parsing

Shah, A. K., Amador, B., Dey, A., Creekmore, M., Ocampo, B., Denmark, S. & Zanibbi, R., Sep 2024, In: International Journal on Document Analysis and Recognition. 27, 3, p. 395-414 20 p.

Research output: Contribution to journal › Article › peer-review

Effects of Ring Size and Steric Encumbrance on Boron-to-Palladium Transmetalation from Arylboronic Esters

Delaney, C. P., Zahrt, A. F., Kassel, V. M. & Denmark, S. E., Nov 15 2024, In: Journal of Organic Chemistry. 89, 22, p. 16170-16184 15 p.

Research output: Contribution to journal › Article › peer-review

Machine Learning to Develop Peptide Catalysts─Successes, Limitations, and Opportunities

Schnitzer, T., Schnurr, M., Zahrt, A. F., Sakhaee, N., Denmark, S. E. & Wennemers, H., Feb 28 2024, In: ACS Central Science. 10, 2, p. 367-373 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Molecule Maker Lab Institute: Accelerating, advancing, and democratizing molecular innovation

Burke, M. D., Denmark, S. E., Diao, Y., Han, J., Switzky, R. & Zhao, H., Mar 1 2024, In: AI Magazine. 45, 1, p. 117-123 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

molli: A General Purpose Python Toolkit for Combinatorial Small Molecule Library Generation, Manipulation, and Feature Extraction

Shved, A. S., Ocampo, B. E., Burlova, E. S., Olen, C. L., Rinehart, N. I. & Denmark, S. E., Nov 11 2024, In: Journal of Chemical Information and Modeling. 64, 21, p. 8083-8090 8 p.

Research output: Contribution to journal › Article › peer-review

Organoselenium-Catalyzed Enantioselective Synthesis of 2-Oxazolidinones from Alkenes

Cunningham, C. C., Panger, J. L., Lupi, M. & Denmark, S. E., Aug 9 2024, In: Organic Letters. 26, 31, p. 6703-6708 6 p.

Research output: Contribution to journal › Article › peer-review

Rapid, Homogenous, B-Alkyl Suzuki-Miyaura Cross-Coupling of Boronic Esters

Bock, M. J. & Denmark, S. E., Nov 15 2024, In: Journal of Organic Chemistry. 89, 22, p. 16195-16202 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Albert Eschenmoser (1925-2023)

Denmark, S. E. & Sorensen, E. J., Sep 15 2023, In: Science (New York, N.Y.). 381, 6663, p. 1158 1 p.

Research output: Contribution to journal › Article › peer-review

A machine-learning tool to predict substrate-adaptive conditions for Pd-catalyzed C–N couplings

Rinehart, N. I., Saunthwal, R. K., Wellauer, J., Zahrt, A. F., Schlemper, L., Shved, A. S., Bigler, R., Fantasia, S. & Denmark, S. E., Sep 1 2023, In: Science. 381, 6661, p. 965-972 8 p.

Research output: Contribution to journal › Article › peer-review

Extrapolative prediction of enantioselectivity enabled by computer-driven workflow, new molecular representations and machine learning

Denmark, S. E. (Inventor), Zahrt, A. F. (Inventor), Henle, J. J. (Inventor), Rose, B. T. (Inventor), Wang, Y. (Inventor) & Darrow, W. (Inventor), May 30 2023, U.S. Patent No. 11664093, Aug 26 2019

Research output: Patent

Non-invasive Analysis Of Embryo Metabolites

Rubessa, M. (Inventor), Wheeler, M. B. (Inventor), Ambrosi, A. (Inventor), Denmark, S. E. (Inventor) & Gonzalez-Pena, D. (Inventor), Oct 3 2023, U.S. Patent No. 11774454

Research output: Patent

2022

Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts

Lexa, K. W., Belyk, K. M., Henle, J., Xiang, B., Sheridan, R. P., Denmark, S. E., Ruck, R. T. & Sherer, E. C., Mar 18 2022, In: Organic Process Research and Development. 26, 3, p. 670-682 13 p.

Research output: Contribution to journal › Review article › peer-review

Enantioselective Inter- and Intramolecular Sulfenofunctionalization of Unactivated Cyclic and (Z)-Alkenes

Matviitsuk, A., Panger, J. L. & Denmark, S. E., 2022, In: ACS Catalysis. 12, p. 7377-7385 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Extraction of selected platinum-group metals from supported catalyst

Denmark, S. E. (Inventor) & Ibrahim, M. Y. S. (Inventor), Aug 30 2022, U.S. Patent No. 11427887, Nov 26 2018

Research output: Patent

High-Level Data Fusion Enables the Chemoinformatically Guided Discovery of Chiral Disulfonimide Catalysts for Atropselective Iodination of 2-Amino-6-arylpyridines

Rose, B. T., Timmerman, J. C., Bawel, S. A., Chin, S., Zhang, H. & Denmark, S. E., Dec 21 2022, In: Journal of the American Chemical Society. 144, 50, p. 22950-22964 15 p.

Research output: Contribution to journal › Article › peer-review

Potassium Trimethylsilanolate-Promoted, Anhydrous Suzuki-Miyaura Cross-Coupling Reaction Proceeds via the "boronate Mechanism": Evidence for the Alternative Fork in the Trail

Delaney, C. P., Marron, D. P., Shved, A. S., Zare, R. N., Waymouth, R. M. & Denmark, S. E., Mar 16 2022, In: Journal of the American Chemical Society. 144, 10, p. 4345-4364 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

A Conformer-Dependent, Quantitative Quadrant Model

Zahrt, A. F., Rinehart, N. I. & Denmark, S. E., May 7 2021, In: European Journal of Organic Chemistry. 2021, 17, p. 2343-2354 12 p.

Research output: Contribution to journal › Article › peer-review

A Unified Strategy for the Asymmetric Synthesis of Highly Substituted 1,2-Amino Alcohols Leading to Highly Substituted Bisoxazoline Ligands

Shrestha, B., Rose, B. T., Olen, C. L., Roth, A., Kwong, A. C., Wang, Y. & Denmark, S. E., Feb 19 2021, In: Journal of Organic Chemistry. 86, 4, p. 3490-3534 45 p.

Research output: Contribution to journal › Article › peer-review

Catalytic, Enantioselective Diamination of Alkenes

Tao, Z. L. & Denmark, S. E., Nov 3 2021, In: Synthesis (Germany). 53, 21, p. 3951-3962 12 p., ss-2021-r0324-sr.

Research output: Contribution to journal › Review article › peer-review

Catalytic, Enantioselective Syn-Oxyamination of Alkenes

Mumford, E. M., Hemric, B. N. & Denmark, S. E., Aug 25 2021, In: Journal of the American Chemical Society. 143, 33, p. 13408-13417 10 p.

Research output: Contribution to journal › Article › peer-review

Computational methods for training set selection and error assessment applied to catalyst design: Guidelines for deciding which reactions to run first and which to run next

Zahrt, A. F., Rose, B. T., Darrow, W. T., Henle, J. J. & Denmark, S. E., Apr 2021, In: Reaction Chemistry and Engineering. 6, 4, p. 694-708 15 p.

Research output: Contribution to journal › Article › peer-review

Dreams, False Starts, Dead Ends, and Redemption: A Chronicle of the Evolution of a Chemoinformatic Workflow for the Optimization of Enantioselective Catalysts

Rinehart, N. I., Zahrt, A. F., Henle, J. J. & Denmark, S. E., May 4 2021, In: Accounts of chemical research. 54, 9, p. 2041-2054 14 p.

Research output: Contribution to journal › Article › peer-review

Heteroaryl-Heteroaryl, Suzuki-Miyaura, Anhydrous Cross-Coupling Reactions Enabled by Trimethyl Borate

Kassel, V. M., Hanneman, C. M., Delaney, C. P. & Denmark, S. E., Sep 1 2021, In: Journal of the American Chemical Society. 143, 34, p. 13845-13853 9 p.

Research output: Contribution to journal › Article › peer-review

Leveraging Machine Learning for Enantioselective Catalysis: From Dream to Reality

Rinehart, N. I., Zahrt, A. F. & Denmark, S. E., Aug 2021, In: Chimia. 75, 7-8, p. 592-597 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Lewis Base Catalyzed, Sulfenium Ion Initiated Enantioselective, Spiroketalization Cascade

Hilby, K. M. & Denmark, S. E., Nov 5 2021, In: Journal of Organic Chemistry. 86, 21, p. 14250-14289 40 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Stereochemical language in supramolecular polymer chemistry: How we can do better

Palmans, A. R. A., Meijer, E. W. & Denmark, S. E., Jun 15 2021, In: Journal of Polymer Science. 59, 12, p. 1171-1174 4 p.

Research output: Contribution to journal › Article › peer-review

Synthesis of Enantioenriched 3,4-Disubstituted Chromans through Lewis Base Catalyzed Carbosulfenylation

Menard, T., Laverny, A. & Denmark, S. E., Nov 5 2021, In: Journal of Organic Chemistry. 86, 21, p. 14290-14310 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Anhydrous, homogeneous, suzuki-miyaura cross-coupling of boronic esters using potassium trimethylsilanolate

Delaney, C. P., Heyboer, E. M. & Denmark, S. E., 2020, In: Organic Syntheses. 97, p. 245-261 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Acyclic Olefins

Bigler, R., Mack, K. A., Shen, J., Tosatti, P., Han, C., Bachmann, S., Zhang, H., Scalone, M., Pfaltz, A., Denmark, S. E., Hildbrand, S. & Gosselin, F., Feb 10 2020, In: Angewandte Chemie - International Edition. 59, 7, p. 2844-2849 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Catalytic, Enantioselective Sulfenofunctionalization of Alkenes: Development and Recent Advances

Matviitsuk, A., Panger, J. L. & Denmark, S. E., Nov 2 2020, In: Angewandte Chemie - International Edition. 59, 45, p. 19796-19819 24 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Cautionary Guidelines for Machine Learning Studies with Combinatorial Datasets

Zahrt, A. F., Henle, J. J. & Denmark, S. E., Nov 9 2020, In: ACS Combinatorial Science. 22, 11, p. 586-591 6 p.

Research output: Contribution to journal › Article › peer-review

Demystifying the asymmetry-amplifying, autocatalytic behaviour of the Soai reaction through structural, mechanistic and computational studies

Athavale, S. V., Simon, A., Houk, K. N. & Denmark, S. E., Apr 1 2020, In: Nature Chemistry. 12, 4, p. 412-423 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Development of a Computer-Guided Workflow for Catalyst Optimization. Descriptor Validation, Subset Selection, and Training Set Analysis

Henle, J. J., Zahrt, A. F., Rose, B. T., Darrow, W. T., Wang, Y. & Denmark, S. E., Jul 1 2020, In: Journal of the American Chemical Society. 142, 26, p. 11578-11592 15 p.

Research output: Contribution to journal › Article › peer-review

Enantioselective Synthesis of γ-Lactams by Lewis Base Catalyzed Sulfenoamidation of Alkenes

Panger, J. L. & Denmark, S. E., Apr 3 2020, In: Organic Letters. 22, 7, p. 2501-2505 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Potassium trimethylsilanolate enables rapid, homogeneous suzuki-miyaura cross-coupling of boronic esters

Delaney, C. P., Kassel, V. M. & Denmark, S. E., Jan 3 2020, In: ACS Catalysis. 10, 1, p. 73-80 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Quantitative Structure-Selectivity Relationships in Enantioselective Catalysis: Past, Present, and Future

Zahrt, A. F., Athavale, S. V. & Denmark, S. E., Feb 12 2020, In: Chemical reviews. 120, 3, p. 1620-1689 70 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Structural contributions to autocatalysis and asymmetric amplification in the soai reaction

Athavale, S. V., Simon, A., Houk, K. N. & Denmark, S. E., Oct 28 2020, In: Journal of the American Chemical Society. 142, 43, p. 18387-18406 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

(R)-n,n’-dimethyl-1,1’-binaphthyldiamine

Denmark, S. E. & Ryabchuk, P. G., 2019, In: Organic Syntheses. 96, p. 382-399 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A Dinuclear Mechanism Implicated in Controlled Carbene Polymerization

Zhukhovitskiy, A. V., Kobylianskii, I. J., Thomas, A. A., Evans, A. M., Delaney, C. P., Flanders, N. C., Denmark, S. E., DIchtel, W. R. & Toste, F. D., Apr 24 2019, In: Journal of the American Chemical Society. 141, 16, p. 6473-6478 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Catalytic, Enantioselective syn-Diamination of Alkenes

Tao, Z., Gilbert, B. B. & Denmark, S. E., Dec 4 2019, In: Journal of the American Chemical Society. 141, 48, p. 19161-19170 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Dynamically Chiral Helical Polymers: A New Frontier in Asymmetric Catalysis?

Denmark, S. E., Jul 24 2019, In: ACS Central Science. 5, 7, p. 1117-1119 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Enantio- and Diastereoselective, Lewis Base Catalyzed, Cascade Sulfenoacetalization of Alkenyl Aldehydes

Matviitsuk, A. & Denmark, S. E., Sep 2 2019, In: Angewandte Chemie - International Edition. 58, 36, p. 12486-12490 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Enantioselective, lewis base-catalyzed, intermolecular sulfenoamination of alkenes

Roth, A. & Denmark, S. E., Sep 4 2019, In: Journal of the American Chemical Society. 141, 35, p. 13767-13771 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Evaluating continuous chirality measure as a 3D descriptor in chemoinformatics applied to asymmetric catalysis

Zahrt, A. F. & Denmark, S. E., Mar 29 2019, In: Tetrahedron. 75, 13, p. 1841-1851 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Lewis base activation of silicon lewis acids

Rossi, S. & Denmark, S. E., Dec 10 2019, Organosilicon Chemistry: Novel Approaches and Reactions. Wiley, p. 333-415 83 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Organoselenium-catalyzed enantioselective syn-dichlorination of unbiased alkenes

Gilbert, B. B., Eey, S. T. C., Ryabchuk, P., Garry, O. & Denmark, S. E., Aug 2 2019, In: Tetrahedron. 75, 31, p. 4086-4098 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Prediction of higher-selectivity catalysts by computer-driven workflow and machine learning

Zahrt, A. F., Henle, J. J., Rose, B. T., Wang, Y., Darrow, W. T. & Denmark, S. E., Jan 18 2019, In: Science. 363, 6424, eaau5631.

Research output: Contribution to journal › Article › peer-review

Open Access

Preface for volume 100

Denmark, S. E., 2019, In: Organic Reactions. 100, p. xxi-xxvii

Research output: Contribution to journal › Editorial › peer-review

Scott E Denmark

Research output

Search results