Satish K Nair

1991 …2019
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Research Output 1991 2019

2019

Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor

Dong, S. H., Kulikovsky, A., Zukher, I., Estrada, P., Dubiley, S., Severinov, K. & Nair, S. K., Jan 1 2019, In : Chemical Science. 10, 8, p. 2391-2395 5 p.

Research output: Contribution to journalArticle

Open Access
Biosynthesis
Nucleotides
Anti-Bacterial Agents
Peptides
Ubiquitin-Activating Enzymes

Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae

Huo, L., Zhao, X., Acedo, J. Z., Estrada, P., Nair, S. K. & van der Donk, W. A., Jan 1 2019, (Accepted/In press) In : ChemBioChem.

Research output: Contribution to journalArticle

Hydro-Lyases
Biosynthesis
Methyltransferases
Bacteria
Genes

Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics

Bothwell, I. R., Cogan, D. P., Kim, T., Reinhardt, C. J., van der Donk, W. A. & Nair, S. K., Aug 27 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17245-17250 6 p.

Research output: Contribution to journalArticle

Open Access
Hydro-Lyases
RNA, Transfer, Glu
Peptides
Nisin
Glutamic Acid

Characterization of the flavin monooxygenase involved in biosynthesis of the antimalarial FR-900098

Nguyen, K., DeSieno, M. A., Bae, B., Johannes, T. W., Cobb, R. E., Zhao, H. & Nair, S. K., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 6, p. 1506-1518 13 p.

Research output: Contribution to journalArticle

dimethylaniline monooxygenase (N-oxide forming)
Flavin-Adenine Dinucleotide
biosynthesis
Biosynthesis
Antimalarials

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

Bobeica, S. C., Dong, S. H., Huo, L., Mazo, N., McLaughlin, M. I., Jiménez-Osés, G., Nair, S. K. & van der Donk, W. A., Jan 14 2019, In : eLife. 8

Research output: Contribution to journalArticle

Protein Sorting Signals
Glycine
Peptide Hydrolases
Bacteria
Peptides

Mechanistic Basis for Ribosomal Peptide Backbone Modifications

Dong, S. H., Liu, A., Mahanta, N., Mitchell, D. A. & Nair, S. K., Jan 1 2019, In : ACS Central Science.

Research output: Contribution to journalArticle

Open Access
Peptides
Enzymes
Thioamides
Substrates
Coenzymes

Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants

Chekan, J. R., Ongpipattanakul, C., Wright, T. R., Zhang, B., Martin Bollinger, J., Rajakovich, L. J., Krebs, C., Cicchillo, R. M. & Nair, S. K., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13299-13304 6 p.

Research output: Contribution to journalArticle

Open Access
Dioxygenases
Genetically Modified Plants
Herbicides
2,4-Dichlorophenoxyacetic Acid
Indoleacetic Acids

Molecular Basis of Bacillus subtilis ATCC 6633 Self-Resistance to the Phosphono-oligopeptide Antibiotic Rhizocticin

Petronikolou, N., Ortega, M. A., Borisova, S. A., Nair, S. K. & Metcalf, W. W., Apr 19 2019, In : ACS chemical biology. 14, 4, p. 742-750 9 p.

Research output: Contribution to journalArticle

Oligopeptides
Bacilli
Bacillus subtilis
Anti-Bacterial Agents
Threonine

Reiterative synthesis by the ribosome and recognition of the N-terminal formyl group by biosynthetic machinery contribute to evolutionary conservation of the length of antibiotic microcin c peptide precursor

Zukher, I., Pavlov, M., Tsibulskaya, D., Kulikovsky, A., Zyubko, T., Bikmetov, D., Serebryakova, M., Nair, S. K., Ehrenberg, M., Dubiley, S. & Severinova, K., Mar 1 2019, In : mBio. 10, 2, e00768-19.

Research output: Contribution to journalArticle

Open Access
Ribosomes
Anti-Bacterial Agents
Peptides
Amino Acids
Operon
2018

A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases

Estrada, P., Morita, M., Hao, Y., Schmidt, E. W. & Nair, S. K., Jul 5 2018, In : Journal of the American Chemical Society. 140, 26, p. 8124-8127 4 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Isoprene
isoprene
Biological Products
peptide

Biosynthetic Proteases That Catalyze the Macrocyclization of Ribosomally Synthesized Linear Peptides

Ongpipattanakul, C. & Nair, S. K., Jun 12 2018, In : Biochemistry. 57, 23, p. 3201-3209 9 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Peptides
Macrocyclic Compounds
Proteolysis
Small Molecule Libraries

Enzymatic reconstitution of ribosomal peptide backbone thioamidation

Mahanta, N., Liu, A., Dong, S., Nair, S. K. & Mitchell, D. A., Mar 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 12, p. 3030-3035 6 p.

Research output: Contribution to journalArticle

Oxidoreductases
Peptides
Archaea
Post Translational Protein Processing
Proteins

Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside

Petronikolou, N., Hollatz, A. J., Schuler, M. A. & Nair, S. K., Apr 16 2018, In : ChemBioChem. 19, 8, p. 784-788 5 p.

Research output: Contribution to journalArticle

Iridoid Glycosides
Methylation
Methyltransferases
Secologanin Tryptamine Alkaloids
Indole Alkaloids

Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis

Ongpipattanakul, C. & Nair, S. K., Oct 19 2018, In : ACS chemical biology. 13, 10, p. 2989-2999 11 p.

Research output: Contribution to journalArticle

Methylation
Biosynthesis
Biological Products
Peptides
Catalysts

Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis

Morita, M., Hao, Y., Jokela, J. K., Sardar, D., Lin, Z., Sivonen, K., Nair, S. K. & Schmidt, E. W., May 16 2018, In : Journal of the American Chemical Society. 140, 19, p. 6044-6048 5 p.

Research output: Contribution to journalArticle

Biosynthesis
Cyanobacteria
Tyrosine
cyanobacterium
Geranyltranstransferase

Structural and Biochemical Studies of a Biocatalyst for the Enzymatic Production of Wax Esters

Petronikolou, N. & Nair, S. K., Jul 6 2018, In : ACS Catalysis. 8, 7, p. 6334-6344 11 p.

Research output: Contribution to journalArticle

Biocatalysts
Waxes
Diacylglycerol O-Acyltransferase
Esters
Enzymes

Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop “Out” Conformation for LasR

O'Reilly, M. C., Dong, S. H., Rossi, F. M., Karlen, K. M., Kumar, R. S., Nair, S. K. & Blackwell, H. E., Sep 20 2018, In : Cell chemical biology. 25, 9, p. 1128-1139.e3

Research output: Contribution to journalArticle

Quorum Sensing
Conformations
Ligands
Pseudomonas aeruginosa
Pathogens

Structural basis of transcriptional regulation by cour, a repressor of coumarate catabolism, in rhodopseudomonas palustris

Cogan, D. P., Baraquet, C., Harwood, C. S. & Nair, S. K., Jan 1 2018, In : Journal of Biological Chemistry. 293, 30, p. 11727-11735 9 p.

Research output: Contribution to journalArticle

Rhodopseudomonas
Ligands
Operon
DNA
Bearings (structural)

Structure-Guided Analyses of a Key Enzyme Involved in the Biosynthesis of an Antivitamin

Kapoor, I. & Nair, S. K., Sep 11 2018, In : Biochemistry. 57, 36, p. 5282-5288 7 p.

Research output: Contribution to journalArticle

Flavin Mononucleotide
Biosynthesis
Catalytic Domain
Phosphates
Reaction intermediates

Substrate-assisted enzymatic formation of lysinoalanine in duramycin

An, L., Cogan, D. P., Navo, C. D., Jiménez-Osés, G., Nair, S. K. & van der Donk, W. A., Oct 1 2018, In : Nature chemical biology. 14, 10, p. 928-933 6 p.

Research output: Contribution to journalArticle

Lysinoalanine
Viperidae
Catalysis
Cystic Fibrosis
duramycin

The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis

Gu, W., Dong, S. H., Sarkar, S., Nair, S. K. & Schmidt, E. W., Jan 1 2018, Methods in Enzymology. Moore, B. S. (ed.). Academic Press Inc., p. 113-163 51 p. (Methods in Enzymology; vol. 604).

Research output: Chapter in Book/Report/Conference proceedingChapter

Biochemistry
Biosynthesis
Enzymes
Dimethylallyltranstransferase
Methyltransferases
2017

Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants

Chekan, J. R., Estrada, P., Covello, P. S. & Nair, S. K., Jun 20 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 25, p. 6551-6556 6 p.

Research output: Contribution to journalArticle

Cyclic Peptides
Enzymes
Peptides
Plant Structures
Libraries

Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads

Olivares, P., Ulrich, E. C., Chekan, J. R., van der Donk, W. A. & Nair, S. K., Feb 17 2017, In : ACS chemical biology. 12, 2, p. 456-463 8 p.

Research output: Contribution to journalArticle

Fosfomycin
Biosynthesis
Enzymes
Anti-Bacterial Agents
Pseudomonas syringae

Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products

Sardar, D., Hao, Y., Lin, Z., Morita, M., Nair, S. K. & Schmidt, E. W., Mar 1 2017, In : Journal of the American Chemical Society. 139, 8, p. 2884-2887 4 p.

Research output: Contribution to journalArticle

Biological Products
peptide
Peptides
Biosynthesis
Enzymes

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes

Repka, L. M., Chekan, J. R., Nair, S. K. & Van Der Donk, W. A., Apr 26 2017, In : Chemical reviews. 117, 8, p. 5457-5520 64 p.

Research output: Contribution to journalArticle

Sulfides
Bioactivity
Bacteriocins
Peptides
Cyclization

Molecular basis for the substrate specificity of quorum signal synthases

Dong, S. H., Frane, N. D., Christensen, Q. H., Greenberg, E. P., Nagarajan, R. & Nair, S. K., Aug 22 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 34, p. 9092-9097 6 p.

Research output: Contribution to journalArticle

Substrate Specificity
Methionine
Acyl Carrier Protein
Proteobacteria
Lactones

Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4

Hu, X., Dong, S. H., Chen, J., Zhou, X. Z., Chen, R., Nair, S., Lu, K. P. & Chen, L. F., Sep 7 2017, In : Oncogene. 36, 36, p. 5177-5188 12 p.

Research output: Contribution to journalArticle

Peptidylprolyl Isomerase
Stomach Neoplasms
Neoplasms
Ubiquitination
Threonine
Peptide Biosynthesis
Cycloaddition Reaction
Anti-Bacterial Agents
Catalytic Domain
Organic Chemistry

The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes

Estrada, P., Manandhar, M., Dong, S. H., Deveryshetty, J., Agarwal, V., Cronan, J. E. & Nair, S. K., Jun 1 2017, In : Nature chemical biology. 13, 6, p. 668-674 7 p.

Research output: Contribution to journalArticle

Amino Acyl-tRNA Synthetases
Catalytic Domain
Coenzyme A Ligases
Enzymes
Coenzyme A

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis

Ortega, M. A., Cogan, D. P., Mukherjee, S., Garg, N., Li, B., Thibodeaux, G. N., Maffioli, S. I., Donadio, S., Sosio, M., Escano, J., Smith, L., Nair, S. K. & Van Der Donk, W. A., Feb 17 2017, In : ACS chemical biology. 12, 2, p. 548-557 10 p.

Research output: Contribution to journalArticle

Biosynthesis
Cysteine
Bacteriocins
Substrates
Bioinformatics
2016

Molecular basis for resistance against phosphonate antibiotics and herbicides

Chekan, J. R., Cogan, D. P. & Nair, S. K., Jan 1 2016, In : MedChemComm. 7, 1, p. 28-36 9 p.

Research output: Contribution to journalReview article

glyphosate
Fosfomycin
Organophosphonates
Herbicides
Bioactivity

Molecular basis for the broad substrate selectivity of a peptide prenyltransferase

Hao, Y., Pierce, E., Roe, D., Morita, M., McIntosh, J. A., Agarwal, V., Cheatham, T. E., Schmidt, E. W. & Nair, S. K., Dec 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 49, p. 14037-14042 6 p.

Research output: Contribution to journalArticle

Dimethylallyltranstransferase
Peptides
Prenylation
Terpenes
Enzymes

Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis

Ortega, M. A., Hao, Y., Walker, M. C., Donadio, S., Sosio, M., Nair, S. K. & van der Donk, W., Mar 17 2016, In : Cell chemical biology. 23, 3, p. 370-380 11 p.

Research output: Contribution to journalArticle

RNA, Transfer, Glu
Hydro-Lyases
Bacteriocins
Actinobacteria
Biosynthesis

Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates

Chekan, J. R., Koos, J. D., Zong, C., Maksimov, M. O., Link, A. J. & Nair, S. K., Dec 21 2016, In : Journal of the American Chemical Society. 138, 50, p. 16452-16458 7 p.

Research output: Contribution to journalArticle

peptide
Peptides
topology
Topology
substrate
2015

A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase

Peck, S. C., Chekan, J. R., Ulrich, E. C., Nair, S. K. & Van Der Donk, W. A., Feb 2015, In : Journal of the American Chemical Society. 137, 9, p. 3217-3220 4 p.

Research output: Contribution to journalArticle

Dioxygenases
catalysis
Catalysis
Isotopes
Iron

Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage

Tang, W., Dong, S. H., Repka, L. M., He, C., Nair, S. K. & Van Der Donk, W. A., Sep 2 2015, In : Chemical Science. 6, 11, p. 6270-6279 10 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Peptides
Biosynthesis
Subtilisin
Bacteriocins

Biochemical Studies of Mycobacterial Fatty Acid Methyltransferase: A Catalyst for the Enzymatic Production of Biodiesel

Petronikolou, N. & Nair, S. K., Nov 19 2015, In : Chemistry and Biology. 22, 11, p. 1480-1490 11 p.

Research output: Contribution to journalArticle

Biofuels
Fatty Acids
Metabolism
Biological Products
Catalysts

Insights into Methyltransferase Specificity and Bioactivity of Derivatives of the Antibiotic Plantazolicin

Hao, Y., Blair, P. M., Sharma, A., Mitchell, D. A. & Nair, S. K., May 15 2015, In : ACS chemical biology. 10, 5, p. 1209-1216 8 p.

Research output: Contribution to journalArticle

Methyltransferases
Bioactivity
Biological Products
Bacillus anthracis
Anti-Bacterial Agents

Structural Basis for Specificity and Flexibility in a Plant 4-Coumarate:CoA Ligase

Li, Z. & Nair, S. K., Nov 3 2015, In : Structure. 23, 11, p. 2032-2042 11 p.

Research output: Contribution to journalArticle

Coenzyme A Ligases
Adenosine Monophosphate
Tobacco
Protein Isoforms
Adenosine Triphosphate

Structure, Function and Inhibition of the Phosphoethanolamine Methyltransferases of the Human Malaria Parasites Plasmodium vivax and Plasmodium knowlesi

Garg, A., Lukk, T., Kumar, V., Choi, J. Y., Augagneur, Y., Voelker, D. R., Nair, S. & Mamoun, C. B., 2015, In : Scientific reports. 5, 9064.

Research output: Contribution to journalArticle

Plasmodium knowlesi
Vivax Malaria
Antimalarials
Parasites
Phosphatidylcholines

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

Ortega, M. A., Hao, Y., Zhang, Q., Walker, M. C., van der Donk, W. A. & Nair, S. K., Jan 22 2015, In : Nature. 517, 7535, p. 509-512 4 p.

Research output: Contribution to journalArticle

Hydro-Lyases
Bacteriocins
Transfer RNA
Dehydration
Nisin

Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-d-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor

Cobb, R. E., Bae, B., Li, Z., Desieno, M. A., Nair, S. K. & Zhao, H., Feb 14 2015, In : Chemical Communications. 51, 13, p. 2526-2528 3 p.

Research output: Contribution to journalArticle

Biosynthesis
Phosphates
Antimalarials
Derivatives
xylulose-5-phosphate

The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold

Dong, S. H., Tang, W., Lukk, T., Yu, Y., Nair, S. K. & van der donk, W. A., Jul 30 2015, In : eLife. 4, JULY2015, e07607.

Research output: Contribution to journalArticle

Perforin
Ligases
Dehydration
Phosphotransferases
Lipids
2014

Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

Zou, Z., Huang, B., Wu, X., Zhang, H., Qi, J., Bradner, J., Nair, S. K. & Chen, L-F., May 1 2014, In : Oncogene. 33, 18, p. 2395-2404 10 p.

Research output: Contribution to journalArticle

Lysine
Neoplasms
Proteins
Severe Combined Immunodeficiency
Ubiquitination

Chemical rescue and inhibition studies to determine the role of Arg301 in phosphite dehydrogenase

Hung, J. E., Fogle, E. J., Garg, N., Chekan, J. R., Nair, S. K. & Van Der Donk, W. A., Jan 31 2014, In : PloS one. 9, 1, e87134.

Research output: Contribution to journalArticle

Phosphites
mutants
catalytic activity
active sites
Catalytic Domain

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis

Dunbar, K. L., Chekan, J. R., Cox, C. L., Burkhart, B. J., Nair, S. K. & Mitchell, D. A., Oct 1 2014, In : Nature chemical biology. 10, 10, p. 823-829 7 p.

Research output: Contribution to journalArticle

Oxazoles
Thiazoles
Protein C
Adenosine Triphosphate
Catalysis

Exploring the substrate promiscuity of an antibiotic inactivating enzyme

Agarwal, V., Vondenhoff, G., Gadakh, B., Severinov, K., Van Aerschot, A. & Nair, S. K., Oct 1 2014, In : MedChemComm. 5, 10, p. 1567-1570 4 p.

Research output: Contribution to journalArticle

Nucleotides
Anti-Bacterial Agents
Aspartate-tRNA Ligase
Substrates
Enzymes

Roles of small laccases from streptomyces in lignin degradation

Majumdar, S., Lukk, T., Solbiati, J. O., Bauer, S., Nair, S. K., Cronan, J. E. & Gerlt, J. A., Jun 24 2014, In : Biochemistry. 53, 24, p. 4047-4058 12 p.

Research output: Contribution to journalArticle

Laccase
Lignin
Streptomyces
Degradation
Streptomyces coelicolor

Structural and biochemical basis for mannan utilization by Caldanaerobius polysaccharolyticus strain ATCC BAA-17

Chekan, J. R., Kwon, I. H., Agarwal, V., Dodd, D., Revindran, V., Mackie, R. I., Cann, I. & Nair, S. K., Dec 12 2014, In : Journal of Biological Chemistry. 289, 50, p. 34965-34977 13 p.

Research output: Contribution to journalArticle

Mannans
Mannose
Oligosaccharides
Fermentation
Polysaccharides

Structure and function of phosphonoacetaldehyde dehydrogenase: The missing link in phosphonoacetate formation

Agarwal, V., Peck, S. C., Chen, J. H., Borisova, S. A., Chekan, J. R., Van Der Donk, W. A. & Nair, S. K., Jan 16 2014, In : Chemistry and Biology. 21, 1, p. 125-135 11 p.

Research output: Contribution to journalArticle

Phosphonoacetic Acid
Organophosphonates
Oxidoreductases
Catalytic Domain
Aldehyde Dehydrogenase