Satish K Nair

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Research Output

2020

Biochemical basis for the regulation of biosynthesis of antiparasitics by bacterial hormones

Kapoor, I., Olivares, P. & Nair, S. K., Jun 8 2020, (Accepted/In press) In : eLife. 9, e57824.

Research output: Contribution to journalArticle

Open Access

Characterization of a Dehydratase and Methyltransferase in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides in Lachnospiraceae

Huo, L., Zhao, X., Acedo, J. Z., Estrada, P., Nair, S. K. & van der Donk, W. A., Jan 15 2020, In : ChemBioChem. 21, 1-2, p. 190-199 10 p.

Research output: Contribution to journalArticle

Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

Nayak, D. D., Liu, A., Agrawal, N., Rodriguez-Carerro, R., Dong, S. H., Mitchell, D. A., Nair, S. K. & Metcalf, W. W., Jan 1 2020, In : PLoS biology. 18, 2, e3000507.

Research output: Contribution to journalArticle

Open Access

Natural product biosynthesis: What’s next? An introduction to the JBC Reviews Thematic Series

Nair, S. K. & Jez, J. M., Jan 10 2020, In : Journal of Biological Chemistry. 295, 2, p. 335-336 2 p.

Research output: Contribution to journalReview article

Open Access
2019

Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor

Dong, S. H., Kulikovsky, A., Zukher, I., Estrada, P., Dubiley, S., Severinov, K. & Nair, S. K., Jan 1 2019, In : Chemical Science. 10, 8, p. 2391-2395 5 p.

Research output: Contribution to journalArticle

Open Access

Characterization of glutamyl-tRNA–dependent dehydratases using nonreactive substrate mimics

Bothwell, I. R., Cogan, D. P., Kim, T., Reinhardt, C. J., van der Donk, W. A. & Nair, S. K., Aug 27 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17245-17250 6 p.

Research output: Contribution to journalArticle

Open Access

Characterization of the flavin monooxygenase involved in biosynthesis of the antimalarial FR-900098

Nguyen, K., DeSieno, M. A., Bae, B., Johannes, T. W., Cobb, R. E., Zhao, H. & Nair, S. K., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 6, p. 1506-1518 13 p.

Research output: Contribution to journalArticle

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

Bobeica, S. C., Dong, S. H., Huo, L., Mazo, N., McLaughlin, M. I., Jiménez-Osés, G., Nair, S. K. & van der Donk, W. A., Jan 14 2019, In : eLife. 8

Research output: Contribution to journalArticle

Mechanistic Basis for Ribosomal Peptide Backbone Modifications

Dong, S. H., Liu, A., Mahanta, N., Mitchell, D. A. & Nair, S. K., May 22 2019, In : ACS Central Science. 5, 5, p. 842-851 10 p.

Research output: Contribution to journalArticle

Open Access

Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants

Chekan, J. R., Ongpipattanakul, C., Wright, T. R., Zhang, B., Martin Bollinger, J., Rajakovich, L. J., Krebs, C., Cicchillo, R. M. & Nair, S. K., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13299-13304 6 p.

Research output: Contribution to journalArticle

Open Access

Molecular Basis of Bacillus subtilis ATCC 6633 Self-Resistance to the Phosphono-oligopeptide Antibiotic Rhizocticin

Petronikolou, N., Ortega, M. A., Borisova, S. A., Nair, S. K. & Metcalf, W. W., Apr 19 2019, In : ACS chemical biology. 14, 4, p. 742-750 9 p.

Research output: Contribution to journalArticle

Reiterative synthesis by the ribosome and recognition of the N-terminal formyl group by biosynthetic machinery contribute to evolutionary conservation of the length of antibiotic microcin c peptide precursor

Zukher, I., Pavlov, M., Tsibulskaya, D., Kulikovsky, A., Zyubko, T., Bikmetov, D., Serebryakova, M., Nair, S. K., Ehrenberg, M., Dubiley, S. & Severinova, K., Mar 1 2019, In : mBio. 10, 2, e00768-19.

Research output: Contribution to journalArticle

Open Access

Steric complementarity directs sequence promiscuous leader binding in RiPP biosynthesis

Chekan, J. R., Ongpipattanakul, C. & Nair, S. K., Nov 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 48, p. 24049-24055 7 p.

Research output: Contribution to journalArticle

2018

A Single Amino Acid Switch Alters the Isoprene Donor Specificity in Ribosomally Synthesized and Post-Translationally Modified Peptide Prenyltransferases

Estrada, P., Morita, M., Hao, Y., Schmidt, E. W. & Nair, S. K., Jul 5 2018, In : Journal of the American Chemical Society. 140, 26, p. 8124-8127 4 p.

Research output: Contribution to journalArticle

Biosynthetic Proteases That Catalyze the Macrocyclization of Ribosomally Synthesized Linear Peptides

Ongpipattanakul, C. & Nair, S. K., Jun 12 2018, In : Biochemistry. 57, 23, p. 3201-3209 9 p.

Research output: Contribution to journalArticle

Enzymatic reconstitution of ribosomal peptide backbone thioamidation

Mahanta, N., Liu, A., Dong, S., Nair, S. K. & Mitchell, D. A., Mar 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 12, p. 3030-3035 6 p.

Research output: Contribution to journalArticle

Loganic Acid Methyltransferase: Insights into the Specificity of Methylation on an Iridoid Glycoside

Petronikolou, N., Hollatz, A. J., Schuler, M. A. & Nair, S. K., Apr 16 2018, In : ChemBioChem. 19, 8, p. 784-788 5 p.

Research output: Contribution to journalArticle

Molecular Basis for Autocatalytic Backbone N-Methylation in RiPP Natural Product Biosynthesis

Ongpipattanakul, C. & Nair, S. K., Oct 19 2018, In : ACS chemical biology. 13, 10, p. 2989-2999 11 p.

Research output: Contribution to journalArticle

Post-Translational Tyrosine Geranylation in Cyanobactin Biosynthesis

Morita, M., Hao, Y., Jokela, J. K., Sardar, D., Lin, Z., Sivonen, K., Nair, S. K. & Schmidt, E. W., May 16 2018, In : Journal of the American Chemical Society. 140, 19, p. 6044-6048 5 p.

Research output: Contribution to journalArticle

Structural and Biochemical Studies of a Biocatalyst for the Enzymatic Production of Wax Esters

Petronikolou, N. & Nair, S. K., Jul 6 2018, In : ACS Catalysis. 8, 7, p. 6334-6344 11 p.

Research output: Contribution to journalArticle

Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop “Out” Conformation for LasR

O'Reilly, M. C., Dong, S. H., Rossi, F. M., Karlen, K. M., Kumar, R. S., Nair, S. K. & Blackwell, H. E., Sep 20 2018, In : Cell chemical biology. 25, 9, p. 1128-1139.e3

Research output: Contribution to journalArticle

Structural basis of transcriptional regulation by cour, a repressor of coumarate catabolism, in rhodopseudomonas palustris

Cogan, D. P., Baraquet, C., Harwood, C. S. & Nair, S. K., Jul 27 2018, In : Journal of Biological Chemistry. 293, 30, p. 11727-11735 9 p.

Research output: Contribution to journalArticle

Structure-Guided Analyses of a Key Enzyme Involved in the Biosynthesis of an Antivitamin

Kapoor, I. & Nair, S. K., Sep 11 2018, In : Biochemistry. 57, 36, p. 5282-5288 7 p.

Research output: Contribution to journalArticle

Substrate-assisted enzymatic formation of lysinoalanine in duramycin

An, L., Cogan, D. P., Navo, C. D., Jiménez-Osés, G., Nair, S. K. & van der Donk, W. A., Oct 1 2018, In : Nature chemical biology. 14, 10, p. 928-933 6 p.

Research output: Contribution to journalArticle

The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis

Gu, W., Dong, S. H., Sarkar, S., Nair, S. K. & Schmidt, E. W., Jan 1 2018, Methods in Enzymology. Moore, B. S. (ed.). Academic Press Inc., p. 113-163 51 p. (Methods in Enzymology; vol. 604).

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants

Chekan, J. R., Estrada, P., Covello, P. S. & Nair, S. K., Jun 20 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 25, p. 6551-6556 6 p.

Research output: Contribution to journalArticle

Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads

Olivares, P., Ulrich, E. C., Chekan, J. R., Van Der Donk, W. A. & Nair, S. K., Feb 17 2017, In : ACS chemical biology. 12, 2, p. 456-463 8 p.

Research output: Contribution to journalArticle

Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products

Sardar, D., Hao, Y., Lin, Z., Morita, M., Nair, S. K. & Schmidt, E. W., Mar 1 2017, In : Journal of the American Chemical Society. 139, 8, p. 2884-2887 4 p.

Research output: Contribution to journalArticle

Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes

Repka, L. M., Chekan, J. R., Nair, S. K. & Van Der Donk, W. A., Apr 26 2017, In : Chemical reviews. 117, 8, p. 5457-5520 64 p.

Research output: Contribution to journalArticle

Molecular basis for the substrate specificity of quorum signal synthases

Dong, S. H., Frane, N. D., Christensen, Q. H., Greenberg, E. P., Nagarajan, R. & Nair, S. K., Aug 22 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 34, p. 9092-9097 6 p.

Research output: Contribution to journalArticle

Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4

Hu, X., Dong, S. H., Chen, J., Zhou, X. Z., Chen, R., Nair, S., Lu, K. P. & Chen, L. F., Sep 7 2017, In : Oncogene. 36, 36, p. 5177-5188 12 p.

Research output: Contribution to journalArticle

The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes

Estrada, P., Manandhar, M., Dong, S. H., Deveryshetty, J., Agarwal, V., Cronan, J. E. & Nair, S. K., Jun 1 2017, In : Nature chemical biology. 13, 6, p. 668-674 7 p.

Research output: Contribution to journalArticle

Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis

Ortega, M. A., Cogan, D. P., Mukherjee, S., Garg, N., Li, B., Thibodeaux, G. N., Maffioli, S. I., Donadio, S., Sosio, M., Escano, J., Smith, L., Nair, S. K. & Van Der Donk, W. A., Feb 17 2017, In : ACS chemical biology. 12, 2, p. 548-557 10 p.

Research output: Contribution to journalArticle

2016

Molecular basis for resistance against phosphonate antibiotics and herbicides

Chekan, J. R., Cogan, D. P. & Nair, S. K., Jan 1 2016, In : MedChemComm. 7, 1, p. 28-36 9 p.

Research output: Contribution to journalReview article

Molecular basis for the broad substrate selectivity of a peptide prenyltransferase

Hao, Y., Pierce, E., Roe, D., Morita, M., McIntosh, J. A., Agarwal, V., Cheatham, T. E., Schmidt, E. W. & Nair, S. K., Dec 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 49, p. 14037-14042 6 p.

Research output: Contribution to journalArticle

Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis

Ortega, M. A., Hao, Y., Walker, M. C., Donadio, S., Sosio, M., Nair, S. K. & van der Donk, W., Mar 17 2016, In : Cell chemical biology. 23, 3, p. 370-380 11 p.

Research output: Contribution to journalArticle

Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates

Chekan, J. R., Koos, J. D., Zong, C., Maksimov, M. O., Link, A. J. & Nair, S. K., Dec 21 2016, In : Journal of the American Chemical Society. 138, 50, p. 16452-16458 7 p.

Research output: Contribution to journalArticle

2015

A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase

Peck, S. C., Chekan, J. R., Ulrich, E. C., Nair, S. K. & Van Der Donk, W. A., Feb 2015, In : Journal of the American Chemical Society. 137, 9, p. 3217-3220 4 p.

Research output: Contribution to journalArticle

Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage

Tang, W., Dong, S. H., Repka, L. M., He, C., Nair, S. K. & Van Der Donk, W. A., Sep 2 2015, In : Chemical Science. 6, 11, p. 6270-6279 10 p.

Research output: Contribution to journalArticle

Biochemical Studies of Mycobacterial Fatty Acid Methyltransferase: A Catalyst for the Enzymatic Production of Biodiesel

Petronikolou, N. & Nair, S. K., Nov 19 2015, In : Chemistry and Biology. 22, 11, p. 1480-1490 11 p.

Research output: Contribution to journalArticle

Insights into Methyltransferase Specificity and Bioactivity of Derivatives of the Antibiotic Plantazolicin

Hao, Y., Blair, P. M., Sharma, A., Mitchell, D. A. & Nair, S. K., May 15 2015, In : ACS chemical biology. 10, 5, p. 1209-1216 8 p.

Research output: Contribution to journalArticle

Structural Basis for Specificity and Flexibility in a Plant 4-Coumarate:CoA Ligase

Li, Z. & Nair, S. K., Nov 3 2015, In : Structure. 23, 11, p. 2032-2042 11 p.

Research output: Contribution to journalArticle

Structure, Function and Inhibition of the Phosphoethanolamine Methyltransferases of the Human Malaria Parasites Plasmodium vivax and Plasmodium knowlesi

Garg, A., Lukk, T., Kumar, V., Choi, J. Y., Augagneur, Y., Voelker, D. R., Nair, S. & Mamoun, C. B., 2015, In : Scientific reports. 5, 9064.

Research output: Contribution to journalArticle

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

Ortega, M. A., Hao, Y., Zhang, Q., Walker, M. C., Van Der Donk, W. A. & Nair, S. K., Jan 22 2015, In : Nature. 517, 7535, p. 509-512 4 p.

Research output: Contribution to journalArticle

Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-d-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor

Cobb, R. E., Bae, B., Li, Z., Desieno, M. A., Nair, S. K. & Zhao, H., Feb 14 2015, In : Chemical Communications. 51, 13, p. 2526-2528 3 p.

Research output: Contribution to journalArticle

The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold

Dong, S. H., Tang, W., Lukk, T., Yu, Y., Nair, S. K. & van der donk, W. A., Jul 30 2015, In : eLife. 4, JULY2015, e07607.

Research output: Contribution to journalArticle

2014

Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

Zou, Z., Huang, B., Wu, X., Zhang, H., Qi, J., Bradner, J., Nair, S. & Chen, L. F., May 1 2014, In : Oncogene. 33, 18, p. 2395-2404 10 p.

Research output: Contribution to journalArticle

Chemical rescue and inhibition studies to determine the role of Arg301 in phosphite dehydrogenase

Hung, J. E., Fogle, E. J., Garg, N., Chekan, J. R., Nair, S. K. & Van Der Donk, W. A., Jan 31 2014, In : PloS one. 9, 1, e87134.

Research output: Contribution to journalArticle

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis

Dunbar, K. L., Chekan, J. R., Cox, C. L., Burkhart, B. J., Nair, S. K. & Mitchell, D. A., Oct 1 2014, In : Nature chemical biology. 10, 10, p. 823-829 7 p.

Research output: Contribution to journalArticle