Sarah Joy Spinella

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Article
2019

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors

Singh, R., Fazal, Z., Corbet, A. K., Bikorimana, E., Rodriguez, J. C., Khan, E. M., Shahid, K., Spinella, S. J. & Spinella, M. J., Jun 8 2019, In : Cancers. 11, 6, 796.

Research output: Contribution to journalArticle

Open Access
2017

Deubiquitinase USP18 loss mislocalizes and destabilizes KRAS in lung cancer

Mustachio, L. M., Lu, Y., Tafe, L. J., Memoli, V., Rodriguez-Canales, J., Mino, B., Villalobos, P. A., Wistuba, I., Katayama, H., Hanash, S. M., Roszik, J., Kawakami, M., Cho, K. J., Hancock, J. F., Chinyengetere, F., Hu, S., Liu, X., Freemantle, S. J. & Dmitrovsky, E., Jul 2017, In : Molecular Cancer Research. 15, 7, p. 905-914 10 p.

Research output: Contribution to journalArticle

G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer

Yim, C. Y., Bikorimana, E., Khan, E., Warzecha, J. M., Shin, L., Rodriguez, J., Dmitrovsky, E., Freemantle, S. J. & Spinella, M. J., Nov 2 2017, In : Cell Cycle. 16, 21, p. 2146-2155 10 p.

Research output: Contribution to journalArticle

Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer

Kawakami, M., Mustachio, L. M., Rodriguez-Canales, J., Mino, B., Roszik, J., Tong, P., Wang, J., Lee, J. J., Myung, J. H., Heymach, J. V., Johnson, F. M., Hong, S., Zheng, L., Hu, S., Villalobos, P. A., Behrens, C., Wistuba, I., Freemantle, S., Liu, X. & Dmitrovsky, E., Jun 1 2017, In : Journal of the National Cancer Institute. 109, 6

Research output: Contribution to journalArticle

Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine

Albany, C., Hever-Jardine, M. P., von Herrmann, K. M., Yim, C. Y., Tam, J., Warzecha, J. M., Shin, L., Bock, S. E., Curran, B. S., Chaudhry, A. S., Kim, F., Sandusky, G. E., Taverna, P., Freemantle, S. J., Christensen, B. C., Einhorn, L. H. & Spinella, M. J., Jan 1 2017, In : Oncotarget. 8, 2, p. 2949-2959 11 p.

Research output: Contribution to journalArticle

The ISG15-specific protease USP18 regulates stability of PTEN

Mustachio, L. M., Kawakami, M., Lu, Y., Rodriguez-Canales, J., Mino, B., Behrens, C., Wistuba, I., Bota-Rabassedas, N., Yu, J., Jack Lee, J., Roszik, J., Zheng, L., Liu, X., Freemantle, S. J. & Dmitrovsky, E., Jan 1 2017, In : Oncotarget. 8, 1, p. 3-14 12 p.

Research output: Contribution to journalArticle

2016

Dinaciclib induces anaphase catastrophe in lung cancer cells via inhibition of cyclin-dependent kinases 1 and 2

Danilov, A. V., Hu, S., Orr, B., Godek, K., Mustachio, L. M., Sekula, D., Liu, X., Kawakami, M., Johnson, F. M., Compton, D. A., Freemantle, S. J. & Dmitrovsky, E., Nov 2016, In : Molecular Cancer Therapeutics. 15, 11, p. 2758-2766 9 p.

Research output: Contribution to journalArticle

GOS2 suppresses oncogenic transformation by repressing a MYC-regulated transcriptional program

Yim, C. Y., Sekula, D. J., Hever-Jardine, M. P., Liu, X., Warzecha, J. M., Tam, J., Freemantle, S. J., Dmitrovsky, E. & Spinella, M. J., Mar 1 2016, In : Cancer Research. 76, 5, p. 1204-1213 10 p.

Research output: Contribution to journalArticle

Wnt pathway activation by ADP-ribosylation

Yang, E., Tacchelly-Benites, O., Wang, Z., Randall, M. P., Tian, A., Benchabane, H., Freemantle, S., Pikielny, C., Tolwinski, N. S., Lee, E. & Ahmed, Y., May 3 2016, In : Nature communications. 7, 11430.

Research output: Contribution to journalArticle

2015

CDK2 inhibition causes anaphase catastrophe in lung cancer through the centrosomal protein CP110

Hu, S., Danilov, A. V., Godek, K., Orr, B., Tafe, L. J., Rodriguez-Canales, J., Behrens, C., Mino, B., Moran, C. A., Memoli, V. A., Mustachio, L. M., Galimberti, F., Ravi, S., De Castro, A., Lu, Y., Sekula, D., Andrew, A. S., Wistuba, I. I., Freemantle, S., Compton, D. A. & 1 others, Dmitrovsky, E., May 15 2015, In : Cancer Research. 75, 10, p. 2029-2038 10 p.

Research output: Contribution to journalArticle

Effective Capture of Circulating Tumor Cells from a Transgenic Mouse Lung Cancer Model Using Dendrimer Surfaces Immobilized with Anti-EGFR

Myung, J. H., Roengvoraphoj, M., Tam, K. A., Ma, T., Memoli, V. A., Dmitrovsky, E., Freemantle, S. J. & Hong, S., Oct 6 2015, In : Analytical chemistry. 87, 19, p. 10096-10102 7 p.

Research output: Contribution to journalArticle

Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas

Chinyengetere, F., Sekula, D. J., Lu, Y., Giustini, A. J., Sanglikar, A., Kawakami, M., Ma, T., Burkett, S. S., Eisenberg, B. L., Wells, W. A., Hoopes, P. J., Demicco, E. G., Lazar, A. J., Torres, K. E., Memoli, V., Freemantle, S. J. & Dmitrovsky, E., Nov 10 2015, In : BMC Cancer. 15, 1, 886.

Research output: Contribution to journalArticle

Specific CP110 phosphorylation sites mediate anaphase catastrophe after CDK2 inhibition: Evidence for cooperation with USP33 knockdown

Hu, S., Lu, Y., Orr, B., Godek, K., Mustachio, L. M., Kawakami, M., Sekula, D., Compton, D. A., Freemantle, S. & Dmitrovsky, E., Nov 1 2015, In : Molecular Cancer Therapeutics. 14, 11, p. 2576-2585 10 p.

Research output: Contribution to journalArticle

2014

All-trans-retinoic acid antagonizes the hedgehog pathway by inducing patched

Busch, A. M., Galimberti, F., Nehls, K. E., Roengvoraphoj, M., Sekula, D., Li, B., Guo, Y., DiRenzo, J., Fiering, S. N., Spinella, M. J., Robbins, D. J., Memoli, V. A., Freemantle, S. J. & Dmitrovsky, E., Apr 2014, In : Cancer Biology and Therapy. 15, 4, p. 463-472 10 p.

Research output: Contribution to journalArticle

Mice lacking G0S2 are lean and cold-tolerant

Ma, T., Lopez-Aguiar, A. G. N., Li, A., Lu, Y., Sekula, D., Nattie, E. E., Freemantle, S. & Dmitrovsky, E., May 2014, In : Cancer Biology and Therapy. 15, 5, p. 643-650 8 p.

Research output: Contribution to journalArticle

2013

Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer

Ma, T., Galimberti, F., Erkmen, C. P., Memoli, V., Chinyengetere, F., Sempere, L., Beumer, J. H., Anyang, B. N., Nugent, W., Johnstone, D., Tsongalis, G. J., Kurie, J. M., Li, H., Di Renzo, J., Guo, Y., Freemantle, S. J., Dragnev, K. H. & Dmitrovsky, E., Aug 1 2013, In : Molecular Cancer Therapeutics. 12, 8, p. 1545-1555 11 p.

Research output: Contribution to journalArticle

Evidence for tankyrases as antineoplastic targets in lung cancer

Busch, A. M., Johnson, K. C., Stan, R. V., Sanglikar, A., Ahmed, Y., Dmitrovsky, E. & Freemantle, S. J., Apr 28 2013, In : BMC Cancer. 13, 211.

Research output: Contribution to journalArticle

Repression of exogenous gene expression by the retinoic acid target gene G0S2

Ma, T., Dong, J. P., Sekula, D. J., Fei, D. L., Lamph, W. W., Henderson, M., Lu, Y., Blumen, S., Freemantle, S. J. & Dmitrovsky, E., May 1 2013, In : International journal of oncology. 42, 5, p. 1743-1753 11 p.

Research output: Contribution to journalArticle

2012

Evidence for the ubiquitin protease UBP43 as an antineoplastic target

Guo, Y., Chinyengetere, F., Dolinko, A. V., Lopez-Aguiar, A., Lu, Y., Galimberti, F., Ma, T., Feng, Q., Sekula, D., Freemantle, S. J., Andrew, A. S., Memoli, V. & Dmitrovsky, E., Sep 1 2012, In : Molecular Cancer Therapeutics. 11, 9, p. 1968-1977 10 p.

Research output: Contribution to journalArticle

Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations

Galimberti, F., Busch, A. M., Chinyengetere, F., Ma, T., Sekula, D., Memoli, V. A., Dragnev, K. H., Liu, F., Johnson, K. C., Guo, Y., Freemantle, S. J., Andrew, A. S., Greninger, P., Robbins, D. J., Settleman, J., Benes, C. & Dmitrovsky, E., Nov 1 2012, In : International journal of oncology. 41, 5, p. 1751-1761 11 p.

Research output: Contribution to journalArticle

2011

Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models

Dragnev, K. H., Ma, T., Cyrus, J., Galimberti, F., Memoli, V., Busch, A. M., Tsongalis, G. J., Seltzer, M., Johnstone, D., Erkmen, C. P., Nugent, W., Rigas, J. R., Liu, X., Freemantle, S. J., Kurie, J. M., Waxman, S. & Dmitrovsky, E., Jun 1 2011, In : Cancer Prevention Research. 4, 6, p. 818-828 11 p.

Research output: Contribution to journalArticle

Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells

Mao, P., Hever, M. P., Niemaszyk, L. M., Haghkerdar, J. M., Yanco, E. G., Desai, D., Beyrouthy, M. J., Kerley-Hamilton, J. S., Freemantle, S. J. & Spinella, M. J., Jun 3 2011, In : Journal of Biological Chemistry. 286, 22, p. 19381-19391 11 p.

Research output: Contribution to journalArticle

2010

Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARa and inhibits the growth of acute promyelocytic leukemia

Guo, Y., Dolinko, A. V., Chinyengetere, F., Stanton, B., Bomberger, J. M., Demidenko, E., Zhou, D. C., Gallagher, R., Ma, T., Galimberti, F., Liu, X., Sekula, D., Freemantle, S. & Dmitrovsky, E., Dec 1 2010, In : Cancer Research. 70, 23, p. 9875-9885 11 p.

Research output: Contribution to journalArticle

MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors

Liu, X., Sempere, L. F., Ouyang, H., Memoli, V. A., Andrew, A. S., Luo, Y., Demidenko, E., Korc, M., Shi, W., Preis, M., Dragnev, K. H., Li, H., Direnzo, J., Bak, M., Freemantle, S. J., Kauppinen, S. & Dmitrovsky, E., Apr 1 2010, In : Journal of Clinical Investigation. 120, 4, p. 1298-1309 12 p.

Research output: Contribution to journalArticle

2009

High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors

Beyrouthy, M. J., Garner, K. M., Hever, M. P., Freemantle, S. J., Eastman, A., Dmitrovsky, E. & Spinella, M. J., Dec 15 2009, In : Cancer Research. 69, 24, p. 9360-9366 7 p.

Research output: Contribution to journalArticle

Retinoic acid mediates long-paced oscillationsin retinoid receptor activity: Evidence for a potential role for RIP140

Heim, K. C., Gamsby, J. J., Hever, M. P., Freemantle, S. J., Loros, J. J., Dunlap, J. C. & Spinella, M. J., Oct 28 2009, In : PloS one. 4, 10, e7639.

Research output: Contribution to journalArticle

Uncovering growth-Suppressive micro rNAs in lung cancer

Liu, X., Sempere, L. F., Galimberti, F., Freemantle, S. J., Black, C., Dragnev, K. H., Yan, M., Fiering, S., Memoli, V., Li, H., Direnzo, J., Korc, M., Cole, C. N., Bak, M., Kauppinen, S. & Dmitrovsky, E., Feb 15 2009, In : Clinical Cancer Research. 15, 4, p. 1177-1183 7 p.

Research output: Contribution to journalArticle

Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting

Snow, G. E., Kasper, A. C., Busch, A. M., Schwarz, E., Ewings, K. E., Bee, T., Spinella, M. J., Dmitrovsky, E. & Freemantle, S. J., Oct 29 2009, In : BMC Cancer. 9, 1 p., 1471.

Research output: Contribution to journalArticle

2008

UBE1L represses PML/RARα by targeting the PML domain for ISG15ylation

Shah, S. J., Blumen, S., Pitha-Rowe, I., Kitareewan, S., Freemantle, S. J., Feng, Q. & Dmitrovsky, E., Apr 1 2008, In : Molecular Cancer Therapeutics. 7, 4, p. 905-914 10 p.

Research output: Contribution to journalArticle

2007

Repression of cyclin D1 as a target for germ cell tumors

Freemantle, S. J., Vaseva, A. V., Ewings, K. E., Bee, T., Krizan, K. A., Kelley, M. R., Hattab, E. M., Memoli, V. A., Black, C. C., Spinella, M. J. & Dmitrovsky, E., Feb 1 2007, In : International journal of oncology. 30, 2, p. 333-340 8 p.

Research output: Contribution to journalArticle

Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells

Heim, K. C., White, K. A., Deng, D., Tomlinson, C. R., Moore, J. H., Freemantle, S. J. & Spinella, M. J., Sep 19 2007, In : Molecular Cancer. 6, 57.

Research output: Contribution to journalArticle

The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins

Kerley-Hamilton, J. S., Pike, A. M., Hutchinson, J. A., Freemantle, S. J. & Spinella, M. J., Apr 1 2007, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1769, 4, p. 209-219 11 p.

Research output: Contribution to journalArticle

Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas

Ma, Y., Fiering, S., Black, C., Liu, X., Yuan, Z., Memoli, V. A., Robbins, D. J., Bentley, H. A., Tsongalis, G. J., Demidenko, E., Freemantle, S. J. & Dmitrovsky, E., Mar 6 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 10, p. 4089-4094 6 p.

Research output: Contribution to journalArticle

Uncovering residues that regulate cyclin D1 proteasomal degradation

Feng, Q., Sekula, D., Müller, R., Freemantle, S. J. & Dmitrovsky, E., Aug 2 2007, In : Oncogene. 26, 35, p. 5098-5106 9 p.

Research output: Contribution to journalArticle

2005

A novel retinoic acid receptor β isoform and retinoid resistance in lung carcinogenesis

Petty, W. J., Li, N., Biddle, A., Bounds, R., Nitkin, C., Ma, Y., Dragnev, K. H., Freemantle, S. J. & Dmitrovsky, E., Nov 16 2005, In : Journal of the National Cancer Institute. 97, 22, p. 1645-1651 7 p.

Research output: Contribution to journalArticle

Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity

Giuliano, C. J., Kerley-Hamilton, J. S., Bee, T., Freemantle, S. J., Manickaratnam, R., Dmitrovsky, E. & Spinella, M. J., Oct 15 2005, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1731, 1, p. 48-56 9 p.

Research output: Contribution to journalArticle

Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms

Ma, Y., Feng, Q., Sekula, D., Diehl, J. A., Freemantle, S. J. & Dmitrovsky, E., Jul 15 2005, In : Cancer Research. 65, 14, p. 6476-6483 8 p.

Research output: Contribution to journalArticle

2004

Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation.

Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E. & Ambros, V., 2004, In : Genome biology. 5, 3, p. R13

Research output: Contribution to journalArticle

Specific Chemopreventive Agents Trigger Proteasomal Degradation of G 1 Cyclins: Implications for Combination Therapy

Dragnev, K. H., Pitha-Rowe, I., Ma, Y., Petty, W. J., Sekula, D., Murphy, B., Rendi, M., Suh, N., Desai, N. B., Sporn, M. B., Freemantle, S. J. & Dmitrovsky, E., Apr 1 2004, In : Clinical Cancer Research. 10, 7, p. 2570-2577 8 p.

Research output: Contribution to journalArticle

2003

Microarray analysis uncovers retinoid targets in human bronchial epithelial cells

Ma, Y., Koza-Taylor, P. H., DiMattia, D. A., Hames, L., Fu, H., Dragnev, K. H., Turi, T., Beebe, J. S., Freemantle, S. J. & Dmitrovsky, E., Jul 31 2003, In : Oncogene. 22, 31, p. 4924-4932 9 p.

Research output: Contribution to journalArticle

Negative feedback at the level of nuclear receptor coregulation. Self-limitation of retinoid signaling by RIP140

White, K. A., Yore, M. M., Warburton, S. L., Vaseva, A. V., Rieder, E., Freemantle, S. J. & Spinella, M. J., Nov 7 2003, In : Journal of Biological Chemistry. 278, 45, p. 43889-43892 4 p.

Research output: Contribution to journalArticle

2002

Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2

Freemantle, S. J., Portland, H. B., Ewings, K., Dmitrovsky, F., DiPetrillo, K., Spinella, M. J. & Dmitrovsky, E., May 29 2002, In : Gene. 291, 1-2, p. 17-27 11 p.

Research output: Contribution to journalArticle

Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma

Spinella, S. J., Kerley, J. S., Olsen, S. L., Gross, R. H. & Spinella, M. J., Jan 1 2002, In : Oncogene. 21, 18, p. 2880-2889 10 p.

Research output: Contribution to journalArticle

Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma

Freemantle, S. J., Kerley, J. S., Olsen, S. L., Gross, R. H. & Spinella, M. J., Jan 1 2002, In : Oncogene. 21, 18, p. 2880-2889 10 p.

Research output: Contribution to journalArticle

Evidence for the epidermal growth factor receptor as a target for lung cancer prevention

Lonardo, F., Dragnev, K. H., Spinella, S. J., Ma, Y., Memoli, N., Sekula, D., Dragnev, K. H., Dmitrovsky, E., Memoli, N., Dragnev, K. H., Dmitrovsky, E., Knauth, E. A. & Beebe, J. S., Jan 1 2002, In : Clinical Cancer Research. 8, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

UBE1L is a retinoid target that triggers PML/RARα degradation and apoptosis in acute promyelocytic leukemia

Kitareewan, S., Pitha-Rowe, I., Sekula, D., Lowrey, C. H., Nemeth, M. J., Golub, T. R., Freemantle, S. J. & Dmitrovsky, E., Mar 19 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 6, p. 3806-3811 6 p.

Research output: Contribution to journalArticle

2001

Cyclin proteolysis as a retinoid cancer prevention mechanism

Dragnev, K. H., Freemantle, S. J., Spinella, M. J. & Dmitrovsky, E., Jan 1 2001, In : Annals of the New York Academy of Sciences. 952, p. 13-22 10 p.

Research output: Contribution to journalArticle

1999

Retinoic acid promotes ubiquitination and proteolysis of cyclin D1 during induced tumor cell differentiation

Spinella, M. J., Freemantle, S. J., Sekula, D., Chang, J. H., Christie, A. J. & Dmitrovsky, E., Jul 30 1999, In : Journal of Biological Chemistry. 274, 31, p. 22013-22018 6 p.

Research output: Contribution to journalArticle

1997

Transcription of the human folylpoly-γ-glutamate synthetase gene

Freemantle, S. J. & Moran, R. G., Oct 3 1997, In : Journal of Biological Chemistry. 272, 40, p. 25373-25379 7 p.

Research output: Contribution to journalArticle