Sarah Joy Spinella

1992 …2019
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Research Output 1992 2019

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors

Singh, R., Fazal, Z., Corbet, A. K., Bikorimana, E., Rodriguez, J. C., Khan, E. M., Shahid, K., Spinella, S. J. & Spinella, M. J., Jun 8 2019, In : Cancers. 11, 6, 796.

Research output: Contribution to journalArticle

Open Access
Polycomb Repressive Complex 2

Evidence for the ISG15-specific deubiquitinase usp18 as an antineoplastic target

Mustachio, L. M., Lu, Y., Kawakami, M., Roszik, J., Freemantle, S. J., Liu, X. & Dmitrovsky, E., Feb 1 2018, In : Cancer Research. 78, 3, p. 587-592 6 p.

Research output: Contribution to journalReview article

Ubiquitin-Specific Proteases
Antineoplastic Agents

Deubiquitinase USP18 loss mislocalizes and destabilizes KRAS in lung cancer

Mustachio, L. M., Lu, Y., Tafe, L. J., Memoli, V., Rodriguez-Canales, J., Mino, B., Villalobos, P. A., Wistuba, I., Katayama, H., Hanash, S. M., Roszik, J., Kawakami, M., Cho, K. J., Hancock, J. F., Chinyengetere, F., Hu, S., Liu, X., Freemantle, S. J. & Dmitrovsky, E., Jul 2017, In : Molecular Cancer Research. 15, 7, p. 905-914 10 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Oncogene Proteins
Cyclin E
Protein Synthesis Inhibitors
Deubiquitinating Enzymes

G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer

Yim, C. Y., Bikorimana, E., Khan, E., Warzecha, J. M., Shin, L., Rodriguez, J., Dmitrovsky, E., Freemantle, S. J. & Spinella, M. J., Nov 2 2017, In : Cell Cycle. 16, 21, p. 2146-2155 10 p.

Research output: Contribution to journalArticle

Switch Genes
Phosphatidylinositol 3-Kinases
Breast Neoplasms
Estrogen Receptor Modulators
Gene Expression

Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer

Kawakami, M., Mustachio, L. M., Rodriguez-Canales, J., Mino, B., Roszik, J., Tong, P., Wang, J., Lee, J. J., Myung, J. H., Heymach, J. V., Johnson, F. M., Hong, S., Zheng, L., Hu, S., Villalobos, P. A., Behrens, C., Wistuba, I., Freemantle, S., Liu, X. & Dmitrovsky, E., Jun 1 2017, In : Journal of the National Cancer Institute. 109, 6

Research output: Contribution to journalArticle

Lung Neoplasms
Circulating Neoplastic Cells