Rutilio Fratti

19962019
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Fingerprint Fingerprint is based on mining the text of the expert's scholarly documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

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SNARE Proteins Medicine & Life Sciences
Vacuoles Medicine & Life Sciences
Fusion reactions Chemical Compounds
Phagosomes Medicine & Life Sciences
Yeast Chemical Compounds
Membrane Fusion Medicine & Life Sciences
Yeasts Medicine & Life Sciences
Membranes Chemical Compounds

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Research Output 1996 2019

A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion

Sparks, R. P., Arango, A. S., Starr, M. L., Aboff, Z. L., Hurst, L. R., Rivera-Kohr, D. A., Zhang, C., Harnden, K. A., Jenkins, J. L., Guida, W. C., Tajkhorshid, E. & Fratti, R. A., Jan 1 2019, In : Journal of Biological Chemistry. 294, 46, p. 17168-17185 18 p.

Research output: Contribution to journalReview article

Open Access
N-Ethylmaleimide-Sensitive Proteins
SNARE Proteins
Phosphatidic Acids
Vacuoles
Carrier Proteins

A specific small-molecule inhibitor of protein kinase CI activity improves metabolic dysfunction in human adipocytes from obese individuals

Sparks, R., Lui, A., Bader, D., Patel, R., Murr, M., Guida, W., Fratti, R. & Patel, N. A., Jan 1 2019, In : Journal of Biological Chemistry. 294, 41, p. 14896-14910 15 p.

Research output: Contribution to journalArticle

Open Access
Surface plasmon resonance
Protein Kinase Inhibitors
Adipocytes
Caspase 3
Surface Plasmon Resonance

Copper blocks V-ATPase activity and SNARE complex formation to inhibit yeast vacuole fusion

Miner, G. E., Sullivan, K. D., Zhang, C., Hurst, L. R., Starr, M. L., Rivera-Kohr, D. A., Jones, B. C., Guo, A. & Fratti, R., Nov 1 2019, In : Traffic. 20, 11, p. 841-850 10 p.

Research output: Contribution to journalArticle

SNARE Proteins
Vacuoles
Yeast
Adenosine Triphosphatases
Copper

Determination of sec18-lipid interactions by liposome-binding assay

Starr, M. L. & Fratti, R., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 211-220 10 p. (Methods in Molecular Biology; vol. 1860).

Research output: Chapter in Book/Report/Conference proceedingChapter

Liposomes
Lipids
Proteins
SNARE Proteins
Unilamellar Liposomes

Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming

Starr, M. L., Sparks, R. P., Arango, A. S., Hurst, L. R., Zhao, Z., Lihan, M., Jenkins, J. L., Tajkhorshid, E. & Fratti, R., Jan 1 2019, In : Journal of Biological Chemistry. 294, 9, p. 3100-3116 17 p.

Research output: Contribution to journalArticle

SNARE Proteins
Phosphatidic Acids
Protein Subunits
Membranes
N-Ethylmaleimide-Sensitive Proteins