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Research Output 1981 2019

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2019

Imatinib treatments have long-term impact on placentation and embryo survival

Salem, W., Li, K., Krapp, C., Ingles, S. A., Bartolomei, M. S., Chung, K., Paulson, R. J., Nowak, R. A. & McGinnis, L. K., Dec 1 2019, In : Scientific reports. 9, 1, 2535.

Research output: Contribution to journalArticle

Open Access
Placentation
Embryonic Structures
Survival
Pregnancy
Placenta
2018

An interview with Dr Sudhansu K. Dey

Nowak, R. A., Jan 1 2018, In : Biology of reproduction. 98, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Open Access
Interviews
Peritoneal Macrophages
Epigenomics
Histone Code
Gene Expression
Scavenger Receptors

Di (2-ethylhexyl) phthalate (DEHP) alters proliferation and uterine gland numbers in the uteri of adult exposed mice

Richardson, K. A., Hannon, P. R., Johnson-Walker, Y. J., Myint, M. S., Flaws, J. A. & Nowak, R. A., Apr 2018, In : Reproductive Toxicology. 77, p. 70-79 10 p.

Research output: Contribution to journalArticle

Uterus
phthalic acid
Endocrine Disruptors
Environmental Exposure
Blood vessels

Methylmercury alters proliferation, migration, and antioxidant capacity in human HTR8/SV-neo trophoblast cells

Tucker, E. K. & Nowak, R. A., Jun 2018, In : Reproductive Toxicology. 78, p. 60-68 9 p.

Research output: Contribution to journalArticle

Trophoblasts
Toxicity
Antioxidants
Genes
Cells

Sex differences influence intestinal epithelial stem cell proliferation independent of obesity

Zhou, W., Davis, E. A., Li, K., Nowak, R. A. & Dailey, M. J., Jul 2018, In : Physiological Reports. 6, 13, e13746.

Research output: Contribution to journalArticle

Sex Characteristics
Stem Cells
Obesity
Epithelial Cells
Cell Proliferation

The AKT/BCL-2 Axis Mediates Survival of Uterine Leiomyoma in a Novel 3D Spheroid Model

Vidimar, V., Chakravarti, D., Bulun, S. E., Yin, P., Nowak, R. A., Wei, J. J. & Kim, J. J., Mar 1 2018, In : Endocrinology. 159, 3, p. 1453-1462 10 p.

Research output: Contribution to journalArticle

Leiomyoma
Survival
Paraquat
Tumor Microenvironment
Myometrium
2017

Effects of coconut oil on glycemia, inflammation, and urogenital microbial parameters in female Ossabaw mini-pigs

Newell-Fugate, A. E., Lenz, K., Skenandore, C., Nowak, R. A., White, B. A. & Braundmeier-Fleming, A., Jul 2017, In : PloS one. 12, 7, e0179542.

Research output: Contribution to journalArticle

coconut oil
blood glucose
Swine
Nutrition
inflammation
Orphan Nuclear Receptors
Embryonic Structures
2016

Exosomes mediate embryo and maternal interactions at implantation and during pregnancy

Burnett, L. A. & Nowak, R. A., Jan 1 2016, In : Frontiers in Bioscience - Scholar. 8, 1, p. 79-96 18 p.

Research output: Contribution to journalArticle

Exosomes
Embryonic Structures
Mothers
Pregnancy
Molecules

Halofuginone suppresses growth of human uterine leiomyoma cells in a mouse xenograft model

Koohestani, F., Qiang, W., MacNeill, A. L., Druschitz, S. A., Serna, V. A., Adur, M., Kurita, T. & Nowak, R. A., Jan 1 2016, In : Human Reproduction. 31, 7, p. 1540-1551 12 p.

Research output: Contribution to journalArticle

Leiomyoma
Heterografts
Growth
Steroid Receptors
Cell Proliferation

Progesterone alleviates Endometriosis via inhibition of uterine cell proliferation, inflammation and angiogenesis in an immunocompetent mouse model

Li, Y., Adur, M. K., Kannan, A., Davila, J., Zhao, Y., Nowak, R. A., Bagchi, M. K., Bagchi, I. C. & Li, Q., Oct 2016, In : PloS one. 11, 10, e0165347.

Research output: Contribution to journalArticle

Cell proliferation
Endometriosis
angiogenesis
lesions (animal)
Progesterone
2015

Effects of obesity and metabolic syndrome on steroidogenesis and folliculogenesis in the female Ossabaw mini-pig

Newell-Fugate, A. E., Taibl, J. N., Alloosh, M., Sturek, M., Bahr, J. M., Nowak, R. A. & Krisher, R. L., Jun 5 2015, In : PloS one. 10, 6, e0128749.

Research output: Contribution to journalArticle

steroidogenesis
follicular development
metabolic syndrome
Nutrition
obesity

Loss of CD147 results in impaired epithelial cell differentiation and malformation of the meibomian gland

Mauris, J., Dieckow, J., Schob, S., Pulli, B., Hatton, M. P., Jeong, S., Bauskar, A., Gabison, E., Nowak, R. & Argüeso, P., Apr 16 2015, In : Cell Death and Disease. 6, 4, e1726.

Research output: Contribution to journalArticle

Meibomian Glands
Cell Differentiation
Epithelial Cells
Lipids
Sebaceous Glands
2013

Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147

Malesevic, M., Gutknecht, D., Prell, E., Klein, C., Schumann, M., Nowak, R. A., Simon, J. C., Schiene-Fischer, C. & Saalbach, A., Sep 26 2013, In : Journal of Medicinal Chemistry. 56, 18, p. 7302-7311 10 p.

Research output: Contribution to journalArticle

Cyclosporins
Cyclophilins
Leukocytes
Anti-Inflammatory Agents
Inflammation

Basigin null mutant male mice are sterile and exhibit impaired interactions between germ cells and Sertoli cells

Bi, J., Li, Y., Sun, F., Saalbach, A., Klein, C., Miller, D. J., Hess, R. A. & Nowak, R. A., Aug 15 2013, In : Developmental Biology. 380, 2, p. 145-156 12 p.

Research output: Contribution to journalArticle

CD147 Antigens
Sertoli Cells
Germ Cells
Testis
Knockout Mice

Extracellular matrix collagen alters cell proliferation and cell cycle progression of human uterine leiomyoma smooth muscle cells

Koohestani, F., Braundmeier, A. G., Mahdian, A., Seo, J., Bi, J. J. & Nowak, R. A., Sep 11 2013, In : PloS one. 8, 9, e75844.

Research output: Contribution to journalArticle

Cell proliferation
Leiomyoma
extracellular matrix
smooth muscle
myocytes

Influence of cloning by chromatin transfer on placental gene expression at Day 45 of pregnancy in cattle

Mesquita, F. S., Machado, S. A., Drnevich, J., Borowicz, P., Wang, Z. & Nowak, R. A., Jan 30 2013, In : Animal reproduction science. 136, 4, p. 231-244 14 p.

Research output: Contribution to journalArticle

Chromatin
chromatin
Organism Cloning
molecular cloning
pregnancy

Localization of parathyroid hormone-related protein in the preimplantation mouse embryo is associated with events of blastocyst hatching

Erbach, G. T., Biggers, J. D., Manning, P. C. & Nowak, R. A., Aug 1 2013, In : Journal of Assisted Reproduction and Genetics. 30, 8, p. 1009-1015 7 p.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Blastocyst
Embryonic Structures
Morula
Parathyroid Hormone Receptor Type 1

Loss of the repressor REST in uterine fibroids promotes aberrant G protein-coupled receptor 10 expression and activates mammalian target of rapamycin pathway

Varghese, B. V., Koohestani, F., McWilliams, M., Colvin, A., Gunewardena, S., Kinsey, W. H., Nowak, R. A., Nothnick, W. B. & Chennathukuzhi, V. M., Feb 5 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 6, p. 2187-2192 6 p.

Research output: Contribution to journalArticle

Leiomyoma
Sirolimus
G-Protein-Coupled Receptors
Myometrium
Prolactin-Releasing Hormone
2012

EMMPRIN is secreted by human uterine epithelial cells in microvesicles and stimulates metalloproteinase production by human uterine fibroblast cells

Braundmeier, A. G., Dayger, C. A., Mehrotra, P., Belton, R. J. & Nowak, R. A., Dec 2012, In : Reproductive Sciences. 19, 12, p. 1292-1301 10 p.

Research output: Contribution to journalArticle

CD147 Antigens
Metalloproteases
Fibroblasts
Epithelial Cells
Matrix Metalloproteinases

Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate

Braundmeier, A., Jackson, K., Hastings, J., Koehler, J., Nowak, R. A. & Fazleabas, A., Jun 2012, In : Human Reproduction. 27, 6, p. 1712-1722 11 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Endometriosis
Primates
Endometrium
Population

Role of microRNA-21 and programmed cell death 4 in the pathogenesis of human uterine leiomyomas

Fitzgerald, J. B., Chennathukuzhi, V., Koohestani, F., Nowak, R. A. & Christenson, L. K., Sep 2012, In : Fertility and Sterility. 98, 3

Research output: Contribution to journalArticle

Leiomyoma
MicroRNAs
Cell Death
Apoptosis
Peptide Elongation Factor 2

Stimulation of GPR30 increases release of EMMPRIN-containing microvesicles in human uterine epithelial cells

Burnett, L. A., Light, M. M., Mehrotra, P. & Nowak, R. A., Dec 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 12, p. 4613-4622 10 p.

Research output: Contribution to journalArticle

CD147 Antigens
G-Protein-Coupled Receptors
Matrix Metalloproteinases
Epithelial Cells
European Union

Validation of the aging hen (Gallus gallus Domesticus) as an animal model for uterine leiomyomas

Machado, S. A., Bahr, J. M., Hales, D. B., Braundmeie, A. G., Quade, B. J. & Nowak, R. A., Oct 1 2012, In : Biology of reproduction. 87, 4, Article 86.

Research output: Contribution to journalArticle

Leiomyoma
Chickens
Animal Models
Smooth Muscle
Neoplasms
2011

Disrupting the EMMPRIN (CD147)-cyclophilin a interaction reduces infarct size and preserves systolic function after myocardial ischemia and reperfusion

Seizer, P., Ochmann, C., Schönberger, T., Zach, S., Rose, M., Borst, O., Klingel, K., Kandolf, R., MacDonald, H. R., Nowak, R. A., Engelhardt, S., Lang, F., Gawaz, M. & May, A. E., Jun 1 2011, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 31, 6, p. 1377-1386 10 p.

Research output: Contribution to journalArticle

Cyclophilin A
Cyclophilins
Myocardial Reperfusion
Myocardial Ischemia
Myocardial Reperfusion Injury
2010

Expression of basigin in reproductive tissues of estrogen receptor-α or -β null mice

Chen, L., Bi, J., Nakai, M., Bunick, D., Couse, J. F., Korach, K. S. & Nowak, R. A., Jun 1 2010, In : Reproduction. 139, 6, p. 1057-1066 10 p.

Research output: Contribution to journalArticle

CD147 Antigens
Estrogen Receptors
Ovary
Uterus
Oviducts

Extracellular matrix metalloproteinase inducer expression in the baboon endometrium: Menstrual cycle and endometriosis

Braundmeier, A. G., Fazleabas, A. T. & Nowak, R. A., Dec 1 2010, In : Reproduction. 140, 6, p. 911-920 10 p.

Research output: Contribution to journalArticle

CD147 Antigens
Papio
Endometriosis
Menstrual Cycle
Endometrium

Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells.

Mesquita, F. S., Dyer, S. N., Heinrich, D. A., Bulun, S. E., Marsh, E. E. & Nowak, R. A., Feb 2010, In : Biology of reproduction. 82, 2, p. 341-351 11 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Leiomyoma
Smooth Muscle Myocytes
Reactive Oxygen Species
Intercellular Signaling Peptides and Proteins

The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells

Grudzien, M. M., Low, P. S., Manning, P. C., Arredondo, M., Belton, R. J. & Nowak, R. A., Mar 1 2010, In : Fertility and Sterility. 93, 4, p. 1290-1298 9 p.

Research output: Contribution to journalArticle

Leiomyoma
Smooth Muscle Myocytes
Collagen
Collagen Type I
Caspase 7
2009

Basigin-mediated gene expression changes in mouse uterine stromal cells during implantation

Chen, L., Belton, R. J. & Nowak, R. A., Feb 1 2009, In : Endocrinology. 150, 2, p. 966-976 11 p.

Research output: Contribution to journalArticle

CD147 Antigens
Stromal Cells
Gene Expression
Peptide Hydrolases
Tissue Inhibitor of Metalloproteinases
2008

Basigin-2 is a cell surface receptor for soluble basigin ligand

Belton, R. J., Chen, L., Mesquita, F. S. & Nowak, R. A., Jun 27 2008, In : Journal of Biological Chemistry. 283, 26, p. 17805-17814 10 p.

Research output: Contribution to journalArticle

CD147 Antigens
Cell Surface Receptors
Ligands
Recombinant proteins
Recombinant Proteins
2007

Changes in small intestinal nutrient transport and barrier function after lipopolysaccharide exposure in two pig breeds

Albin, D. M., Wubben, J. E., Rowlett, J. M., Tappenden, K. A. & Nowak, R. A., Oct 1 2007, In : Journal of animal science. 85, 10, p. 2517-2523 7 p.

Research output: Contribution to journalArticle

nutrient transport
swine breeds
Meishan
Yorkshire (swine breed)
lipopolysaccharides

Expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinase during mouse embryonic development

Chen, L., Nakai, M., Belton, R. J. & Nowak, R. A., Feb 1 2007, In : Reproduction. 133, 2, p. 405-414 10 p.

Research output: Contribution to journalArticle

CD147 Antigens
Matrix Metalloproteinases
Blastocyst
Embryonic Development
Matrix Metalloproteinase 2
2006
CD147 Antigens
Matrix Metalloproteinases
Fibroblasts
Transforming Growth Factors
Cytokines

Extracellular matrix metalloproteinase inducer regulates metalloproteinases in human uterine endometrium

Braundmeier, A. G., Fazleabas, A. T., Lessey, B. A., Guo, H., Toole, B. P. & Nowak, R. A., Jun 15 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 6, p. 2358-2365 8 p.

Research output: Contribution to journalArticle

CD147 Antigens
Metalloproteases
Endometrium
Matrix Metalloproteinases
Fibroblasts
CD147 Antigens
Gene Knockout Techniques
tissue distribution
gene targeting
Tissue Distribution
2004

Estrogen Induces CCN5 Expression in the Rat Uterus in Vivo

Mason, H. R., Grove-Strawser, D., Rubin, B. S., Nowak, R. A. & Castellot, J. J., Feb 1 2004, In : Endocrinology. 145, 2, p. 976-982 7 p.

Research output: Contribution to journalArticle

Uterus
Estrogens
Genes
Progesterone
Messenger RNA

The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells

Mason, H. R., Lake, A. C., Wubben, J. E., Nowak, R. A. & Castellot, J. J., Mar 1 2004, In : Molecular Human Reproduction. 10, 3, p. 181-187 7 p.

Research output: Contribution to journalArticle

Myometrium
Leiomyoma
Smooth Muscle Myocytes
Growth
Genes
2003

Heparin inhibits the motility and proliferation of human myometrial and leiomyoma smooth muscle cells

Mason, H. R., Nowak, R. A., Morton, C. C. & Castellot, J. J., Jun 1 2003, In : American Journal of Pathology. 162, 6, p. 1895-1904 10 p.

Research output: Contribution to journalArticle

Leiomyoma
Smooth Muscle Myocytes
Heparin
Myometrium
Women's Health

HMGA2 expression in uterine leiomyomata and myometrium: Quantitative analysis and tissue culture studies

Gross, K. L., Neskey, D. M., Manchanda, N., Weremowicz, S., Kleinman, M. S., Nowak, R. A., Ligon, A. H., Rogalla, P., Drechsler, K., Bullerdiek, J. & Morton, C. C., Sep 1 2003, In : Genes Chromosomes and Cancer. 38, 1, p. 68-79 12 p.

Research output: Contribution to journalArticle

Myometrium
Leiomyoma
Southern Blotting
Real-Time Polymerase Chain Reaction
Cultured Cells
2002

Granulocyte macrophage colony-stimulating factor in adenomyosis and autologous endometrium

Propst, A. M., Quade, B. J., Nowak, R. A. & Stewart, E. A., Mar 28 2002, In : Journal of the Society for Gynecologic Investigation. 9, 2, p. 93-97 5 p.

Research output: Contribution to journalArticle

Adenomyosis
Granulocyte-Macrophage Colony-Stimulating Factor
Endometrium
Granulocyte-Macrophage Colony-Stimulating Factor Receptors
Ligands
2001

Adenomyosis demonstrates increased expression of the basic fibroblast growth factor receptor/ligand system compared with autologous endometrium

Propst, A. M., Quade, B. J., Gargiulo, A. R., Nowak, R. A. & Stewart, E. A., Jan 1 2001, In : Menopause. 8, 5, p. 368-371 4 p.

Research output: Contribution to journalArticle

Adenomyosis
Fibroblast Growth Factor Receptors
Fibroblast Growth Factor 2
Endometrium
Ligands
Leiomyoma
Transforming Growth Factors
Smooth Muscle Myocytes
Muscle
Cells
2000

Novel therapeutic strategies for leiomyomas: Targeting growth factors and their receptors

Nowak, R. A., Dec 21 2000, In : Environmental health perspectives. 108, SUPPL. 5, p. 849-853 5 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Leiomyoma
targeting
Tumors
Intercellular Signaling Peptides and Proteins
1999
Leiomyoma
Steroids
Hormones
Therapeutics
Uterine Myomectomy

HMGIC expression in human adult and fetal tissues and in uterine leiomyomata

Gattas, G. J. F., Quade, B. J., Nowak, R. A. & Morton, C. C., Aug 1 1999, In : Genes Chromosomes and Cancer. 25, 4, p. 316-322 7 p.

Research output: Contribution to journalArticle

Leiomyoma
Fetus
Myometrium
Cell Culture Techniques
Kidney

Messenger ribonucleic acid for the gonadal luteinizing hormone/human chorionic gonadotropin receptor is not present in human endometrium

Stewart, E. A., Sahakian, M., Rhoades, A., Van Voorhis, B. J. & Nowak, R. A., Feb 1 1999, In : Fertility and Sterility. 71, 2, p. 368-372 5 p.

Research output: Contribution to journalArticle

Gonadal Hormones
LH Receptors
Luteinizing Hormone
Endometrium
RNA

Onapristone suppresses prolactin production in explant cultures of leiomyoma

Austin, D. J., Nowak, R. A. & Stewart, E. A., Jun 16 1999, In : Gynecologic and Obstetric Investigation. 47, 4, p. 268-271 4 p.

Research output: Contribution to journalArticle

Leiomyoma
Prolactin
Myometrium
Mifepristone
Follicular Phase

Prolactin is an autocrine or paracrine growth factor for human myometrial and leiomyoma cells

Nowak, R. A., Mora, S., Diehl, T., Rhoades, A. R. & Stewart, E. A., Sep 1 1999, In : Gynecologic and Obstetric Investigation. 48, 2, p. 127-132 6 p.

Research output: Contribution to journalArticle

Leiomyoma
Prolactin
Intercellular Signaling Peptides and Proteins
Prolactin Receptors
Cell Count