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Research Output 1998 2019

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2019

A comparison of mid-infrared spectral regions on accuracy of tissue classification

Mittal, S. & Bhargava, R., Apr 21 2019, In : Analyst. 144, 8, p. 2635-2642 8 p.

Research output: Contribution to journalArticle

Dermatoglyphics
Tissue
Infrared radiation
Pixels
Breast

A fully automated, faster noise rejection approach to increasing the analytical capability of chemical imaging for digital histopathology

Gupta, S., Mittal, S., Kajdacsy-Balla, A., Bhargava, R. & Bajaj, C., Apr 1 2019, In : PloS one. 14, 4, e0205219.

Research output: Contribution to journalArticle

Open Access
histopathology
Noise
image analysis
Imaging techniques
Signal to noise ratio

Bulk Protein and Oil Prediction in Soybeans Using Transmission Raman Spectroscopy: A Comparison of Approaches to Optimize Accuracy

Singh, R., Wrobel, T. P., Mukherjee, P., Gryka, M., Kole, M., Harrison, S. & Bhargava, R., Jun 1 2019, In : Applied Spectroscopy. 73, 6, p. 687-697 11 p.

Research output: Contribution to journalArticle

soybeans
Raman spectroscopy
Oils
oils
proteins

Controlled dissolution of freeform 3D printed carbohydrate glass scaffolds in hydrogels using a hydrophobic spray coating

Gryka, M. C., Comi, T. J., Forsyth, R. A., Hadley, P. M., Deb, S. & Bhargava, R., Mar 1 2019, In : Additive Manufacturing. 26, p. 193-201 9 p.

Research output: Contribution to journalArticle

Hydrogels
Carbohydrates
Scaffolds
Dissolution
Glass

Deep learning for FTIR histology: leveraging spatial and spectral features with convolutional neural networks

Berisha, S., Lotfollahi, M., Jahanipour, J., Gurcan, I., Walsh, M., Bhargava, R., Van Nguyen, H. & Mayerich, D., Mar 7 2019, In : Analyst. 144, 5, p. 1642-1653 12 p.

Research output: Contribution to journalArticle

Histology
histology
Fourier Analysis
Fourier transform
Fourier transforms

Enzyme-catalysed biodegradation of carbon dots follows sequential oxidation in a time dependent manner

Srivastava, I., Sar, D., Mukherjee, P., Schwartz-Duval, A. S., Huang, Z., Jaramillo, C., Civantos, A., Tripathi, I., Allain, J. P., Bhargava, R. & Pan, D., May 7 2019, In : Nanoscale. 11, 17, p. 8226-8236 11 p.

Research output: Contribution to journalArticle

Biodegradation
Carbon
Enzymes
Oxidation
Degradation

Extended Multiplicative Signal Correction for Infrared Microspectroscopy of Heterogeneous Samples with Cylindrical Domains

Rasskazov, I. L., Singh, R., Carney, P. S. & Bhargava, R., Aug 1 2019, In : Applied Spectroscopy. 73, 8, p. 859-869 11 p.

Research output: Contribution to journalArticle

Scattering
Infrared radiation
Mie scattering
scattering
Fibers

Freeform Assembly Planning

Gelber, M. K., Hurst, G. & Bhargava, R., Jul 1 2019, In : IEEE Transactions on Automation Science and Engineering. 16, 3, p. 1315-1329 15 p., 8554172.

Research output: Contribution to journalArticle

Printing
Planning
3D printers
D region
Functional materials

Multicolor Discrete Frequency Infrared Spectroscopic Imaging

Yeh, K., Lee, D. & Bhargava, R., Feb 5 2019, In : Analytical chemistry. 91, 3, p. 2177-2185 9 p.

Research output: Contribution to journalArticle

Infrared radiation
Scanning
Imaging techniques
Imaging systems
Image quality

Polymeric microfluidic continuous flow mixer combined with hyperspectral FT-IR imaging for studying rapid biomolecular events

Jang, H., Pawate, A. S., Bhargava, R. & Kenis, P. J. A., Jan 1 2019, In : Lab on a chip. 19, 15, p. 2598-2609 12 p.

Research output: Contribution to journalArticle

Microfluidics
Protein Folding
Infrared imaging
Fourier Analysis
Cycloparaffins

Relating strain hardening moduli in high density polyethylene copolymers to anisotropic molecular deformation using infrared spectroscopic imaging

Mukherjee, P., Ghosh, A., Lamborn, M. J., Monwar, M. M., Fodor, J. S., DesLauriers, P. J. & Bhargava, R., May 20 2019, In : Polymer. 172, p. 398-403 6 p.

Research output: Contribution to journalArticle

Polyethylene
High density polyethylenes
Strain hardening
Copolymers
Infrared radiation
2018

A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability

Jadaliha, M., Gholamalamdari, O., Tang, W., Zhang, Y., Petracovici, A., Hao, Q., Tariq, A., Kim, T. G., Holton, S. E., Singh, D. K., Li, X. L., Freier, S. M., Ambs, S., Bhargava, R., Lal, A., Prasanth, S. G., Ma, J. & Kannanganattu, P. K., Nov 1 2018, In : PLoS Genetics. 14, 11, e1007802.

Research output: Contribution to journalArticle

Long Noncoding RNA
tumor suppressor genes
RNA Stability
Tumor Suppressor Genes
tumor

Application of Vibrational Spectroscopy and Imaging to Point-of-Care Medicine: A Review

Pahlow, S., Weber, K., Popp, J., Wood, B. R., Kochan, K., Rüther, A., Perez-Guaita, D., Heraud, P., Stone, N., Dudgeon, A., Gardner, B., Reddy, R., Mayerich, D. & Bhargava, R., Sep 1 2018, In : Applied Spectroscopy. 72, 1_suppl, p. 52-84 33 p.

Research output: Contribution to journalArticle

Point-of-Care Systems
Single-Cell Analysis
Intraoperative Monitoring
Vibrational spectroscopy
urine

FT-IR- and Raman-based biochemical profiling of the early stage of pulmonary metastasis of breast cancer in mice

Chrabaszcz, K., Kochan, K., Fedorowicz, A., Jasztal, A., Buczek, E., Leslie, L. S., Bhargava, R., Malek, K., Chlopicki, S. & Marzec, K. M., May 7 2018, In : Analyst. 143, 9, p. 2042-2050 9 p.

Research output: Contribution to journalArticle

Raman spectroscopy
Glycogen
Lipids
cancer
lipid

Model-guided design and characterization of a high-precision 3D printing process for carbohydrate glass

Gelber, M. K., Hurst, G., Comi, T. J. & Bhargava, R., Aug 1 2018, In : Additive Manufacturing. 22, p. 38-50 13 p.

Research output: Contribution to journalArticle

Carbohydrates
Printing
Glass
Nozzles
3D printers

Multimodal Chemical Analysis of the Brain by High Mass Resolution Mass Spectrometry and Infrared Spectroscopic Imaging

Neumann, E. K., Comi, T. J., Spegazzini, N., Mitchell, J. W., Rubakhin, S., Gillette, M. L., Bhargava, R. & Sweedler, J. V., Oct 2 2018, In : Analytical chemistry. 90, 19, p. 11572-11580 9 p.

Research output: Contribution to journalArticle

Mass spectrometry
Brain
Infrared radiation
Imaging techniques
Chemical analysis

Pixelated spatial gene expression analysis from tissue

Ganguli, A., Ornob, A., Spegazzini, N., Liu, Y., Damhorst, G., Ghonge, T., Thornton, B., Konopka, C. J., Dobrucki, W., Clare, S. E., Bhargava, R., Smith, A. M., Kosari, F. & Bashir, R., Dec 1 2018, In : Nature communications. 9, 1, 202.

Research output: Contribution to journalArticle

gene expression
Gene expression
Tissue
Gene Expression
ribonucleic acids

Plasmon-enhanced upconversion: Engineering enhancement and quenching at nano and macro scales

Rasskazov, I. L., Wang, L., Murphy, C. J., Bhargava, R. & Carney, P. S., Jan 1 2018, In : Optical Materials Express. 8, 12, p. 3787-3804 18 p.

Research output: Contribution to journalArticle

Metal nanoparticles
Macros
Quenching
Photons
Electromagnetic fields

Probe-Sample Interaction-Independent Atomic Force Microscopy-Infrared Spectroscopy: Toward Robust Nanoscale Compositional Mapping

Kenkel, S., Mittal, A., Mittal, S. & Bhargava, R., Aug 7 2018, In : Analytical chemistry. 90, 15, p. 8845-8855 11 p.

Research output: Contribution to journalArticle

Infrared spectroscopy
Atomic force microscopy
Infrared radiation
Imaging techniques
Infrared imaging

Relating Post-yield Mechanical Behavior in Polyethylenes to Spatially Varying Molecular Deformation Using Infrared Spectroscopic Imaging: Homopolymers

Mukherjee, P., Ghosh, A., Spegazzini, N., Lamborn, M. J., Monwar, M. M., Deslauriers, P. J. & Bhargava, R., May 22 2018, In : Macromolecules. 51, 10, p. 3836-3844 9 p.

Research output: Contribution to journalArticle

Polyethylenes
Homopolymerization
Polyethylene
High density polyethylenes
Infrared radiation

Selecting optimal features from Fourier transform infrared spectroscopy for discrete-frequency imaging

Mankar, R., Walsh, M. J., Bhargava, R., Prasad, S. & Mayerich, D., Mar 7 2018, In : Analyst. 143, 5, p. 1147-1156 10 p.

Research output: Contribution to journalArticle

Histology
histology
Fourier Transform Infrared Spectroscopy
FTIR spectroscopy
Fourier transform infrared spectroscopy

Simultaneous cancer and tumor microenvironment subtyping using confocal infrared microscopy for all-digital molecular histopathology

Mittal, S., Yeh, K., Suzanne Leslie, L., Kenkel, S., Kajdacsy-Balla, A. & Bhargava, R., Jun 19 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 25, p. E5651-E5660

Research output: Contribution to journalArticle

Tumor Microenvironment
Confocal Microscopy
Breast
Epithelial Cells
Research
2017

BIM-Sim: Interactive simulation of broadband imaging using mie theory

Berisha, S., van Dijk, T., Bhargava, R., Carney, P. S. & Mayerich, D., Feb 20 2017, In : Frontiers in Physics. 5, FEB, 5.

Research output: Contribution to journalArticle

Mie Theory
Interactive Simulation
Electromagnetic Fields
Mie scattering
Electromagnetic fields

Characterization of the structure of low-e substrates and consequences for IR transflection measurements

DeVetter, B. M., Kenkel, S., Mittal, S., Bhargava, R. & Wrobel, T. P., Jul 1 2017, In : Vibrational Spectroscopy. 91, p. 119-127 9 p.

Research output: Contribution to journalArticle

Infrared radiation
Substrates
Gold
Infrared spectroscopy
Glass

Dielectric Sphere Clusters as a Model to Understand Infrared Spectroscopic Imaging Data Recorded from Complex Samples

Rasskazov, I. L., Spegazzini, N., Carney, P. S. & Bhargava, R., Oct 17 2017, In : Analytical chemistry. 89, 20, p. 10813-10818 6 p.

Research output: Contribution to journalArticle

Infrared radiation
Imaging techniques
Polymethyl Methacrylate
Scattering
Multiple scattering

Mapping Solvation Environments in Porous Metal-Organic Frameworks with Infrared Chemical Imaging

Ghosh, A., Mukherjee, P., Deb, S. & Bhargava, R., Nov 2 2017, In : Journal of Physical Chemistry Letters. 8, 21, p. 5325-5330 6 p.

Research output: Contribution to journalArticle

Solvation
solvation
Metals
Infrared radiation
Imaging techniques

PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes

Singh, D. K., Gholamalamdari, O., Jadaliha, M., Li, X. L., Lin, Y. C., Zhang, Y., Guang, S., Hashemikhabir, S., Tiwari, S., Zhu, Y. J., Khan, A., Thomas, A., Chakraborty, A., Macias, V., Balla, A. K., Bhargava, R., Janga, S. C., Ma, J., Prasanth, S. G., Lal, A. & 1 others, Kannanganattu, P. K., Oct 1 2017, In : Carcinogenesis. 38, 10, p. 966-975 10 p., bgx062.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
cdc Genes
Breast Neoplasms
RNA Polymerase II
Cell Line

Quantitative Chemical Imaging of Nonplanar Microfluidics

Gelber, M. K., Kole, M. R., Kim, N., Aluru, N. R. & Bhargava, R., Feb 7 2017, In : Analytical chemistry. 89, 3, p. 1716-1723 8 p.

Research output: Contribution to journalArticle

Microfluidics
Stimulated Raman scattering
Imaging techniques
Aberrations
Refractive index

Rapid visualization of macromolecular orientation by discrete frequency mid-infrared spectroscopic imaging

Wrobel, T. P., Mukherjee, P. & Bhargava, R., Jan 7 2017, In : Analyst. 142, 1, p. 75-79 5 p.

Research output: Contribution to journalArticle

Semiconductor Lasers
Fourier Analysis
Molecular Structure
visualization
Microscopy

Refractive index sensing and surface-enhanced Raman spectroscopy using silver-gold layered bimetallic plasmonic crystals

Kang, S., Lehman, S. E., Schulmerich, M. V., Le, A. P., Lee, T. W., Gray, S. K., Bhargava, R. & Nuzzo, R. G., Jan 1 2017, In : Beilstein Journal of Nanotechnology. 8, 1, p. 2492-2503 12 p.

Research output: Contribution to journalArticle

Silver
Gold
Raman spectroscopy
Refractive index
silver
2016

Automated prostate tissue referencing for cancer detection and diagnosis

Kwak, J. T., Hewitt, S. M., Kajdacsy-Balla, A. A., Sinha, S. & Bhargava, R., Jun 1 2016, In : BMC bioinformatics. 17, 1, 227.

Research output: Contribution to journalArticle

Prostate
Cancer
Tissue
Neoplasms
Retrieval

Characterization of core-shell microstructure and self-healing performance of electrospun fiber coatings

Doan, T. Q., Leslie, L. S., Kim, S. Y., Bhargava, R., White, S. R. & Sottos, N. R., Dec 19 2016, In : Polymer. 107, p. 263-272 10 p.

Research output: Contribution to journalArticle

Coatings
Microstructure
Fibers
Crosslinking
Corrosion

Clinical Spectroscopy: General discussion

Goodacre, R., Sergo, V., Barr, H., Sammon, C., Schultz, Z. D., Baker, M. J., Graham, D., Marques, M. P., Sulé-Suso, J., Livermore, J., Faulds, K., Sinjab, F., Matousek, P., Campbell, C. J., Dluhy, R., Gardner, P., Phillips, C., Diem, M., Wood, B., Apolonskiy, A. & 21 others, Kazarian, S., Fullwood, L., Gough, K., Petrich, W., Lloyd, G., Ibrahim, O., Cinque, G., Sockalingum, G. D., Stone, N., Kendall, C., McAughtrie, S., Perez-Guaita, D., Clark, L., Gerwert, K., Bonifacio, A., Notingher, I., Lasch, P., Bhargava, R., Lepert, G., Mader, K. & Paterson, C., Jan 1 2016, In : Faraday Discussions. 187, p. 429-460 32 p.

Research output: Contribution to journalArticle

Spectrum analysis
spectrum analysis
animals
Animals
Spectroscopy

Defined Host–Guest Chemistry on Nanocarbon for Sustained Inhibition of Cancer

Ostadhossein, F., Misra, S. K., Mukherjee, P., Ostadhossein, A., Daza, E., Tiwari, S., Mittal, S., Gryka, M. C., Bhargava, R. & Pan, D., Nov 9 2016, In : Small. 12, 42, p. 5845-5861 17 p.

Research output: Contribution to journalArticle

Transcription Factor 3
STAT3 Transcription Factor
Transcription factors
Niclosamide
Transducers

Development of a practical spatial-spectral analysis protocol for breast histopathology using Fourier transform infrared spectroscopic imaging

Pounder, F. N., Reddy, R. K. & Bhargava, R., Jan 1 2016, In : Faraday Discussions. 187, p. 43-68 26 p.

Research output: Contribution to journalArticle

breast
Spectrum analysis
spectrum analysis
Tumors
Fourier transforms

Emerging Themes in Image Informatics and Molecular Analysis for Digital Pathology

Bhargava, R. & Madabhushi, A., Jul 11 2016, In : Annual Review of Biomedical Engineering. 18, p. 387-412 26 p.

Research output: Contribution to journalArticle

Informatics
Pathology
Precision Medicine
Molecular Pathology
Telepathology

Infrared emission spectroscopy of atmospheric-pressure ball plasmoids

Dubowsky, S. E., Deutsch, B., Bhargava, R. & McCall, B. J., Apr 1 2016, In : Journal of Molecular Spectroscopy. 322, p. 1-8 8 p.

Research output: Contribution to journalArticle

Emission spectroscopy
Atmospheric pressure
balls
Infrared spectroscopy
atmospheric pressure

Measuring and Predicting the Internal Structure of Semiconductor Nanocrystals through Raman Spectroscopy

Mukherjee, P., Lim, S. J., Wrobel, T. P., Bhargava, R. & Smith, A. M., Aug 31 2016, In : Journal of the American Chemical Society. 138, 34, p. 10887-10896 10 p.

Research output: Contribution to journalArticle

Quantum Dots
Raman Spectrum Analysis
Raman spectroscopy
Nanoparticles
Nanocrystals

Multi-functionality Redefined with Colloidal Carotene Carbon Nanoparticles for Synchronized Chemical Imaging, Enriched Cellular Uptake and Therapy

Misra, S. K., Mukherjee, P., Chang, H. H., Tiwari, S., Gryka, M., Bhargava, R. & Pan, D., Jul 11 2016, In : Scientific Reports. 6, 29299.

Research output: Contribution to journalArticle

Carotenoids
Nanoparticles
Carbon
Ligands
Phospholipids

Quantitative microscopic evaluation of mucin areas and its percentage in mucinous carcinoma of the breast using tissue histological images

Saha, M., Arun, I., Basak, B., Agarwal, S., Ahmed, R., Chatterjee, S., Bhargava, R. & Chakraborty, C., Jun 1 2016, In : Tissue and Cell. 48, 3, p. 265-273 9 p.

Research output: Contribution to journalArticle

Mucinous Adenocarcinoma
Mucins
Breast
Color
Carcinoma, Ductal, Breast

Single cell analysis/data handling: General discussion

Baker, M. J., Goodacre, R., Sammon, C., Marques, M. P., Gardner, P., Tipping, W., Sulé-Suso, J., Wood, B., Byrne, H. J., Hermes, M., Matousek, P., Campbell, C. J., El-Mashtoly, S., Frost, J., Phillips, C., Diem, M., Kohler, A., Lau, K., Kazarian, S., Petrich, W. & 15 others, Lloyd, G., Delfino, I., Cinque, G., Isabelle, M., Stone, N., Kendall, C., Jamieson, L., Perez-Guaita, D., Clark, L., Gerwert, K., Notingher, I., Quaroni, L., Bhargava, R., Meade, A. & Lyng, F., Jan 1 2016, In : Faraday Discussions. 187, p. 299-327 29 p.

Research output: Contribution to journalArticle

Single-Cell Analysis
Papillomavirus Infections
Raman Spectrum Analysis
Uterine Cervical Neoplasms
Sensitivity and Specificity

Spectral Pathology: General discussion

Sammon, C., Schultz, Z. D., Kazarian, S., Barr, H., Goodacre, R., Graham, D., Baker, M. J., Gardner, P., Wood, B., Campbell, C. J., Dluhy, R., El-Mashtoly, S., Phillips, C., Frost, J., Diem, M., Kohler, A., Haris, P., Apolonskiy, A., Amrania, H., Lasch, P. & 10 others, Zhang, Z., Petrich, W., Sockalingum, G. D., Stone, N., Gerwert, K., Notingher, I., Bhargava, R., Kröger-Lui, N., Isabelle, M. & Pilling, M., Jan 1 2016, In : Faraday Discussions. 187, p. 155-186 32 p.

Research output: Contribution to journalArticle

Pathology

Towards Translation of Discrete Frequency Infrared Spectroscopic Imaging for Digital Histopathology of Clinical Biopsy Samples

Tiwari, S., Raman, J., Reddy, V., Ghetler, A., Tella, R. P., Han, Y., Moon, C. R., Hoke, C. D. & Bhargava, R., Oct 18 2016, In : Analytical chemistry. 88, 20, p. 10183-10190 8 p.

Research output: Contribution to journalArticle

Biopsy
Infrared imaging
Infrared radiation
Imaging techniques
Fourier transforms

Vibrational spectroscopy and imaging for concurrent cellular trafficking of co-localized doxorubicin and deuterated phospholipid vesicles

Misra, S. K., Mukherjee, P., Ohoka, A., Schwartz-Duval, A. S., Tiwari, S., Bhargava, R. & Pan, D., Feb 7 2016, In : Nanoscale. 8, 5, p. 2826-2831 6 p.

Research output: Contribution to journalArticle

Vibrational spectroscopy
Phospholipids
Doxorubicin
Nanoparticles
Imaging techniques
2015

Compositional prior information in computed infrared spectroscopic imaging

Deutsch, B., Reddy, R., Mayerich, D., Bhargava, R. & Carney, P. S., Jun 1 2015, In : Journal of the Optical Society of America A: Optics and Image Science, and Vision. 32, 6, p. 1126-1131 6 p.

Research output: Contribution to journalArticle

Optical Devices
Optical Coherence Tomography
Fourier Analysis
Spectrum Analysis
Infrared radiation

Computational chemical imaging for cardiovascular pathology: Chemical microscopic imaging accurately determines cardiac transplant rejection

Tiwari, S., Reddy, V. B., Bhargava, R. & Raman, J., May 1 2015, In : PloS one. 10, 5, e0125183.

Research output: Contribution to journalArticle

heart transplant
graft rejection
Transplants
Biopsy
Graft Rejection

Consumer-grade polyurethane foam functions as a large and selective absorption sink for bisphenol A in aqueous media

Han, J., Qiu, W., Tiwari, S., Bhargava, R., Gao, W. & Xing, B., Apr 28 2015, In : Journal of Materials Chemistry A. 3, 16, p. 8870-8881 12 p.

Research output: Contribution to journalArticle

Polyurethanes
Foams
Sorption
Hydrogen bonds
polyurethane foam

Enhancement and extinction effects in surface-enhanced stimulated Raman spectroscopy

Chng, B. X. K., Van Dijk, T., Bhargava, R. & Carney, P. S., Mar 2 2015, In : Physical Chemistry Chemical Physics. 17, 33, p. 21348-21355 8 p.

Research output: Contribution to journalArticle

Raman spectroscopy
extinction
Nanoparticles
nanoparticles
augmentation

Fast infrared chemical imaging with a quantum cascade laser

Yeh, K., Kenkel, S., Liu, J. N. & Bhargava, R., Jan 6 2015, In : Analytical chemistry. 87, 1, p. 485-493 9 p.

Research output: Contribution to journalArticle

Quantum cascade lasers
Infrared imaging
Infrared radiation
Imaging techniques
Imaging systems

High definition infrared spectroscopic imaging for lymph node histopathology

Leslie, L. S., Wrobel, T. P., Mayerich, D., Bindra, S., Emmadi, R. & Bhargava, R., Jun 3 2015, In : PloS one. 10, 6, e0127238.

Research output: Contribution to journalArticle

Biopsy
histopathology
lymph nodes
Fourier transforms
Coloring Agents