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Research Output

2020

All-digital histopathology by infrared-optical hybrid microscopy

Schnell, M., Mittal, S., Falahkheirkhah, K., Mittal, A., Yeh, K., Kenkel, S., Kajdacsy-Balla, A., Carney, P. S. & Bhargava, R., Feb 18 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 7, p. 3388-3396 9 p., 201912400.

Research output: Contribution to journalArticle

Closed-loop atomic force microscopy-infrared spectroscopic imaging for nanoscale molecular characterization

Kenkel, S., Mittal, S. & Bhargava, R., Dec 1 2020, In : Nature communications. 11, 1, 3225.

Research output: Contribution to journalArticle

Open Access

High-resolution label-free imaging of tissue morphology with confocal phase microscopy

Schnell, M., Gupta, S., Wrobel, T. P., Drage, M. G., Bhargava, R. & Carney, P. S., Sep 20 2020, In : Optica. 7, 9, p. 1173-1180 8 p.

Research output: Contribution to journalArticle

Infrared Spectroscopic Imaging Visualizes a Prognostic Extracellular Matrix-Related Signature in Breast Cancer

Tiwari, S., Triulzi, T., Holton, S., Regondi, V., Paolini, B., Tagliabue, E. & Bhargava, R., Dec 1 2020, In : Scientific reports. 10, 1, 5442.

Research output: Contribution to journalArticle

Open Access

LncRNA-mediated regulation of SOX9 expression in basal subtype breast cancer cells

Tariq, A., Hao, Q., Sun, Q., Singh, D. K., Jadaliha, M., Zhang, Y., Chetlangia, N., Ma, J., Holton, S. E., Bhargava, R., Lal, A., Prasanth, S. G. & Prasanth, K. V., Jan 1 2020, In : RNA. 26, 2, p. 175-185 11 p.

Research output: Contribution to journalArticle

On-demand Milifluidic Synthesis of Quantum Dots in Digital Droplet Reactors

Richard, C., McGee, R., Goenka, A., Mukherjee, P. & Bhargava, R., Mar 4 2020, In : Industrial and Engineering Chemistry Research. 59, 9, p. 3730-3735 6 p.

Research output: Contribution to journalArticle

Polarimetric infrared spectroscopic imaging using quantum cascade lasers

Phal, Y., Yeh, K. & Bhargava, R., 2020, Advanced Chemical Microscopy for Life Science and Translational Medicine. Cheng, J-X., Min, W. & Simpson, G. J. (eds.). SPIE, 1125210. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11252).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2019

A comparison of mid-infrared spectral regions on accuracy of tissue classification

Mittal, S. & Bhargava, R., Apr 21 2019, In : Analyst. 144, 8, p. 2635-2642 8 p.

Research output: Contribution to journalArticle

A fully automated, faster noise rejection approach to increasing the analytical capability of chemical imaging for digital histopathology

Gupta, S., Mittal, S., Kajdacsy-Balla, A., Bhargava, R. & Bajaj, C., Apr 2019, In : PloS one. 14, 4, e0205219.

Research output: Contribution to journalArticle

Open Access

Bulk Protein and Oil Prediction in Soybeans Using Transmission Raman Spectroscopy: A Comparison of Approaches to Optimize Accuracy

Singh, R., Wrobel, T. P., Mukherjee, P., Gryka, M., Kole, M., Harrison, S. & Bhargava, R., Jun 1 2019, In : Applied Spectroscopy. 73, 6, p. 687-697 11 p.

Research output: Contribution to journalArticle

Controlled dissolution of freeform 3D printed carbohydrate glass scaffolds in hydrogels using a hydrophobic spray coating

Gryka, M. C., Comi, T. J., Forsyth, R. A., Hadley, P. M., Deb, S. & Bhargava, R., Mar 2019, In : Additive Manufacturing. 26, p. 193-201 9 p.

Research output: Contribution to journalArticle

Deep learning for FTIR histology: leveraging spatial and spectral features with convolutional neural networks

Berisha, S., Lotfollahi, M., Jahanipour, J., Gurcan, I., Walsh, M., Bhargava, R., Van Nguyen, H. & Mayerich, D., Mar 7 2019, In : Analyst. 144, 5, p. 1642-1653 12 p.

Research output: Contribution to journalArticle

Digital Assessment of Stained Breast Tissue Images for Comprehensive Tumor and Microenvironment Analysis

Mittal, S., Stoean, C., Kajdacsy-Balla, A. & Bhargava, R., Oct 1 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 246.

Research output: Contribution to journalArticle

Open Access

Enzyme-catalysed biodegradation of carbon dots follows sequential oxidation in a time dependent manner

Srivastava, I., Sar, D., Mukherjee, P., Schwartz-Duval, A. S., Huang, Z., Jaramillo, C., Civantos, A., Tripathi, I., Allain, J. P., Bhargava, R. & Pan, D., May 7 2019, In : Nanoscale. 11, 17, p. 8226-8236 11 p.

Research output: Contribution to journalArticle

Extended Multiplicative Signal Correction for Infrared Microspectroscopy of Heterogeneous Samples with Cylindrical Domains

Rasskazov, I. L., Singh, R., Carney, P. S. & Bhargava, R., Aug 1 2019, In : Applied Spectroscopy. 73, 8, p. 859-869 11 p.

Research output: Contribution to journalArticle

Freeform Assembly Planning

Gelber, M. K., Hurst, G. & Bhargava, R., Jul 2019, In : IEEE Transactions on Automation Science and Engineering. 16, 3, p. 1315-1329 15 p., 8554172.

Research output: Contribution to journalArticle

Multicolor Discrete Frequency Infrared Spectroscopic Imaging

Yeh, K., Lee, D. & Bhargava, R., Feb 5 2019, In : Analytical chemistry. 91, 3, p. 2177-2185 9 p.

Research output: Contribution to journalArticle

Nanoscale imaging of biological samples with responsivity corrected atomic force microscopy-infrared (AFM-IR) spectroscopy

Kenkel, S. & Bhargava, R., Jan 1 2019, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI. Nicolau, D. V., Fixler, D. & Goldys, E. M. (eds.). SPIE, 108910A. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10891).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Polymeric microfluidic continuous flow mixer combined with hyperspectral FT-IR imaging for studying rapid biomolecular events

Jang, H., Pawate, A. S., Bhargava, R. & Kenis, P. J. A., Aug 7 2019, In : Lab on a chip. 19, 15, p. 2598-2609 12 p.

Research output: Contribution to journalArticle

Relating strain hardening moduli in high density polyethylene copolymers to anisotropic molecular deformation using infrared spectroscopic imaging

Mukherjee, P., Ghosh, A., Lamborn, M. J., Monwar, M. M., Fodor, J. S., DesLauriers, P. J. & Bhargava, R., May 20 2019, In : Polymer. 172, p. 398-403 6 p.

Research output: Contribution to journalArticle

2018

Agile optoelectronic fiber sources for hyperspectral chemical sensing from SWIR to LWIR

Kang, I., Grant, A., Dinu, M., Jaques, J., Pfister, L., Bhargava, R. & Carney, P. S., 2018, Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XXIV. Messinger, D. W. & Velez-Reyes, M. (eds.). SPIE, 106441E. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 10644).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability

Jadaliha, M., Gholamalamdari, O., Tang, W., Zhang, Y., Petracovici, A., Hao, Q., Tariq, A., Kim, T. G., Holton, S. E., Singh, D. K., Li, X. L., Freier, S. M., Ambs, S., Bhargava, R., Lal, A., Prasanth, S. G., Ma, J. & Prasanth, K. V., Nov 2018, In : PLoS genetics. 14, 11, e1007802.

Research output: Contribution to journalArticle

Application of Vibrational Spectroscopy and Imaging to Point-of-Care Medicine: A Review

Pahlow, S., Weber, K., Popp, J., Wood, B. R., Kochan, K., Rüther, A., Perez-Guaita, D., Heraud, P., Stone, N., Dudgeon, A., Gardner, B., Reddy, R., Mayerich, D. & Bhargava, R., Sep 1 2018, In : Applied Spectroscopy. 72, 1_suppl, p. 52-84 33 p.

Research output: Contribution to journalArticle

FT-IR- and Raman-based biochemical profiling of the early stage of pulmonary metastasis of breast cancer in mice

Chrabaszcz, K., Kochan, K., Fedorowicz, A., Jasztal, A., Buczek, E., Leslie, L. S., Bhargava, R., Malek, K., Chlopicki, S. & Marzec, K. M., May 7 2018, In : Analyst. 143, 9, p. 2042-2050 9 p.

Research output: Contribution to journalArticle

Infrared Spectroscopic Imaging Advances as an Analytical Technology for Biomedical Sciences

Wrobel, T. P. & Bhargava, R., Feb 6 2018, In : Analytical chemistry. 90, 3, p. 1444-1463 20 p.

Research output: Contribution to journalReview article

Model-guided design and characterization of a high-precision 3D printing process for carbohydrate glass

Gelber, M. K., Hurst, G., Comi, T. J. & Bhargava, R., Aug 2018, In : Additive Manufacturing. 22, p. 38-50 13 p.

Research output: Contribution to journalArticle

Multimodal Chemical Analysis of the Brain by High Mass Resolution Mass Spectrometry and Infrared Spectroscopic Imaging

Neumann, E. K., Comi, T. J., Spegazzini, N., Mitchell, J. W., Rubakhin, S. S., Gillette, M. U., Bhargava, R. & Sweedler, J. V., Oct 2 2018, In : Analytical chemistry. 90, 19, p. 11572-11580 9 p.

Research output: Contribution to journalArticle

Pixelated spatial gene expression analysis from tissue

Ganguli, A., Ornob, A., Spegazzini, N., Liu, Y., Damhorst, G., Ghonge, T., Thornton, B., Konopka, C. J., Dobrucki, W., Clare, S. E., Bhargava, R., Smith, A. M., Kosari, F. & Bashir, R., Dec 1 2018, In : Nature communications. 9, 1, 202.

Research output: Contribution to journalArticle

Plasmon-enhanced upconversion: Engineering enhancement and quenching at nano and macro scales

Rasskazov, I. L., Wang, L., Murphy, C. J., Bhargava, R. & Carney, P. S., Jan 1 2018, In : Optical Materials Express. 8, 12, p. 3787-3804 18 p.

Research output: Contribution to journalArticle

Probe-Sample Interaction-Independent Atomic Force Microscopy-Infrared Spectroscopy: Toward Robust Nanoscale Compositional Mapping

Kenkel, S., Mittal, A., Mittal, S. & Bhargava, R., Aug 7 2018, In : Analytical chemistry. 90, 15, p. 8845-8855 11 p.

Research output: Contribution to journalArticle

Relating Post-yield Mechanical Behavior in Polyethylenes to Spatially Varying Molecular Deformation Using Infrared Spectroscopic Imaging: Homopolymers

Mukherjee, P., Ghosh, A., Spegazzini, N., Lamborn, M. J., Monwar, M. M., Deslauriers, P. J. & Bhargava, R., May 22 2018, In : Macromolecules. 51, 10, p. 3836-3844 9 p.

Research output: Contribution to journalArticle

Selecting optimal features from Fourier transform infrared spectroscopy for discrete-frequency imaging

Mankar, R., Walsh, M. J., Bhargava, R., Prasad, S. & Mayerich, D., Mar 7 2018, In : Analyst. 143, 5, p. 1147-1156 10 p.

Research output: Contribution to journalArticle

Simultaneous cancer and tumor microenvironment subtyping using confocal infrared microscopy for all-digital molecular histopathology

Mittal, S., Yeh, K., Suzanne Leslie, L., Kenkel, S., Kajdacsy-Balla, A. & Bhargava, R., Jun 19 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 25, p. E5651-E5660

Research output: Contribution to journalArticle

2017

BIM-Sim: Interactive simulation of broadband imaging using mie theory

Berisha, S., van Dijk, T., Bhargava, R., Carney, P. S. & Mayerich, D., Feb 20 2017, In : Frontiers in Physics. 5, FEB, 5.

Research output: Contribution to journalArticle

Characterization of the structure of low-e substrates and consequences for IR transflection measurements

DeVetter, B. M., Kenkel, S., Mittal, S., Bhargava, R. & Wrobel, T. P., Jul 2017, In : Vibrational Spectroscopy. 91, p. 119-127 9 p.

Research output: Contribution to journalArticle

Dielectric Sphere Clusters as a Model to Understand Infrared Spectroscopic Imaging Data Recorded from Complex Samples

Rasskazov, I. L., Spegazzini, N., Carney, P. S. & Bhargava, R., Oct 17 2017, In : Analytical chemistry. 89, 20, p. 10813-10818 6 p.

Research output: Contribution to journalArticle

Keeping current: An update on the structure and evaluation of a program for graduate women interested in engineering Academia

Jackson, N. D., Tyler, K. I., Li, Y., Chen, W. T., Liu, C. & Bhargava, R., Jun 24 2017, In : ASEE Annual Conference and Exposition, Conference Proceedings. 2017-June

Research output: Contribution to journalConference article

Mapping Solvation Environments in Porous Metal-Organic Frameworks with Infrared Chemical Imaging

Ghosh, A., Mukherjee, P., Deb, S. & Bhargava, R., Nov 2 2017, In : Journal of Physical Chemistry Letters. 8, 21, p. 5325-5330 6 p.

Research output: Contribution to journalArticle

Overcoming difficulties in research statement preparation for the academic job search: Expansion of a peer-focused professional development program

Tyler, K. I., Li, Y., Jackson, N. D., Chen, W. T., Liu, C. & Bhargava, R., Jun 24 2017, In : ASEE Annual Conference and Exposition, Conference Proceedings. 2017-June

Research output: Contribution to journalConference article

PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes

Singh, D. K., Gholamalamdari, O., Jadaliha, M., Li, X. L., Lin, Y. C., Zhang, Y., Guang, S., Hashemikhabir, S., Tiwari, S., Zhu, Y. J., Khan, A., Thomas, A., Chakraborty, A., Macias, V., Balla, A. K., Bhargava, R., Janga, S. C., Ma, J., Prasanth, S. G., Lal, A. & 1 others, Prasanth, K. V., Oct 1 2017, In : Carcinogenesis. 38, 10, p. 966-975 10 p., bgx062.

Research output: Contribution to journalArticle

Quantitative Chemical Imaging of Nonplanar Microfluidics

Gelber, M. K., Kole, M. R., Kim, N., Aluru, N. R. & Bhargava, R., Feb 7 2017, In : Analytical chemistry. 89, 3, p. 1716-1723 8 p.

Research output: Contribution to journalArticle

Rapid visualization of macromolecular orientation by discrete frequency mid-infrared spectroscopic imaging

Wrobel, T. P., Mukherjee, P. & Bhargava, R., Jan 7 2017, In : Analyst. 142, 1, p. 75-79 5 p.

Research output: Contribution to journalArticle

Refractive index sensing and surface-enhanced Raman spectroscopy using silver-gold layered bimetallic plasmonic crystals

Kang, S., Lehman, S. E., Schulmerich, M. V., Le, A. P., Lee, T. W., Gray, S. K., Bhargava, R. & Nuzzo, R. G., 2017, In : Beilstein Journal of Nanotechnology. 8, 1, p. 2492-2503 12 p.

Research output: Contribution to journalArticle

The Chemistry of Thought: The Role of the Measurement Sciences in Brain Research

Andrews, A. M., Bhargava, R., Kennedy, R., Li, L. & Sweedler, J. V., May 2 2017, In : Analytical chemistry. 89, 9, 1 p.

Research output: Contribution to journalEditorial

2016

A four class model for digital breast histopathology using high-definition Fourier transform infrared (FT-IR) spectroscopic imaging

Mittal, S., Wrobel, T. P., Leslie, L. S., Kadjacsy-Balla, A. & Bhargava, R., Jan 1 2016, Medical Imaging 2016: Digital Pathology. Madabhushi, A. & Gurcan, M. N. (eds.). SPIE, 979118. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 9791).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Automated prostate tissue referencing for cancer detection and diagnosis

Kwak, J. T., Hewitt, S. M., Kajdacsy-Balla, A. A., Sinha, S. & Bhargava, R., Jun 1 2016, In : BMC bioinformatics. 17, 1, 227.

Research output: Contribution to journalArticle

Characterization of core-shell microstructure and self-healing performance of electrospun fiber coatings

Doan, T. Q., Leslie, L. S., Kim, S. Y., Bhargava, R., White, S. R. & Sottos, N. R., Dec 19 2016, In : Polymer. 107, p. 263-272 10 p.

Research output: Contribution to journalArticle

Clinical Spectroscopy: General discussion

Goodacre, R., Sergo, V., Barr, H., Sammon, C., Schultz, Z. D., Baker, M. J., Graham, D., Marques, M. P., Sulé-Suso, J., Livermore, J., Faulds, K., Sinjab, F., Matousek, P., Campbell, C. J., Dluhy, R., Gardner, P., Phillips, C., Diem, M., Wood, B., Apolonskiy, A. & 21 others, Kazarian, S., Fullwood, L., Gough, K., Petrich, W., Lloyd, G., Ibrahim, O., Cinque, G., Sockalingum, G. D., Stone, N., Kendall, C., McAughtrie, S., Perez-Guaita, D., Clark, L., Gerwert, K., Bonifacio, A., Notingher, I., Lasch, P., Bhargava, R., Lepert, G., Mader, K. & Paterson, C., 2016, In : Faraday Discussions. 187, p. 429-460 32 p.

Research output: Contribution to journalArticle