Rohit Bhargava

Search results

• 2020

  All-digital histopathology by infrared-optical hybrid microscopy

  Schnell, M., Mittal, S., Falahkheirkhah, K., Mittal, A., Yeh, K., Kenkel, S., Kajdacsy-Balla, A., Carney, P. S. & Bhargava, R., Feb 18 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 7, p. 3388-3396 9 p., 201912400.

  Research output: Contribution to journal › Article › peer-review

  • Microscopy
  • Pathology
  • Coloring Agents
  • Light
  • Optical Devices

• Closed-loop atomic force microscopy-infrared spectroscopic imaging for nanoscale molecular characterization

  Kenkel, S., Mittal, S. & Bhargava, R., Dec 1 2020, In: Nature communications. 11, 1, 3225.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Atomic force microscopy
  • Atomic Force Microscopy
  • Molecular Imaging
  • Infrared radiation
  • Silicon

• Freeform three-dimensionally printed microchannels via surface-initiated photopolymerization combined with sacrificial molding

  Chen, L., Kenkel, S. M., Hsieh, P-H., Gryka, M. C. & Bhargava, R., Oct 22 2020, In: ACS applied materials & interfaces.

  Research output: Contribution to journal › Article › peer-review

  • Photopolymerization
  • Palatinit
  • Microchannels
  • Molding
  • Eosine Yellowish-(YS)

• High-resolution label-free imaging of tissue morphology with confocal phase microscopy

  Schnell, M., Gupta, S., Wrobel, T. P., Drage, M. G., Bhargava, R. & Carney, P. S., Sep 20 2020, In: Optica. 7, 9, p. 1173-1180 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Microscopic examination
  • Labels
  • Tissue
  • Imaging techniques
  • microscopy

• Identification of early liver toxicity gene biomarkers using comparative supervised machine learning

  Smith, B. P., Auvil, L. S., Welge, M., Bushell, C. B., Bhargava, R., Elango, N., Johnson, K. & Madak-Erdogan, Z., Dec 1 2020, In: Scientific reports. 10, 1, 19128.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Supervised Machine Learning
  • Biomarkers
  • Liver
  • Genes
  • Datasets

• Impact of Plasmonic Photothermal Effects on the Reactivity of Au Nanoparticle Modified Graphene Electrodes Visualized Using Scanning Electrochemical Microscopy

  Schorr, N. B., Counihan, M. J., Bhargava, R. & Rodríguez-López, J., Mar 3 2020, In: Analytical chemistry. 92, 5, p. 3666-3673 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Gold nanoparticles
  • Plasmonics
  • Graphite
  • Microscopic examination
  • Scanning

• Infrared Spectroscopic Imaging Visualizes a Prognostic Extracellular Matrix-Related Signature in Breast Cancer

  Tiwari, S., Triulzi, T., Holton, S., Regondi, V., Paolini, B., Tagliabue, E. & Bhargava, R., Dec 1 2020, In: Scientific reports. 10, 1, 5442.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Extracellular Matrix
  • Transcriptome
  • Breast Neoplasms
  • Gene Expression
  • Multigene Family

• LncRNA-mediated regulation of SOX9 expression in basal subtype breast cancer cells

  Tariq, A., Hao, Q., Sun, Q., Singh, D. K., Jadaliha, M., Zhang, Y., Chetlangia, N., Ma, J., Holton, S. E., Bhargava, R., Lal, A., Prasanth, S. G. & Prasanth, K. V., Jan 1 2020, In: RNA. 26, 2, p. 175-185 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Breast Neoplasms
  • Long Noncoding RNA
  • Triple Negative Breast Neoplasms
  • SOX9 Transcription Factor
  • Cell Proliferation

• On-demand Milifluidic Synthesis of Quantum Dots in Digital Droplet Reactors

  Richard, C., McGee, R., Goenka, A., Mukherjee, P. & Bhargava, R., Mar 4 2020, In: Industrial and Engineering Chemistry Research. 59, 9, p. 3730-3735 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Semiconductor quantum dots
  • Microfluidics
  • cadmium selenide
  • Liquids
  • cadmium sulfide

• Polarimetric infrared spectroscopic imaging using quantum cascade lasers

  Phal, Y., Yeh, K. & Bhargava, R., 2020, Advanced Chemical Microscopy for Life Science and Translational Medicine. Cheng, J-X., Min, W. & Simpson, G. J. (eds.). SPIE, 1125210. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11252).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Quantum cascade lasers
  • Semiconductor Lasers
  • quantum cascade lasers
  • Light polarization
  • Infrared radiation
• 2019

  A comparison of mid-infrared spectral regions on accuracy of tissue classification

  Mittal, S. & Bhargava, R., Apr 21 2019, In: Analyst. 144, 8, p. 2635-2642 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dermatoglyphics
  • Infrared radiation
  • Tissue
  • tissue
  • Pixels

• A fully automated, faster noise rejection approach to increasing the analytical capability of chemical imaging for digital histopathology

  Gupta, S., Mittal, S., Kajdacsy-Balla, A., Bhargava, R. & Bajaj, C., Apr 2019, In: PloS one. 14, 4, e0205219.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hyperspectral imaging
  • histopathology
  • Noise
  • image analysis
  • Imaging techniques

• Bulk Protein and Oil Prediction in Soybeans Using Transmission Raman Spectroscopy: A Comparison of Approaches to Optimize Accuracy

  Singh, R., Wrobel, T. P., Mukherjee, P., Gryka, M., Kole, M., Harrison, S. & Bhargava, R., Jun 1 2019, In: Applied Spectroscopy. 73, 6, p. 687-697 11 p.

  Research output: Contribution to journal › Article › peer-review

  • soybeans
  • Raman spectroscopy
  • Oils
  • Proteins
  • oils

• Controlled dissolution of freeform 3D printed carbohydrate glass scaffolds in hydrogels using a hydrophobic spray coating

  Gryka, M. C., Comi, T. J., Forsyth, R. A., Hadley, P. M., Deb, S. & Bhargava, R., Mar 2019, In: Additive Manufacturing. 26, p. 193-201 9 p.

  Research output: Contribution to journal › Article › peer-review

  • octadecane
  • Carbohydrates
  • Hydrogels
  • Scaffolds
  • Dissolution

• Deep learning for FTIR histology: leveraging spatial and spectral features with convolutional neural networks

  Berisha, S., Lotfollahi, M., Jahanipour, J., Gurcan, I., Walsh, M., Bhargava, R., Van Nguyen, H. & Mayerich, D., Mar 7 2019, In: Analyst. 144, 5, p. 1642-1653 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Deep Learning
  • Histology
  • histology
  • Fourier Analysis
  • Deep learning

• Digital Assessment of Stained Breast Tissue Images for Comprehensive Tumor and Microenvironment Analysis

  Mittal, S., Stoean, C., Kajdacsy-Balla, A. & Bhargava, R., Oct 1 2019, In: Frontiers in Bioengineering and Biotechnology. 7, 246.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tumor Microenvironment
  • Tumors
  • Tissue
  • Epithelial Cells
  • Deep Learning

• Enzyme-catalysed biodegradation of carbon dots follows sequential oxidation in a time dependent manner

  Srivastava, I., Sar, D., Mukherjee, P., Schwartz-Duval, A. S., Huang, Z., Jaramillo, C., Civantos, A., Tripathi, I., Allain, J. P., Bhargava, R. & Pan, D., May 7 2019, In: Nanoscale. 11, 17, p. 8226-8236 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Biodegradation
  • Enzymes
  • Carbon
  • Oxidation
  • Degradation

• Extended Multiplicative Signal Correction for Infrared Microspectroscopy of Heterogeneous Samples with Cylindrical Domains

  Rasskazov, I. L., Singh, R., Carney, P. S. & Bhargava, R., Aug 1 2019, In: Applied Spectroscopy. 73, 8, p. 859-869 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Scattering
  • Infrared radiation
  • Mie scattering
  • scattering
  • Absorption spectra

• Freeform Assembly Planning

  Gelber, M. K., Hurst, G. & Bhargava, R., Jul 2019, In: IEEE Transactions on Automation Science and Engineering. 16, 3, p. 1315-1329 15 p., 8554172.

  Research output: Contribution to journal › Article › peer-review

  • Printing
  • Planning
  • Sugar Alcohols
  • D region
  • Functional materials

• Multicolor Discrete Frequency Infrared Spectroscopic Imaging

  Yeh, K., Lee, D. & Bhargava, R., Feb 5 2019, In: Analytical Chemistry. 91, 3, p. 2177-2185 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Infrared radiation
  • Scanning
  • Imaging techniques
  • Imaging systems
  • Fourier transforms

• Nanoscale imaging of biological samples with responsivity corrected atomic force microscopy-infrared (AFM-IR) spectroscopy

  Kenkel, S. & Bhargava, R., Jan 1 2019, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI. Nicolau, D. V., Fixler, D. & Goldys, E. M. (eds.). SPIE, 108910A. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10891).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Infrared spectroscopy
  • Atomic force microscopy
  • Atomic Force Microscopy
  • Spectrum Analysis
  • Near field scanning optical microscopy

• Polymeric microfluidic continuous flow mixer combined with hyperspectral FT-IR imaging for studying rapid biomolecular events

  Jang, H., Pawate, A. S., Bhargava, R. & Kenis, P. J. A., Aug 7 2019, In: Lab on a chip. 19, 15, p. 2598-2609 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cycloparaffins
  • Microfluidics
  • Infrared imaging
  • Fourier Analysis
  • Protein Folding

• Relating strain hardening moduli in high density polyethylene copolymers to anisotropic molecular deformation using infrared spectroscopic imaging

  Mukherjee, P., Ghosh, A., Lamborn, M. J., Monwar, M. M., Fodor, J. S., DesLauriers, P. J. & Bhargava, R., May 20 2019, In: Polymer. 172, p. 398-403 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Copolymers
  • High density polyethylenes
  • Polyethylene
  • Strain hardening
  • Infrared radiation

• Reply to Paraskevaidi et al. Epithelial and microenvironment characterization is key to understanding and improving diagnoses

  Yeh, K., Mittal, S. & Bhargava, R., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 11, p. 4753-4754 2 p.

  Research output: Contribution to journal › Letter › peer-review
• 2018

  Agile optoelectronic fiber sources for hyperspectral chemical sensing from SWIR to LWIR

  Kang, I., Grant, A., Dinu, M., Jaques, J., Pfister, L., Bhargava, R. & Carney, P. S., 2018, Algorithms and Technologies for Multispectral, Hyperspectral, and Ultraspectral Imagery XXIV. Messinger, D. W. & Velez-Reyes, M. (eds.). SPIE, 106441E. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 10644).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Optoelectronics
  • Sensing
  • Infrared
  • Optoelectronic devices
  • Wavelength

• A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability

  Jadaliha, M., Gholamalamdari, O., Tang, W., Zhang, Y., Petracovici, A., Hao, Q., Tariq, A., Kim, T. G., Holton, S. E., Singh, D. K., Li, X. L., Freier, S. M., Ambs, S., Bhargava, R., Lal, A., Prasanth, S. G., Ma, J. & Prasanth, K. V., Nov 2018, In: PLoS genetics. 14, 11, e1007802.

  Research output: Contribution to journal › Article › peer-review

  • tumor suppressor genes
  • non-coding RNA
  • breast neoplasms
  • Long Noncoding RNA
  • RNA Stability

• Application of Vibrational Spectroscopy and Imaging to Point-of-Care Medicine: A Review

  Pahlow, S., Weber, K., Popp, J., Wood, B. R., Kochan, K., Rüther, A., Perez-Guaita, D., Heraud, P., Stone, N., Dudgeon, A., Gardner, B., Reddy, R., Mayerich, D. & Bhargava, R., Sep 1 2018, In: Applied Spectroscopy. 72, 1_suppl, p. 52-84 33 p.

  Research output: Contribution to journal › Article › peer-review

• FT-IR- and Raman-based biochemical profiling of the early stage of pulmonary metastasis of breast cancer in mice

  Chrabaszcz, K., Kochan, K., Fedorowicz, A., Jasztal, A., Buczek, E., Leslie, L. S., Bhargava, R., Malek, K., Chlopicki, S. & Marzec, K. M., May 7 2018, In: Analyst. 143, 9, p. 2042-2050 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycogen
  • Lipids
  • Raman spectroscopy
  • cancer
  • lipid

• Infrared Spectroscopic Imaging Advances as an Analytical Technology for Biomedical Sciences

  Wrobel, T. P. & Bhargava, R., Feb 6 2018, In: Analytical Chemistry. 90, 3, p. 1444-1463 20 p.

  Research output: Contribution to journal › Review article › peer-review

• Model-guided design and characterization of a high-precision 3D printing process for carbohydrate glass

  Gelber, M. K., Hurst, G., Comi, T. J. & Bhargava, R., Aug 2018, In: Additive Manufacturing. 22, p. 38-50 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Carbohydrates
  • Printing
  • Glass
  • Palatinit
  • Nozzles

• Multimodal Chemical Analysis of the Brain by High Mass Resolution Mass Spectrometry and Infrared Spectroscopic Imaging

  Neumann, E. K., Comi, T. J., Spegazzini, N., Mitchell, J. W., Rubakhin, S. S., Gillette, M. U., Bhargava, R. & Sweedler, J. V., Oct 2 2018, In: Analytical Chemistry. 90, 19, p. 11572-11580 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometry
  • Infrared radiation
  • Brain
  • Imaging techniques
  • Chemical analysis

• Pixelated spatial gene expression analysis from tissue

  Ganguli, A., Ornob, A., Spegazzini, N., Liu, Y., Damhorst, G., Ghonge, T., Thornton, B., Konopka, C. J., Dobrucki, W., Clare, S. E., Bhargava, R., Smith, A. M., Kosari, F. & Bashir, R., Dec 1 2018, In: Nature communications. 9, 1, 202.

  Research output: Contribution to journal › Article › peer-review

  • gene expression
  • Gene expression
  • Tissue
  • ribonucleic acids
  • Amplification

• Plasmon-enhanced upconversion: Engineering enhancement and quenching at nano and macro scales

  Rasskazov, I. L., Wang, L., Murphy, C. J., Bhargava, R. & Carney, P. S., Jan 1 2018, In: Optical Materials Express. 8, 12, p. 3787-3804 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Plasmons
  • Metal nanoparticles
  • Quenching
  • Macros
  • Photons

• Probe-Sample Interaction-Independent Atomic Force Microscopy-Infrared Spectroscopy: Toward Robust Nanoscale Compositional Mapping

  Kenkel, S., Mittal, A., Mittal, S. & Bhargava, R., Aug 7 2018, In: Analytical Chemistry. 90, 15, p. 8845-8855 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Infrared spectroscopy
  • Atomic force microscopy
  • Infrared radiation
  • Epithelial Cells
  • Imaging techniques

• Relating Post-yield Mechanical Behavior in Polyethylenes to Spatially Varying Molecular Deformation Using Infrared Spectroscopic Imaging: Homopolymers

  Mukherjee, P., Ghosh, A., Spegazzini, N., Lamborn, M. J., Monwar, M. M., Deslauriers, P. J. & Bhargava, R., May 22 2018, In: Macromolecules. 51, 10, p. 3836-3844 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Polyethylenes
  • Homopolymerization
  • Infrared radiation
  • High density polyethylenes
  • Imaging techniques

• Selecting optimal features from Fourier transform infrared spectroscopy for discrete-frequency imaging

  Mankar, R., Walsh, M. J., Bhargava, R., Prasad, S. & Mayerich, D., Mar 7 2018, In: Analyst. 143, 5, p. 1147-1156 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Histology
  • Fourier transform infrared spectroscopy
  • histology
  • Fourier Transform Infrared Spectroscopy
  • FTIR spectroscopy

• Simultaneous cancer and tumor microenvironment subtyping using confocal infrared microscopy for all-digital molecular histopathology

  Mittal, S., Yeh, K., Suzanne Leslie, L., Kenkel, S., Kajdacsy-Balla, A. & Bhargava, R., Jun 19 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 25, p. E5651-E5660

  Research output: Contribution to journal › Article › peer-review

  • Tumor Microenvironment
  • Confocal Microscopy
  • Breast
  • Epithelial Cells
  • Semiconductor Lasers
• 2017

  BIM-Sim: Interactive simulation of broadband imaging using mie theory

  Berisha, S., van Dijk, T., Bhargava, R., Carney, P. S. & Mayerich, D., Feb 20 2017, In: Frontiers in Physics. 5, FEB, 5.

  Research output: Contribution to journal › Article › peer-review

  • Mie Theory
  • Interactive Simulation
  • Broadband
  • Electromagnetic Fields
  • Mie scattering

• Characterization of the structure of low-e substrates and consequences for IR transflection measurements

  DeVetter, B. M., Kenkel, S., Mittal, S., Bhargava, R. & Wrobel, T. P., Jul 2017, In: Vibrational Spectroscopy. 91, p. 119-127 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Infrared radiation
  • Substrates
  • Infrared spectroscopy
  • Gold
  • Light propagation

• Dielectric Sphere Clusters as a Model to Understand Infrared Spectroscopic Imaging Data Recorded from Complex Samples

  Rasskazov, I. L., Spegazzini, N., Carney, P. S. & Bhargava, R., Oct 17 2017, In: Analytical chemistry. 89, 20, p. 10813-10818 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Infrared radiation
  • Imaging techniques
  • Polymethyl Methacrylate
  • Scattering
  • Polydispersity

• Keeping current: An update on the structure and evaluation of a program for graduate women interested in engineering Academia

  Jackson, N. D., Tyler, K. I., Li, Y., Chen, W. T., Liu, C. & Bhargava, R., Jun 24 2017, In: ASEE Annual Conference and Exposition, Conference Proceedings. 2017-June

  Research output: Contribution to journal › Conference article › peer-review

  • Students
  • Feedback
  • Technical presentations
  • Pipelines
  • Engineers

• Mapping Solvation Environments in Porous Metal-Organic Frameworks with Infrared Chemical Imaging

  Ghosh, A., Mukherjee, P., Deb, S. & Bhargava, R., Nov 2 2017, In: Journal of Physical Chemistry Letters. 8, 21, p. 5325-5330 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Metal-Organic Frameworks
  • Solvation
  • solvation
  • Infrared radiation
  • Imaging techniques

• Overcoming difficulties in research statement preparation for the academic job search: Expansion of a peer-focused professional development program

  Tyler, K. I., Li, Y., Jackson, N. D., Chen, W. T., Liu, C. & Bhargava, R., Jun 24 2017, In: ASEE Annual Conference and Exposition, Conference Proceedings. 2017-June

  Research output: Contribution to journal › Conference article › peer-review

  • Technical presentations
  • Students

• PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes

  Singh, D. K., Gholamalamdari, O., Jadaliha, M., Li, X. L., Lin, Y. C., Zhang, Y., Guang, S., Hashemikhabir, S., Tiwari, S., Zhu, Y. J., Khan, A., Thomas, A., Chakraborty, A., Macias, V., Balla, A. K., Bhargava, R., Janga, S. C., Ma, J., Prasanth, S. G., Lal, A. & 1 others, Prasanth, K. V., Oct 1 2017, In: Carcinogenesis. 38, 10, p. 966-975 10 p., bgx062.

  Research output: Contribution to journal › Article › peer-review

  • cdc Genes
  • Triple Negative Breast Neoplasms
  • Breast Neoplasms
  • RNA Polymerase II
  • lens epithelium-derived growth factor

• Quantitative Chemical Imaging of Nonplanar Microfluidics

  Gelber, M. K., Kole, M. R., Kim, N., Aluru, N. R. & Bhargava, R., Feb 7 2017, In: Analytical chemistry. 89, 3, p. 1716-1723 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Stimulated Raman scattering
  • Microfluidics
  • Aberrations
  • Refractive index
  • Imaging techniques

• Rapid visualization of macromolecular orientation by discrete frequency mid-infrared spectroscopic imaging

  Wrobel, T. P., Mukherjee, P. & Bhargava, R., Jan 7 2017, In: Analyst. 142, 1, p. 75-79 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Semiconductor Lasers
  • Molecular Structure
  • Fourier Analysis
  • Polymers
  • Infrared radiation

• Refractive index sensing and surface-enhanced Raman spectroscopy using silver-gold layered bimetallic plasmonic crystals

  Kang, S., Lehman, S. E., Schulmerich, M. V., Le, A. P., Lee, T. W., Gray, S. K., Bhargava, R. & Nuzzo, R. G., 2017, In: Beilstein Journal of Nanotechnology. 8, 1, p. 2492-2503 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Plasmonics
  • Raman spectroscopy
  • Refractive index
  • Silver
  • Gold

• The Chemistry of Thought: The Role of the Measurement Sciences in Brain Research

  Andrews, A. M., Bhargava, R., Kennedy, R., Li, L. & Sweedler, J. V., May 2 2017, In: Analytical Chemistry. 89, 9, p. 4757 1 p.

  Research output: Contribution to journal › Editorial › peer-review
• 2016

  A four class model for digital breast histopathology using high-definition Fourier transform infrared (FT-IR) spectroscopic imaging

  Mittal, S., Wrobel, T. P., Leslie, L. S., Kadjacsy-Balla, A. & Bhargava, R., Jan 1 2016, Medical Imaging 2016: Digital Pathology. Madabhushi, A. & Gurcan, M. N. (eds.). SPIE, 979118. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 9791).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Fourier Analysis
  • breast
  • Fourier transforms
  • Infrared radiation
  • Tissue

• Automated prostate tissue referencing for cancer detection and diagnosis

  Kwak, J. T., Hewitt, S. M., Kajdacsy-Balla, A. A., Sinha, S. & Bhargava, R., Jun 1 2016, In: BMC bioinformatics. 17, 1, 227.

  Research output: Contribution to journal › Article › peer-review

  • Cancer
  • Tissue
  • Prostate
  • Retrieval
  • Similarity