1991 …2019
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Research Output 1991 2019

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2019

Aging sensitizes male mice to cognitive dysfunction induced by central HIV-1 gp120

Sparkman, N. L., Buchanan, J. B., Dos Santos, N. L., Johnson, R. W. & Burton, M. D., Oct 15 2019, In : Experimental Gerontology. 126, 110694.

Research output: Contribution to journalArticle

HIV-1
Animals
Aging of materials
AIDS Dementia Complex
Brain

Behavioral response to fiber feedingis cohort-dependent and associated with gut microbiota composition in mice

Mailing, L. J., Allen, J. M., Pence, B. D., Rytych, J., Sun, Y., Bhattacharya, T. K., Park, P., Cross, T. W. L., McCusker, R. H., Swanson, K. S., Fahey, G. C., Rhodes, J. S., Kelley, K. W., Johnson, R. W. & Woods, J. A., Feb 1 2019, In : Behavioural Brain Research. 359, p. 731-736 6 p.

Research output: Contribution to journalArticle

Cellulose
Microbiota
Learning
Bilophila
Aptitude

Dietary iron deficiency impaired peripheral immunity but did not alter brain microglia in PRRSV-infected neonatal piglets

Leyshon, B. J., Ji, P., Caputo, M. P., Matt, S. M. & Johnson, R. W., Jan 1 2019, In : Frontiers in immunology. 10, FEB, 3150.

Research output: Contribution to journalArticle

Open Access
Porcine respiratory and reproductive syndrome virus
Dietary Iron
Microglia
Immunity
Iron

Herring roe oil supplementation alters microglial cell gene expression and reduces peripheral inflammation after immune activation in a neonatal piglet model

Caputo, M. P., Radlowski, E. C., Lawson, M. A., Antonson, A. M., Watson, J. E., Matt, S. M., Leyshon, B. J., Das, A. & Johnson, R. W., Jan 1 2019, In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Oils
Inflammation
Gene Expression
Unsaturated Fatty Acids
Occipital Lobe

Role of human Keap1 S53 and S293 residues in modulating the binding of Keap1 to Nrf2

Wei, S., Pei, Y., Wang, Y., Guan, H., Huang, Y., Xing, T., Johnson, R. W. & Wang, D., Mar 1 2019, In : Biochimie. 158, p. 73-81 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Oxidative stress
Oxidative Stress
Assays
Proteolysis
2018

Altered hippocampal gene expression and morphology in fetal piglets following maternal respiratory viral infection

Antonson, A. M., Balakrishnan, B., Radlowski, E. C., Petr, G. & Johnson, R. W., Jun 1 2018, In : Developmental Neuroscience. 40, 2, p. 104-119 16 p.

Research output: Contribution to journalArticle

Virus Diseases
Respiratory Tract Infections
Mothers
Porcine respiratory and reproductive syndrome virus
Gene Expression

Butyrate and dietary soluble fiber improve neuroinflammation associated with aging in mice

Matt, S. M., Allen, J. M., Lawson, M. A., Mailing, L. J., Woods, J. A. & Johnson, R. W., Aug 14 2018, In : Frontiers in immunology. 9, AUG, 1832.

Research output: Contribution to journalArticle

Butyrates
Dietary Fiber
Diet
Inulin
Volatile Fatty Acids

Effect of imidacloprid ingestion on immune responses to porcine reproductive and respiratory syndrome virus

Hernandez, J., Volland, A., Leyshon, B. J., Juda, M., Ridlon, J. M., Johnson, R. W. & Steelman, A. J., Dec 1 2018, In : Scientific Reports. 8, 1, 11615.

Research output: Contribution to journalArticle

Porcine respiratory and reproductive syndrome virus
Eating
Swine
Viral RNA
Nicotinic Receptors

Inhibition of DNA methylation with zebularine alters lipopolysaccharide sickness behavior and neuroinflammation in mice

Matt, S. M., Zimmerman, J. D., Lawson, M. A., Bustamante, A. C., Uddin, M. & Johnson, R. W., Sep 18 2018, In : Frontiers in Neuroscience. 12, SEP, 636.

Research output: Contribution to journalArticle

pyrimidin-2-one beta-ribofuranoside
Illness Behavior
DNA Methylation
Lipopolysaccharides
Methyltransferases

Microglia priming by interleukin-6 signaling is enhanced in aged mice

Garner, K. M., Amin, R., Johnson, R. W., Scarlett, E. J. & Burton, M. D., Nov 15 2018, In : Journal of Neuroimmunology. 324, p. 90-99 10 p.

Research output: Contribution to journalArticle

Microglia
Interleukin-6
Illness Behavior
Cytokines
Lipopolysaccharides
2017

Anti-inflammatory ω-3 endocannabinoid epoxides

McDougle, D. R., Watson, J. E., Abdeen, A. A., Adili, R., Caputo, M. P., Krapf, J. E., Johnson, R. W., Kilian, K., Holinstat, M. & Das, A., Jul 25 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. E6034-E6043

Research output: Contribution to journalArticle

Endocannabinoids
Epoxy Compounds
Anti-Inflammatory Agents
Acids
Cytokines

Dose-dependent decrease in mortality with no cognitive or muscle function improvements due to dietary EGCG supplementation in aged mice

Pence, B. D., Bhattacharya, T. K., Park, P., Rytych, J. L., Allen, J. M., Sun, Y., McCusker, R. H., Kelley, K. W., Johnson, R. W., Rhodes, J. S. & Woods, J. A., May 1 2017, In : Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 42, 5, p. 495-502 8 p.

Research output: Contribution to journalArticle

Muscles
Mortality
Cognition
Diet
epigallocatechin gallate

Influenza infection triggers disease in a genetic model of experimental autoimmune encephalomyelitis

Blackmore, S., Hernandez, J., Juda, M., Ryder, E., Freund, G. G., Johnson, R. W. & Steelman, A. J., Jul 25 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. E6107-E6116

Research output: Contribution to journalArticle

Autoimmune Experimental Encephalomyelitis
Genetic Models
Human Influenza
Multiple Sclerosis
Virus Diseases

Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice

Pence, B. D., Bhattacharya, T. K., Park, P., Rytych, J. L., Allen, J. M., Sun, Y., McCusker, R. H., Kelley, K. W., Johnson, R. W., Rhodes, J. S. & Woods, J. A., Nov 1 2017, In : Experimental Gerontology. 98, p. 22-29 8 p.

Research output: Contribution to journalArticle

beta-Alanine
Muscle
Muscles
Mortality
Cognition

Maternal viral infection during pregnancy elicits anti-social behavior in neonatal piglet offspring independent of postnatal microglial cell activation

Antonson, A. M., Radlowski, E. C., Lawson, M. A., Rytych, J. L. & Johnson, R. W., Jan 1 2017, In : Brain, Behavior, and Immunity. 59, p. 300-312 13 p.

Research output: Contribution to journalArticle

Porcine respiratory and reproductive syndrome virus
Social Behavior
Virus Diseases
Mothers
Microglia
Illness Behavior
Lipopolysaccharides
Hippocampus
NF-E2-Related Factor 2
Liver
2016

Aging and peripheral lipopolysaccharide can modulate epigenetic regulators and decrease IL-1β promoter DNA methylation in microglia

Matt, S. M., Lawson, M. A. & Johnson, R. W., Nov 1 2016, In : Neurobiology of Aging. 47, p. 1-9 9 p.

Research output: Contribution to journalArticle

Microglia
DNA Methylation
Interleukin-1beta
Epigenomics
Lipopolysaccharides

Dietary luteolin reduces proinflammatory microglia in the brain of senescent mice

Burton, M. D., Rytych, J. L., Amin, R. & Johnson, R. W., Aug 1 2016, In : Rejuvenation research. 19, 4, p. 286-292 7 p.

Research output: Contribution to journalArticle

Luteolin
Microglia
Brain
Interleukin-1
Interleukin-6

Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development

Schachtschneider, K. M., Liu, Y., Rund, L. A., Madsen, O., Johnson, R. W., Groenen, M. A. M. & Schook, L. B., Nov 3 2016, In : BMC genomics. 17, 1, 856.

Research output: Contribution to journalArticle

DNA Methylation
Swine
Iron
Genes
Blood-Brain Barrier

Peripheral viral infection induced microglial sensome genes and enhanced microglial cell activity in the hippocampus of neonatal piglets

Ji, P., Schachtschneider, K. M., Schook, L. B., Walker, F. R. & Johnson, R. W., May 1 2016, In : Brain, Behavior, and Immunity. 54, p. 243-251 9 p.

Research output: Contribution to journalArticle

Microglia
Virus Diseases
Hippocampus
Porcine respiratory and reproductive syndrome virus
Genes

Postnatal iron deficiency alters brain development in piglets

Leyshon, B. J., Radlowski, E. C., Mudd, A. T., Steelman, A. J. & Johnson, R. W., Jan 1 2016, In : Journal of Nutrition. 146, 7, p. 1420-1427 8 p.

Research output: Contribution to journalArticle

Iron
Brain
Hippocampus
Corpus Callosum
Hematocrit
NF-E2-Related Factor 2
Microglia
Gene expression
Young Adult
Brain
2015

Early postnatal respiratory viral infection alters hippocampal neurogenesis, cell fate, and neuron morphology in the neonatal piglet

Conrad, M. S., Harasim, S., Rhodes, J. S., Van Alstine, W. G. & Johnson, R. W., Feb 1 2015, In : Brain, Behavior, and Immunity. 44, p. 82-90 9 p.

Research output: Contribution to journalArticle

Porcine respiratory and reproductive syndrome virus
Neurogenesis
Virus Diseases
Respiratory Tract Infections
Neurons

Early postnatal respiratory viral infection induces structural and neurochemical changes in the neonatal piglet brain

Conrad, M. S., Sutton, B. P., Larsen, R., van Alstine, W. G. & Johnson, R. W., Jan 1 2015, In : Brain, Behavior, and Immunity. 48, p. 326-335 10 p.

Research output: Contribution to journalArticle

Porcine respiratory and reproductive syndrome virus
Virus Diseases
Respiratory Tract Infections
Brain
Cerebral Aqueduct

Effects of exercise and dietary epigallocatechin gallate and β-alanine on skeletal muscle in aged mice

Pence, B. D., Gibbons, T. E., Bhattacharya, T. K., Mach, H., Ossyra, J. M., Petr, G., Martin, S. A., Wang, L., Rubakhin, S. S., Sweedler, J. V., McCusker, R. H., Kelley, K. W., Rhodes, J. S., Johnson, R. W. & Woods, J. A., Oct 26 2015, In : Applied Physiology, Nutrition and Metabolism. 41, 2, p. 181-190 10 p.

Research output: Contribution to journalArticle

Running
Alanine
Skeletal Muscle
Gene Expression
Hand Strength

Exercise but not (-)-epigallocatechin-3-gallate or β-alanine enhances physical fitness, brain plasticity, and behavioral performance in mice

Bhattacharya, T. K., Pence, B. D., Ossyra, J. M., Gibbons, T. E., Perez, S., McCusker, R. H., Kelley, K. W., Johnson, R. W., Woods, J. A. & Rhodes, J. S., Jun 1 2015, In : Physiology and Behavior. 145, p. 29-37 9 p.

Research output: Contribution to journalArticle

Physical Fitness
Alanine
Exercise
Running
Brain
piglets
brain
Brain
behavior problems
postpartum period
2014

A neonatal piglet model for investigating brain and cognitive development in small for gestational age human infants

Radlowski, E. C., Conrad, M. S., Lezmi, S., Dilger, R. N., Sutton, B., Larsen, R. & Johnson, R. W., Mar 17 2014, In : PloS one. 9, 3, e91951.

Research output: Contribution to journalArticle

small for gestational age
Small for Gestational Age Infant
cognitive development
Metabolites
Gestational Age
Sus scrofa
Magnetic resonance
magnetic resonance imaging
Magnetic resonance imaging
piglets

Dietary broccoli mildly improves neuroinflammation in aged mice but does not reduce lipopolysaccharide-induced sickness behavior

Townsend, B. E., Chen, Y. J., Jeffery, E. H. & Johnson, R. W., Jan 1 2014, In : Nutrition Research. 34, 11, p. 990-999 10 p.

Research output: Contribution to journalArticle

Illness Behavior
Brassica
Lipopolysaccharides
Oxidative Stress
Brain

Early supplementation of phospholipids and gangliosides affects brain and cognitive development in neonatal piglets

Liu, H., Radlowski, E. C., Conrad, M. S., Li, Y., Dilger, R. N. & Johnson, R. W., Jan 1 2014, In : Journal of Nutrition. 144, 12, p. 1903-1909 7 p.

Research output: Contribution to journalArticle

Gangliosides
Phospholipids
Brain
Human Milk
Diet

Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning

Elmore, M. R. P., Burton, M. D., Conrad, M. S., Rytych, J. L., Van Alstine, W. G. & Johnson, R. W., Feb 7 2014, In : Journal of Neuroscience. 34, 6, p. 2120-2129 10 p.

Research output: Contribution to journalArticle

Microglia
Virus Diseases
Porcine respiratory and reproductive syndrome virus
Respiratory Tract Infections
Hippocampus

Voluntary wheel running, but not a diet containing (-)-epigallocatechin-3-gallate and β-alanine, improves learning, memory and hippocampal neurogenesis in aged mice

Gibbons, T. E., Pence, B. D., Petr, G., Ossyra, J. M., Mach, H. C., Bhattacharya, T. K., Perez, S., Martin, S. A., McCusker, R. H., Kelley, K. W., Rhodes, J. S., Johnson, R. W. & Woods, J. A., Oct 1 2014, In : Behavioural Brain Research. 272, p. 131-140 10 p.

Research output: Contribution to journalArticle

Neurogenesis
Bromodeoxyuridine
Running
Alanine
Learning
2013
Interleukin-6
Cytokine Receptor gp130
Microglia
Infection
Illness Behavior
2012

Brain growth of the domestic pig (Sus scrofa) from 2 to 24 weeks of age: A longitudinal MRI study

Conrad, M. S., Dilger, R. N. & Johnson, R. W., Oct 1 2012, In : Developmental Neuroscience. 34, 4, p. 291-298 8 p.

Research output: Contribution to journalArticle

Sus scrofa
Longitudinal Studies
Brain
Growth
Swine

Early life iron deficiency impairs spatial cognition in neonatal piglets

Rytych, J. L., Elmore, M. R. P., Burton, M. D., Conrad, M. S., Donovan, S. M., Dilger, R. N. & Johnson, R. W., Nov 1 2012, In : Journal of Nutrition. 142, 11, p. 2050-2056 7 p.

Research output: Contribution to journalArticle

Sudden Infant Death
Cognition
Iron
Hippocampus
Prefrontal Cortex

Effects of mannan oligosaccharide on cytokine secretions by porcine alveolar macrophages and serum cytokine concentrations in nursery pigs

Che, T. M., Johnson, R. W., Kelley, K. W., Dawson, K. A., Moran, C. A. & Pettigrew, J. E., Feb 1 2012, In : Journal of animal science. 90, 2, p. 657-668 12 p.

Research output: Contribution to journalArticle

Mannans
Nurseries
Alveolar Macrophages
Oligosaccharides
oligosaccharides

Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection

Jurgens, H. A. & Johnson, R. W., Aug 1 2012, In : Brain, Behavior, and Immunity. 26, 6, p. 1006-1016 11 p.

Research output: Contribution to journalArticle

Cognition
Human Influenza
Infection
Virus Diseases
Hippocampus

Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1

Chiu, G. S., Chatterjee, D., Darmody, P. T., Walsh, J. P., Meling, D. D., Johnson, R. W. & Freund, G. G., Oct 3 2012, In : Journal of Neuroscience. 32, 40, p. 13945-13955 11 p.

Research output: Contribution to journalArticle

Caspase 1
Adenosine
Anterograde Amnesia
Caffeine
Interleukin-1

Influenza Infection Induces Neuroinflammation, Alters Hippocampal Neuron Morphology, and Impairs Cognition in Adult Mice

Jurgens, H. A., Amancherla, K. & Johnson, R. W., Mar 21 2012, In : Journal of Neuroscience. 32, 12, p. 3958-3968 11 p.

Research output: Contribution to journalArticle

Cognition
Human Influenza
Neurons
Infection
Brain
Cytokine Receptor gp130
Fear
Interleukin-6
Brain
Infection

Magnetic resonance imaging of the neonatal piglet brain

Conrad, M. S., Dilger, R. N., Nickolls, A. & Johnson, R. W., Feb 1 2012, In : Pediatric Research. 71, 2, p. 179-184 6 p.

Research output: Contribution to journalArticle

Magnetic Resonance Imaging
Brain
Histological Techniques
Diencephalon
Sus scrofa

Mannan oligosaccharide increases serum concentrations of antibodies and inflammatory mediators in weanling pigs experimentally infected with porcine reproductive and respiratory syndrome virus

Che, T. M., Song, M., Liu, Y., Johnson, R. W., Kelley, K. W., Van Alstine, W. G., Dawson, K. A. & Pettigrew, J. E., Aug 1 2012, In : Journal of animal science. 90, 8, p. 2784-2793 10 p.

Research output: Contribution to journalArticle

Porcine respiratory and reproductive syndrome virus
Mannans
Porcine reproductive and respiratory syndrome virus
weanlings
Oligosaccharides

Place and direction learning in a spatial T-maze task by neonatal piglets

Elmore, M. R. P., Dilger, R. N. & Johnson, R. W., Jul 1 2012, In : Animal cognition. 15, 4, p. 667-676 10 p.

Research output: Contribution to journalArticle

Scopolamine Hydrobromide
piglets
learning
Learning
Reward
2011
Illness Behavior
Cytokine Receptor gp130
Lipopolysaccharides
Interleukin-6
Brain

Mannan oligosaccharide improves immune responses and growth efficiency of nursery pigs experimentally infected with porcine reproductive and respiratory syndrome virus

Che, T. M., Johnson, R. W., Kelley, K. W., Van Alstine, W. G., Dawson, K. A., Moran, C. A. & Pettigrew, J. E., Aug 2011, In : Journal of Animal Science. 89, 8, p. 2592-2602 11 p.

Research output: Contribution to journalArticle

Porcine respiratory and reproductive syndrome virus
Mannans
Nurseries
Porcine reproductive and respiratory syndrome virus
Oligosaccharides

Mannan oligosaccharide modulates gene expression profile in pigs experimentally infected with porcine reproductive and respiratory syndrome virus

Che, T. M., Johnson, R. W., Kelley, K. W., van Alstine, W. G., Dawson, K. A., Moran, C. A. & Pettigrew, J. E., Oct 2011, In : Journal of Animal Science. 89, 10, p. 3016-3029 14 p.

Research output: Contribution to journalArticle

Porcine respiratory and reproductive syndrome virus
Mannans
Porcine reproductive and respiratory syndrome virus
Oligosaccharides
Transcriptome
2010
Methamphetamine
Fever
Microglia
Injections
Cytokines

Behavioral assessment of cognitive function using a translational neonatal piglet model

Dilger, R. N. & Johnson, R. W., Oct 1 2010, In : Brain, Behavior, and Immunity. 24, 7, p. 1156-1165 10 p.

Research output: Contribution to journalArticle

Poly I-C
Cognition
Injections
Learning
Cues

Can consuming flavonoids restore old microglia to their youthful state?

Jang, S. & Johnson, R. W., Dec 1 2010, In : Nutrition reviews. 68, 12, p. 719-728 10 p.

Research output: Contribution to journalArticle

Microglia
Flavonoids
Brain
Cytokines
Cognition