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Research Output

2020

Altered Hippocampal Epigenetic Regulation Underlying Reduced Cognitive Development in Response to Early Life Environmental Insults

Schachtschneider, K. M., Welge, M. E., Auvil, L., Chaki, S., Rund, L. A., Madsen, O., Elmore, M. R. P., Johnson, R. W., Groenen, M. A. M. & Schook, L. B., Feb 4 2020, In : Genes. 11, 2, 162.

Research output: Contribution to journalArticle

Open Access

Hydrolyzed Fat Formula Increases Brain White Matter in Small for Gestational Age and Appropriate for Gestational Age Neonatal Piglets

Caputo, M. P., Williams, J. N., Drnevich, J., Radlowski, E. C., Larsen, R. J., Sutton, B. P., Leyshon, B. J., Hussain, J., Nakamura, M. T., Kuchan, M. J., Das, T. & Johnson, R. W., Feb 12 2020, In : Frontiers in Pediatrics. 8, 32.

Research output: Contribution to journalArticle

Open Access
2019

Aging sensitizes male mice to cognitive dysfunction induced by central HIV-1 gp120

Sparkman, N. L., Buchanan, J. B., Dos Santos, N. L., Johnson, R. W. & Burton, M. D., Oct 15 2019, In : Experimental Gerontology. 126, 110694.

Research output: Contribution to journalArticle

Behavioral response to fiber feedingis cohort-dependent and associated with gut microbiota composition in mice

Mailing, L. J., Allen, J. M., Pence, B. D., Rytych, J., Sun, Y., Bhattacharya, T. K., Park, P., Cross, T. W. L., McCusker, R. H., Swanson, K. S., Fahey, G. C., Rhodes, J. S., Kelley, K. W., Johnson, R. W. & Woods, J. A., Feb 1 2019, In : Behavioural Brain Research. 359, p. 731-736 6 p.

Research output: Contribution to journalArticle

Dietary iron deficiency impaired peripheral immunity but did not alter brain microglia in PRRSV-infected neonatal piglets

Leyshon, B. J., Ji, P., Caputo, M. P., Matt, S. M. & Johnson, R. W., Jan 1 2019, In : Frontiers in immunology. 10, FEB, 3150.

Research output: Contribution to journalArticle

Open Access

Herring roe oil supplementation alters microglial cell gene expression and reduces peripheral inflammation after immune activation in a neonatal piglet model

Caputo, M. P., Radlowski, E. C., Lawson, M. A., Antonson, A. M., Watson, J. E., Matt, S. M., Leyshon, B. J., Das, A. & Johnson, R. W., Oct 2019, In : Brain, Behavior, and Immunity. 81, p. 455-469 15 p.

Research output: Contribution to journalArticle

Maternal viral infection causes global alterations in porcine fetal microglia

Antonson, A. M., Lawson, M. A., Caputo, M. P., Matt, S. M., Leyshon, B. J. & Johnson, R. W., Oct 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 40, p. 20190-20200 11 p.

Research output: Contribution to journalArticle

Open Access

Role of human Keap1 S53 and S293 residues in modulating the binding of Keap1 to Nrf2

Wei, S., Pei, Y., Wang, Y., Guan, H., Huang, Y., Xing, T., Johnson, R. W. & Wang, D., Mar 2019, In : Biochimie. 158, p. 73-81 9 p.

Research output: Contribution to journalArticle

2018

Altered hippocampal gene expression and morphology in fetal piglets following maternal respiratory viral infection

Antonson, A. M., Balakrishnan, B., Radlowski, E. C., Petr, G. & Johnson, R. W., Jun 1 2018, In : Developmental Neuroscience. 40, 2, p. 104-119 16 p.

Research output: Contribution to journalArticle

Butyrate and dietary soluble fiber improve neuroinflammation associated with aging in mice

Matt, S. M., Allen, J. M., Lawson, M. A., Mailing, L. J., Woods, J. A. & Johnson, R. W., Aug 14 2018, In : Frontiers in immunology. 9, AUG, 1832.

Research output: Contribution to journalArticle

Effect of imidacloprid ingestion on immune responses to porcine reproductive and respiratory syndrome virus

Hernandez, J., Volland, A., Leyshon, B. J., Juda, M., Ridlon, J. M., Johnson, R. W. & Steelman, A. J., Dec 1 2018, In : Scientific reports. 8, 1, 11615.

Research output: Contribution to journalArticle

Inhibition of DNA methylation with zebularine alters lipopolysaccharide sickness behavior and neuroinflammation in mice

Matt, S. M., Zimmerman, J. D., Lawson, M. A., Bustamante, A. C., Uddin, M. & Johnson, R. W., Sep 18 2018, In : Frontiers in Neuroscience. 12, SEP, 636.

Research output: Contribution to journalArticle

Microglia priming by interleukin-6 signaling is enhanced in aged mice

Garner, K. M., Amin, R., Johnson, R. W., Scarlett, E. J. & Burton, M. D., Nov 15 2018, In : Journal of Neuroimmunology. 324, p. 90-99 10 p.

Research output: Contribution to journalArticle

2017

Anti-inflammatory ω-3 endocannabinoid epoxides

McDougle, D. R., Watson, J. E., Abdeen, A. A., Adili, R., Caputo, M. P., Krapf, J. E., Johnson, R. W., Kilian, K. A., Holinstat, M. & Das, A., Jul 25 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. E6034-E6043

Research output: Contribution to journalArticle

Dose-dependent decrease in mortality with no cognitive or muscle function improvements due to dietary EGCG supplementation in aged mice

Pence, B. D., Bhattacharya, T. K., Park, P., Rytych, J. L., Allen, J. M., Sun, Y., McCusker, R. H., Kelley, K. W., Johnson, R. W., Rhodes, J. S. & Woods, J. A., May 1 2017, In : Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 42, 5, p. 495-502 8 p.

Research output: Contribution to journalArticle

Influenza infection triggers disease in a genetic model of experimental autoimmune encephalomyelitis

Blackmore, S., Hernandez, J., Juda, M., Ryder, E., Freund, G. G., Johnson, R. W. & Steelman, A. J., Jul 25 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. E6107-E6116

Research output: Contribution to journalArticle

Long-term supplementation with EGCG and beta-alanine decreases mortality but does not affect cognitive or muscle function in aged mice

Pence, B. D., Bhattacharya, T. K., Park, P., Rytych, J. L., Allen, J. M., Sun, Y., McCusker, R. H., Kelley, K. W., Johnson, R. W., Rhodes, J. S. & Woods, J. A., Nov 2017, In : Experimental Gerontology. 98, p. 22-29 8 p.

Research output: Contribution to journalArticle

Maternal viral infection during pregnancy elicits anti-social behavior in neonatal piglet offspring independent of postnatal microglial cell activation

Antonson, A. M., Radlowski, E. C., Lawson, M. A., Rytych, J. L. & Johnson, R. W., Jan 1 2017, In : Brain, Behavior, and Immunity. 59, p. 300-312 13 p.

Research output: Contribution to journalArticle

2016

Aging and peripheral lipopolysaccharide can modulate epigenetic regulators and decrease IL-1β promoter DNA methylation in microglia

Matt, S. M., Lawson, M. A. & Johnson, R. W., Nov 1 2016, In : Neurobiology of Aging. 47, p. 1-9 9 p.

Research output: Contribution to journalArticle

Dietary luteolin reduces proinflammatory microglia in the brain of senescent mice

Burton, M. D., Rytych, J. L., Amin, R. & Johnson, R. W., Aug 2016, In : Rejuvenation research. 19, 4, p. 286-292 7 p.

Research output: Contribution to journalArticle

Impact of neonatal iron deficiency on hippocampal DNA methylation and gene transcription in a porcine biomedical model of cognitive development

Schachtschneider, K. M., Liu, Y., Rund, L. A., Madsen, O., Johnson, R. W., Groenen, M. A. M. & Schook, L. B., Nov 3 2016, In : BMC genomics. 17, 1, 856.

Research output: Contribution to journalArticle

Neuro-immune dysfunction during brain aging: new insights in microglial cell regulation

Matt, S. M. & Johnson, R. W., Feb 2016, In : Current Opinion in Pharmacology. 26, p. 96-101 6 p.

Research output: Contribution to journalReview article

Peripheral viral infection induced microglial sensome genes and enhanced microglial cell activity in the hippocampus of neonatal piglets

Ji, P., Schachtschneider, K. M., Schook, L. B., Walker, F. R. & Johnson, R. W., May 1 2016, In : Brain, Behavior, and Immunity. 54, p. 243-251 9 p.

Research output: Contribution to journalArticle

Postnatal iron deficiency alters brain development in piglets

Leyshon, B. J., Radlowski, E. C., Mudd, A. T., Steelman, A. J. & Johnson, R. W., Jan 1 2016, In : Journal of Nutrition. 146, 7, p. 1420-1427 8 p.

Research output: Contribution to journalArticle

2015

Early postnatal respiratory viral infection alters hippocampal neurogenesis, cell fate, and neuron morphology in the neonatal piglet

Conrad, M. S., Harasim, S., Rhodes, J. S., Van Alstine, W. G. & Johnson, R. W., Feb 1 2015, In : Brain, Behavior, and Immunity. 44, p. 82-90 9 p.

Research output: Contribution to journalArticle

Early postnatal respiratory viral infection induces structural and neurochemical changes in the neonatal piglet brain

Conrad, M. S., Sutton, B. P., Larsen, R., van Alstine, W. G. & Johnson, R. W., Jan 1 2015, In : Brain, Behavior, and Immunity. 48, p. 326-335 10 p.

Research output: Contribution to journalArticle

Effects of exercise and dietary epigallocatechin gallate and β-alanine on skeletal muscle in aged mice

Pence, B. D., Gibbons, T. E., Bhattacharya, T. K., Mach, H., Ossyra, J. M., Petr, G., Martin, S. A., Wang, L., Rubakhin, S. S., Sweedler, J. V., McCusker, R. H., Kelley, K. W., Rhodes, J. S., Johnson, R. W. & Woods, J. A., Oct 26 2015, In : Applied Physiology, Nutrition and Metabolism. 41, 2, p. 181-190 10 p.

Research output: Contribution to journalArticle

Exercise but not (-)-epigallocatechin-3-gallate or β-alanine enhances physical fitness, brain plasticity, and behavioral performance in mice

Bhattacharya, T. K., Pence, B. D., Ossyra, J. M., Gibbons, T. E., Perez, S., McCusker, R. H., Kelley, K. W., Johnson, R. W., Woods, J. A. & Rhodes, J. S., Jun 1 2015, In : Physiology and Behavior. 145, p. 29-37 9 p.

Research output: Contribution to journalArticle

Feeding the beast: Can microglia in the senescent brain be regulated by diet?

Johnson, R. W., Jan 1 2015, In : Brain, Behavior, and Immunity. 43, p. 1-8 8 p.

Research output: Contribution to journalReview article

2014

A neonatal piglet model for investigating brain and cognitive development in small for gestational age human infants

Radlowski, E. C., Conrad, M. S., Lezmi, S., Dilger, R. N., Sutton, B., Larsen, R. & Johnson, R. W., Mar 17 2014, In : PloS one. 9, 3, e91951.

Research output: Contribution to journalArticle

Dietary broccoli mildly improves neuroinflammation in aged mice but does not reduce lipopolysaccharide-induced sickness behavior

Townsend, B. E., Chen, Y. J., Jeffery, E. H. & Johnson, R. W., Jan 1 2014, In : Nutrition Research. 34, 11, p. 990-999 10 p.

Research output: Contribution to journalArticle

Early supplementation of phospholipids and gangliosides affects brain and cognitive development in neonatal piglets

Liu, H., Radlowski, E. C., Conrad, M. S., Li, Y., Dilger, R. N. & Johnson, R. W., Jan 1 2014, In : Journal of Nutrition. 144, 12, p. 1903-1909 7 p.

Research output: Contribution to journalArticle

Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning

Elmore, M. R. P., Burton, M. D., Conrad, M. S., Rytych, J. L., Van Alstine, W. G. & Johnson, R. W., Feb 7 2014, In : Journal of Neuroscience. 34, 6, p. 2120-2129 10 p.

Research output: Contribution to journalArticle

Voluntary wheel running, but not a diet containing (-)-epigallocatechin-3-gallate and β-alanine, improves learning, memory and hippocampal neurogenesis in aged mice

Gibbons, T. E., Pence, B. D., Petr, G., Ossyra, J. M., Mach, H. C., Bhattacharya, T. K., Perez, S., Martin, S. A., McCusker, R. H., Kelley, K. W., Rhodes, J. S., Johnson, R. W. & Woods, J. A., Oct 1 2014, In : Behavioural Brain Research. 272, p. 131-140 10 p.

Research output: Contribution to journalArticle

2013

Perinatal iron deficiency and neurocognitive development

Radlowski, E. C. & Johnson, R. W., Sep 23 2013, In : Frontiers in Human Neuroscience. SEP, 585.

Research output: Contribution to journalReview article

Reply to Maitre et al

Johnson, R. W., Donovan, S. M. & Dilger, R. N., Apr 1 2013, In : Journal of Nutrition. 143, 4, 1 p.

Research output: Contribution to journalLetter

2012

Brain growth of the domestic pig (Sus scrofa) from 2 to 24 weeks of age: A longitudinal MRI study

Conrad, M. S., Dilger, R. N. & Johnson, R. W., Oct 1 2012, In : Developmental Neuroscience. 34, 4, p. 291-298 8 p.

Research output: Contribution to journalArticle

Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation

Jurgens, H. A. & Johnson, R. W., Jan 1 2012, In : Experimental Neurology. 233, 1, p. 40-48 9 p.

Research output: Contribution to journalReview article

Early life iron deficiency impairs spatial cognition in neonatal piglets

Rytych, J. L., Elmore, M. R. P., Burton, M. D., Conrad, M. S., Donovan, S. M., Dilger, R. N. & Johnson, R. W., Nov 1 2012, In : Journal of Nutrition. 142, 11, p. 2050-2056 7 p.

Research output: Contribution to journalArticle

Effects of mannan oligosaccharide on cytokine secretions by porcine alveolar macrophages and serum cytokine concentrations in nursery pigs

Che, T. M., Johnson, R. W., Kelley, K. W., Dawson, K. A., Moran, C. A. & Pettigrew, J. E., Feb 1 2012, In : Journal of animal science. 90, 2, p. 657-668 12 p.

Research output: Contribution to journalArticle

Environmental enrichment attenuates hippocampal neuroinflammation and improves cognitive function during influenza infection

Jurgens, H. A. & Johnson, R. W., Aug 1 2012, In : Brain, Behavior, and Immunity. 26, 6, p. 1006-1016 11 p.

Research output: Contribution to journalArticle

Fueling the immune response: What's the cost?

Johnson, R. W., Jan 1 2012, Feed Efficiency in Swine. Wageningen Academic Publishers, p. 211-223 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1

Chiu, G. S., Chatterjee, D., Darmody, P. T., Walsh, J. P., Meling, D. D., Johnson, R. W. & Freund, G. G., Oct 3 2012, In : Journal of Neuroscience. 32, 40, p. 13945-13955 11 p.

Research output: Contribution to journalArticle

Influenza Infection Induces Neuroinflammation, Alters Hippocampal Neuron Morphology, and Impairs Cognition in Adult Mice

Jurgens, H. A., Amancherla, K. & Johnson, R. W., Mar 21 2012, In : Journal of Neuroscience. 32, 12, p. 3958-3968 11 p.

Research output: Contribution to journalArticle