Raven H Huang

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Research Output

2019

Ribotoxins Kill Cells by Chopping off the Head of tRNAs

Huang, R. H., Nov 5 2019, In : Structure. 27, 11, p. 1613-1614 2 p.

Research output: Contribution to journalShort survey

2018

Biosynthetic capacity, metabolic variety and unusual biology in the CPR and DPANN radiations

Castelle, C. J., Brown, C. T., Anantharaman, K., Probst, A. J., Huang, R. H. & Banfield, J. F., Oct 1 2018, In : Nature Reviews Microbiology. 16, 10, p. 629-645 17 p.

Research output: Contribution to journalArticle

Double methylation of tRNA-U54 to 2-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7

Keller, P., Freund, I., Marchand, V., Bec, G., Huang, R., Motorin, Y., Eigenbrod, T., Dalpke, A. & Helm, M., 2018, In : Nucleic acids research. 46, 18, p. 9764-9775 12 p.

Research output: Contribution to journalArticle

Open Access

Reconstitution and substrate specificity for isopentenyl pyrophosphate of the antiviral radical SAM enzyme viperin

Chakravarti, A., Selvadurai, K., Shahoei, R., Lee, H., Fatma, S., Tajkhorshid, E. & Huang, R. H., Sep 7 2018, In : Journal of Biological Chemistry. 293, 36, p. 14122-14133 12 p.

Research output: Contribution to journalReview article

2015

Reconstitution and structure of a bacterial Pnkp1-Rnl-Hen1 RNA repair complex

Wang, P., Selvadurai, K. & Huang, R. H., Apr 17 2015, In : Nature communications. 6, 6876.

Research output: Contribution to journalArticle

2014

Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism

Selvadurai, K., Wang, P., Seimetz, J. & Huang, R. H., Oct 1 2014, In : Nature chemical biology. 10, 10, p. 810-812 3 p.

Research output: Contribution to journalArticle

2012

Cas protein Cmr2 full of surprises

Huang, R. H., Mar 7 2012, In : Structure. 20, 3, p. 389-390 2 p.

Research output: Contribution to journalShort survey

Molecular basis of bacterial protein Hen1 activating the ligase activity of bacterial protein Pnkp for RNA repair

Wang, P., Chan, C. M., Christensen, D., Zhang, C., Selvadurai, K. & Huang, R. H., Aug 14 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 33, p. 13248-13253 6 p.

Research output: Contribution to journalArticle

Probing the substrate specificity of the bacterial Pnkp/Hen1 RNA repair system using synthetic RNAs

Zhang, C., Chan, C. M., Wang, P. & Huang, R. H., Feb 1 2012, In : RNA. 18, 2, p. 335-344 10 p.

Research output: Contribution to journalArticle

Unique 2′-O-methylation by hen1 in eukaryotic RNA interference and bacterial RNA repair

Huang, R. H., May 22 2012, In : Biochemistry. 51, 20, p. 4087-4095 9 p.

Research output: Contribution to journalArticle

2009

Enzymatic characterization and mutational studies of TruD - the fifth family of pseudouridine synthases

Chan, C. M. & Huang, R. H., Sep 1 2009, In : Archives of Biochemistry and Biophysics. 489, 1-2, p. 15-19 5 p.

Research output: Contribution to journalArticle

Reconstituting bacterial RNA repair and modification in vitro

Chan, C. M., Zhou, C. & Huang, R. H., Oct 9 2009, In : Science. 326, 5950, 1 p.

Research output: Contribution to journalShort survey

Structural and biochemical insights into 2′-O-methylation at the 3′-terminal nucleotide of RNA by Hen1

Chio, M. C., Zhou, C., Brunzelle, J. S. & Huang, R. H., Oct 20 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 42, p. 17699-17704 6 p.

Research output: Contribution to journalArticle

2008

Crystal structure of QueC from Bacillus subtilis: An enzyme involved in preQ1 biosynthesis

Cicmil, N. & Huang, R. H., Aug 15 2008, In : Proteins: Structure, Function and Genetics. 72, 3, p. 1084-1088 5 p.

Research output: Contribution to journalArticle

Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors

Jones, L. L., Colf, L. A., Bankovich, A. J., Stone, J. D., Gao, Y. G., Choi, M. C., Huang, R. H., Garcia, K. C. & Kranz, D. M., Nov 25 2008, In : Biochemistry. 47, 47, p. 12398-12408 11 p.

Research output: Contribution to journalArticle

2007

Structure of tRNA Dimethylallyltransferase: RNA Modification through a Channel

Xie, W., Zhou, C. & Huang, R. H., Mar 30 2007, In : Journal of Molecular Biology. 367, 3, p. 872-881 10 p.

Research output: Contribution to journalArticle

2006

Molecular Basis of Inhibition of the Ribonuclease Activity in Colicin E5 by Its Cognate Immunity Protein

Luna-Chávez, C., Lin, Y. L. & Huang, R. H., Apr 28 2006, In : Journal of Molecular Biology. 358, 2, p. 571-579 9 p.

Research output: Contribution to journalArticle

2005

Biochemical and structural studies of A-to-I editing by tRNA:A34 deaminases at the wobble position of transfer RNA

Elias, Y. & Huang, R. H., Sep 13 2005, In : Biochemistry. 44, 36, p. 12057-12065 9 p.

Research output: Contribution to journalArticle

Dissecting the roles of a strictly conserved tyrosine in substrate recognition and catalysis by pseudouridine 55 synthase

Phannachet, K., Elias, Y. & Huang, R. H., Nov 29 2005, In : Biochemistry. 44, 47, p. 15488-15494 7 p.

Research output: Contribution to journalArticle

Structural and mutational studies of the catalytic domain of colicin E5: A tRNA-specific ribonuclease

Lin, Y. L., Elias, Y. & Huang, R. H., Aug 9 2005, In : Biochemistry. 44, 31, p. 10494-10500 7 p.

Research output: Contribution to journalArticle

2004

Conformational change of pseudouridine 55 synthase upon its association with RNA substrate

Phannachet, K. & Huang, R. H., 2004, In : Nucleic acids research. 32, 4, p. 1422-1429 8 p.

Research output: Contribution to journalArticle

2003

Chemical trapping and crystal structure of a catalytic tRNA guanine transglycosylase covalent intermediate

Xie, W., Liu, X. & Huang, R. H., Oct 1 2003, In : Nature Structural Biology. 10, 10, p. 781-788 8 p.

Research output: Contribution to journalArticle