Personal profile

Research Interests

Research Topics

Archaea, Bioinformatics, Genome Organization, Host-Pathogen Interactions, Microbial Ecology, Microbial Physiology, Molecular Evolution, Virology

Disease Research Interests

Infectious Diseases


B.A, (Biology, SiSP), Wesleyan University, 1993
Ph.D., (Microbiology), University of California, Berkeley, 1998-2004
Postdoctoral Researcher, (Geomicrobiolgy), University of California, Berkeley, 2004-2006

Professional Information

The Whitaker Lab studies the evolution of Archaea, Bacteria and Viruses in natural and clinical environments.

All who are paying attention now appreciate the complexity, connectivity, and interdependence of biological systems wherein a single 30kb piece of single-stranded RNA can have planetary impacts. It is now abundantly clear that all living organisms are connected to each other through hidden microbial networks, and that while these connections are highly localized, microbial meta-populations act globally. Solving the global challenges of infectious disease, antibiotic resistance, and stabilization of healthy microbial ecosystems depends upon understanding the evolutionary dynamics of microbes and co-evolution of microbes and their own infectious elements. The Whitaker Lab studies on the dynamics of microbes and their viruses using a combination of genomics, experimental evolution, modeling, and molecular biology in a diversity of systems to provide a comparative context for discovering foundational rules of infection genomics. We focus on understanding how the physiology and evolution of rapidly changing components of microbial genomes including CRISPR-Cas immunity and genomic islands change microbial interactions in their natural contexts.

Viral Symbiosis

Viruses are the next frontier of microbiology not only because they are often pathogens, but also because they are the infectious source of genome innovation. Our research explores how viruses that are integrated in their host’s genome confer new evolutionary traits to their hosts and change their eco-evolutionary interactions with other organisms. With funding from the Gordon and Betty Moore Foundation our lab studies how viral symbioses results in dynamics and eco-evolutionary feedbacks in highly structured, wild archaeal and viral populations from Yellowstone hot springs. We focus on terrestrial hot springs as an example of highly structured populations in which local adaptation and random processes will likely play an important role in shaping symbiotic interactions.

One Health

Viruses (phage) that infect bacterial pathogens such as P. aeruginosa are a key determinant of virulence, pathogenicity, epidemiology, adaptation, and evolution within and between the human host islands. We explore the transmission dynamics of P. aeruginosa phage within and between P. aeruginosa strains and how CRISPR-Cas immunity reflects the coevolutionary dynamics of P. aeruginosa and its viral populations. We extend this to other pathogen systems in which CRISPR-Cas systems are active to develop predictive models for the spread of virulence and antibiotic resistance in these systems. Through the Infection Genomics for One Health Theme at the Carl R. Woese Institute of Genomic Biology we extend the theoretical and molecular understanding of these systems further into a diversity of systems that connect observation to experiment across the continuum of symbiosis from antagonism to mutualism.

Archaeal Cell Biology

The movement of new genes and alleles into, and out of, microbial genomes defines rates of adaptation, population diversity, and genome architecture. Working in the only experimentally tractable crenarchaea (Sulfolobus) as our model system we are exploring the physiological and evolutionary basis of archaeal genome architecture including viruses, plasmids, and other mobile elements and their organization and integration into the multi-origin chromosome of the last genetically tractable common ancestor to eukaryotic cells.

Honors & Awards

Teachers Ranked as Excellent
Allen Distinguished Investigator Award (2017)
University Scholar Award (2020)
American Academy of Microbiology Fellow
Co-Director of the Microbial Diversity Course at the Marine Biological Lab in Woods Hole, MA

Office Address

601 S. Goodwin Ave.
Urbana, IL 61801

Office Phone

(217) 244-8420


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