Prasanth Kumar Kannanganattu, Associate Professor

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Article
2020

LncRNA-mediated regulation of SOX9 expression in basal subtype breast cancer cells

Tariq, A., Hao, Q., Sun, Q., Singh, D. K., Jadaliha, M., Zhang, Y., Chetlangia, N., Ma, J., Holton, S. E., Bhargava, R., Lal, A., Prasanth, S. G. & Prasanth, K. V., Jan 1 2020, In : RNA. 26, 2, p. 175-185 11 p.

Research output: Contribution to journalArticle

ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization

Hsu, R. Y. C., Lin, Y. C., Redon, C., Sun, Q., Singh, D. K., Wang, Y., Aggarwal, V., Mitra, J., Matur, A., Moriarity, B., Ha, T., Aladjem, M. I., Prasanth, K. V. & Prasanth, S. G., May 22 2020, In : iScience. 23, 5, 101038.

Research output: Contribution to journalArticle

Open Access
2019

Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE-/- mice

Gast, M., Rauch, B. H., Nakagawa, S., Haghikia, A., Jasina, A., Haas, J., Nath, N., Jensen, L., Stroux, A., Böhm, A., Friebel, J., Rauch, U., Skurk, C., Blankenberg, S., Zeller, T., Prasanth, K. V., Meder, B., Kuss, A., Landmesser, U. & Poller, W., Feb 1 2019, In : Cardiovascular research. 115, 2, p. 302-314 13 p.

Research output: Contribution to journalArticle

2018

A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability

Jadaliha, M., Gholamalamdari, O., Tang, W., Zhang, Y., Petracovici, A., Hao, Q., Tariq, A., Kim, T. G., Holton, S. E., Singh, D. K., Li, X. L., Freier, S. M., Ambs, S., Bhargava, R., Lal, A., Prasanth, S. G., Ma, J. & Prasanth, K. V., Nov 2018, In : PLoS genetics. 14, 11, e1007802.

Research output: Contribution to journalArticle

MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs

Sun, Q., Tripathi, V., Yoon, J. H., Singh, D. K., Hao, Q., Min, K. W., Davila, S., Zealy, R. W., Li, X. L., Polycarpou-Schwarz, M., Lehrmann, E., Zhang, Y., Becker, K. G., Freier, S. M., Zhu, Y., Diederichs, S., Prasanth, S. G., Lal, A., Gorospe, M. & Prasanth, K. V., 2018, In : Nucleic acids research. 46, 19, p. 10405-10416 12 p.

Research output: Contribution to journalArticle

PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication

Lin, Y. C., Wang, Y., Hsu, R., Giri, S., Wopat, S., Arif, M. K., Chakraborty, A., Prasanth, K. V. & Prasanth, S. G., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13282-13287 6 p.

Research output: Contribution to journalArticle

2017

ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins

Anantharaman, A., Tripathi, V., Khan, A., Yoon, J. H., Singh, D. K., Gholamalamdari, O., Guang, S., Ohlson, J., Wahlstedt, H., Öhman, M., Jantsch, M. F., Conrad, N. K., Ma, J., Gorospe, M., Prasanth, S. G. & Prasanth, K. V., Apr 20 2017, In : Nucleic acids research. 45, 7, p. 4189-4201 13 p.

Research output: Contribution to journalArticle

Long noncoding RNA MALAT1 promotes hepatocellular carcinoma development by SRSF1 upregulation and mTOR activation

Malakar, P., Shilo, A., Mogilevsky, A., Stein, I., Pikarsky, E., Nevo, Y., Benyamini, H., Elgavish, S., Zong, X., Prasanth, K. V. & Karni, R., Mar 1 2017, In : Cancer Research. 77, 5, p. 1155-1167 13 p.

Research output: Contribution to journalArticle

Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer

Li, X. L., Subramanian, M., Jones, M. F., Chaudhary, R., Singh, D. K., Zong, X., Gryder, B., Sindri, S., Mo, M., Schetter, A., Wen, X., Parvathaneni, S., Kazandjian, D., Jenkins, L. M., Tang, W., Elloumi, F., Martindale, J. L., Huarte, M., Zhu, Y., Robles, A. I. & 9 others, Frier, S. M., Rigo, F., Cam, M., Ambs, S., Sharma, S., Harris, C. C., Dasso, M., Prasanth, K. V. & Lal, A., Sep 5 2017, In : Cell Reports. 20, 10, p. 2408-2423 16 p.

Research output: Contribution to journalArticle

Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity

Chen, X., He, L., Zhao, Y., Li, Y., Zhang, S., Sun, K., So, K., Chen, F., Zhou, L., Lu, L., Wang, L., Zhu, X., Bao, X., Esteban, M. A., Nakagawa, S., Prasanth, K. V., Wu, Z., Sun, H. & Wang, H., Mar 14 2017, In : Cell Discovery. 3, 17002.

Research output: Contribution to journalArticle

Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

Chaudhary, R., Gryder, B., Woods, W. S., Subramanian, M., Jones, M. F., Li, X. L., Jenkins, L. M., Shabalina, S. A., Mo, M., Dasso, M., Yang, Y., Wakefield, L. M., Zhu, Y., Frier, S. M., Moriarity, B. S., Prasanth, K. V., Perez-Pinera, P. & Lal, A., Jun 5 2017, In : eLife. 6, e23244.

Research output: Contribution to journalArticle

PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes

Singh, D. K., Gholamalamdari, O., Jadaliha, M., Li, X. L., Lin, Y. C., Zhang, Y., Guang, S., Hashemikhabir, S., Tiwari, S., Zhu, Y. J., Khan, A., Thomas, A., Chakraborty, A., Macias, V., Balla, A. K., Bhargava, R., Janga, S. C., Ma, J., Prasanth, S. G., Lal, A. & 1 others, Prasanth, K. V., Oct 1 2017, In : Carcinogenesis. 38, 10, p. 966-975 10 p., bgx062.

Research output: Contribution to journalArticle

Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution

Fei, J., Jadaliha, M., Harmon, T. S., Li, I. T. S., Hua, B., Hao, Q., Holehouse, A. S., Reyer, M., Sun, Q., Freier, S. M., Pappu, R. V., Prasanth, K. V. & Ha, T., Dec 1 2017, In : Journal of cell science. 130, 24, p. 4180-4192 13 p.

Research output: Contribution to journalArticle

Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization

Wang, Y., Khan, A., Marks, A. B., Smith, O. K., Giri, S., Lin, Y. C., Creager, R., MacAlpine, D. M., Prasanth, K. V., Aladjem, M. I. & Prasanth, S. G., Mar 17 2017, In : Nucleic acids research. 45, 5, p. 2490-2502 13 p.

Research output: Contribution to journalArticle

2016

Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer

Jadaliha, M., Zong, X., Malakar, P., Ray, T., Singh, D. K., Freier, S. M., Jensen, T., Prasanth, S. G., Karni, R., Ray, P. S. & Prasanth, K. V., Jan 1 2016, In : Oncotarget. 7, 26, p. 40418-40436 19 p.

Research output: Contribution to journalArticle

Long non-coding RNA malat-1 is dispensable during pressure overload-induced cardiac remodeling and failure in mice

Peters, T., Hermans-Beijnsberger, S., Beqqali, A., Bitsch, N., Nakagawa, S., Prasanth, K. V., De Windt, L. J., Van Oort, R. J., Heymans, S. & Schroen, B., Feb 2016, In : PloS one. 11, 2, e0150236.

Research output: Contribution to journalArticle

Natural antisense RNA promotes 3′ end processing and maturation of MALAT1 lncRNA

Zong, X., Nakagawa, S., Freier, S. M., Fei, J., Ha, T., Prasanth, S. G. & Prasanth, K. V., Jan 29 2016, In : Nucleic acids research. 44, 6, p. 2898-2908 11 p.

Research output: Contribution to journalArticle

Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner

Giri, S., Chakraborty, A., Sathyan, K. M., Prasanth, K. V. & Prasanth, S. G., 2016, In : Journal of cell science. 129, 2, p. 417-429 13 p.

Research output: Contribution to journalArticle

Paraspeckles modulate the intranuclear distribution of paraspeckle-associated Ctn RNA

Anantharaman, A., Jadaliha, M., Tripathi, V., Nakagawa, S., Hirose, T., Jantsch, M. F., Prasanth, S. G. & Prasanth, K. V., Sep 26 2016, In : Scientific reports. 6, 34043.

Research output: Contribution to journalArticle

2015

BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase

Khan, A., Giri, S., Wang, Y., Chakraborty, A., Ghosh, A. K., Anantharaman, A., Aggarwal, V., Sathyan, K. M., Ha, T., Prasanth, K. V. & Prasanth, S. G., Jul 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8338-8343 6 p.

Research output: Contribution to journalArticle

Growth differentiation factor-15 encodes a novel microRNA 3189 that functions as a potent regulator of cell death

Jones, M. F., Ling Li, X., Subramanian, M., Shabalina, S. A., Hara, T., Zhu, Y., Huang, J., Yang, Y., Wakefield, L. M., Prasanth, K. V. & Lal, A., Oct 9 2015, In : Cell Death and Differentiation. 22, 10, p. 1641-1653 13 p.

Research output: Contribution to journalArticle

Knockdown of nuclear-retained long noncoding RNAs using modified DNA antisense oligonucleotides

Zong, X., Huang, L., Tripathi, V., Peralta, R., Freier, S. M., Guo, S. & Prasanth, K. V., Jan 1 2015, In : Methods in Molecular Biology. 1262, p. 321-331 11 p.

Research output: Contribution to journalArticle

The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin

Giri, S., Aggarwal, V., Pontis, J., Shen, Z., Chakraborty, A., Khan, A., Mizzen, C., Prasanth, K. V., Ait-Si-Ali, S., Ha, T. & Prasanth, S. G., Apr 29 2015, In : eLife. 2015, 4, p. 1-54 54 p., e06496.

Research output: Contribution to journalArticle

2014

Dynamic phosphorylation of HP1α regulates mitotic progression in human cells

Chakraborty, A., Prasanth, K. V. & Prasanth, S. G., Mar 12 2014, In : Nature communications. 5, 3445.

Research output: Contribution to journalArticle

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity

Yoon, J. H., De, S., Srikantan, S., Abdelmohsen, K., Grammatikakis, I., Kim, J., Kim, K. M., Noh, J. H., White, E. J. F., Martindale, J. L., Yang, X., Kang, M. J., Wood, W. H., Noren Hooten, N., Evans, M. K., Becker, K. G., Tripathi, V., Prasanth, K. V., Wilson, G. M., Tuschl, T. & 3 others, Ingolia, N. T., Hafner, M. & Gorospe, M., 2014, In : Nature communications. 5, 5248.

Research output: Contribution to journalArticle

2013

Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB

Tripathi, V., Shen, Z., Chakraborty, A., Giri, S., Freier, S. M., Wu, X., Zhang, Y., Gorospe, M., Prasanth, S. G., Lal, A. & Prasanth, K. V., 2013, In : PLoS genetics. 9, 3, e1003368.

Research output: Contribution to journalArticle

2012

Dynamic association of orca with prereplicative complex components regulates dna replication initiation

Shen, Z., Chakraborty, A., Jain, A., Giri, S., Ha, T., Prasanth, K. V. & Prasanth, S. G., Aug 1 2012, In : Molecular and cellular biology. 32, 15, p. 3107-3120 14 p.

Research output: Contribution to journalArticle

Malat1 is not an essential component of nuclear speckles in mice

Nakagawa, S., Ip, J. Y., Shioi, G., Tripathi, V., Zong, X., Hirose, T. & Prasanth, K. V., Aug 1 2012, In : RNA. 18, 8, p. 1487-1499 13 p.

Research output: Contribution to journalArticle

SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles

Tripathi, V., Song, D. Y., Zong, X., Shevtsov, S. P., Hearn, S., Fu, X. D., Dundr, M. & Prasanth, K. V., Sep 15 2012, In : Molecular biology of the cell. 23, 18, p. 3694-3706 13 p.

Research output: Contribution to journalArticle

2011

A BEN-domain-containing protein associates with heterochromatin and represses transcription

Sathyan, K. M., Shen, Z., Tripathi, V., Prasanth, K. V. & Prasanth, S. G., Sep 15 2011, In : Journal of cell science. 124, 18, p. 3149-3163 15 p.

Research output: Contribution to journalArticle

2010

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression

Bernard, D., Prasanth, K. V., Tripathi, V., Colasse, S., Nakamura, T., Xuan, Z., Zhang, M. Q., Sedel, F., Jourdren, L., Coulpier, F., Triller, A., Spector, D. L. & Bessis, A., Sep 2010, In : EMBO Journal. 29, 18, p. 3082-3093 12 p.

Research output: Contribution to journalArticle

A WD-repeat protein stabilizes ORC binding to chromatin

Shen, Z., Sathyan, K. M., Geng, Y., Zheng, R., Chakraborty, A., Freeman, B., Wang, F., Prasanth, K. V. & Prasanth, S. G., Oct 8 2010, In : Molecular cell. 40, 1, p. 99-111 13 p.

Research output: Contribution to journalArticle

Nuclear organization and dynamics of 7SK RNA in regulating gene expression

Prasanth, K. V., Camiolo, M., Chan, G., Tripathi, V., Denis, L., Nakamura, T., Hübner, M. R. & Spector, D. L., Dec 1 2010, In : Molecular biology of the cell. 21, 23, p. 4184-4196 13 p.

Research output: Contribution to journalArticle

Polypurine-repeat-containing RNAs: A novel class of long non-coding RNA in mammalian cells

Zheng, R., Shen, Z., Tripathi, V., Xuan, Z., Freier, S. M., Bennett, C. F., Prasanth, S. G. & Prasanth, K. V., Nov 1 2010, In : Journal of cell science. 123, 21, p. 3734-3744 11 p.

Research output: Contribution to journalArticle

The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation

Tripathi, V., Ellis, J. D., Shen, Z., Song, D. Y., Pan, Q., Watt, A. T., Freier, S. M., Bennett, C. F., Sharma, A., Bubulya, P. A., Blencowe, B. J., Prasanth, S. G. & Prasanth, K. V., Sep 2010, In : Molecular cell. 39, 6, p. 925-938 14 p.

Research output: Contribution to journalArticle

2006

PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein

Lee, H., Quinn, J. C., Prasanth, K. V., Swiss, V. A., Economides, K. D., Camacho, M. M., Spector, D. L. & Abate-Shen, C., Apr 1 2006, In : Genes and Development. 20, 7, p. 784-794 11 p.

Research output: Contribution to journalArticle

Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm

Politz, J. C. R., Tuft, R. A., Prasanth, K. V., Baudendistel, N., Fogarty, K. E., Lifshitz, L. M., Langowski, J., Spector, D. L. & Pederson, T., Mar 2006, In : Molecular biology of the cell. 17, 3, p. 1239-1249 11 p.

Research output: Contribution to journalArticle

2005

Regulating gene expression through RNA nuclear retention

Prasanth, K. V., Prasanth, S. G., Xuan, Z., Hearn, S., Freier, S. M., Bennett, C. F., Zhang, M. Q. & Spector, D. L., Oct 21 2005, In : Cell. 123, 2, p. 249-263 15 p.

Research output: Contribution to journalArticle

2004

Dynamics of pre-replication complex proteins during the cell division cycle

Prasanth, S. G., Méndez, J., Prasanth, K. V. & Stillman, B., Jan 29 2004, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 359, 1441, p. 7-16 10 p.

Research output: Contribution to journalArticle

From silencing to gene expression: Real-time analysis in single cells

Janicki, S. M., Tsukamoto, T., Salghetti, S. E., Tansey, W. P., Sachidanandam, R., Prasanth, K. V., Ried, T., Shav-Tal, Y., Bertrand, E., Singer, R. H. & Spector, D. L., Mar 5 2004, In : Cell. 116, 5, p. 683-698 16 p.

Research output: Contribution to journalArticle

Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance

Prasanth, S. G., Prasanth, K. V., Siddiqui, K., Spector, D. L. & Stillman, B., Jul 7 2004, In : EMBO Journal. 23, 13, p. 2651-2663 13 p.

Research output: Contribution to journalArticle

Hypophosphorylated SR splicing factors transiently localize around active nucleolar organizing regions in telophase daughter nuclei

Bubulya, P. A., Prasanth, K. V., Deerinck, T. J., Gerlich, D., Beaudouin, J., Ellisman, M. H., Ellenberg, J. & Spector, D. L., Oct 11 2004, In : Journal of Cell Biology. 167, 1, p. 51-63 13 p.

Research output: Contribution to journalArticle

2003

Sequential entry of components of gene expression machinery into daughter nucleiv

Prasanth, K. V., Sacco-Bubulya, P. A., Prasanth, S. G. & Spector, D. L., Mar 1 2003, In : Molecular biology of the cell. 14, 3, p. 1043-1057 15 p.

Research output: Contribution to journalArticle

2002

Orc6 involved in DNA replication, chromosome segregation, and cytokinesis

Prasanth, S. G., Prasanth, K. V. & Stillman, B., Aug 9 2002, In : Science. 297, 5583, p. 1026-1031 6 p.

Research output: Contribution to journalArticle

Regulation of heat shock proteins, Hsp70 and Hsp64, in heat-shocked malpighian tubules of Drosophila melanogaster larvae

Lakhotia, S. C., Srivastava, P. & Prasanth, K. V., Oct 2002, In : Cell Stress and Chaperones. 7, 4, p. 347-356 10 p.

Research output: Contribution to journalArticle

2001

Developmental regulation and complex organization of the promoter of the non-coding hsrω gene of Drosophila melanogaster

Lakhotia, S. C., Rajendra, T. K. & Prasanth, K. V., Jan 1 2001, In : Journal of Biosciences. 26, 1, p. 25-38 14 p.

Research output: Contribution to journalArticle

Male sterility associated with overexpression of the noncoding hsr ω gene in cyst cells of testis of Drosophila melanogaster

Rajendra, T. K., Prasanth, K. V. & Lakhotia, S. C., Aug 2001, In : Journal of genetics. 80, 2, p. 97-110 14 p.

Research output: Contribution to journalArticle

2000

Omega speckles - A novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila

Prasanth, K. V., Rajendra, T. K., Lal, A. K. & Lakhotia, S. C., Nov 23 2000, In : Journal of cell science. 113, 19, p. 3485-3497 13 p.

Research output: Contribution to journalArticle