Prasanth Kumar Kannanganattu, Associate Professor

If you made any changes in Pure these will be visible here soon.

Research Output

2020

LncRNA-mediated regulation of SOX9 expression in basal subtype breast cancer cells

Tariq, A., Hao, Q., Sun, Q., Singh, D. K., Jadaliha, M., Zhang, Y., Chetlangia, N., Ma, J., Holton, S. E., Bhargava, R., Lal, A., Prasanth, S. G. & Prasanth, K. V., Jan 1 2020, In : RNA. 26, 2, p. 175-185 11 p.

Research output: Contribution to journalArticle

ORCA/LRWD1 Regulates Homologous Recombination at ALT-Telomeres by Modulating Heterochromatin Organization

Hsu, R. Y. C., Lin, Y. C., Redon, C., Sun, Q., Singh, D. K., Wang, Y., Aggarwal, V., Mitra, J., Matur, A., Moriarity, B., Ha, T., Aladjem, M. I., Prasanth, K. V. & Prasanth, S. G., May 22 2020, In : iScience. 23, 5, 101038.

Research output: Contribution to journalArticle

Open Access
2019

Immune system-mediated atherosclerosis caused by deficiency of long non-coding RNA MALAT1 in ApoE-/- mice

Gast, M., Rauch, B. H., Nakagawa, S., Haghikia, A., Jasina, A., Haas, J., Nath, N., Jensen, L., Stroux, A., Böhm, A., Friebel, J., Rauch, U., Skurk, C., Blankenberg, S., Zeller, T., Prasanth, K. V., Meder, B., Kuss, A., Landmesser, U. & Poller, W., Feb 1 2019, In : Cardiovascular research. 115, 2, p. 302-314 13 p.

Research output: Contribution to journalArticle

2018

A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability

Jadaliha, M., Gholamalamdari, O., Tang, W., Zhang, Y., Petracovici, A., Hao, Q., Tariq, A., Kim, T. G., Holton, S. E., Singh, D. K., Li, X. L., Freier, S. M., Ambs, S., Bhargava, R., Lal, A., Prasanth, S. G., Ma, J. & Prasanth, K. V., Nov 2018, In : PLoS genetics. 14, 11, e1007802.

Research output: Contribution to journalArticle

MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs

Sun, Q., Tripathi, V., Yoon, J. H., Singh, D. K., Hao, Q., Min, K. W., Davila, S., Zealy, R. W., Li, X. L., Polycarpou-Schwarz, M., Lehrmann, E., Zhang, Y., Becker, K. G., Freier, S. M., Zhu, Y., Diederichs, S., Prasanth, S. G., Lal, A., Gorospe, M. & Prasanth, K. V., 2018, In : Nucleic acids research. 46, 19, p. 10405-10416 12 p.

Research output: Contribution to journalArticle

Nuclear Long Noncoding RNAs: Key Regulators of Gene Expression

Sun, Q., Hao, Q. & Prasanth, K. V., Feb 2018, In : Trends in Genetics. 34, 2, p. 142-157 16 p.

Research output: Contribution to journalReview article

PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication

Lin, Y. C., Wang, Y., Hsu, R., Giri, S., Wopat, S., Arif, M. K., Chakraborty, A., Prasanth, K. V. & Prasanth, S. G., Dec 26 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 52, p. 13282-13287 6 p.

Research output: Contribution to journalArticle

2017

ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins

Anantharaman, A., Tripathi, V., Khan, A., Yoon, J. H., Singh, D. K., Gholamalamdari, O., Guang, S., Ohlson, J., Wahlstedt, H., Öhman, M., Jantsch, M. F., Conrad, N. K., Ma, J., Gorospe, M., Prasanth, S. G. & Prasanth, K. V., Apr 20 2017, In : Nucleic acids research. 45, 7, p. 4189-4201 13 p.

Research output: Contribution to journalArticle

Long noncoding RNA MALAT1 promotes hepatocellular carcinoma development by SRSF1 upregulation and mTOR activation

Malakar, P., Shilo, A., Mogilevsky, A., Stein, I., Pikarsky, E., Nevo, Y., Benyamini, H., Elgavish, S., Zong, X., Prasanth, K. V. & Karni, R., Mar 1 2017, In : Cancer Research. 77, 5, p. 1155-1167 13 p.

Research output: Contribution to journalArticle

Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer

Li, X. L., Subramanian, M., Jones, M. F., Chaudhary, R., Singh, D. K., Zong, X., Gryder, B., Sindri, S., Mo, M., Schetter, A., Wen, X., Parvathaneni, S., Kazandjian, D., Jenkins, L. M., Tang, W., Elloumi, F., Martindale, J. L., Huarte, M., Zhu, Y., Robles, A. I. & 9 others, Frier, S. M., Rigo, F., Cam, M., Ambs, S., Sharma, S., Harris, C. C., Dasso, M., Prasanth, K. V. & Lal, A., Sep 5 2017, In : Cell Reports. 20, 10, p. 2408-2423 16 p.

Research output: Contribution to journalArticle

Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity

Chen, X., He, L., Zhao, Y., Li, Y., Zhang, S., Sun, K., So, K., Chen, F., Zhou, L., Lu, L., Wang, L., Zhu, X., Bao, X., Esteban, M. A., Nakagawa, S., Prasanth, K. V., Wu, Z., Sun, H. & Wang, H., Mar 14 2017, In : Cell Discovery. 3, 17002.

Research output: Contribution to journalArticle

Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

Chaudhary, R., Gryder, B., Woods, W. S., Subramanian, M., Jones, M. F., Li, X. L., Jenkins, L. M., Shabalina, S. A., Mo, M., Dasso, M., Yang, Y., Wakefield, L. M., Zhu, Y., Frier, S. M., Moriarity, B. S., Prasanth, K. V., Perez-Pinera, P. & Lal, A., Jun 5 2017, In : eLife. 6, e23244.

Research output: Contribution to journalArticle

PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes

Singh, D. K., Gholamalamdari, O., Jadaliha, M., Li, X. L., Lin, Y. C., Zhang, Y., Guang, S., Hashemikhabir, S., Tiwari, S., Zhu, Y. J., Khan, A., Thomas, A., Chakraborty, A., Macias, V., Balla, A. K., Bhargava, R., Janga, S. C., Ma, J., Prasanth, S. G., Lal, A. & 1 others, Prasanth, K. V., Oct 1 2017, In : Carcinogenesis. 38, 10, p. 966-975 10 p., bgx062.

Research output: Contribution to journalArticle

Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution

Fei, J., Jadaliha, M., Harmon, T. S., Li, I. T. S., Hua, B., Hao, Q., Holehouse, A. S., Reyer, M., Sun, Q., Freier, S. M., Pappu, R. V., Prasanth, K. V. & Ha, T., Dec 1 2017, In : Journal of cell science. 130, 24, p. 4180-4192 13 p.

Research output: Contribution to journalArticle

RNA-editing enzymes ADAR1 and ADAR2 coordinately regulate the editing and expression of Ctn RNA

Anantharaman, A., Gholamalamdari, O., Khan, A., Yoon, J. H., Jantsch, M. F., Hartner, J. C., Gorospe, M., Prasanth, S. G. & Prasanth, K. V., Sep 2017, In : FEBS Letters. 591, 18, p. 2890-2904 15 p.

Research output: Contribution to journalLetter

Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization

Wang, Y., Khan, A., Marks, A. B., Smith, O. K., Giri, S., Lin, Y. C., Creager, R., MacAlpine, D. M., Prasanth, K. V., Aladjem, M. I. & Prasanth, S. G., Mar 17 2017, In : Nucleic acids research. 45, 5, p. 2490-2502 13 p.

Research output: Contribution to journalArticle

2016

Easy Stress Relief by EZH2

Prasanth, S. G. & Prasanth, K. V., Dec 15 2016, In : Cell. 167, 7, p. 1678-1680 3 p.

Research output: Contribution to journalShort survey

Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer

Jadaliha, M., Zong, X., Malakar, P., Ray, T., Singh, D. K., Freier, S. M., Jensen, T., Prasanth, S. G., Karni, R., Ray, P. S. & Prasanth, K. V., Jan 1 2016, In : Oncotarget. 7, 26, p. 40418-40436 19 p.

Research output: Contribution to journalArticle

Long noncoding RNA MALAT1-derived mascRNA is involved in cardiovascular innate immunity

Gast, M., Schroen, B., Voigt, A., Haas, J., Kuehl, U., Lassner, D., Skurk, C., Escher, F., Wang, X., Kratzer, A., Michalik, K., Papageorgiou, A., Peters, T., Loebel, M., Wilk, S., Althof, N., Prasanth, K. V., Katus, H., Meder, B., Nakagawa, S. & 6 others, Scheibenbogen, C., Schultheiss, H. P., Landmesser, U., Dimmeler, S., Heymans, S. & Poller, W., Apr 1 2016, In : Journal of Molecular Cell Biology. 8, 2, p. 178-181 4 p.

Research output: Contribution to journalLetter

Long non-coding RNA malat-1 is dispensable during pressure overload-induced cardiac remodeling and failure in mice

Peters, T., Hermans-Beijnsberger, S., Beqqali, A., Bitsch, N., Nakagawa, S., Prasanth, K. V., De Windt, L. J., Van Oort, R. J., Heymans, S. & Schroen, B., Feb 2016, In : PloS one. 11, 2, e0150236.

Research output: Contribution to journalArticle

Natural antisense RNA promotes 3′ end processing and maturation of MALAT1 lncRNA

Zong, X., Nakagawa, S., Freier, S. M., Fei, J., Ha, T., Prasanth, S. G. & Prasanth, K. V., Jan 29 2016, In : Nucleic acids research. 44, 6, p. 2898-2908 11 p.

Research output: Contribution to journalArticle

Orc5 induces large-scale chromatin decondensation in a GCN5-dependent manner

Giri, S., Chakraborty, A., Sathyan, K. M., Prasanth, K. V. & Prasanth, S. G., 2016, In : Journal of cell science. 129, 2, p. 417-429 13 p.

Research output: Contribution to journalArticle

Paraspeckles modulate the intranuclear distribution of paraspeckle-associated Ctn RNA

Anantharaman, A., Jadaliha, M., Tripathi, V., Nakagawa, S., Hirose, T., Jantsch, M. F., Prasanth, S. G. & Prasanth, K. V., Sep 26 2016, In : Scientific reports. 6, 34043.

Research output: Contribution to journalArticle

2015

BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase

Khan, A., Giri, S., Wang, Y., Chakraborty, A., Ghosh, A. K., Anantharaman, A., Aggarwal, V., Sathyan, K. M., Ha, T., Prasanth, K. V. & Prasanth, S. G., Jul 7 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 27, p. 8338-8343 6 p.

Research output: Contribution to journalArticle

Fourier transform infrared (FT-IR) spectroscopy and imaging of the nucleus to characterize DNA contributions in different phases of the cell cycle

Tiwari, S., Zong, X., Holton, S. E., Prasanth, K. V. & Bhargava, R., Jan 1 2015, Medical Imaging 2015: Biomedical Applications in Molecular, Structural, and Functional Imaging. Gimi, B. & Molthen, R. C. (eds.). SPIE, 941720. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 9417).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Growth differentiation factor-15 encodes a novel microRNA 3189 that functions as a potent regulator of cell death

Jones, M. F., Ling Li, X., Subramanian, M., Shabalina, S. A., Hara, T., Zhu, Y., Huang, J., Yang, Y., Wakefield, L. M., Prasanth, K. V. & Lal, A., Oct 9 2015, In : Cell Death and Differentiation. 22, 10, p. 1641-1653 13 p.

Research output: Contribution to journalArticle

Knockdown of nuclear-retained long noncoding RNAs using modified DNA antisense oligonucleotides

Zong, X., Huang, L., Tripathi, V., Peralta, R., Freier, S. M., Guo, S. & Prasanth, K. V., Jan 1 2015, In : Methods in Molecular Biology. 1262, p. 321-331 11 p.

Research output: Contribution to journalArticle

RNA fluorescence in situ hybridization in cultured mammalian cells

Tripathi, V., Fei, J., Ha, T. & Kannanganattu, P. K., 2015, Regulatory Non-Coding RNAs: Methods and Protocols. Springer New York, Vol. 1206. p. 123-136 14 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin

Giri, S., Aggarwal, V., Pontis, J., Shen, Z., Chakraborty, A., Khan, A., Mizzen, C., Prasanth, K. V., Ait-Si-Ali, S., Ha, T. & Prasanth, S. G., Apr 29 2015, In : eLife. 2015, 4, p. 1-54 54 p., e06496.

Research output: Contribution to journalArticle

2014

Dynamic phosphorylation of HP1α regulates mitotic progression in human cells

Chakraborty, A., Prasanth, K. V. & Prasanth, S. G., Mar 12 2014, In : Nature communications. 5, 3445.

Research output: Contribution to journalArticle

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity

Yoon, J. H., De, S., Srikantan, S., Abdelmohsen, K., Grammatikakis, I., Kim, J., Kim, K. M., Noh, J. H., White, E. J. F., Martindale, J. L., Yang, X., Kang, M. J., Wood, W. H., Noren Hooten, N., Evans, M. K., Becker, K. G., Tripathi, V., Prasanth, K. V., Wilson, G. M., Tuschl, T. & 3 others, Ingolia, N. T., Hafner, M. & Gorospe, M., 2014, In : Nature communications. 5, 5248.

Research output: Contribution to journalArticle

2013

Functional insights into the role of nuclear-retained long noncoding RNAs in gene expression control in mammalian cells

Singh, D. K. & Prasanth, K. V., Dec 1 2013, In : Chromosome Research. 21, 6-7, p. 695-711 17 p.

Research output: Contribution to journalReview article

Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB

Tripathi, V., Shen, Z., Chakraborty, A., Giri, S., Freier, S. M., Wu, X., Zhang, Y., Gorospe, M., Prasanth, S. G., Lal, A. & Prasanth, K. V., 2013, In : PLoS genetics. 9, 3, e1003368.

Research output: Contribution to journalArticle

2012

Dynamic association of orca with prereplicative complex components regulates dna replication initiation

Shen, Z., Chakraborty, A., Jain, A., Giri, S., Ha, T., Prasanth, K. V. & Prasanth, S. G., Aug 1 2012, In : Molecular and cellular biology. 32, 15, p. 3107-3120 14 p.

Research output: Contribution to journalArticle

Malat1 is not an essential component of nuclear speckles in mice

Nakagawa, S., Ip, J. Y., Shioi, G., Tripathi, V., Zong, X., Hirose, T. & Prasanth, K. V., Aug 1 2012, In : RNA. 18, 8, p. 1487-1499 13 p.

Research output: Contribution to journalArticle

Policing Cells under Stress: Noncoding RNAs Capture Proteins in Nucleolar Detention Centers

Prasanth, K. V., Jan 27 2012, In : Molecular cell. 45, 2, p. 141-142 2 p.

Research output: Contribution to journalShort survey

SRSF1 regulates the assembly of pre-mRNA processing factors in nuclear speckles

Tripathi, V., Song, D. Y., Zong, X., Shevtsov, S. P., Hearn, S., Fu, X. D., Dundr, M. & Prasanth, K. V., Sep 15 2012, In : Molecular biology of the cell. 23, 18, p. 3694-3706 13 p.

Research output: Contribution to journalArticle

2011

A BEN-domain-containing protein associates with heterochromatin and represses transcription

Sathyan, K. M., Shen, Z., Tripathi, V., Prasanth, K. V. & Prasanth, S. G., Sep 15 2011, In : Journal of cell science. 124, 18, p. 3149-3163 15 p.

Research output: Contribution to journalArticle

EXIST with matrix-associated proteins

Nakagawa, S. & Prasanth, K. V., Jun 1 2011, In : Trends in Cell Biology. 21, 6, p. 321-327 7 p.

Research output: Contribution to journalReview article

RNA splicing control: Yet another gene regulatory role for long nuclear noncoding RNAs

Zong, X., Tripathi, V. & Prasanth, K. V., Jan 1 2011, In : RNA Biology. 8, 6

Research output: Contribution to journalComment/debate

2010

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression

Bernard, D., Prasanth, K. V., Tripathi, V., Colasse, S., Nakamura, T., Xuan, Z., Zhang, M. Q., Sedel, F., Jourdren, L., Coulpier, F., Triller, A., Spector, D. L. & Bessis, A., Sep 2010, In : EMBO Journal. 29, 18, p. 3082-3093 12 p.

Research output: Contribution to journalArticle

A WD-repeat protein stabilizes ORC binding to chromatin

Shen, Z., Sathyan, K. M., Geng, Y., Zheng, R., Chakraborty, A., Freeman, B., Wang, F., Prasanth, K. V. & Prasanth, S. G., Oct 8 2010, In : Molecular cell. 40, 1, p. 99-111 13 p.

Research output: Contribution to journalArticle

Nuclear organization and dynamics of 7SK RNA in regulating gene expression

Prasanth, K. V., Camiolo, M., Chan, G., Tripathi, V., Denis, L., Nakamura, T., Hübner, M. R. & Spector, D. L., Dec 1 2010, In : Molecular biology of the cell. 21, 23, p. 4184-4196 13 p.

Research output: Contribution to journalArticle

Polypurine-repeat-containing RNAs: A novel class of long non-coding RNA in mammalian cells

Zheng, R., Shen, Z., Tripathi, V., Xuan, Z., Freier, S. M., Bennett, C. F., Prasanth, S. G. & Prasanth, K. V., Nov 1 2010, In : Journal of cell science. 123, 21, p. 3734-3744 11 p.

Research output: Contribution to journalArticle

The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation

Tripathi, V., Ellis, J. D., Shen, Z., Song, D. Y., Pan, Q., Watt, A. T., Freier, S. M., Bennett, C. F., Sharma, A., Bubulya, P. A., Blencowe, B. J., Prasanth, S. G. & Prasanth, K. V., Sep 2010, In : Molecular cell. 39, 6, p. 925-938 14 p.

Research output: Contribution to journalArticle

2007

Eukaryotic regulatory RNAs: An answer to the 'genome complexity' conundrum

Prasanth, K. V. & Spector, D. L., Jan 1 2007, In : Genes and Development. 21, 1, p. 11-42 32 p.

Research output: Contribution to journalReview article

2006

PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein

Lee, H., Quinn, J. C., Prasanth, K. V., Swiss, V. A., Economides, K. D., Camacho, M. M., Spector, D. L. & Abate-Shen, C., Apr 1 2006, In : Genes and Development. 20, 7, p. 784-794 11 p.

Research output: Contribution to journalArticle

Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm

Politz, J. C. R., Tuft, R. A., Prasanth, K. V., Baudendistel, N., Fogarty, K. E., Lifshitz, L. M., Langowski, J., Spector, D. L. & Pederson, T., Mar 2006, In : Molecular biology of the cell. 17, 3, p. 1239-1249 11 p.

Research output: Contribution to journalArticle

2005

Regulating gene expression through RNA nuclear retention

Prasanth, K. V., Prasanth, S. G., Xuan, Z., Hearn, S., Freier, S. M., Bennett, C. F., Zhang, M. Q. & Spector, D. L., Oct 21 2005, In : Cell. 123, 2, p. 249-263 15 p.

Research output: Contribution to journalArticle