19952019
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Research Output 1995 2019

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Article
2005

The relationship between aminoglycosides' RNA binding proclivity and their antiplasmid effect on an IncB plasmid

Thomas, J. R., DeNap, J. C. B., Wong, M. L. & Hergenrother, P. J., May 10 2005, In : Biochemistry. 44, 18, p. 6800-6808 9 p.

Research output: Contribution to journalArticle

Aminoglycosides
Plasmids
RNA
Anti-Bacterial Agents
Bacteria

Using peptidic inhibitors to systematically probe the S1′ site of caspase-3 and caspase-7

Goode, D. R., Sharma, A. K. & Hergenrother, P. J., Aug 4 2005, In : Organic Letters. 7, 16, p. 3529-3532 4 p.

Research output: Contribution to journalArticle

Caspase 7
Caspases
Caspase 3
inhibitors
Substitution reactions
2004
Poly Adenosine Diphosphate Ribose
Ribose
Diphosphates
Enzyme Assays
NAD
Assays
Throughput
Adenosine Diphosphate Ribose
poly ADP-ribose glycohydrolase
Molecules

Combating drug-resistant bacteria: Small molecule mimics of plasmid incompatibility as antiplasmid compounds

DeNap, J. C. B., Thomas, J. R., Musk, D. J. & Hergenrother, P. J., Dec 1 2004, In : Journal of the American Chemical Society. 126, 47, p. 15402-15404 3 p.

Research output: Contribution to journalArticle

incompatibility
Antibiotics
plasmid
Bacteria
drug

Deoxystreptamine dimers bind to RNA hairpin loops

Liu, X., Thomas, J. R. & Hergenrother, P. J., Aug 4 2004, In : Journal of the American Chemical Society. 126, 30, p. 9196-9197 2 p.

Research output: Contribution to journalArticle

RNA
Dimers
Aminoglycosides
Molecules
secondary structure
2003

Altering substrate specificity of phosphatidylcholine-preferring phospholipase C of Bacillus cereus by random mutagenesis of the headgroup binding site

Antikainen, N. M., Hergenrother, P. J., Harris, M. M., Corbett, W. & Martin, S. F., Feb 18 2003, In : Biochemistry. 42, 6, p. 1603-1610 8 p.

Research output: Contribution to journalArticle

Bacillus cereus
Mutagenesis
Type C Phospholipases
Substrate Specificity
Phosphatidylcholines

An abiotic strategy for the enantioselective synthesis of erythromycin B

Hergenrother, P., Hodgson, A., Judd, A. S., Lee, W. C. & Martin, S. F., Jul 28 2003, In : Angewandte Chemie - International Edition. 42, 28, p. 3278-3281 4 p.

Research output: Contribution to journalArticle

Macrolides
Antibiotics
Carbohydrates
Acids
Anti-Bacterial Agents

Efficient synthesis of enantiopure β-amino-γ-keto acids from L-homoserine

Sharma, A. K. & Hergenrother, P. J., Jun 12 2003, In : Organic Letters. 5, 12, p. 2107-2109 3 p.

Research output: Contribution to journalArticle

Homoserine
Keto Acids
amino acids
Amino acids
Amino Acids

Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells

Nesterenko, V., Putt, K. S. & Hergenrother, P. J., Dec 3 2003, In : Journal of the American Chemical Society. 125, 48, p. 14672-14673 2 p.

Research output: Contribution to journalArticle

apoptosis
Cell death
cancer
Cells
Apoptosis

The use of pH to influence regio- and chemoselectivity in the asymmetric aminohydroxylation of styrenes

Nesterenko, V., Byers, J. T. & Hergenrother, P. J., Feb 6 2003, In : Organic Letters. 5, 3, p. 281-284 4 p.

Research output: Contribution to journalArticle

Styrenes
Regioselectivity
Reaction products
styrenes
reaction products
2002

Characterization of erythromycin analogs by collisional activated dissociation and infrared multiphoton dissociation in a quadrupole ion trap

Crowe, M. C., Brodbelt, J. S., Goolsby, B. J. & Hergenrother, P., Jun 2002, In : Journal of the American Society for Mass Spectrometry. 13, 6, p. 630-649 20 p.

Research output: Contribution to journalArticle

Erythromycin
Ions
Infrared radiation
Chemical activation
Macrolides

Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays

Kuruvilla, F. G., Shamji, A. F., Sternson, S. M., Hergenrother, P. J. & Schreiber, S. L., Apr 11 2002, In : Nature. 416, 6881, p. 653-657 5 p.

Research output: Contribution to journalArticle

Glucose
Proteins
Protein Binding
Transcription Factors
Genome
2000

A novel class of zinc-binding inhibitors for the phosphatidylcholine-preferring phospholipase C from Bacillus cereus

Martin, S. F., Follows, B. C., Hergenrother, P. J. & Franklin, C. L., Jul 28 2000, In : Journal of Organic Chemistry. 65, 15, p. 4509-4514 6 p.

Research output: Contribution to journalArticle

Bacillus cereus
Diglycerides
Type C Phospholipases
Phosphatidylcholines
Hydroxyl Radical

Cyclopropylacetylene: [Cyclopropane, ethynyl-]

Corley, E. G., Thompson, A. S., Huntington, M., Hergenrother, P. J. & Martin, S. F., Jan 1 2000, In : Organic Syntheses. 77, 1 p.

Research output: Contribution to journalArticle

cyclopropane

Determination of the substrate specificity of the phospholipase D from Streptomyces chromofuscus via an inorganic phosphate quantitation assay

Martin, S. F., Deblanc, R. L. & Hergenrother, P., Feb 15 2000, In : Analytical Biochemistry. 278, 2, p. 106-110 5 p.

Research output: Contribution to journalArticle

Phospholipase D
Streptomyces
Substrate Specificity
Assays
Phosphatidylglycerols

The choline binding site of phospholipase C (Bacillus cereus): Insights into substrate specificity

Martin, S. F., Follows, B. C., Hergenrother, P. J. & Trotter, B. K., Mar 28 2000, In : Biochemistry. 39, 12, p. 3410-3415 6 p.

Research output: Contribution to journalArticle

Bacillus cereus
Type C Phospholipases
Substrate Specificity
Choline
Binding Sites
1999
Bacillus cereus
Deuterium
Type C Phospholipases
Phosphatidylcholines
Viscosity
1998
Type C Phospholipases
Phosphatidylcholines
Phospholipids
Bacillus cereus
Phospholipase D

General base catalysis by the phosphatidylcholine-preferring phospholipase C from Bacillus cereus: The role of Glu4 and Asp55

Martin, S. F. & Hergenrother, P. J., Apr 21 1998, In : Biochemistry. 37, 16, p. 5755-5760 6 p.

Research output: Contribution to journalArticle

Bacillus cereus
Type C Phospholipases
Phosphatidylcholines
Catalysis
Catalyst activity
1997

Chromogenic assay for phospholipase D from Streptomyces chromofuscus: Application to the evaluation of substrate analogs

Hergenrother, P. J., Haas, M. K. & Martin, S. F., Jul 1 1997, In : Lipids. 32, 7, p. 783-788 6 p.

Research output: Contribution to journalArticle

Streptomyces chromofuscus
Chromogenics
Phospholipase D
phospholipase D
Streptomyces
Chromogenics
Bacillus cereus
Type C Phospholipases
Kinetic parameters
Assays
1996

Expression and site-directed mutagenesis of the phosphatidylcholine- preferring phospholipase C of Bacillus cereus: Probing the role of the active site Glu146

Martin, S. F., Spaller, M. R. & Hergenrother, P. J., Oct 19 1996, In : Biochemistry. 35, 39, p. 12970-12977 8 p.

Research output: Contribution to journalArticle

Bacillus cereus
Mutagenesis
Type C Phospholipases
Site-Directed Mutagenesis
Phosphatidylcholines
1995

Chromogenic assay for phospholipase C from bacillus cereus

Hergenrother, P. J., Spaller, M. R., Haas, M. K. & Martin, S. F., Aug 1995, In : Analytical Biochemistry. 229, 2, p. 313-316 4 p.

Research output: Contribution to journalArticle

Chromogenics
Bacillus cereus
Type C Phospholipases
Phosphatidylcholines
Assays