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Research Output 1995 2019

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2012

An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis

Huang, X., Dong, Y., Bey, E. A., Kilgore, J. A., Bair, J. S., Li, L. S., Patel, M., Parkinson, E. I., Wang, Y., Williams, N. S., Gao, J., Hergenrother, P. J. & Boothman, D. A., Jun 15 2012, In : Cancer Research. 72, 12, p. 3038-3047 10 p.

Research output: Contribution to journalArticle

Necrosis
Neoplasms
NAD
Oxidation-Reduction
Reactive Oxygen Species

Differential effects of procaspase-3 activating compounds in the induction of cancer cell death

West, D. C., Qin, Y., Peterson, Q. P., Thomas, D. L., Palchaudhuri, R., Morrison, K. C., Lucas, P. W., Palmer, A. E., Fan, T. M. & Hergenrother, P. J., May 7 2012, In : Molecular Pharmaceutics. 9, 5, p. 1425-1434 10 p.

Research output: Contribution to journalArticle

Caspase 3
Cell Death
Neoplasms
Apoptosis
2-carboxyarabinitol 1-phosphate

Identification of a Novel Protein Synthesis Inhibitor Active against Gram-Positive Bacteria

Eibergen, N. R., Im, I., Patel, N. Y. & Hergenrother, P. J., Mar 1 2012, In : ChemBioChem. 13, 4, p. 574-583 10 p.

Research output: Contribution to journalArticle

Protein Synthesis Inhibitors
Gram-Positive Bacteria
Bacteria
Staphylococcus aureus
Methicillin

Parallel synthesis and biological evaluation of 837 analogues of procaspase-activating compound 1 (PAC-1)

Hsu, D. C., Roth, H. S., West, D. C., Botham, R. C., Novotny, C. J., Schmid, S. C. & Hergenrother, P. J., Jan 9 2012, In : ACS Combinatorial Science. 14, 1, p. 44-50 7 p.

Research output: Contribution to journalArticle

Caspase 3
Cells
Cell culture
Apoptosis
Hydrazones

Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG)

Finch, K. E., Knezevic, C. E., Nottbohm, A. C., Partlow, K. C. & Hergenrother, P. J., Mar 16 2012, In : ACS chemical biology. 7, 3, p. 563-570 8 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
ADP-ribosylarginine hydrolase
Molecules
DNA Damage
Poly Adenosine Diphosphate Ribose

Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase

Dunstan, M. S., Barkauskaite, E., Lafite, P., Knezevic, C. E., Brassington, A., Ahel, M., Hergenrother, P. J., Leys, D. & Ahel, I., Jul 6 2012, In : Nature communications. 3, 878.

Research output: Contribution to journalArticle

ribose
adenosine diphosphate
Glycoside Hydrolases
inhibitors
Tetrahymena thermophila

Whole cell microtubule analysis by flow cytometry

Morrison, K. C. & Hergenrother, P. J., Jan 1 2012, In : Analytical Biochemistry. 420, 1, p. 26-32 7 p.

Research output: Contribution to journalArticle

Flow cytometry
Tubulin
Microtubules
Flow Cytometry
Polymerization
2011

Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism

Hoyt, M. T., Palchaudhuri, R. & Hergenrother, P., Aug 1 2011, In : Investigational New Drugs. 29, 4, p. 562-573 12 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Neoplasms
Cell Cycle Checkpoints
Biological Products
Antineoplastic Agents

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells

Granchi, C., Roy, S., Giacomelli, C., MacChia, M., Tuccinardi, T., Martinelli, A., Lanza, M., Betti, L., Giannaccini, G., Lucacchini, A., Funel, N., León, L. G., Giovannetti, E., Peters, G. J., Palchaudhuri, R., Calvaresi, E. C., Hergenrother, P. J. & Minutolo, F., Mar 24 2011, In : Journal of Medicinal Chemistry. 54, 6, p. 1599-1612 14 p.

Research output: Contribution to journalArticle

Starvation
L-Lactate Dehydrogenase
Protein Isoforms
Glycolysis
Neoplasms

Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs

Lucas, P. W., Schmit, J. M., Peterson, Q. P., West, D. C., Hsu, D. C., Novotny, C. J., Dirikolu, L., Churchwell, M. I., Doerge, D. R., Garrett, L. D., Hergenrother, P. & Fan, T. M., Oct 1 2011, In : Investigational New Drugs. 29, 5, p. 901-911 11 p.

Research output: Contribution to journalArticle

Caspase 3
Pharmacokinetics
Dogs
Lymphoma
2-carboxyarabinitol 1-phosphate

Toxin-antitoxin (TA) systems are prevalent and transcribed in clinical isolates of Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus

Williams, J. J., Halvorsen, E. M., Dwyer, E. M., Difazio, R. M. & Hergenrother, P. J., Sep 1 2011, In : FEMS microbiology letters. 322, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

Antitoxins
Methicillin-Resistant Staphylococcus aureus
Pseudomonas aeruginosa
Bacteria
Reverse Transcriptase Polymerase Chain Reaction

Triphenylmethyl derivatives enhances the anticancer effect of immunotoxins

Risberg, K., Guldvik, I. J., Palchaudhuri, R., Xi, Y., Ju, J., Fodstad, Ø., Hergenrother, P. J. & Andersson, Y., Jun 1 2011, In : Journal of Immunotherapy. 34, 5, p. 438-447 10 p.

Research output: Contribution to journalArticle

Immunotoxins
Organophosphonates
Stearoyl-CoA Desaturase
Neoplasms
Nude Rats

Txe, an endoribonuclease of the enterococcal Axe-Txe toxin-antitoxin system, cleaves mRNA and inhibits protein synthesis

Halvorsen, E. M., Williams, J. J., Bhimani, A. J., Billings, E. A. & Hergenrother, P. J., Feb 1 2011, In : Microbiology. 157, 2, p. 387-397 11 p.

Research output: Contribution to journalArticle

Endoribonucleases
Antitoxins
Messenger RNA
Poisons
Operon
2010

A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor α

Kretzer, N. M., Cherian, M. T., Mao, C., Aninye, I. O., Reynolds, P. D., Schiff, R., Hergenrother, P., Nordeen, S. K., Wilson, E. M. & Shapiro, D. J., Dec 31 2010, In : Journal of Biological Chemistry. 285, 53, p. 41863-41873 11 p.

Research output: Contribution to journalArticle

Cell growth
Proteasome Endopeptidase Complex
Gene expression
Estrogen Receptors
Estrogens

Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death

Bair, J. S., Palchaudhuri, R. & Hergenrother, P. J., Apr 21 2010, In : Journal of the American Chemical Society. 132, 15, p. 5469-5478 10 p.

Research output: Contribution to journalArticle

Cell death
Helper-Inducer T-Lymphocytes
cancer
Cell Death
Cells

Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound

Peterson, Q. P., Hsu, D. C., Novotny, C. J., West, D. C., Kim, D., Schmit, J. M., Dirikolu, L., Hergenrother, P. J. & Fan, T. M., Sep 15 2010, In : Cancer Research. 70, 18, p. 7232-7241 10 p.

Research output: Contribution to journalArticle

Caspase 3
Canidae
Dogs
Caspases
Neoplasms

Identification of novel synthetic toll-like receptor 2 agonists by high throughput screening

Guan, Y., Omueti-Ayoade, K., Mutha, S. K., Hergenrother, P. J. & Tapping, R. I., Jul 30 2010, In : Journal of Biological Chemistry. 285, 31, p. 23755-23762 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 2
Toll-Like Receptors
Screening
Throughput
Small Molecule Libraries

N -((1-benzyl-1 H -1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: Synthesis and evaluation of antiproliferative activity against select cancer cell lines

Stefely, J. A., Palchaudhuri, R., Miller, P. A., Peterson, R. J., Moraski, G. C., Hergenrother, P. J. & Miller, M. J., Apr 22 2010, In : Journal of Medicinal Chemistry. 53, 8, p. 3389-3395 7 p.

Research output: Contribution to journalArticle

Tubulin
HeLa Cells
Polymerization
Computer Simulation
Cell Line

Phenylcinnamides as novel antimitotic agents

Leslie, B. J., Holaday, C. R., Nguyen, T. & Hergenrother, P. J., May 27 2010, In : Journal of Medicinal Chemistry. 53, 10, p. 3964-3972 9 p.

Research output: Contribution to journalArticle

Antimitotic Agents
P-Glycoprotein
Neoplasms
Cell Death
M Phase Cell Cycle Checkpoints

Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis

Peterson, Q. P., Goode, D. R., West, D. C., Botham, R. C. & Hergenrother, P., Feb 1 2010, In : Nature Protocols. 5, 2, p. 294-302 9 p.

Research output: Contribution to journalArticle

Caspase 7
Caspases
Caspase 3
Peptides
Substrates
2009

A Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates

Chan, L. L., Lidstone, E. A., Finch, K. E., Heeres, J. T., Hergenrother, P. J. & Cunningham, B. T., Dec 2009, In : Journal of Laboratory Automation. 14, 6, p. 348-359 12 p.

Research output: Contribution to journalArticle

Optics and Photonics
Biosensing Techniques
Photonic crystals
Biosensors
Assays
Optics and Photonics
Biosensing Techniques
Photonic crystals
Biosensors
Assays

Identifying modulators of protein-protein interactions using photonic crystal biosensors

Heeres, J. T., Kim, S. H., Leslie, B. J., Lidstone, E. A., Cunningham, B. T. & Hergenrother, P. J., Dec 30 2009, In : Journal of the American Chemical Society. 131, 51, p. 18202-18203 2 p.

Research output: Contribution to journalArticle

Optics and Photonics
Biosensing Techniques
Photonic crystals
Biosensors
Modulators

Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells

Rosenthal, A. S., Chen, X., Liu, J. O., West, D. C., Hergenrother, P. J., Shapiro, T. A. & Posner, G. H., Feb 26 2009, In : Journal of Medicinal Chemistry. 52, 4, p. 1198-1203 6 p.

Research output: Contribution to journalArticle

Sulfones
Malaria
Mefloquine
Neoplasms
Cell Line

PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition

Peterson, Q. P., Goode, D. R., West, D. C., Ramsey, K. N., Lee, J. J. Y. & Hergenrother, P. J., Apr 24 2009, In : Journal of Molecular Biology. 388, 1, p. 144-158 15 p.

Research output: Contribution to journalArticle

Caspase 3
Zinc
Apoptosis
2-carboxyarabinitol 1-phosphate
In Vitro Techniques

Procaspase-3 activation as an anti-cancer strategy: Structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3

Peterson, Q. P., Hsu, D. C., Goode, D. R., Novotny, C. J., Totten, R. K. & Hergenrother, P. J., Sep 24 2009, In : Journal of Medicinal Chemistry. 52, 18, p. 5721-5731 11 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Caspase 3
Neoplasms
Zinc
Cell Culture Techniques

Small molecule ligands for bulged RNA secondary structures

Meyer, S. T. & Hergenrother, P. J., Sep 17 2009, In : Organic Letters. 11, 18, p. 4052-4055 4 p.

Research output: Contribution to journalArticle

wedges
affinity
selectivity
RNA
Intercalating Agents

Total synthesis and cytoprotective properties of dykellic acid

Thompson, C. M., Quinn, C. A. & Hergenrother, P. J., Jan 8 2009, In : Journal of Medicinal Chemistry. 52, 1, p. 117-125 9 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Cell Death
Rotenone
Caspase Inhibitors
Etoposide
2008

A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors

Chan, L. L., Pineda, M., Heeres, J. T., Hergenrother, P. J. & Cunningham, B. T., Jul 18 2008, In : ACS chemical biology. 3, 7, p. 437-448 12 p.

Research output: Contribution to journalArticle

Optics and Photonics
Biosensing Techniques
Photonic crystals
Biosensors
DNA-Binding Proteins

A new small molecule inhibitor of estrogen receptor α binding to estrogen response elements blocks estrogen-dependent growth of cancer cells

Mao, C., Patterson, N. M., Cherian, M. T., Aninye, I. O., Zhang, C., Montoya, J. B., Cheng, J., Putt, K. S., Hergenrother, P. J., Wilson, E. M., Nardulli, A. M., Nordeen, S. K. & Shapiro, D. J., May 9 2008, In : Journal of Biological Chemistry. 283, 19, p. 12819-12830 12 p.

Research output: Contribution to journalArticle

Response Elements
Estrogen Receptors
Estrogens
Cells
Molecules
Biofilms
Pseudomonas aeruginosa
biofilm
Iron
lungs

Identification of promiscuous small molecule activators in high-throughput enzyme activation screens

Goode, D. R., Totten, R. K., Heeres, J. T. & Hergenrother, P. J., Apr 24 2008, In : Journal of Medicinal Chemistry. 51, 8, p. 2346-2349 4 p.

Research output: Contribution to journalArticle

Enzyme Activation
Chemical activation
Throughput
Enzyme Activators
Molecules

The complex role of the triphenylmethyl motif in anticancer compounds

Palchaudhuri, R., Nesterenko, V. & Hergenrother, P. J., Aug 6 2008, In : Journal of the American Chemical Society. 130, 31, p. 10274-10281 8 p.

Research output: Contribution to journalArticle

cancer
Cells
assay
Assays
polymerization
Structure-Activity Relationship
Melanoma
Cells
Apoptosis
Cell Line
2007

A colorimetric substrate for poly(ADP-ribose) polymerase-1, VPARP, and tankyrase-1

Nottbohm, A. C., Dothager, R. S., Putt, K. S., Hoyt, M. T. & Hergenrother, P. J., Jun 29 2007, In : Angewandte Chemie - International Edition. 46, 12, p. 2066-2069 4 p.

Research output: Contribution to journalArticle

Tankyrases
Administrative data processing
Poly(ADP-ribose) Polymerases
Substrates
Adenosine Diphosphate

A continuous fluorometric assay for the assessment of MazF ribonuclease activity

Wang, N. R. & Hergenrother, P. J., Dec 15 2007, In : Analytical Biochemistry. 371, 2, p. 173-183 11 p.

Research output: Contribution to journalArticle

Antitoxins
Ribonucleases
Assays
Plasmids
Biochemistry

A novel synthetic analogue of a constituent of Isodon excisus inhibits transcription of CYP1A1, -1A2 and -1B1 by preventing activation of the aryl hydrocarbon receptor

Sienkiewicz, P., Ciolino, H. P., Leslie, B. J., Hergenrother, P. J., Singletary, K. & Yeh, G. C., May 1 2007, In : Carcinogenesis. 28, 5, p. 1052-1057 6 p.

Research output: Contribution to journalArticle

Isodon
Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Carcinogens
Cytochrome P-450 Enzyme System

Increased poly(ADP-ribose) polymerase activity during porcine hemorrhagic shock is transient and predictive of mortality

Skarda, D. E., Putt, K. S., Hergenrother, P. J., Mulier, K. E. & Beilman, G. J., Oct 1 2007, In : Resuscitation. 75, 1, p. 135-144 10 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Hemorrhagic Shock
Resuscitation
Swine
Mortality

Multiplex targeting, tracking, and imaging of apoptosis by fluorescent surface enhanced raman spectroscopic dots

Kyeong, N. Y., Lee, S. M., Ji, Y. H., Park, H., Woo, M. A., Mi, S. N., Hwang, S. K., Kwon, J. T., Jin, H., Kim, Y. K., Hergenrother, P. J., Dae, H. J., Lee, Y. S. & Cho, M. H., Jul 1 2007, In : Bioconjugate Chemistry. 18, 4, p. 1155-1162 8 p.

Research output: Contribution to journalArticle

Cell death
Apoptosis
Imaging techniques
Molecular Imaging
Fluorescent Dyes

Total synthesis of erythromycin B

Breton, P., Hergenrother, P. J., Hida, T., Hodgson, A., Judd, A. S., Kraynack, E., Kym, P. R., Lee, W. C., Loft, M. S., Yamashita, M. & Martin, S. F., Jun 25 2007, In : Tetrahedron. 63, 26, p. 5709-5729 21 p.

Research output: Contribution to journalArticle

Acids
Lactones
Bearings (structural)
Glycosylation
Cyclization
Antitoxins
Plasmids
Genes
Enterococcus
Vancomycin
2006

Biochemical and thermodynamic characterization of compounds that bind to RNA hairpin loops: Toward an understanding of selectivity

Thomas, J. R., Liu, X. & Hergenrother, P. J., Sep 12 2006, In : Biochemistry. 45, 36, p. 10928-10938 11 p.

Research output: Contribution to journalArticle

Thermodynamics
RNA
Aminoglycosides
Molecules
Binding energy

Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy

Putt, K. S., Chen, G. W., Pearson, J. M., Sandhorst, J. S., Hoagland, M. S., Kwon, J. T., Hwang, S. K., Jin, H., Churchwell, M. I., Cho, M. H., Doerge, D. R., Helferich, W. G. & Hergenrother, P. J., Oct 2006, In : Nature chemical biology. 2, 10, p. 543-550 8 p.

Research output: Contribution to journalArticle

Caspase 3
Caspases
Neoplasms
Apoptosis
Enzyme Precursors

The compound 13-D selectively induces apoptosis in white blood cancers versus other cancer cell types

Putt, K. S., Nesterenko, V., Dothager, R. S. & Hergenrother, P. J., Dec 1 2006, In : ChemBioChem. 7, 12, p. 1916-1922 7 p.

Research output: Contribution to journalArticle

Blood
Cell death
Cells
Apoptosis
Cell Death
2005

Bacterial death comes full circle: Targeting plasmid replication in drug-resistant bacteria

Denap, J. C. B. & Hergenrother, P. J., Mar 21 2005, In : Organic and Biomolecular Chemistry. 3, 6, p. 959-966 8 p.

Research output: Contribution to journalArticle

plasmids
death
bacteria
Bacteria
drugs

Direct quantitation of poly(ADP-Ribose) polymerase (PARP) activity as a means to distinguish necrotic and apoptotic death in cell and tissue samples

Putt, K. S., Beilman, G. J. & Hergenrother, P. J., Jan 1 2005, In : ChemBioChem. 6, 1, p. 53-55 3 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Cell Death
Necrosis
Tissue
Hemorrhagic Shock

Iron salts perturb biofilm formation and disrupt existing biofilms of Pseudomonas aeruginosa

Musk, D. J., Banko, D. A. & Hergenrother, P. J., Jul 1 2005, In : Chemistry and Biology. 12, 7, p. 789-796 8 p.

Research output: Contribution to journalArticle

Biofilms
Pseudomonas aeruginosa
Iron
Salts
Genes

Size-specific ligands for RNA hairpin loops

Thomas, J. R., Liu, X. & Hergenrother, P. J., Sep 14 2005, In : Journal of the American Chemical Society. 127, 36, p. 12434-12435 2 p.

Research output: Contribution to journalArticle

RNA
ligand
Ligands
targeting
Dimers
Screening
Students
student
drug
Group

Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest

Dothager, R. S., Putt, K. S., Allen, B. J., Leslie, B. J., Nesterenko, V. & Hergenrother, P. J., Jun 22 2005, In : Journal of the American Chemical Society. 127, 24, p. 8686-8696 11 p.

Research output: Contribution to journalArticle

apoptosis
Cell death
drug
Cells
Apoptosis