19952019
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Research Output 1995 2019

(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition

Rack, J. G. M., Ariza, A., Drown, B. S., Henfrey, C., Bartlett, E., Shirai, T., Hergenrother, P. & Ahel, I., Dec 20 2018, In : Cell chemical biology. 25, 12, p. 1533-1546.e12

Research output: Contribution to journalArticle

Hydrolases
Adenosine Diphosphate
Ribose
Substrates
Enzymes

Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine

Garcia, A., Drown, B. S. & Hergenrother, P. J., Oct 7 2016, In : Organic Letters. 18, 19, p. 4852-4855 4 p.

Research output: Contribution to journalArticle

complex compounds
alkaloids
Biological Products
Alkaloids
rings

A colorimetric substrate for poly(ADP-ribose) polymerase-1, VPARP, and tankyrase-1

Nottbohm, A. C., Dothager, R. S., Putt, K. S., Hoyt, M. T. & Hergenrother, P. J., Jun 29 2007, In : Angewandte Chemie - International Edition. 46, 12, p. 2066-2069 4 p.

Research output: Contribution to journalArticle

Tankyrases
Administrative data processing
Poly(ADP-ribose) Polymerases
Substrates
Adenosine Diphosphate

A continuous fluorometric assay for the assessment of MazF ribonuclease activity

Wang, N. R. & Hergenrother, P. J., Dec 15 2007, In : Analytical Biochemistry. 371, 2, p. 173-183 11 p.

Research output: Contribution to journalArticle

Antitoxins
Ribonucleases
Assays
Plasmids
Biochemistry

A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors

Chan, L. L., Pineda, M., Heeres, J. T., Hergenrother, P. J. & Cunningham, B. T., Jul 18 2008, In : ACS chemical biology. 3, 7, p. 437-448 12 p.

Research output: Contribution to journalArticle

Optics and Photonics
Biosensing Techniques
Photonic crystals
Biosensors
DNA-Binding Proteins

Altering substrate specificity of phosphatidylcholine-preferring phospholipase C of Bacillus cereus by random mutagenesis of the headgroup binding site

Antikainen, N. M., Hergenrother, P. J., Harris, M. M., Corbett, W. & Martin, S. F., Feb 18 2003, In : Biochemistry. 42, 6, p. 1603-1610 8 p.

Research output: Contribution to journalArticle

Bacillus cereus
Mutagenesis
Type C Phospholipases
Substrate Specificity
Phosphatidylcholines

A method for identifying small molecule aggregators using photonic crystal biosensor microplates

Chan, L. L., Lidstone, E. A., Finch, K. E., Heeres, J. T., Hergenrother, P. J. & Cunningham, B. T., Jan 1 2009, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, p. 788-791 4 p. 5333796. (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Optics and Photonics
Biosensing Techniques
Photonic crystals
Biosensors
Assays

A Method for Identifying Small-Molecule Aggregators Using Photonic Crystal Biosensor Microplates

Chan, L. L., Lidstone, E. A., Finch, K. E., Heeres, J. T., Hergenrother, P. J. & Cunningham, B. T., Dec 2009, In : Journal of Laboratory Automation. 14, 6, p. 348-359 12 p.

Research output: Contribution to journalArticle

Optics and Photonics
Biosensing Techniques
Photonic crystals
Biosensors
Assays
Optics and Photonics
Biosensing Techniques
Photonic crystals
Biosensors
Assays

An abiotic strategy for the enantioselective synthesis of erythromycin B

Hergenrother, P., Hodgson, A., Judd, A. S., Lee, W. C. & Martin, S. F., Jul 28 2003, In : Angewandte Chemie - International Edition. 42, 28, p. 3278-3281 4 p.

Research output: Contribution to journalArticle

Macrolides
Antibiotics
Carbohydrates
Acids
Anti-Bacterial Agents
Poly Adenosine Diphosphate Ribose
Ribose
Diphosphates
Enzyme Assays
NAD

A new small molecule inhibitor of estrogen receptor α binding to estrogen response elements blocks estrogen-dependent growth of cancer cells

Mao, C., Patterson, N. M., Cherian, M. T., Aninye, I. O., Zhang, C., Montoya, J. B., Cheng, J., Putt, K. S., Hergenrother, P. J., Wilson, E. M., Nardulli, A. M., Nordeen, S. K. & Shapiro, D. J., May 9 2008, In : Journal of Biological Chemistry. 283, 19, p. 12819-12830 12 p.

Research output: Contribution to journalArticle

Response Elements
Estrogen Receptors
Estrogens
Cells
Molecules

An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis

Huang, X., Dong, Y., Bey, E. A., Kilgore, J. A., Bair, J. S., Li, L. S., Patel, M., Parkinson, E. I., Wang, Y., Williams, N. S., Gao, J., Hergenrother, P. J. & Boothman, D. A., Jun 15 2012, In : Cancer Research. 72, 12, p. 3038-3047 10 p.

Research output: Contribution to journalArticle

Necrosis
Neoplasms
NAD
Oxidation-Reduction
Reactive Oxygen Species

A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor α

Kretzer, N. M., Cherian, M. T., Mao, C., Aninye, I. O., Reynolds, P. D., Schiff, R., Hergenrother, P., Nordeen, S. K., Wilson, E. M. & Shapiro, D. J., Dec 31 2010, In : Journal of Biological Chemistry. 285, 53, p. 41863-41873 11 p.

Research output: Contribution to journalArticle

Cell growth
Proteasome Endopeptidase Complex
Gene expression
Estrogen Receptors
Estrogens
Assays
Throughput
Adenosine Diphosphate Ribose
poly ADP-ribose glycohydrolase
Molecules

A novel class of zinc-binding inhibitors for the phosphatidylcholine-preferring phospholipase C from Bacillus cereus

Martin, S. F., Follows, B. C., Hergenrother, P. J. & Franklin, C. L., Jul 28 2000, In : Journal of Organic Chemistry. 65, 15, p. 4509-4514 6 p.

Research output: Contribution to journalArticle

Bacillus cereus
Diglycerides
Type C Phospholipases
Phosphatidylcholines
Hydroxyl Radical

A novel synthetic analogue of a constituent of Isodon excisus inhibits transcription of CYP1A1, -1A2 and -1B1 by preventing activation of the aryl hydrocarbon receptor

Sienkiewicz, P., Ciolino, H. P., Leslie, B. J., Hergenrother, P. J., Singletary, K. & Yeh, G. C., May 1 2007, In : Carcinogenesis. 28, 5, p. 1052-1057 6 p.

Research output: Contribution to journalArticle

Isodon
Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Carcinogens
Cytochrome P-450 Enzyme System

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy

Luu, L. M., Nguyen, L., Peng, S., Lee, J. Y., Lee, H. Y., Wong, C. H., Hergenrother, P., Chan, H. Y. E. & Zimmerman, S. C., Jan 1 2016, In : ChemMedChem. 11, 13, p. 1428-1435 8 p.

Research output: Contribution to journalArticle

Trinucleotide Repeats
Myotonic Dystrophy
Drosophila
Lead compounds
Defects

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

Huigens, R. W., Morrison, K. C., Hicklin, R. W., Timothy, T. A., Richter, M. F. & Hergenrother, P. J., Mar 1 2013, In : Nature Chemistry. 5, 3, p. 195-202 8 p.

Research output: Contribution to journalArticle

Biological Products
Screening
Lead compounds
Chemical properties
Carbon

Artificial activation of toxin-antitoxin systems as an antibacterial strategy

Williams, J. J. & Hergenrother, P., Jun 1 2012, In : Trends in Microbiology. 20, 6, p. 291-298 8 p.

Research output: Contribution to journalReview article

Antitoxins
Bacterial Chromosomes
Bacterial Genomes
Genes
Plasmids

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

Palchaudhuri, R., Lambrecht, M. J., Botham, R. C., Partlow, K. C., van Ham, T. J., Putt, K. S., Nguyen, L. T., Kim, S. H., Peterson, R. T., Fan, T. M. & Hergenrother, P. J., Dec 1 2015, In : Cell Reports. 13, 9, p. 2027-2036 10 p.

Research output: Contribution to journalArticle

Apoptosis
Molecules
Voltage-Dependent Anion Channels
Mitochondrial Membrane Potential
Cell death

Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

Granchi, C., Calvaresi, E. C., Tuccinardi, T., Paterni, I., Macchia, M., Martinelli, A., Hergenrother, P. J. & Minutolo, F., Oct 14 2013, In : Organic and Biomolecular Chemistry. 11, 38, p. 6588-6596 9 p.

Research output: Contribution to journalArticle

Scaffolds
inhibitors
carboxylates
cancer
Cells

Bacterial death comes full circle: Targeting plasmid replication in drug-resistant bacteria

Denap, J. C. B. & Hergenrother, P. J., Mar 21 2005, In : Organic and Biomolecular Chemistry. 3, 6, p. 959-966 8 p.

Research output: Contribution to journalArticle

plasmids
death
bacteria
Bacteria
drugs

Biochemical and thermodynamic characterization of compounds that bind to RNA hairpin loops: Toward an understanding of selectivity

Thomas, J. R., Liu, X. & Hergenrother, P. J., Sep 12 2006, In : Biochemistry. 45, 36, p. 10928-10938 11 p.

Research output: Contribution to journalArticle

Thermodynamics
RNA
Aminoglycosides
Molecules
Binding energy
Bacillus cereus
Deuterium
Type C Phospholipases
Phosphatidylcholines
Viscosity

Characterization of erythromycin analogs by collisional activated dissociation and infrared multiphoton dissociation in a quadrupole ion trap

Crowe, M. C., Brodbelt, J. S., Goolsby, B. J. & Hergenrother, P., Jun 2002, In : Journal of the American Society for Mass Spectrometry. 13, 6, p. 630-649 20 p.

Research output: Contribution to journalArticle

Erythromycin
Ions
Infrared radiation
Chemical activation
Macrolides

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer

Granchi, C., Fortunato, S., Meini, S., Rizzolio, F., Caligiuri, I., Tuccinardi, T., Lee, H. Y., Hergenrother, P. & Minutolo, F., Jul 19 2017, In : Journal of Agricultural and Food Chemistry. 65, 28, p. 5639-5649 11 p.

Research output: Contribution to journalArticle

saffron
lactate dehydrogenase
L-Lactate Dehydrogenase
chemical derivatives
Derivatives
Biofilms
Pseudomonas aeruginosa
biofilm
Iron
lungs

Chemical countermeasures for the control of bacterial biofilms: Effective compounds and promising targets

Musk, D. J. & Hergenrother, P. J., Jul 1 2006, In : Current Medicinal Chemistry. 13, 18, p. 2163-2177 15 p.

Research output: Contribution to journalReview article

Biofilms
Quorum Sensing
Infection
Bacterial Infections
Bacteria

Chemistry and biology of deoxynyboquinone, a potent inducer of cancer cell death

Bair, J. S., Palchaudhuri, R. & Hergenrother, P. J., Apr 21 2010, In : Journal of the American Chemical Society. 132, 15, p. 5469-5478 10 p.

Research output: Contribution to journalArticle

Cell death
Helper-Inducer T-Lymphocytes
cancer
Cell Death
Cells

Chromogenic assay for phospholipase C from bacillus cereus

Hergenrother, P. J., Spaller, M. R., Haas, M. K. & Martin, S. F., Aug 1995, In : Analytical Biochemistry. 229, 2, p. 313-316 4 p.

Research output: Contribution to journalArticle

Chromogenics
Bacillus cereus
Type C Phospholipases
Phosphatidylcholines
Assays

Chromogenic assay for phospholipase D from Streptomyces chromofuscus: Application to the evaluation of substrate analogs

Hergenrother, P. J., Haas, M. K. & Martin, S. F., Jul 1 1997, In : Lipids. 32, 7, p. 783-788 6 p.

Research output: Contribution to journalArticle

Streptomyces chromofuscus
Chromogenics
Phospholipase D
phospholipase D
Streptomyces

Combating drug-resistant bacteria: Small molecule mimics of plasmid incompatibility as antiplasmid compounds

DeNap, J. C. B., Thomas, J. R., Musk, D. J. & Hergenrother, P. J., Dec 1 2004, In : Journal of the American Chemical Society. 126, 47, p. 15402-15404 3 p.

Research output: Contribution to journalArticle

incompatibility
Antibiotics
plasmid
Bacteria
drug

Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism

Hoyt, M. T., Palchaudhuri, R. & Hergenrother, P., Aug 1 2011, In : Investigational New Drugs. 29, 4, p. 562-573 12 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Neoplasms
Cell Cycle Checkpoints
Biological Products
Antineoplastic Agents

Cyclopropylacetylene: [Cyclopropane, ethynyl-]

Corley, E. G., Thompson, A. S., Huntington, M., Hergenrother, P. J. & Martin, S. F., Jan 1 2000, In : Organic Syntheses. 77, 1 p.

Research output: Contribution to journalArticle

cyclopropane

Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria

Parkinson, E. I., Bair, J. S., Nakamura, B. A., Lee, H. Y., Kuttab, H. I., Southgate, E. H., Lezmi, S., Lau, G. W. & Hergenrother, P. J., Apr 22 2015, In : Nature communications. 6, 6947.

Research output: Contribution to journalArticle

DNA Gyrase
Fluoroquinolones
bacteria
mice
Bacteria

Deoxynyboquinones as NQO1-Activated Cancer Therapeutics

Parkinson, E. I. & Hergenrother, P., Oct 20 2015, In : Accounts of chemical research. 48, 10, p. 2715-2723 9 p.

Research output: Contribution to journalArticle

Substrates
Cells
Biological Products
Toxicity
Tumors

Deoxystreptamine dimers bind to RNA hairpin loops

Liu, X., Thomas, J. R. & Hergenrother, P. J., Aug 4 2004, In : Journal of the American Chemical Society. 126, 30, p. 9196-9197 2 p.

Research output: Contribution to journalArticle

RNA
Dimers
Aminoglycosides
Molecules
secondary structure

Derivatives of procaspase-activating compound 1 (PAC-1) and their anticancer activities

Roth, H. S. & Hergenrother, P. J., Jan 1 2016, In : Current Medicinal Chemistry. 23, 3, p. 201-241 41 p.

Research output: Contribution to journalArticle

Cell Culture Techniques
Derivatives
Clinical Trials, Phase I
Structure-Activity Relationship
Cell culture

Detection of endogenous MazF enzymatic activity in Staphylococcus aureus

Van Rensburg, J. J. & Hergenrother, P. J., Oct 8 2013, In : Analytical Biochemistry. 443, 1, p. 81-87 7 p.

Research output: Contribution to journalArticle

Antitoxins
Staphylococcus aureus
Assays
Endoribonucleases
Gene encoding

Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor

Zhang, M., Peh, J., Hergenrother, P. J. & Cunningham, B. T., Nov 2 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., p. 2073-2076 4 p. 6944024. (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Laser resonators
Biosensing Techniques
Biosensors
Lasers
Proteins

Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor

Zhang, M., Peh, J., Hergenrother, P. J. & Cunningham, B. T., Apr 23 2014, In : Journal of the American Chemical Society. 136, 16, p. 5840-5843 4 p.

Research output: Contribution to journalArticle

Laser resonators
Biosensing Techniques
Biosensors
cavity
Lasers

Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor

Zhang, M., Peh, J., Hergenrother, P. & Cunningham, B. T., Nov 2 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., p. 2073-2076 4 p. 6944024. (2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Laser resonators
Biosensing Techniques
Biosensors
Lasers
Proteins
Chromogenics
Bacillus cereus
Type C Phospholipases
Kinetic parameters
Assays

Determination of the substrate specificity of the phospholipase D from Streptomyces chromofuscus via an inorganic phosphate quantitation assay

Martin, S. F., Deblanc, R. L. & Hergenrother, P., Feb 15 2000, In : Analytical Biochemistry. 278, 2, p. 106-110 5 p.

Research output: Contribution to journalArticle

Phospholipase D
Streptomyces
Substrate Specificity
Assays
Phosphatidylglycerols

Differential effects of procaspase-3 activating compounds in the induction of cancer cell death

West, D. C., Qin, Y., Peterson, Q. P., Thomas, D. L., Palchaudhuri, R., Morrison, K. C., Lucas, P. W., Palmer, A. E., Fan, T. M. & Hergenrother, P. J., May 7 2012, In : Molecular Pharmaceutics. 9, 5, p. 1425-1434 10 p.

Research output: Contribution to journalArticle

Caspase 3
Cell Death
Neoplasms
Apoptosis
2-carboxyarabinitol 1-phosphate

Direct quantitation of poly(ADP-Ribose) polymerase (PARP) activity as a means to distinguish necrotic and apoptotic death in cell and tissue samples

Putt, K. S., Beilman, G. J. & Hergenrother, P. J., Jan 1 2005, In : ChemBioChem. 6, 1, p. 53-55 3 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Cell Death
Necrosis
Tissue
Hemorrhagic Shock

Discovery and canine preclinical assessment of a nontoxic procaspase-3-activating compound

Peterson, Q. P., Hsu, D. C., Novotny, C. J., West, D. C., Kim, D., Schmit, J. M., Dirikolu, L., Hergenrother, P. J. & Fan, T. M., Sep 15 2010, In : Cancer Research. 70, 18, p. 7232-7241 10 p.

Research output: Contribution to journalArticle

Caspase 3
Canidae
Dogs
Caspases
Neoplasms

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells

Granchi, C., Roy, S., Giacomelli, C., MacChia, M., Tuccinardi, T., Martinelli, A., Lanza, M., Betti, L., Giannaccini, G., Lucacchini, A., Funel, N., León, L. G., Giovannetti, E., Peters, G. J., Palchaudhuri, R., Calvaresi, E. C., Hergenrother, P. J. & Minutolo, F., Mar 24 2011, In : Journal of Medicinal Chemistry. 54, 6, p. 1599-1612 14 p.

Research output: Contribution to journalArticle

Starvation
L-Lactate Dehydrogenase
Protein Isoforms
Glycolysis
Neoplasms