19952019
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Research Output 1995 2019

1995

Chromogenic assay for phospholipase C from bacillus cereus

Hergenrother, P. J., Spaller, M. R., Haas, M. K. & Martin, S. F., Aug 1995, In : Analytical Biochemistry. 229, 2, p. 313-316 4 p.

Research output: Contribution to journalArticle

Chromogenics
Bacillus cereus
Type C Phospholipases
Phosphatidylcholines
Assays
1996

Expression and site-directed mutagenesis of the phosphatidylcholine- preferring phospholipase C of Bacillus cereus: Probing the role of the active site Glu146

Martin, S. F., Spaller, M. R. & Hergenrother, P. J., Oct 19 1996, In : Biochemistry. 35, 39, p. 12970-12977 8 p.

Research output: Contribution to journalArticle

Bacillus cereus
Mutagenesis
Type C Phospholipases
Site-Directed Mutagenesis
Phosphatidylcholines
1997

Chromogenic assay for phospholipase D from Streptomyces chromofuscus: Application to the evaluation of substrate analogs

Hergenrother, P. J., Haas, M. K. & Martin, S. F., Jul 1 1997, In : Lipids. 32, 7, p. 783-788 6 p.

Research output: Contribution to journalArticle

Streptomyces chromofuscus
Chromogenics
Phospholipase D
phospholipase D
Streptomyces
Chromogenics
Bacillus cereus
Type C Phospholipases
Kinetic parameters
Assays
1998
Type C Phospholipases
Phosphatidylcholines
Phospholipids
Bacillus cereus
Phospholipase D

General base catalysis by the phosphatidylcholine-preferring phospholipase C from Bacillus cereus: The role of Glu4 and Asp55

Martin, S. F. & Hergenrother, P. J., Apr 21 1998, In : Biochemistry. 37, 16, p. 5755-5760 6 p.

Research output: Contribution to journalArticle

Bacillus cereus
Type C Phospholipases
Phosphatidylcholines
Catalysis
Catalyst activity
1999
Bacillus cereus
Deuterium
Type C Phospholipases
Phosphatidylcholines
Viscosity
2000

A novel class of zinc-binding inhibitors for the phosphatidylcholine-preferring phospholipase C from Bacillus cereus

Martin, S. F., Follows, B. C., Hergenrother, P. J. & Franklin, C. L., Jul 28 2000, In : Journal of Organic Chemistry. 65, 15, p. 4509-4514 6 p.

Research output: Contribution to journalArticle

Bacillus cereus
Diglycerides
Type C Phospholipases
Phosphatidylcholines
Hydroxyl Radical

Cyclopropylacetylene: [Cyclopropane, ethynyl-]

Corley, E. G., Thompson, A. S., Huntington, M., Hergenrother, P. J. & Martin, S. F., Jan 1 2000, In : Organic Syntheses. 77, 1 p.

Research output: Contribution to journalArticle

cyclopropane

Determination of the substrate specificity of the phospholipase D from Streptomyces chromofuscus via an inorganic phosphate quantitation assay

Martin, S. F., Deblanc, R. L. & Hergenrother, P., Feb 15 2000, In : Analytical Biochemistry. 278, 2, p. 106-110 5 p.

Research output: Contribution to journalArticle

Phospholipase D
Streptomyces
Substrate Specificity
Assays
Phosphatidylglycerols

Small-molecule microarrays: Covalent attachment and screening of alcohol-containing small molecules on glass slides [20]

Hergenrother, P., Depew, K. M. & Schreiber, S. L., Aug 16 2000, In : Journal of the American Chemical Society. 122, 32, p. 7849-7850 2 p.

Research output: Contribution to journalLetter

The choline binding site of phospholipase C (Bacillus cereus): Insights into substrate specificity

Martin, S. F., Follows, B. C., Hergenrother, P. J. & Trotter, B. K., Mar 28 2000, In : Biochemistry. 39, 12, p. 3410-3415 6 p.

Research output: Contribution to journalArticle

Bacillus cereus
Type C Phospholipases
Substrate Specificity
Choline
Binding Sites
2002

Characterization of erythromycin analogs by collisional activated dissociation and infrared multiphoton dissociation in a quadrupole ion trap

Crowe, M. C., Brodbelt, J. S., Goolsby, B. J. & Hergenrother, P., Jun 2002, In : Journal of the American Society for Mass Spectrometry. 13, 6, p. 630-649 20 p.

Research output: Contribution to journalArticle

Erythromycin
Ions
Infrared radiation
Chemical activation
Macrolides

Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays

Kuruvilla, F. G., Shamji, A. F., Sternson, S. M., Hergenrother, P. J. & Schreiber, S. L., Apr 11 2002, In : Nature. 416, 6881, p. 653-657 5 p.

Research output: Contribution to journalArticle

Glucose
Proteins
Protein Binding
Transcription Factors
Genome
2003

Altering substrate specificity of phosphatidylcholine-preferring phospholipase C of Bacillus cereus by random mutagenesis of the headgroup binding site

Antikainen, N. M., Hergenrother, P. J., Harris, M. M., Corbett, W. & Martin, S. F., Feb 18 2003, In : Biochemistry. 42, 6, p. 1603-1610 8 p.

Research output: Contribution to journalArticle

Bacillus cereus
Mutagenesis
Type C Phospholipases
Substrate Specificity
Phosphatidylcholines

An abiotic strategy for the enantioselective synthesis of erythromycin B

Hergenrother, P., Hodgson, A., Judd, A. S., Lee, W. C. & Martin, S. F., Jul 28 2003, In : Angewandte Chemie - International Edition. 42, 28, p. 3278-3281 4 p.

Research output: Contribution to journalArticle

Macrolides
Antibiotics
Carbohydrates
Acids
Anti-Bacterial Agents

Efficient synthesis of enantiopure β-amino-γ-keto acids from L-homoserine

Sharma, A. K. & Hergenrother, P. J., Jun 12 2003, In : Organic Letters. 5, 12, p. 2107-2109 3 p.

Research output: Contribution to journalArticle

Homoserine
Keto Acids
amino acids
Amino acids
Amino Acids

Identification from a Combinatorial Library of a Small Molecule that Selectively Induces Apoptosis in Cancer Cells

Nesterenko, V., Putt, K. S. & Hergenrother, P. J., Dec 3 2003, In : Journal of the American Chemical Society. 125, 48, p. 14672-14673 2 p.

Research output: Contribution to journalArticle

apoptosis
Cell death
cancer
Cells
Apoptosis

The use of pH to influence regio- and chemoselectivity in the asymmetric aminohydroxylation of styrenes

Nesterenko, V., Byers, J. T. & Hergenrother, P. J., Feb 6 2003, In : Organic Letters. 5, 3, p. 281-284 4 p.

Research output: Contribution to journalArticle

Styrenes
Regioselectivity
Reaction products
styrenes
reaction products
2004
Poly Adenosine Diphosphate Ribose
Ribose
Diphosphates
Enzyme Assays
NAD
Assays
Throughput
Adenosine Diphosphate Ribose
poly ADP-ribose glycohydrolase
Molecules

Combating drug-resistant bacteria: Small molecule mimics of plasmid incompatibility as antiplasmid compounds

DeNap, J. C. B., Thomas, J. R., Musk, D. J. & Hergenrother, P. J., Dec 1 2004, In : Journal of the American Chemical Society. 126, 47, p. 15402-15404 3 p.

Research output: Contribution to journalArticle

incompatibility
Antibiotics
plasmid
Bacteria
drug

Deoxystreptamine dimers bind to RNA hairpin loops

Liu, X., Thomas, J. R. & Hergenrother, P. J., Aug 4 2004, In : Journal of the American Chemical Society. 126, 30, p. 9196-9197 2 p.

Research output: Contribution to journalArticle

RNA
Dimers
Aminoglycosides
Molecules
secondary structure
2005

Bacterial death comes full circle: Targeting plasmid replication in drug-resistant bacteria

Denap, J. C. B. & Hergenrother, P. J., Mar 21 2005, In : Organic and Biomolecular Chemistry. 3, 6, p. 959-966 8 p.

Research output: Contribution to journalArticle

plasmids
death
bacteria
Bacteria
drugs

Direct quantitation of poly(ADP-Ribose) polymerase (PARP) activity as a means to distinguish necrotic and apoptotic death in cell and tissue samples

Putt, K. S., Beilman, G. J. & Hergenrother, P. J., Jan 1 2005, In : ChemBioChem. 6, 1, p. 53-55 3 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Cell Death
Necrosis
Tissue
Hemorrhagic Shock

Iron salts perturb biofilm formation and disrupt existing biofilms of Pseudomonas aeruginosa

Musk, D. J., Banko, D. A. & Hergenrother, P. J., Jul 1 2005, In : Chemistry and Biology. 12, 7, p. 789-796 8 p.

Research output: Contribution to journalArticle

Biofilms
Pseudomonas aeruginosa
Iron
Salts
Genes

Microfluidics for combinatorial synthesis and screening on chip

Toepke, M. W., Block, I. D., Nesterenko, V., Choi, C. J., Schudel, B., Cunningham, B. T., Hergenrother, P. & Kenis, P. J. A., Dec 1 2005, 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings. 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Microfluidics
Screening
Fabrication
Assays
Molecules

Size-specific ligands for RNA hairpin loops

Thomas, J. R., Liu, X. & Hergenrother, P. J., Sep 14 2005, In : Journal of the American Chemical Society. 127, 36, p. 12434-12435 2 p.

Research output: Contribution to journalArticle

RNA
ligand
Ligands
targeting
Dimers
Screening
Students
student
drug
Group

Synthesis and identification of small molecules that potently induce apoptosis in melanoma cells through G1 cell cycle arrest

Dothager, R. S., Putt, K. S., Allen, B. J., Leslie, B. J., Nesterenko, V. & Hergenrother, P. J., Jun 22 2005, In : Journal of the American Chemical Society. 127, 24, p. 8686-8696 11 p.

Research output: Contribution to journalArticle

apoptosis
Cell death
drug
Cells
Apoptosis

The relationship between aminoglycosides' RNA binding proclivity and their antiplasmid effect on an IncB plasmid

Thomas, J. R., DeNap, J. C. B., Wong, M. L. & Hergenrother, P. J., May 10 2005, In : Biochemistry. 44, 18, p. 6800-6808 9 p.

Research output: Contribution to journalArticle

Aminoglycosides
Plasmids
RNA
Anti-Bacterial Agents
Bacteria

Using peptidic inhibitors to systematically probe the S1′ site of caspase-3 and caspase-7

Goode, D. R., Sharma, A. K. & Hergenrother, P. J., Aug 4 2005, In : Organic Letters. 7, 16, p. 3529-3532 4 p.

Research output: Contribution to journalArticle

Caspase 7
Caspases
Caspase 3
inhibitors
Substitution reactions
2006

Biochemical and thermodynamic characterization of compounds that bind to RNA hairpin loops: Toward an understanding of selectivity

Thomas, J. R., Liu, X. & Hergenrother, P. J., Sep 12 2006, In : Biochemistry. 45, 36, p. 10928-10938 11 p.

Research output: Contribution to journalArticle

Thermodynamics
RNA
Aminoglycosides
Molecules
Binding energy

Chemical countermeasures for the control of bacterial biofilms: Effective compounds and promising targets

Musk, D. J. & Hergenrother, P. J., Jul 1 2006, In : Current Medicinal Chemistry. 13, 18, p. 2163-2177 15 p.

Research output: Contribution to journalReview article

Biofilms
Quorum Sensing
Infection
Bacterial Infections
Bacteria

Obtaining and screening compound collections: a user's guide and a call to chemists

Hergenrother, P., Jun 1 2006, In : Current Opinion in Chemical Biology. 10, 3, p. 213-218 6 p.

Research output: Contribution to journalReview article

Screening
Ligands
Throughput
Cytology
Proteomics

Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy

Putt, K. S., Chen, G. W., Pearson, J. M., Sandhorst, J. S., Hoagland, M. S., Kwon, J. T., Hwang, S. K., Jin, H., Churchwell, M. I., Cho, M. H., Doerge, D. R., Helferich, W. G. & Hergenrother, P. J., Oct 2006, In : Nature chemical biology. 2, 10, p. 543-550 8 p.

Research output: Contribution to journalArticle

Caspase 3
Caspases
Neoplasms
Apoptosis
Enzyme Precursors

The compound 13-D selectively induces apoptosis in white blood cancers versus other cancer cell types

Putt, K. S., Nesterenko, V., Dothager, R. S. & Hergenrother, P. J., Dec 1 2006, In : ChemBioChem. 7, 12, p. 1916-1922 7 p.

Research output: Contribution to journalArticle

Blood
Cell death
Cells
Apoptosis
Cell Death

The Promises and Pitfalls of Small-Molecule Inhibition of Poly(ADP-Ribose) Glycohydrolase (PARG)

Nottbohm, A. C. & Hergenrother, P. J., Nov 2 2006, Drug Discovery Research: New Frontiers in the Post-Genomic Era. John Wiley & Sons, Inc., p. 163-185 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Poly(ADP-ribose) Polymerases
Molecules
poly ADP-ribose glycohydrolase
2007

A colorimetric substrate for poly(ADP-ribose) polymerase-1, VPARP, and tankyrase-1

Nottbohm, A. C., Dothager, R. S., Putt, K. S., Hoyt, M. T. & Hergenrother, P. J., Jun 29 2007, In : Angewandte Chemie - International Edition. 46, 12, p. 2066-2069 4 p.

Research output: Contribution to journalArticle

Tankyrases
Administrative data processing
Poly(ADP-ribose) Polymerases
Substrates
Adenosine Diphosphate

A continuous fluorometric assay for the assessment of MazF ribonuclease activity

Wang, N. R. & Hergenrother, P. J., Dec 15 2007, In : Analytical Biochemistry. 371, 2, p. 173-183 11 p.

Research output: Contribution to journalArticle

Antitoxins
Ribonucleases
Assays
Plasmids
Biochemistry

A novel synthetic analogue of a constituent of Isodon excisus inhibits transcription of CYP1A1, -1A2 and -1B1 by preventing activation of the aryl hydrocarbon receptor

Sienkiewicz, P., Ciolino, H. P., Leslie, B. J., Hergenrother, P. J., Singletary, K. & Yeh, G. C., May 1 2007, In : Carcinogenesis. 28, 5, p. 1052-1057 6 p.

Research output: Contribution to journalArticle

Isodon
Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Carcinogens
Cytochrome P-450 Enzyme System

DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action

Palchaudhuri, R. & Hergenrother, P., Dec 1 2007, In : Current Opinion in Biotechnology. 18, 6, p. 497-503 7 p.

Research output: Contribution to journalReview article

DNA
Assays
Molecules
Intercalation
Pharmaceutical Preparations

Increased poly(ADP-ribose) polymerase activity during porcine hemorrhagic shock is transient and predictive of mortality

Skarda, D. E., Putt, K. S., Hergenrother, P. J., Mulier, K. E. & Beilman, G. J., Oct 1 2007, In : Resuscitation. 75, 1, p. 135-144 10 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Hemorrhagic Shock
Resuscitation
Swine
Mortality

Multiplex targeting, tracking, and imaging of apoptosis by fluorescent surface enhanced raman spectroscopic dots

Kyeong, N. Y., Lee, S. M., Ji, Y. H., Park, H., Woo, M. A., Mi, S. N., Hwang, S. K., Kwon, J. T., Jin, H., Kim, Y. K., Hergenrother, P. J., Dae, H. J., Lee, Y. S. & Cho, M. H., Jul 1 2007, In : Bioconjugate Chemistry. 18, 4, p. 1155-1162 8 p.

Research output: Contribution to journalArticle

Cell death
Apoptosis
Imaging techniques
Molecular Imaging
Fluorescent Dyes

Poly(ADP-ribose) makes a date with death

Heeres, J. T. & Hergenrother, P. J., Dec 1 2007, In : Current Opinion in Chemical Biology. 11, 6, p. 644-653 10 p.

Research output: Contribution to journalReview article

Apoptosis Inducing Factor
Poly Adenosine Diphosphate Ribose
Mitochondria
Poly(ADP-ribose) Polymerases
Cell death

Reply to 'small molecules not direct activators of caspases' [2]

Hergenrother, P. J., Putt, K. S. & Sandhorst, J. S., Sep 2007, In : Nature chemical biology. 3, 9, 1 p.

Research output: Contribution to journalLetter

Caspase 2

Total synthesis of erythromycin B

Breton, P., Hergenrother, P. J., Hida, T., Hodgson, A., Judd, A. S., Kraynack, E., Kym, P. R., Lee, W. C., Loft, M. S., Yamashita, M. & Martin, S. F., Jun 25 2007, In : Tetrahedron. 63, 26, p. 5709-5729 21 p.

Research output: Contribution to journalArticle

Acids
Lactones
Bearings (structural)
Glycosylation
Cyclization
Antitoxins
Plasmids
Genes
Enterococcus
Vancomycin
2008

A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors

Chan, L. L., Pineda, M., Heeres, J. T., Hergenrother, P. J. & Cunningham, B. T., Jul 18 2008, In : ACS chemical biology. 3, 7, p. 437-448 12 p.

Research output: Contribution to journalArticle

Optics and Photonics
Biosensing Techniques
Photonic crystals
Biosensors
DNA-Binding Proteins