19952019
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Molecules Chemical Compounds
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Neoplasms Medicine & Life Sciences
Assays Chemical Compounds
Biological Products Chemical Compounds
Biosensing Techniques Medicine & Life Sciences

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Research Output 1995 2019

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

Llabani, E., Hicklin, R. W., Lee, H. Y., Motika, S. E., Crawford, L. A., Weerapana, E. & Hergenrother, P., Jun 1 2019, In : Nature Chemistry. 11, 6, p. 521-532 12 p.

Research output: Contribution to journalArticle

Thioredoxins
Biological Products
Screening
Clustered Regularly Interspaced Short Palindromic Repeats
Molecules

Editorial overview: From the iceman to modern medicine

Aye, Y. & Hergenrother, P., Jun 1 2019, In : Current Opinion in Chemical Biology. 50, p. A1-A2

Research output: Contribution to journalEditorial

Modern 1601-history
Medicine

Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene

Bingham, T. W., Hernandez, L. W., Olson, D. G., Svec, R. L., Hergenrother, P. & Sarlah, D., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 657-670 14 p.

Research output: Contribution to journalArticle

Alkaloids
alkaloid
Benzene
Biological Products
benzene

Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. & Fan, T. M., Jan 1 2019, In : Frontiers in Oncology. 9, FEB, 96.

Research output: Contribution to journalArticle

Open Access
Brain Neoplasms
Caspase 3
Canidae
Meningioma
Glioma

Structural analyses of NudT16–ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins

Thirawatananond, P., McPherson, R. L., Malhi, J., Nathan, S., Lambrecht, M. J., Brichacek, M., Hergenrother, P., Leung, A. K. L. & Gabelli, S. B., Dec 1 2019, In : Scientific reports. 9, 1, 5940.

Research output: Contribution to journalArticle

Open Access
Adenosine Diphosphate Ribose
Ribose
Proteins
Poly Adenosine Diphosphate Ribose
ADP-ribosylarginine hydrolase