19952019
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Research Output 1995 2019

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

Llabani, E., Hicklin, R. W., Lee, H. Y., Motika, S. E., Crawford, L. A., Weerapana, E. & Hergenrother, P., Jun 1 2019, In : Nature Chemistry. 11, 6, p. 521-532 12 p.

Research output: Contribution to journalArticle

Thioredoxins
Biological Products
Screening
Clustered Regularly Interspaced Short Palindromic Repeats
Molecules

Editorial overview: From the iceman to modern medicine

Aye, Y. & Hergenrother, P., Jun 2019, In : Current Opinion in Chemical Biology. 50, p. A1-A2

Research output: Contribution to journalEditorial

Modern 1601-history
Medicine

Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene

Bingham, T. W., Hernandez, L. W., Olson, D. G., Svec, R. L., Hergenrother, P. J. & Sarlah, D., Jan 9 2019, In : Journal of the American Chemical Society. 141, 1, p. 657-670 14 p.

Research output: Contribution to journalArticle

Alkaloids
alkaloid
Benzene
Biological Products
benzene

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

Janin, M., Ortiz-Barahona, V., de Moura, M. C., Martínez-Cardús, A., Llinàs-Arias, P., Soler, M., Nachmani, D., Pelletier, J., Schumann, U., Calleja-Cervantes, M. E., Moran, S., Guil, S., Bueno-Costa, A., Piñeyro, D., Perez-Salvia, M., Rosselló-Tortella, M., Piqué, L., Bech-Serra, J. J., De La Torre, C., Vidal, A. & 36 others, Martínez-Iniesta, M., Martín-Tejera, J. F., Villanueva, A., Arias, A., Cuartas, I., Aransay, A. M., La Madrid, A. M., Carcaboso, A. M., Santa-Maria, V., Mora, J., Fernandez, A. F., Fraga, M. F., Aldecoa, I., Pedrosa, L., Graus, F., Vidal, N., Martínez-Soler, F., Tortosa, A., Carrato, C., Balañá, C., Boudreau, M. W., Hergenrother, P. J., Kötter, P., Entian, K. D., Hench, J., Frank, S., Mansouri, S., Zadeh, G., Dans, P. D., Orozco, M., Thomas, G., Blanco, S., Seoane, J., Preiss, T., Pandolfi, P. P. & Esteller, M., Dec 1 2019, In : Acta Neuropathologica. 138, 6, p. 1053-1074 22 p.

Research output: Contribution to journalArticle

Open Access
Methyltransferases
Ribosomes
Epigenomics
Glioma
RNA

Immunohistochemical characterization of procaspase-3 overexpression as a druggable target with PAC-1, a procaspase-3 activator, in canine and human brain cancers

Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., Dickinson, P. J., Hergenrother, P. J. & Fan, T. M., Jan 1 2019, In : Frontiers in Oncology. 9, FEB, 96.

Research output: Contribution to journalArticle

Open Access
Brain Neoplasms
Caspase 3
Canidae
Meningioma
Glioma