Pablo Perez Pinera

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2020

ABC-GWAS: Functional Annotation of Estrogen Receptor-Positive Breast Cancer Genetic Variants

Manjunath, M., Zhang, Y., Zhang, S., Roy, S., Perez-Pinera, P. & Song, J. S., Jul 20 2020, In : Frontiers in Genetics. 11, 730.

Research output: Contribution to journalArticle

Open Access

Epigenetic engineering of yeast reveals dynamic molecular adaptation to methylation stress and genetic modulators of specific DNMT3 family members

Finnegan, A. I., Kim, S., Jin, H., Gapinske, M., Woods, W. S., Perez-Pinera, P. & Song, J. S., May 7 2020, In : Nucleic acids research. 48, 8, p. 4081-4099 19 p.

Research output: Contribution to journalArticle

Open Access

Treatment of a Mouse Model of ALS by In Vivo Base Editing

Lim, C. K. W., Gapinske, M., Brooks, A. K., Woods, W. S., Powell, J. E., Zeballos C., M. A., Winter, J., Perez-Pinera, P. & Gaj, T., Jan 1 2020, (Accepted/In press) In : Molecular Therapy. 28, 4, p. 1177-1189 13 p.

Research output: Contribution to journalArticle

2019

Multiplexed and tunable transcriptional activation by promoter insertion using nuclease-assisted vector integration

Brown, A., Winter, J., Gapinske, M., Tague, N., Woods, W. S. & Perez-Pinera, P., Jul 9 2019, In : Nucleic acids research. 47, 12, p. e67

Research output: Contribution to journalArticle

Open Access

Targeted exon skipping with AAV-mediated split adenine base editors

Winter, J., Luu, A., Gapinske, M., Manandhar, S., Shirguppe, S., Woods, W. S., Song, J. S. & Perez-Pinera, P., Dec 1 2019, In : Cell Discovery. 5, 1, 41.

Research output: Contribution to journalArticle

Open Access
2018

CRISPR-SKIP: Programmable gene splicing with single base editors

Gapinske, M., Luu, A., Winter, J., Woods, W. S., Kostan, K. A., Shiva, N., Song, J. S. & Perez-Pinera, P., Aug 15 2018, In : Genome biology. 19, 1, 107.

Research output: Contribution to journalArticle

Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner

Mancini, A., Xavier-Magalhães, A., Woods, W. S., Nguyen, K. T., Amen, A. M., Hayes, J. L., Fellmann, C., Gapinske, M., McKinney, A. M., Hong, C., Jones, L. E., Walsh, K. M., Bell, R. J. A., Doudna, J. A., Costa, B. M., Song, J. S., Perez-Pinera, P. & Costello, J. F., Sep 10 2018, In : Cancer Cell. 34, 3, p. 513-528.e8

Research output: Contribution to journalArticle

The continuously evolving CRISPR barcoding toolbox Jin-Soo Kim

Gaj, T. & Perez-Pinera, P., Sep 25 2018, In : Genome biology. 19, 1, 143.

Research output: Contribution to journalArticle

Versatile and on-demand biologics co-production in yeast

Cao, J., Perez-Pinera, P., Lowenhaupt, K., Wu, M. R., Purcell, O., De La Fuente-Nunez, C. & Lu, T. K., Dec 1 2018, In : Nature communications. 9, 1, 77.

Research output: Contribution to journalArticle

2017

Damage, Healing, and Remodeling in Optogenetic Skeletal Muscle Bioactuators

Raman, R., Grant, L., Seo, Y., Cvetkovic, C., Gapinske, M., Palasz, A., Dabbous, H., Kong, H., Pinera, P. P. & Bashir, R., Jun 21 2017, In : Advanced Healthcare Materials. 6, 12, 1700030.

Research output: Contribution to journalArticle

Mammalian Synthetic Biology: Engineering Biological Systems

Black, J. B., Perez-Pinera, P. & Gersbach, C. A., Jun 21 2017, In : Annual Review of Biomedical Engineering. 19, p. 249-277 29 p.

Research output: Contribution to journalArticle

Production of Functional Anti-Ebola Antibodies in Pichia pastoris

Purcell, O., Opdensteinen, P., Chen, W., Lowenhaupt, K., Brown, A., Hermann, M., Cao, J., Tenhaef, N., Kallweit, E., Kastilan, R., Sinskey, A. J., Perez-Pinera, P., Buyel, J. F. & Lu, T. K., Dec 15 2017, In : ACS synthetic biology. 6, 12, p. 2183-2190 8 p.

Research output: Contribution to journalArticle

Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

Chaudhary, R., Gryder, B., Woods, W. S., Subramanian, M., Jones, M. F., Li, X. L., Jenkins, L. M., Shabalina, S. A., Mo, M., Dasso, M., Yang, Y., Wakefield, L. M., Zhu, Y., Frier, S. M., Moriarity, B. S., Prasanth, K. V., Perez-Pinera, P. & Lal, A., Jun 5 2017, In : eLife. 6, e23244.

Research output: Contribution to journalArticle

Targeted gene activation using RNA-guided nucleases

Brown, A., Woods, W. S. & Perez-Pinera, P., Jan 1 2017, In : Methods in Molecular Biology. 1468, p. 235-250 16 p.

Research output: Contribution to journalArticle

2016

Design and integration of a problem-based biofabrication course into an undergraduate biomedical engineering curriculum

Raman, R., Mitchell, M., Perez-Pinera, P., Bashir, R. & DeStefano, L., Sep 21 2016, In : Journal of Biological Engineering. 10, 1, 10.

Research output: Contribution to journalArticle

In vivo zinc finger nuclease-mediated targeted integration of a glucose-6-phosphatase transgene promotes survival in mice with glycogen storage disease Type IA

Landau, D. J., Brooks, E. D., Perez-Pinera, P., Amarasekara, H., Mefferd, A., Li, S., Bird, A., Gersbach, C. A. & Koeberl, D. D., Apr 1 2016, In : Molecular Therapy. 24, 4, p. 697-706 10 p.

Research output: Contribution to journalArticle

Multiplexed Targeted Genome Engineering Using a Universal Nuclease-Assisted Vector Integration System

Brown, A., Woods, W. S. & Perez-Pinera, P., Jul 15 2016, In : ACS synthetic biology. 5, 7, p. 582-588 7 p.

Research output: Contribution to journalArticle

Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Perez-Pinera, P., Han, N., Cleto, S., Cao, J., Purcell, O., Shah, K. A., Lee, K., Ram, R. & Lu, T. K., Jul 29 2016, In : Nature communications. 7, 12211.

Research output: Contribution to journalArticle

2015

Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases

Ousterout, D. G., Kabadi, A. M., Thakore, P. I., Perez-Pinera, P., Brown, M. T., Majoros, W. H., Reddy, T. E. & Gersbach, C. A., Mar 5 2015, In : Molecular Therapy. 23, 3, p. 523-532 10 p.

Research output: Contribution to journalArticle

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

Polstein, L. R., Perez-Pinera, P., Kocak, D. D., Vockley, C. M., Bledsoe, P., Song, L., Safi, A., Crawford, G. E., Reddy, T. E. & Gersbach, C. A., Aug 1 2015, In : Genome Research. 25, 8, p. 1158-1169 12 p.

Research output: Contribution to journalArticle

2014

Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells

Nissim, L., Perli, S. D., Fridkin, A., Perez-Pinera, P. & Lu, T. K., May 22 2014, In : Molecular cell. 54, 4, p. 698-710 13 p.

Research output: Contribution to journalArticle

Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage

Brunger, J. M., Huynh, N. P. T., Guenther, C. M., Perez-Pinera, P., Moutos, F. T., Sanchez-Adams, J., Gersbach, C. A. & Guilak, F., Mar 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 9, p. E798-E806

Research output: Contribution to journalArticle

2013

Reading frame correction by targeted genome editing restores dystrophin expression in cells from duchenne muscular dystrophy patients

Ousterout, D. G., Perez-Pinera, P., Thakore, P. I., Kabadi, A. M., Brown, M. T., Qin, X., Fedrigo, O., Mouly, V., Tremblay, J. P. & Gersbach, C. A., Sep 2013, In : Molecular Therapy. 21, 9, p. 1718-1726 9 p.

Research output: Contribution to journalArticle

RNA-guided gene activation by CRISPR-Cas9-based transcription factors

Perez-Pinera, P., Kocak, D. D., Vockley, C. M., Adler, A. F., Kabadi, A. M., Polstein, L. R., Thakore, P. I., Glass, K. A., Ousterout, D. G., Leong, K. W., Guilak, F., Crawford, G. E., Reddy, T. E. & Gersbach, C. A., Oct 1 2013, In : Nature Methods. 10, 10, p. 973-976 4 p.

Research output: Contribution to journalArticle

Synergistic and tunable human gene activation by combinations of synthetic transcription factors

Perez-Pinera, P., Ousterout, D. G., Brunger, J. M., Farin, A. M., Glass, K. A., Guilak, F., Crawford, G. E., Hartemink, A. J. & Gersbach, C. A., Mar 1 2013, In : Nature Methods. 10, 3, p. 239-242 4 p.

Research output: Contribution to journalArticle

2012

Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases

Perez-Pinera, P., Ousterout, D. G., Brown, M. T. & Gersbach, C. A., Apr 2012, In : Nucleic acids research. 40, 8, p. 3741-3752 12 p.

Research output: Contribution to journalArticle

Pleiotrophin Expression during Odontogenesis

Erlandsen, H., Ames, J. E., Tamkenath, A., Mamaeva, O., Stidham, K., Wilson, M. E., Perez-Pinera, P., Deuel, T. F. & MacDougall, M., May 2012, In : Journal of Histochemistry and Cytochemistry. 60, 5, p. 366-375 10 p.

Research output: Contribution to journalArticle

2011

Human odontoblasts express transient receptor protein and acid-sensing ion channel mechanosensor proteins

Solé-Magdalena, A., Revuelta, E. G., Menénez-Díaz, I., Calavia, M. G., Cobo, T., García-Suárez, O., Pérez-Piñera, P., De Carlos, F., Cobo, J. & Vega, J. A., May 2011, In : Microscopy research and technique. 74, 5, p. 457-463 7 p.

Research output: Contribution to journalArticle

Immunotherapy for alzheimer's disease: Rational basis in ongoing clinical trials

Menéndez-González, M., Pérez-Piñera, P., Martínez-Rivera, M., Muñiz, A. L. & Vega, J. A., Feb 1 2011, In : Current Pharmaceutical Design. 17, 5, p. 508-520 13 p.

Research output: Contribution to journalArticle

2010

Differential localization of acid-sensing ion channels 1 and 2 in human cutaneus pacinian corpuscles

Calavia, M. G., Montaño, J. A., García-Suárez, O., Feito, J., Guervós, M. A., Germanà, A., Del Valle, M., Pérez-Piñera, P., Cobo, J. & Vega, J. A., Aug 2010, In : Cellular and Molecular Neurobiology. 30, 6, p. 841-848 8 p.

Research output: Contribution to journalArticle

Expression and cell localization of brain-derived neurotrophic factor and TrkB during zebrafish retinal development

Germanà, A., Sánchez-Ramos, C., Guerrera, M. C., Calavia, M. G., Navarro, M., Zichichi, R., García-Suárez, O., Pérez-Piñera, P. & Vega, J. A., Sep 2010, In : Journal of Anatomy. 217, 3, p. 214-222 9 p.

Research output: Contribution to journalArticle

Immunohistochemical profile of human pancreatic pacinian corpuscles

García-Suárez, O., Calavia, M. G., Pérez-Moltó, F. J., Alvarez-Abad, C., Pérez-Piñera, P., Cobo, J. M. & Vega, J. A., Apr 2010, In : Pancreas. 39, 3, p. 403-410 8 p.

Research output: Contribution to journalArticle

The lamellar cells in human Meissner corpuscles express TrkB

Calavia, M. G., Feito, J., López-Iglesias, L., de Carlos, F., García-Suarez, O., Pérez-Piñera, P., Cobo, J. & Vega, J. A., Jan 4 2010, In : Neuroscience Letters. 468, 2, p. 106-109 4 p.

Research output: Contribution to journalArticle

The neurotrophic factor pleiotrophin modulates amphetamine-seeking behaviour and amphetamine-induced neurotoxic effects: Evidence from pleiotrophin knockout mice

Gramage, E., Putelli, A., Polanco, M. J., González-Martín, C., Ezquerra, L., Alguacil, L. F., Pérez-Pinera, P., Deuel, T. F. & Herradón, G., Oct 1 2010, In : Addiction Biology. 15, 4, p. 403-412 10 p.

Research output: Contribution to journalArticle

2009

Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development

Levanti, M. B., Esteban, I., Ciriaco, E., Pérez-Piñera, P., Cabo, R., García-Suarez, O., Pardo, B., Silos-Santiago, I., Cobo, J. & Vega, J. A., Apr 17 2009, In : Neuroscience Letters. 454, 1, p. 16-21 6 p.

Research output: Contribution to journalArticle

Pleiotrophin inhibits hippocampal long-term potentiation: A role of pleiotrophin in learning and memory

del Olmo, N., Gramage, E., Alguacil, L. F., Pérez-Pinera, P., Deuel, T. F. & Herradón, G., Aug 13 2009, In : Growth Factors. 27, 3, p. 189-194 6 p.

Research output: Contribution to journalArticle

Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: A novel mechanism of tumor-induced vasculogenesis

Chen, H., Campbell, R. A., Chang, Y., Li, M., Wang, C. S., Li, J., Sanchez, E., Share, M., Steinberg, J., Berenson, A., Shalitin, D., Zeng, Z., Gui, D., Perez-Pinera, P., Berenson, R. J., Said, J., Bonavida, B., Deuel, T. F. & Berenson, J. R., Feb 26 2009, In : Blood. 113, 9, p. 1992-2002 11 p.

Research output: Contribution to journalArticle

The expression of ENa+C and ASIC2 proteins in Pacinian corpuscles is differently regulated by TrkB and its ligands BDNF and NT-4

Montaño, J. A., Calavia, M. G., García-Suárez, O., Suarez-Quintanilla, J. A., Gálvez, A., Pérez-Piñera, P., Cobo, J. & Vega, J. A., Oct 2 2009, In : Neuroscience Letters. 463, 2, p. 114-118 5 p.

Research output: Contribution to journalArticle

TrkB is necessary for the normal development of the lung

García-Suárez, O., Pérez-Pinera, P., Laurà, R., Germana, A., Esteban, I., Cabo, R., Silos-Santiago, I., Cobo, J. L. & Vega, J. A., Jul 31 2009, In : Respiratory Physiology and Neurobiology. 167, 3, p. 281-291 11 p.

Research output: Contribution to journalArticle

2008

Characterization of sensory deficits in TrkB knockout mice

Perez-Pinera, P., García-Suarez, O., Germanà, A., Díaz-Esnal, B., de Carlos, F., Silos-Santiago, I., del Valle, M. E., Cobo, J. & Vega, J. A., Mar 5 2008, In : Neuroscience Letters. 433, 1, p. 43-47 5 p.

Research output: Contribution to journalArticle

Value of measuring plasmatic levels of neurosin in the diagnosis of Alzheimer's disease

Menendez-Gonzalez, M., Castro-Santos, P., Suarez, A., Calatayud, M. T., Perez-Pinera, P., Martinez, M., Ribacoba, R. & Gutierrez, C., 2008, In : Journal of Alzheimer's Disease. 14, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

2007

Anaplastic lymphoma kinase is expressed in different subtypes of human breast cancer

Perez-Pinera, P., Chang, Y., Astudillo, A., Mortimer, J. & Deuel, T. F., Jun 29 2007, In : Biochemical and Biophysical Research Communications. 358, 2, p. 399-403 5 p.

Research output: Contribution to journalArticle

Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironment

Chang, Y., Zuka, M., Perez-Pinera, P., Astudillo, A., Mortimer, J., Berenson, J. R. & Deuel, T. F., Jun 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 26, p. 10888-10893 6 p.

Research output: Contribution to journalArticle

The receptor protein tyrosine phosphatase (RPTP)β/ζ is expressed in different subtypes of human breast cancer

Perez-Pinera, P., Garcia-Suarez, O., Menendez-Rodriguez, P., Mortimer, J., Chang, Y., Astudillo, A. & Deuel, T. F., Oct 12 2007, In : Biochemical and Biophysical Research Communications. 362, 1, p. 5-10 6 p.

Research output: Contribution to journalArticle

The Trk tyrosine kinase inhibitor K252a regulates growth of lung adenocarcinomas

Perez-Pinera, P., Hernandez, T., García-Suárez, O., de Carlos, F., Germana, A., Valle, M., Astudillo, A. & Vega, J. A., Jan 2007, In : Molecular and Cellular Biochemistry. 295, 1-2, p. 19-26 8 p.

Research output: Contribution to journalArticle

2006

AINEs y estatinas para el tratamiento de la Enfermedad de Alzheimer

Translated title of the contribution: NSAIs and statins for the treatment of Alzheimer's diseaseMenéndez González, M., Martínez Rivera, M., Pérez Piñera, P. & Calatayud Noguera, M. T., Jun 5 2006, In : Archivos de Medicina. 2, 2

Research output: Contribution to journalArticle

Deletion of DNA sequences of using a polymerase chain reaction based approach

Pérez-Pinera, P., Menéndez-González, M. & Vega, J. A., Oct 15 2006, In : Electronic Journal of Biotechnology. 9, 5, p. 604-609 6 p.

Research output: Contribution to journalArticle

Hypertonicity activates GSK3β in tumor cells

Perez-Pinera, P., Menendez-Gonzalez, M., del Valle, M. & Vega, J. A., Oct 1 2006, In : Molecular and Cellular Biochemistry. 291, 1-2, p. 93-100 8 p.

Research output: Contribution to journalArticle

Identification of the angiogenesis signaling domain in pleiotrophin defines a mechanism of the angiogenic switch

Zhang, N., Zhong, R., Perez-Pinera, P., Herradon, G., Ezquerra, L., Wang, Z. Y. & Deuel, T. F., May 5 2006, In : Biochemical and Biophysical Research Communications. 343, 2, p. 653-658 6 p.

Research output: Contribution to journalArticle